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| 1 | Endoplasmic reticulum stress is involved in podocyte apoptosis induced by saturated fatty acid palmitate显示文摘 | TAO Jian-ling WEN Yu-bing SHI Bing-yang ZHANG Hong RUAN Xiong-zhong LI Hang LI Xue-mei DONG Wen-ji LI Xue-wang | 2012 | Chinese Medical Journal2012，，17： | 15 |
| 2 | Strengths, weaknesses, opportunities and threats (SWOT) analysis of reinitiation into methamphetamine abusers: qualitative findings from an exploration of methamphetamine abusers in Shanghai, China显示文摘Background Despite high relapse rate among methamphetamine (MA) abusers, there still have been little empirical data to date detecting the risk factors related to craving and relapse from the perspective of MA abusers. Therefore, the aim of this study was to use qualitative research methods exploring the strengths, weaknesses, opportunities and threat factors that could facilitate or impede individuals' abstinence in a real-life context from the perspectives of MA abusers. Aim To use qualitative research methods exploring the strengths, weaknesses, opportunities and threat factors relating to individuals' abstinence in a real-life context. Method Semistructured interviews were conducted with 32 MA abusers recruited in Shanghai guided by open-ended questions on narrating the real-life catalysts and inhibitors related to craving, initiation, relapse and abstinence. All data were transcribed verbatim and analysed using a strengths, weaknesses, opportunities and threats (SWOT) analysis. Results The results of the SWOT analysis revealed that contextual factors including peer influence, prevalence and availability of MA, familiar venue of MA use, discrimination, sexual behaviours, alcohol, emotional states and their attitudes towards smoking MA were important factors that contribute to reinitiation and relapse. Surveillance systems, antidrug social workers, vocational skills trainings, moving to another city and family responsibility might serve as counter measures targeti叩 those mentioned weaknesses and threats above. Conclusion This SWOT analysis highlights the complex nature of relapse. Comprehensive interventions strengtheni叩 coping skills such as virtual reality techniques are desperately needed to facilitate individuals1 sustained abstinence. | Youwei Zhu Na Zhong Hang Su Xiaolu Ruan Jiayi Bao Lei Zhang Jiang Du Ding Xu Rongjie Ding Ke Xiao Min Zhao | 2019 | General Psychiatry2019，32，3： | 9 |
| 3 | Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis显示文摘Depression is a serious public-health issue.Recent reports have suggested higher susceptibility to viral infections in depressive patients.However,how depression affects antiviral innate immune signaling remains unknown.Here,we revealed a reduction in expression of Abelson helper integration site 1(AHI1)in the peripheral blood mononuclear cells(PBMCs)and macrophages from the patients with major depressive disorder(MDD),which leads to attenuated antiviral immune response.We found that depression-related arginine vasopressin(AVP)induces reduction of AHI1 in macrophages.Further studies demonstrated that AHI1 is a critical stabilizer of basal type-I-interferon(IFN-I)signaling.Mechanistically,AHI1 recruits OTUD1 to deubiquitinate and stabilize Tyk2,while AHI1 reduction downregulates Tyk2 and IFN-I signaling activity in macrophages from both MDD patients and depression model mice.Interestingly,we identified a clinical analgesic meptazinol that effectively stimulates AHI1 expression,thus enhancing IFN-I antiviral defense in depression model mice.Our study promotes the understanding of the signaling mechanisms of depression-mediated antiviral immune dysfunction,and reveals meptazinol as an enhancer of antiviral innate immunity in depressive patients. | Hong-Guang Zhang Bin Wang Yong Yang Xuan Liu Junjie Wang Ning Xin Shifeng Li Ying Miao Qiuyu Wu Tingting Guo Yukang Yuan Yibo Zuo Xiangjie Chen Tengfei Ren Chunsheng Dong Jun Wang Hang Ruan Miao Sun Xingshun Xu Hui Zheng | 2022 | Cell Research2022，32，10： | 3 |
| 4 | 3.6 W compact all-fiber Pr3+-doped green laser at 521 nm显示文摘Green semiconductor lasers are still undeveloped,so high-power green lasers have heavily relied on nonlinear frequency conversion of near-infrared lasers,precluding compact and low-cost green laser systems.Here,we report the first Watt-level all-fiber CW Pr3t-doped laser operating directly in the green spectral region,addressing the aforementioned difficulties.The compact all-fiber laser consists of a double-clad Pr3t-doped fluoride fiber,two homemade fiber dichroic mirrors at visible wavelengths,and a 443-nm fiber-pigtailed pump source.Benefitting from>10 MW∕cm2 high damage intensity of our designed fiber dielectric mirror,the green laser can stably deliver 3.62-W of continuous-wave power at∼521 nm with a slope efficiency of 20.9%.To the best of our knowledge,this is the largest output power directly from green fiber lasers,which is one order higher than previously reported.Moreover,these green all-fiber laser designs are optimized by using experiments and numerical simulations.Numerical results are in excellent agreement with our experimental results and show that the optimal gain fiber length,output mirror reflectivity,and doping level should be considered to obtain higher power and efficiency.This work may pave a path toward compact high-power green all-fiber lasers for applications in biomedicine,laser display,underwater detection,and spectroscopy. | Jinhai Zou Jinfen Hong Zhuang Zhao Qingyuan Li Qiujun Ruan Hang Wang Yikun Bu Xianchao Guan Min Zhou Zhiyong Feng Zhengqian Luo | 2022 | Advanced Photonics2022，4，5： | 2 |
| 5 | Endoplasmic reticulum stress is involved in acetylated low-density lipoprotein induced apoptosis in THP-1 differentiated macrophages显示文摘背景心血管的疾病在有在先进动脉粥样硬化的死亡支持的长期的肾 disease.Macrophage 的病人是死亡和病态的一个主要原因从腹巨噬细胞表演 apoptosis 的坏死和匾 destabilization.In vitro 数据通过 endoplasmic 蜂窝胃被触发(嗯)免费胆固醇累积引起的应力玩我们使用了的重要 role.Here THP-1 房间旁边区分了为是的五天的 phorbol 12十四酸盐13醋酸盐( PMA )的 100 ng/ml 一在里面 vitro 模型。 | TAO Jian-ling RUAN Xiong-zhong LI Hang LI Xue-mei John E Moorhead Zac Varghese LI Xue-wang | 2009 | Chinese Medical Journal2009，，15： | 2 |
| 6 | Pore Pressure Accumulation of Anisotropically Consolidated Soft Clay Subjected to Complex Loads Under Different Stress Paths显示文摘Owing to different influence factors of foundation soil,the initial stress state of the soil under various working conditions is complex.To simulate this situation,in this paper,a series of tests on undisturbed soft clay under pure principal stress axis rotation were carried out by using the hollow cylinder apparatus(HCA).The influence of initial consolidation angle ζ(the angle between the vertical direction and direction of the applied load in consolidation)and intermediate principal stress coefficient b on pore water pressure accumulation of undisturbed soft clay were mainly studied.The test results show that,during pure principal stress axis rotation,the pore water pressure accumulation of the undisturbed soft clay fluctuates and increases with the rotation of the major principal stress;the values of major principal stress anglesα,corresponding to the peak value of the pore water pressure in a certain cycle,are different with different initial consolidation angles;the pore water pressure accumulation of soft clay is greatly affected by the intermediate principal stress coefficient b.With the fixed initial consolidation angle ζ,the variation trend of the maximum pore water pressure for each cycle is appropriately the same with different b values.With the increase of cycles,the difference value of pore water pressure between b=0 and b=1 in each cycle increases gradually with different initial consolidation angles ζ.While with different initial consolidation anglesζ,the increase of the pore water pressure when b increases from 0 to 0.5 is different with that when b increases from 0.5 to 1;the variation of maximum pore water pressure withζis significantly affected by the value of b;the value of maximum pore water pressure increases with the cycle number increases under all test conditions,but the growth rate decreases gradually.And the variation of maximum pore water pressure with the cycle number N is obviously influenced by both ζ and b. | WANG Yu-ke WAN Yong-shuai RUAN Hang YU Xiang SHAO Jing-gan REN De-bo | 2021 | China Ocean Engineering2021，35，3： | 1 |
| 7 | In vivo microdialysis study of the relationship between lead-induced impairment of learning and neurotransmitter changes in the hippocampus 显示文摘 | Sheng W Hang H W Ruan D Y | 2005 | Envir Toxicol Pharmacol2005，20，： | 1 |
| 8 | Government?s role in disruptive innovation and industry emergence: The case of the electric bike in China显示文摘 | Yi Ruan Chang Chieh Hang Yan Min Wang | 2014 | Technovation2014，，12： | 1 |
| 9 | Calculation of temperature rise in air-cooled induc- tion motors through 3-D coupled electromagnetic fluid- dynamical and thermal finite-element analysis 显示文摘 | hang Yu-jiao Ruan Jiang-jun Huang Tao | 2012 | IEEE Transactions on Magnetics2012，48，2： | 1 |
| 10 | Sinc interpolation based method for compensation of ionospheric dispersion effects on BOC signals with high subcarrier rate显示文摘Binary Offset Carrier(BOC) signals with high subcarrier rate such as Alt BOC(15,10) and cosBOC(15,2.5) have been adopted for the next generation of Global Navigation Satellite System(GNSS) to make full use of the allocated spectrum. However, the two main lobes of the BOC signals are tremendously separated in the frequency spectrum and the group delay of the two lobes are greatly dispersed due to ionospheric dispersion. The signals will suffer extremely severe distortion caused by the group delay dispersion including waveform ripples, power losses and correlation function asymmetries. In this paper, a novel time domain sinc interpolation based ionospheric dispersion compensation method is proposed to eliminate the distortion to the BOC signals.Firstly, the time domain model of BOC signal under the dispersive ionosphere is developed. Afterwards, based on the model, the two signal main lobes are aligned by sinc interpolation so that the ionospheric dispersion effects are almost mitigated. Taking Galileo E5 Alt BOC(15,10) signal as an example, the performance of the proposed method is evaluated by simulation and test. The results show that the proposed method is able to more effectively compensate the ionospheric dispersion with fewer computational loads versus existing methods. | Hang RUAN Lei ZHANG Teng LONG | 2016 | Science China(Information Sciences)2016，59，10： | 1 |
| 11 | Adhesion to fibronectin induces p27 Kip1 nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance (CAM-DR) in RPMI 8,226 cells显示文摘 | Min Fei Qinglei Hang Sicong Hou Songbin He Changgeng Ruan | 2014 | Molecular and Cellular Biochemistry2014，，1： | 1 |
| 12 | Floor positioning method indoors with smartphone’s barometer显示文摘This paper presents an indoor floor positioning method with the smartphone’s barometer for the purpose of solving the problem of low availability and high environmental dependence of the traditional floor positioning technology.First,an initial floor position algorithm with the“entering”detection algorithm has been obtained.Second,the user’s going upstairs or downstairs activities are identified by the characteristics of the air pressure fluctuation.Third,the moving distance in the vertical direction and the floor change during going upstairs or downstairs are estimated to obtain the accurate floor position.In order to solve the problem of the floor misjudgment from different mobile phone’s barometers,this paper calculates the pressure data from the different cell phones,and effectively reduce the errors of the air pressure estimating the elevation which is caused by the heterogeneity of the mobile phones.The experiment results show that the average correct rate of the floor identification is more than 85%for three types of the cell phones while reducing environmental dependence and improving availability.Further,this paper compares and analyzes the three common floor location methods–the WLAN Floor Location(WFL)method based on the fingerprint,the Neural Network Floor Location(NFL)methods,and the Magnetic Floor Location(MFL)method with our method.The experiment results achieve 94.2%correct rate of the floor identification with Huawei mate10 Pro mobile phone. | Min Yu Feng Xue Chao Ruan Hang Guo | 2019 | Geo-Spatial Information Science2019，22，2： | 1 |
| 13 | Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling显示文摘 | Junfang Zhang Hailong Cao Bing Zhang Hanwei Cao Xiuqin Xu Hang Ruan Tingting Yi Li Tan Rui Qu Gang Song Bangmao Wang Tianhui Hu | 2013 | J. Cell. Mol. Med2013，，11： | 1 |
| 14 | In vivo microdialysis study of the relationship between lead- induced impairment of learning and neurotransmitter changes in the hippocampus显示文摘 | Sheng W Hang HW Ruan DY | 2005 | Envir Toxicol Pharmacol2005，20，： | 1 |
| 15 | Novel ISAR imaging algorithm for maneuvering targets based on a modified keystone transform 显示文摘 | Ruan Hang Wu Yanhong Jia Xin | 2014 | Geoscience and Remote Sensing Letters IEEE (S1545-598X)2014，11，1： | 1 |
| 16 | Ultra-stable and color-tunable manganese ions doped lead-free cesium zinc halides nanocrystals in glasses for light-emitting applications显示文摘All inorganic CsPbX_(3)(X=Cl,Br,and I)perovskite nanocrystals have made unprecedented radical progresses for opto-electronic applications,but their instability and toxicity of lead impede their wide applications.Herein,we report the first precipitation of leadfree Mn:Cs_(2)ZnX_(4) nanocrystals in glasses.Efficient green and red photoluminescence are realized from these Mn:Cs_(2)ZnX_(4 )nanocrystals in glasses.By adjusting the size and halide component in these nanocrystals,coordination environment of Mn^(2+)ions can be tuned,leading to tunable photoluminescence with improved quantum efficiency.It is illustrated that in-situ precipitation of these Mn:Cs_(2)ZnX_(4) nanocrystals in glasses significantly improves their thermal-,chemical-,and photo-stabilities,making them promising for light-emitting diodes with stable chromaticity coordinates. | Kai Li Ying Ye Wenchao Zhang Yao Zhou Yudong Zhang Shisheng Lin Hang Lin Jian Ruan Chao Liu | 2022 | Nano Research2022，15，10： | 1 |
| 17 | A new multi-turn beam dump scheme design and simulation for HIAF-BRing machine protection显示文摘Purpose To protect accelerator devices from being damaged by high-power beam,a new beam dump system is under design for HIAF-BRing.Method Based on the optical characteristics,unwanted particles are safely deflected to a specific internal absorber through a local bump orbit generated by active-discharging magnets,which is achieved by paralleling a bleeder resistor of 600 m�to two of dipole magnet power supplies.Results Taking alignment and multipolefield errors into account,discarded beam can be dumped within 5 ms with an efficiency of more than 99.8%at any operation stage.Conclusion The proposed beam dump solution satisfies the machine protection requirements for BRing and can provide a new idea for similar facilities. | Ren Hang Yang Jiancheng Shen Guodong Wang Geng Yao Liping Ruan Shuang Sheng Lina Wu Junxia Zhao He Liu Jie Cai Fucheng Gao Yunzhe Chang Mingxuan Li Minxiang | 2022 | Radiation Detection Technology and Methods2022，6，4： | 1 |
| 18 | Direct generation of 3.17 mJ green pulses in a cavity-dumped Ho^(3+)-doped fiber laser at 543 nm显示文摘High-energy pulsed lasers in the green spectral region are of tremendous interest for applications in space laser ranging,underwater detection,precise processing,and scientific research.Semiconductor pulsed lasers currently are difficult to access to the so-called“green gap,”and high-energy green pulsed lasers still heavily rely on the nonlinear frequency conversion of near-IR lasers,precluding compact and low-cost green laser systems.Here,we address this challenge by demonstrating,for the first time to the best of our knowledge,millijoule-level green pulses generated directly from a fiber laser.The green pulsed fiber laser consists of a 450 nm pump laser diode,a Ho^(3+)-doped ZBLAN fiber,and a cavity-dumping module based on a visible wavelength acousto-optic modulator.Stable pulse operation in the cavity-dumping regime at 543 nm is observed with a tunable repetition rate in a large range of 100 Hz–3 MHz and a pulse duration of 72–116 ns.The maximum pulse energy of 3.17 mJ at 100 Hz is successfully achieved,which is three orders of magnitude higher than those of the rare-earth-doped fiber green lasers previously reported.This work provides a model for compact,high-efficiency,and high-energy visible fiber pulsed lasers. | TIANRAN LI ZIYU WANG JINHAI ZOU JINFEN HONG QIUJUN RUAN HANG WANG ZHIPENG DONG ZHENGQIAN LUO | 2023 | Photonics Research2023，11，3： | 1 |
| 19 | Lipids-induced Apoptosis Is Aggravated by Acyl-coenzyme A:Cholesterol Acyltransferase Inhibitor显示文摘Objective To investigate the role of acyl-coenzyme A:cholesterol acyltransferase inhibitor(ACATI) in apoptosis induced by lipids and whether lipids-induced apoptosis is accompanied by increase of free cholesterol in endoplasmic reticulum(ER),in order to further understand the mechanism of lipids-induced apoptosis in advanced atherosclerosis.Methods Human vascular smooth muscle cells(VSMCs) and phorbol 12-myristate 13-acetate(PMA) differentiated THP-1 macrophages were used.Tritiated thymidine incorporation was applied to detect cell proliferation.Cytotoxicity was assessed by lactate dehydrogenase(LDH) release.4',6-diamidino-2-phenylindole(DAPI) staining,caspase-3,-7 assay,and Annexin-V/propidium iodide(PI) staining were used to detect apoptosis.High performance liquid chromatography was used in intracellular free cholesterol and cholesterol ester assay.ER free cholesterol was quantified.Results Different lipids had different effects on proliferation and cytotoxicity of VSMCs.25-hydroxycholesterol(25OHC) had biphasic effects on the proliferation of VSMCs.At low concentration,it stimulated cell proliferation,but turned to proliferation inhibition as concentration reached 15 μg/mL.25OHC and acetylated low density lipoprotein(AcLDL) could respectively induce apoptosis in human VSMCs and PMA differentiated THP-1 macrophages,which was aggravated by ACATI,accompanied by increase of intracellular free cholesterol content.There was also an increase of cholesterol content in ER with AcLDL-induced apoptosis in THP-1 macrophages.Conclusions Lipids could induce apoptosis,accompanied by increase of intracellular free cholesterol content,which could be augmented by ACATI,suggesting that insults resulting in ER free cholesterol rise might be the initiator of apoptosis. | Jian-ling Tao Xiong-zhong Ruan Hang Li Xue-mei Li Xue-wang Li | 2010 | Chinese Medical Sciences Journal2010，25，2： | 0 |
| 20 | Lysine succinylation,the metabolic bridge between cancer and immunity显示文摘Lysine succinylation is a naturally occurring post-translational modification(PTM)that regulates the stability and function of proteins.It can be regulated by enzymes such as SIRT5 and SIRT7.Recently,the effect and significance of lysine succinylation in cancer and its implication in immunity have been extensively explored.Lysine succinylation is involved in the malignant phenotype of cancer cells.Abnormal regulation of lysine succinylation occurs in different cancers,and inhibitors targeting lysine succinylation regulatory enzymes can be used as potential anti-cancer strategies.Therefore,this review focused on the target protein lysine succinylation and its functions in cancer and immunity,in order to provide a reference for finding more potential clinical cancer targets in the future. | Rui Shen Hongyun Ruan Shuye Lin Bin Liu Hang Song Lu Li Teng Ma | 2023 | Genes & Diseases2023，10，6： | 0 |
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