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| 1 | A New Species of the Genus Tylototriton(Amphibia: Urodela: Salamandridae) from the Southern Dabie Mountains in Anhui Province显示文摘A new species of the genus Tylototriton is described,from Yuexi county,Anhui province,in the south of the Dabie Mountains.It is based on morphological and molecular analysis.The new species is identified as belonging to the Tylototriton asperrimus group and shares a number of similarities with T.wenxianensis,T.broadoridgus and T.dabienicus.The diagnostic characteristics of the new species are as follows: the head length is greater than the width of the head; bony ridges on the head are prominent and necked-in; the distal digit ends,ventral digits,peripheral area of the cloaca and the tail's lower edge are orange.The result from the molecular analysis of the genus Tylototriton(including the type specimen of the new species) based on three mitochondrial genes(ND1,ND2 and CYTB) indicated that the new species was close to T.wenxianensis,T.dabienicus,and T.broadoridgus,but formed an independent clade.This result was consistent with the morphological analysis above,which supports the theory that the population distributed in the south of the Dabie Mountains,namely in from Yuexi county,Anhui province,represented a distinct species,Tylototriton anhuiensis sp.nov. | Lifu QIAN Xiaonan SUN Jiaqi LI Weibo GUO Tao PAN Xing KANG Hui WANG Jianping JIANG Jun WU Baowei ZHANG | 2017 | Asian Herpetological Research2017，18，3： | 6 |
| 2 | Protein expression and fucosylated glycans of the serum haptoglobin-β subunit in hepatitis B virus-based liver diseases显示文摘Glycosylation,调整 glycoproteins 的配置和功能,是最重要的 translational 以后修正。学习是在 glycan 和浆液 haptoglobin- 子单元(Hp-) 的蛋白质部分观察微分模式的这的目的与肝炎 B 从病人净化了病毒(HBV ) 感染,肝肝硬化(LC ) ,或 hepatocellular 癌(HCC ) 。2-D 胶化电气泳动和多路的 proteomics 染色技术被采用调查 Hp- glycan 水平是否与蛋白质水平成正比。Multi-lectin 污点,高效的液体层析(HPLC ) ,和西方的污点分析被执行识别 Hp- 份量上的 glycoform。我们的实验证明到 Hp- 的 glycosylated 形式的全部的浆液 Hp- 的比率与不同的肝疾病在病人之中变化了。全部的 Hp- 蛋白质表示水平比 LC 在 HCC 是高得多的,当 fucosylated Hp- 的一个增长比例也在 HBV 和健康控制与那相比在 LC 和 HCC 病人被观察时。微分 fucosylation 被 HPLC 和反人的 SialylLewis X 抗体进一步作为路易斯十世结构识别。在结论, Hp- glycan 和全部的蛋白质表示的异常引申可以是为早 hepatocarcinogenesis 的有希望的 biomarker。 | Hong Shu Shu Zhang Xiaonan Kang Shan Li Xue Qin Chun Sun Haojie Lu Yinkun Liu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 6 |
| 3 | Serum paraoxonase 1 heteroplasmon, a fucosylated, and sialylated glycoprotein in distinguishing early hepatocellular carcinoma from liver cirrhosis patients显示文摘浆液 glycoproteins 的异常 glycan 结构在 hepatocellular 癌(HCC ) 的不同阶段创造唯一的模式,它为 HCC 的早诊断提供潜在的 glycan biomarkers。在这研究,双人脚踏车 lectin 亲密关系层析使用 aleuria aurantia lectin ( AAL )和小麦细菌凝集素( WGA )被处理从 27 肝肝硬化( LC )和 27 个早 HCC 病人净化 fucosylated 和 sialylated 浆液 glycoproteins ,在哪个 122 glycoproteins 被液体层析双人脚踏车团 spectrometry ( LC-MSMS )最后外面屏蔽。在 LC-MSMS 识别的 122 蛋白质之中,他们中的 8 个仅仅在 HCC 浆液被识别, 6 仅仅在 LC 浆液存在。浆液 paraoxonase (PON1 ) 1 是从 47 个单个病人的 immunoprecipitated 并且在 LC 比那些在 HCC 浆液由 lectins,出现提高的 fucosylation 和 sialylation 弄污浆液。在为 AAL 反应的 PON1 的 ROC 曲线(AUROC ) 下面的区域在把早 HCC 区分开来与 LC 与 71.4% 的敏感和 94.7% 的特性是 0.892。同样, WGA 反应的 PON1 与 95.2% 的敏感和 78.9% 的特性有 0.902 的 AUROC。数据显示浆液 PON1 的 glycan 差别可能为把早 HCC 与 LC 病人区分开来提供同样潜在的 glycan biomarkers。 | Chun Sun Pei Chen Qiaopei Chen Lu Sun Xiaonan Kang Xue Qin Yinkun Liu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，9： | 6 |
| 4 | Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance显示文摘 | Yunwen Hu Shuihua Lu Zhigang Song Wei Wang Pei Hao Jianhua Li Xiaonan Zhang Hui-Ling Yen Bisheng Shi Tao Li Wencai Guan Lei Xu Yi Liu Sen Wang Xiaoling Zhang Di Tian Zhaoqin Zhu Jing He Kai Huang Huijie Chen Lulu Zheng Xuan Li Jie Ping Bin Kang Xiuhong Xi | 2013 | The Lancet2013，，9885： | 1 |
| 5 | Tumor-derived secretory clusterin induces epithelial–mesenchymal transition and facilitates hepatocellular carcinoma metastasis显示文摘 | Cun Wang Kai Jiang Xiaonan Kang Dongmei Gao Chun Sun Yan Li Lu Sun Shu Zhang Xiaohui Liu Weizhong Wu Pengyuan Yang Kun Guo Yinkun Liu | 2012 | International Journal of Biochemistry and Cell Biology2012，，12： | 1 |
| 6 | Pseudo Rabies Virus Protein UL34 Interacted with UL31 to Disrupt the Human Lamin A显示文摘从原子核由的假狂犬病病毒(PRV ) 外出从内部原子膜(INM ) 开始发育。原子薄板形成位于 INM 下面的中间的细丝的一个僵硬网状组织。PRV 感染是否导致薄板的混乱,仍然保持未知。在这份报纸,原子 Lamin A 变得在 PRV 感染期间断裂了,这能被观察。UL34 在原子边界是局部性的,但是 UL31 作为不同补丁在原子核被积累。有趣地, UL31 的部分面对 UL34 在 INM 是局部性的。Immunoprecipitation (IP ) 试金证实了那 PRV UL31, UL34 在 transfected 房间交往了。重要地, UL31 和 UL34 的合作表示直接破坏了 Lamin A,类似于在 PRV 感染期间观察了那。在结论, PRV 感染导致 Lamin A,和 UL34 和 UL31 玩的混乱在 Lamin A 的混乱的一个关键角色。 | WEI Wenqiang HU Zichao KANG Xiaonan WANG Xuan WANG Hongju JI Shaoping | 2018 | Wuhan University Journal of Natural Sciences2018，23，5： | 1 |
| 7 | Prediction of chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma by SELDI-based serum decision tree classification显示文摘 | Jiefeng Cui Xiaonan Kang Zhi Dai Cheng Huang Haijun Zhou Kun Guo Yan Li Yu Zhang Ruixia Sun Jie Chen Yang Li Zhaoyou Tang Toshimasa Uemura Yinkun Liu | 2007 | Journal of Cancer Research and Clinical Oncology2007，，11： | 1 |
| 8 | Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance显示文摘 | Yunwen Hu Shuihua Lu Zhigang Song Wei Wang Pei Hao Jianhua Li Xiaonan Zhang Hui-Ling Yen Bisheng Shi Tao Li Wencai Guan Lei Xu Yi Liu Sen Wang Xiaoling Zhang Di Tian Zhaoqin Zhu Jing He Kai Huang Huijie Chen Lulu Zheng Xuan Li Jie Ping Bin Kang Xiuhong Xi | 2013 | The Lancet2013，，9885： | 1 |
| 9 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 10 | resign of Linear Injector for SSC显示文摘 | He Yuan Wang Zhijun Xiao Chen Du Xiaonan Zhao Hongwei Xia Jiawen Lu Yuanrong Wang Zhi Zhu Kun Kang Minglei Zhou Ouanfeng Chen Jiaer | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
| 11 | The Impact of a Health Forecasting Service on the Visits and Costs in Outpatient and Emergency Departments for COPD Patients--Shanghai Municipality,China,October 2019–April 2020显示文摘What is already known on this topic?The morbidity and mortality of chronic obstructive pulmonary disease(COPD)is associated with adverse weather and air pollution.However,COPD patients are not able to be alerted in advance of high risk environments.What is added by this report?This prospective controlled trial conducted in Pudong New Area of Shanghai from October 2019 to April 2020 provided evidence of COPD risk forecasting service on the reductions in visits and costs of COPD patients in outpatient and emergency departments in China for the first time.What are the implications for public health practice?This study suggests that COPD risk forecasting service could be integrated into existing COPD management in public health to improve the health and economic outcomes. | Xiaofang Ye Zhitao Li Xin Zhou Xiaonan Ruan Tao Lin Ji Zhou Dandan Yang Sixu Yang Xiaodan Chen Kang Wu Xiaonan Wang Juzhong Ke Xiaolin Liu Li Peng Li Luo | 2021 | China CDC weekly2021，3，23： | 0 |
| 12 | Long-term exposure to air pollution and cerebrovascular disease:findings from Beijing Health Management Cohort study显示文摘The relationship between air pollution and cerebrovascular disease has become a popular topic,yet research findings are highly heterogeneous.This study aims to investigate this association based on detailed individual health data and a precise evaluation of their exposure levels.The integrated models of generalized additive model,land use regression model and back propagation neural network were used to evaluate the exposure concentrations.And doubly robust additive model was conducted to explore the association between cerebrovascular disease and air pollution after adjusted for demographic characteristics,physical examination,disease information,geographic and socioeconomic status.A total of 25097 subjects were included in the Beijing Health Management Cohort from 2013 to 2018.With a 1µg/m^(3)increase in the concentrations of PM_(2.5),SO_(2)and NO_(2),the incidence risk of cerebrovascular disease increased by 1.02(95%CI:1.008–1.034),1.06(95%CI:1.034–1.095)and 1.02(95%CI:1.010–1.029)respectively.Whereas CO exposure could decrease the risk,with an odds ratio of 0.38(95%CI:0.212–0.626).In the subgroup analysis,individuals under the age of 50 with normal BMI were at higher risk caused by PM2.5,and So2 was considered more hazardous to women.Meanwhile,the protective effect of CO on women and those with normal BMI was stronger.Successful reduction of long-term exposure to PM2.5,SO_(2)and NO_(2)would lead to substantial benefits for decrease the risk of cerebrovascular disease especially for the health of the susceptible individuals. | Yuhan Zhao Xiaoping Kang Xue Tian Lulu Liu Zemeng Zhao Lili Luo Lixin Tao Xiangtong Liu Xiaonan Wang Xiuhua Guo Juan Xia Yanxia Luo | 2023 | Frontiers of Environmental Science & Engineering2023，17，7： | 0 |
| 13 | The role of autophagy in regulating metabolism in the tumor microenvironment显示文摘Autophagy,as a special programmed cell death,is a critical degradative process that eliminates intracellular abnormal proteins or damage organelles to balance cell energy and favor cell metabolism with autophagy-related(ATG)proteins.Autophagy activation is being increasingly recognized as an essential hallmark in tumorigenesis through influencing the metabolism of stromal cells in the tumor microenvironment(TME)which comprises of tumor cells,cancer-associated fibroblasts(CAFs),cancer-associated endothelial cells(CAEs),immune cells and adipocytes.Tumor cells can reuse autophagy-involved recycling to maintain mitochondrial function and energy supply to meet the metabolic demand of their growth and proliferation.However,the mechanism through which autophagy can promote a crosstalk between tumor and stroma cells is not clear.Reprogramed metabolism is one of the main characteristics of TME leading to higher adaptability of tumor cells with diverse mechanisms.The activation of autophagy has expanded our understanding on the interaction between tumor metabolism and TME.The aim of this review is to report recent advances on the metabolic cross-talk between stromal cells and solid tumor cells induced by autophagy in TME and revealed potential therapeutic targets. | Panpan Zhang Shanshan Cheng Xiaonan Sheng Huijuan Dai Kang He Yueyao Du | 2023 | Genes & Diseases2023，10，2： | 0 |
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