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| 1 | Rhizospheric microbial communities are driven by Panax ginseng at different growth stages and biocontrol bacteria alleviates replanting mortality显示文摘The cultivation of Panax plants is hindered by replanting problems, which may be caused by plantdriven changes in the soil microbial community. Inoculation with microbial antagonists may efficiently alleviate replanting issues. Through high-throughput sequencing, this study revealed that bacterial diversity decreased,whereas fungal diversity increased, in the rhizosphere soils of adult ginseng plants at the root growth stage under different ages. Few microbial community, such as Luteolibacter, Cytophagaceae, Luteibacter, Sphingomonas,Sphingomonadaceae, and Zygomycota, were observed; the relative abundance of microorganisms, namely,Brevundimonas, Enterobacteriaceae, Pandoraea, Cantharellales, Dendryphion, Fusarium, and Chytridiomycota,increased in the soils of adult ginseng plants compared with those in the soils of 2-year-old seedlings. Bacillus subtilis 50-1, a microbial antagonist against the pathogenic Fusarium oxysporum, was isolated through a dual culture technique. These bacteria acted with a biocontrol efficacy of 67.8%. The ginseng death rate and Fusarium abundance decreased by 63.3% and 46.1%, respectively, after inoculation with B. subtilis 50-1. Data revealed that microecological degradation could result from ginseng-driven changes in rhizospheric microbial communities;these changes are associated with the different ages and developmental stages of ginseng plants. Biocontrol using microbial antagonists alleviated the replanting problem. | Linlin Dong Jiang Xu Lianjuan Zhang Ruiyang Cheng Guangfei Wei He Su Juan Yang Jun Qian Ran Xu Shilin Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 27 |
| 2 | Local Officials' Incentives and China's Economic Growth:Tournament Thesis Reexamined and Alternative Explanatory Framework显示文摘解释中国的戏剧的经济生长,研究人员们建议了一篇比赛论文。根据这篇论文,自从政治提升大部分基于本地经济生长,中央政府设置生长目标的能力在生长起了一个关键作用。我们使用省的官员的事业活动性数据测试这篇论文。为两个时间时期(19791995 和 19792002 ) ,经济性能,在年度、平均、相对的学期测量了,没影响这些官员的事业前进。我们然后勾略一个其他的分析框架为 developmentalism 解释中国本地官员的强壮的冲动并且最后,从这个解释框架拉政策含意。 | Fubing Su Ran Tao Lu Xi Ming Li | 2012 | China & World Economy2012，20，4： | 21 |
| 3 | Intestinal immune barrier integrity in rats with nonalcoholic hepatic steatosis and steatohepatitis显示文摘背景不含酒精的脂肪肝疾病( NAFLD )作为在这篇文章的 NAFLD.The 目的 pathogenis 的一个重要角色是完全在 NAFLD.Methods 的发展期间估计肠的有免疫力的障碍功能的长期的肝 injury.Intestinal 障碍戏的主要原因出现了 60 只男 Sprague-Dawley ( SD )老鼠被划分成 2 groups:normal 食谱( ND )组和高脂肪的饮食( HFD ) group.NAFLD 老鼠模型在 HFD 老鼠 group.Portal 血内毒素水平被建立被 li | Su Lin Wang Jian-hua Cong Xu Wang Li-hong Liu Feng Xie Xing-wang Zhang Heng-hui Wang Jiang-hua Fei Ran Liu Yu-lan | 2012 | Chinese Medical Journal2012，，2： | 18 |
| 4 | The M_S7.1 Yushu earthquake surface rupture and large historical earthquakes on the Garzê-Yushu Fault显示文摘As revealed by field investigations,the co-seismic surface rupture zone of the 2010 MS7.1 Yushu earthquake,Qinghai is a characteristic sinistral strike-slip feature consisting of three distinct sinistral primary ruptures,with an overall strike of 310°-320° and a total length of 31 km.In addition,an approximately 2-km-long en-echelon tensile fissure zone was found east of Longbao Town;if this site is taken as the north end of the rupture zone,then the rupture had a total length of ~51 km.The surface rupture zone is composed of a series of fissures arranged in an en-echelon or alternating relationship between compressive bulges and tensile fissures,with a measured maximum horizontal displacement of 1.8 m.The surface rupture zone extends along the mapped Garzê-Yushu Fault,which implicates it as the seismogenic fault for this earthquake.Historically,a few earthquakes with a magnitude of about 7 have occurred along the fault,and additionally traces of paleoearthquakes are evident that characterize the short-period recurrence interval of large earthquakes here.Similar to the seismogenic process of the 2008 Wenchuan earthquake,the Yushu earthquake is also due to the stress accumulation and release on the block boundaries resulting from the eastward expansion of Qinghai-Tibet Plateau.However,in contrast with the Wenchuan earthquake,the Yushu earthquake had a sinistral strike-slip mechanism resulting from the uneven eastward extrusion of the Baryan Har and Sichuan-Yunnan fault blocks. | CHEN LiChun WANG Hu RAN YongKang SUN XinZhe SU GuiWu WANG Ji TAN XiBin LI ZhiMin ZHANG XiaoQing | 2010 | Chinese Science Bulletin2010，55，31： | 17 |
| 5 | Timing of the formation of the Tianhuashan Basin in northern Wuyi as constrained by geochronology of volcanic and plutonic rocks显示文摘The Tianhuashan Basin is one of the most important volcanic basins in the northern Wuyi,southeastern China,comprising two successive volcanic units,the Daguding Formation and the overlying Ehuling Formation,along with several small associated igneous intrusions.The Lengshuikeng super-large-scale Ag-Pb-Zn deposit,which is closely related to these volcanic-intrusive rocks,is located in the northwestern part of the basin.In order to understand the basin evolution and magmatism,we determined LA-ICP-MS U-Pb zircon ages for the volcanic successions and associated intrusive rocks.U-Pb zircon dating of volcanic units yielded precise ages of 144±1 Ma for crystal tuff in the lower member of the Daguding Formation,142±1 Ma for andesite within the upper member of the Daguding Formation,140±1 Ma for tuffite of the first(i.e.,lowermost) member of the Ehuling Formation,and 137±1 Ma for rhyolitic ignimbrite within the third volcano-stratigraphic member of the Ehuling Formation.Three types of intrusive igneous rocks(quartz syenite porphyry,K-feldspar granite porphyry,and rhyolite porphyry) yielded precise weighted mean 206 Pb/238 U ages of 144±1,140±1,and 140±1 Ma,respectively,suggesting that these intrusions along with the aforementioned volcanics were all emplaced during the Early Cretaceous.In addition,the weighted mean 206 Pb/238 U ages determined on zircon from two samples of a granite porphyry intrusion,which hosts ore mineralization of the Lengshuikeng Ag-Pb-Zn deposit,are 158±1 and 157±1 Ma,indicating emplacement in the Late Jurassic.These new geochronological results for igneous rocks of the Tianhuashan Basin constrain the timing of volcanic and plutonic activity in the basin,and have important implications for our understanding the tectonic history of the region,and for identifying metallogenic types and the timing of ore deposition of the Lengshuikeng deposit. | SU HuiMin MAO JingWen HE XiRong LU Ran | 2013 | Science China Earth Sciences2013，56，6： | 16 |
| 6 | Plasma levels of acylated ghrelin in patients with functional dyspepsia显示文摘AIM:To investigate the relationship between plasma acylated ghrelin levels and the pathophysiology of functional dyspepsia.METHODS:Twenty-two female patients with functional dyspepsia and twelve healthy volunteers were recruited for the study.The functional dyspepsia patients were each diagnosed based on the Rome Ⅲ criteria.Eligible patients completed a questionnaire concerning the severity of 10 symptoms.Plasma acylated ghrelin levels before and after a meal were determined in the study participants using a commercial human acylated enzyme immunoassay kit;electrogastrograms were performed for 50 min before and after a standardized 10-min meal containing 265 kcal.RESULTS:There were no significant differences in plasma acylated ghrelin levels between healthy volunteers and patients with functional dyspepsia.However,in patients with functional dyspepsia,there was a negative correlation between fasting plasma acylated ghrelin levels and the sum score of epigastric pain(r =-0.427,P = 0.047) and a positive correlation between the postprandial/fasting plasma acylated ghrelin ratio and the sum score of early satiety(r = 0.428,P =0.047).Additionally,there was a negative correlation between fasting acylated ghrelin plasma levels and fasting normogastria(%)(r =-0.522,P = 0.013).Interestingly,two functional dyspepsia patients showed paradoxically elevated plasma acylated ghrelin levels after the meal.CONCLUSION:Abnormal plasma acylated ghrelin levels before or after a meal may be related to several of the dyspeptic symptoms seen in patients with functional dyspepsia. | Yeon Soo Kim Joon Seong Lee Tae Hee Lee Joo Young Cho Jin Oh Kim Wan Jung Kim Hyun Gun Kim Seong Ran Jeon Hoe Su Jeong | 2012 | World Journal of Gastroenterology2012，18，18： | 12 |
| 7 | Electrolyte materials for intermediate-temperature solid oxide fuel cells显示文摘Solid oxide fuel cells(SOFCs)directly convert chemical energy that is stored in a wide range of fuels into direct current electricity,with high efficiency and low emissions,via a series of electrochemical reactions at elevated operating temperatures(generally 400-1000℃).During such an energy conversion process,the properties of electrolyte materials determine the working principle and operating temperature of the SOFC.When considering the cost and stability,lowering the operating temperature is critical,and this has become one of the developing trends in SOFC research.The key point for realizing a reduction in operating temperature is to maintain low ohmic resistance of the electrolyte and low polarization resistance of the electrodes.In practice,the mechanical and chemical stability of the electrolyte is also a big concern.According to their differences in ion conduction mechanisms,there are three main types of electrolyte material available,namely,oxygen ion-conducting,proton-conducting,and dual ion-conducting electrolytes.In this review,we give a comprehensive summary of the recent advances in the development of these three types of electrolyte material for intermediate-temperature SOFCs.Both conductivity and stability are emphasized.In conclusion,the current challenges and future development prospects are discussed. | Huangang Shi Chao Su Ran Ran Jiafeng Cao Zongping Shao | 2020 | Progress in Natural Science:Materials International2020，30，6： | 12 |
| 8 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 9 | Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation显示文摘Macrophage migration inhibitory factor(MIF)is a chemokine that plays an essential role in immune system function.Previous studies suggested that MIF protects neurons in ischemic conditions.However,few studies are reported on the role of MIF in neurological recovery after ischemic stroke.The purpose of this study is to identify the molecular mechanism of neuroprotection mediated by MIF.Human neuroblastoma cells were incubated in Dulbecco’s modified Eagle’s medium under oxygen-glucose deprivation(OGD)for 4 hours and then returned to normal aerobic environment for reperfusion(OGD/R).30 ng/mL MIF recombinant(30 ng/mL)or ISO-1(MIF antagonist;50μM)was administered to human neuroblastoma cells.Then cell cultures were assigned to one of four groups:control,OGD/R,OGD/R with MIF,OGD/R with ISO-1.Cell viability was analyzed using WST-1 assay.Expression levels of brain-derived neurotrophic factor(BDNF),microtubule-associated protein 2(MAP2),Caspase-3,Bcl2,and Bax were detected by western blot assay and immunocytochemistry in each group to measure apoptotic activity.WST-1 assay results revealed that compared to the OGD/R group,cell survival rate was significantly higher in the OGD/R with MIF group and lower in the OGD/R with ISO-1 group.Western blot assay and immunocytochemistry results revealed that expression levels of BDNF,Bcl2,and MAP2 were significantly higher,and expression levels of Caspase-3 and Bax were significantly lower in the MIF group than in the OGD/R group.Expression levels of BDNF,Bcl2,and MAP2 were significantly lower,and expression levels of Caspase-3 and Bax were significantly higher in the ISO-1 group than in the OGD/R group.MIF administration promoted neuronal cell survival and induced high expression levels of BDNF,MAP2,and Bcl2(anti-apoptosis)and low expression levels of Caspase-3 and Bax(pro-apoptosis)in an OGD/R model.These results suggest that MIF administration is effective for inducing expression of BDNF and leads to neuroprotection of neuronal cells against hypoxic injury. | Su Hwan Bae Mi Ran Yoo Ye Yeong Kim In Kyung Hong Mi Hee Kim Seung Hak Lee Dae Yul Kim | 2020 | Neural Regeneration Research2020，15，8： | 11 |
| 10 | Classification of Irreducible Weight Modules with a Finite-dimensional Weight Space over Twisted Heisenberg-Virasoro Algebra显示文摘We show that the support of an irreducible weight module over the twisted Heisenberg-Virasoro algebra,which has an infinite-dimensional weight space,coincides with the weight lattice andthat all nontrivial weight spaces of such a module are infinite dimensional.As a corollary,we obtainthat every irreducible weight module over the twisted Heisenberg-Virasoro algebra,having a nontrivialfinite-dimensional weight space,is a Harish-Chandra module(and hence is either an irreducible highestor lowest weight module or an irreducible module from the intermediate series). | Ran SHEN Yu Cai SU | 2007 | Acta Mathematica Sinica,English Series2007，23，1： | 11 |
| 11 | Connecting the P300 to the diagnosis and prognosis of unconscious patients显示文摘The residual consciousness of unconscious patients can be detected by studying the P300, a wave among event-related potentials. Previous studies have applied tones, the subject's name and other names as stimuli. However, the results were not satisfactory. In this study, we changed the constituent order of subjects' two-character names to create derived names. The subject's derived names, together with tones and their own names, were used as auditory stimuli in event-related potential experiments. Healthy controls and unconscious patients were included in this study and made to listen to these auditory stimuli. In the two paradigms, a sine tone followed by the subject's own name and the subject's derived name followed by the subject's own name were used as standard and deviant stimuli, respectively. The results showed that all healthy controls had the P300 using both paradigms, and that the P300 in the second paradigm had a longer latency and two peaks. All minimally conscious state patients had the P300 in the first paradigm and the majority of them had the P300 in the second paradigm. Most vegetative state patients had no P300. Patients who showed the P300 in the two paradigms had more residual consciousness, and patients with the two-peak P300 had a higher probability of awakening within a short time. Our experimental findings suggest that the P300 event-related potential could reflect the conscious state of unconscious patients. | Ran Li Wei-qun Song Ju-bao Du Su Huo Gui-xiang Shan | 2015 | Neural Regeneration Research2015，10，3： | 9 |
| 12 | An Improved Approach to Test Diagnosability of Bounded Petri Nets显示文摘For bounded Petri nets, Cabasino et al. propose a diagnosability test method that is based on the analysis of a modified basis reachability graph and a basis reachability diagnoser. However, its complexity is exponential in the number of nodes of the basis reachability diagnoser. In order to reduce the complexity of their method, this paper presents a new diagnosability test approach for bounded Petri nets. We present the concept of an extended basis reachability graph and prove that our approach is of polynomial complexity in the number of nodes of extended basis reachability graphs. An example is given to illustrate the application of the presented approach. | Ning Ran Hongye Su Shouguang Wang | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，2： | 6 |
| 13 | A cross-sectional study of acute cor pulmonale in acute respiratory distress syndrome patients in China显示文摘Background:Increased right ventricle afterload during acute respiratory distress syndrome(ARDS)may induce acute cor pulmonale(ACP),which is associated with a poor clinical outcome.Echocardiography is now considered as a rapid and non-invasive tool for diagnosis of ACP.The aims of this study were to investigate the morbidity and mortality rates of ACP in ARDS patients in intensive care units(ICUs)across the mainland of China and to determine the severity and prognosis of ACP in ARDS patients through an ultrasound protocol(TRIP).And the association between ACP related factors and the ICU mortality will be revealed.Methods:This study is a multicenter and cross-sectional study in China which will include ICU participants when diagnosed as ARDS.The ultrasound protocol,known as the TRIP,is proposed as severity assessment for ACP,which includes tricuspid regurgitation velocity(T),right ventricular size(R),inferior vena cava diameter fluctuation(I),and pulmonary regurgitation velocity(P).The 28-day mortality,ICU/hospital mortality,the length of stay in ICU,mechanical ventilation days,hemodynamic parameters and lab parameters of liver function and kidney function are all recorded.Discussion:This large-scale study would give a sufficient epidemic investigation of ACP in ARDS patients in China.In addition,with the TRIP protocol,we expect that we could stratify ACP with more echocardiography parameters. | Long-Xiang Su Xiu-Ling Shang Ran Zhu Wei He Pan Pan Hong-Min Zhang Li-Na Zhang Da-Wei Liu Rong-Guo Yu Xiao-Ting Wang 无 | 2019 | Chinese Medical Journal2019，，23： | 6 |
| 14 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 15 | Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages显示文摘 | Xianfa Yang Boqiang Hu Yu Hou Yunbo Qiao Ran Wang Yingying Chen Yun Qian Su Feng Jun Chen Chang Liu Guangdun Peng Fuchou Tang Naihe Jing | 2018 | Cell Research2018，28，5： | 5 |
| 16 | Shape-controlled Pt nanocubes directly grown on carbon supports and their electrocatalytic activity toward methanol oxidation显示文摘Synthesis of shape-controlled Pt nanocrystals is substantial and important for enhancing chemical and electrochemical reactions.However,the removal of capping agents,shape-controlling chemicals,on Pt surfaces is essential prior to conducting the catalytic reactions.Here we report a facile one-pot synthesis of Pt nanocubes directly grown on carbon supports(Pt nanocubes/C) with modulating the kinetic reaction factors for shaping the nanocrystals,but without adding any capping agents for preserving the clean Pt surfaces.Well-dispersed Pt nanocubes/C shows enhanced activity and long-term stability toward methanol oxidation reaction compared to the commercial Pt/C catalyst. | Hee Jin Kim Bibi Ruqia Mi Sung Kang Su Bin Lim Ran Choi Ki Min Nam Won Seok Seo Gaehang Lee Sang-Il Choi | 2017 | Science Bulletin2017，62，13： | 5 |
| 17 | Tree of life for the genera of Chinese vascular plants显示文摘我们重建了使用的中国脉管的植物(Tracheophyta ) 的一棵种系发生的树叶绿体基因 atpB, matK, ndhF,和 rbcL 和 mitochondrial matR 定序。我们生产了包括 6098 种类并且包括 13 个 695 DNA 序列, 1803 最新被产生的一个矩阵。我们的分类采样跨越了代表中国脉管的植物的 323 个家庭的 3114 个类,盖住从中国知道的超过 93% 所有类。全面大发展史支持大多数关系在之中并且在最近的分子的种系发生的研究为 lycophytes,蕨纲植物(monilophytes ) ,裸子植物,和被子植物认出的家庭以内。为被子植物,在被子植物发展史组 IV 的大多数家庭作为 monophyletic 被养活,除了 paraphyletic Dipterocarpaceae 和 Santalaceae。一些大类的几个大家庭并且 monophyly 的 infrafamilial 关系被我们的稠密的分类采样很好支持。我们的结果证明 Eberhardtia 的二种是到 Sapotaceae 的所有另外的 taxa 形成的 clade 的姐妹,除了 Sarcosperma。我们经由 SoTree (http://gffzz52bf878016c04d01hukv0vpfqvqnw6ob0.ffgz.tsg.suse.edu.cn/flora/index.shtml ) 做了我们为子树的创造公开地可得到的中国脉管的植物的发展史,为生态学家的一个自动化发展史集会工具。 | Zhi-Duan Chen Tuo Yang Li Lin Li-Min Lu Hong-Lei Li Miao Sun Bing Liu Min Chen Yan-Ting Niu Jian-Fei Ye Zhi-Yong Cao Hong-Mei Liu Xiao-Ming Wang Wei Wang Jing-Bo Zhang Zhen Meng Wei Cao Jian-Hui Li Sheng-Dan Wu Hui-Ling Zhao Zhong-Jian Liu Zhi-Yuan Du Qing-Feng Wang Jing Guo Xin-Xin Tan Jun-Xia Su Lin-Jing Zhang Lei-Lei Yang Yi-Ying Liao Ming-He Li Guo-Qiang Zhang Shih-Wen Chung Jian Zhang Kun-Li Xiang Rui-qi Li Douglas E. Soltis Pamela S. Soltis Shi-Liang Zhou Jin-Hua Ran Xiao-quan Wang Xiao-Hua Jin You-Sheng Chen Tian-Gang Gao Jian-Hua Li Shou-Zhou Zhang An-Ming Lu China Phylogeny Consortium | 2016 | Journal of Systematics and Evolution2016，54，4： | 5 |
| 18 | Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients显示文摘AIM:To investigate the association of serum gammaglutamyl transferase(GGT) levels with chronic hepatitis B infection and hepatitis B e antigen(HBe Ag) seroconversion.METHODS:A retrospective study was performed on clinical data collected from patients who had been positive for hepatitis B surface antigen for > 6 mo and who were antiviral-treatment na?ve(n = 215) attending the Hepatitis Clinic at Nanjing Drum Tower Hospital between August 2010 and December 2013. Healthy individuals without liver disease(n = 83) were included as controls. Patients were categorized into four groups based on disease status as recommended by the European Association for the Study of the Liver:immune tolerance(IT; n = 47),HBe Ag-positive hepatitis(EPH; n = 93),HBe Ag-negative hepatitis(ENH;n = 20),and inactive carrier(IC; n = 55). Prediction of complete response(CR) based on serum GGT was also examined in EPH patients(n = 33) treated for 48 wk with nucleos(t)ide analogue(NA) therapy,including lamivudine plus adefovir combination therapy(n = 20) or entecavir monotherapy(n = 13). CR was defined as a serum hepatitis B virus DNA level < 500 copies/m L and HBe Ag seroconversion by 48 wk of treatment. RESULTS:Serum GGT levels were significantly increased in EPH and ENH patients relative to the IT,IC,and healthy control groups(P < 0.01 for all). However,no significant difference in serum GGT levels was found between the EPH and ENH groups. Baseline serum GGT levels were significantly higher in patients who achieved CR(7/33; 21.2%) compared to patients in the non-CR group(26/33; 78.8%; P = 0.011). In addition,the decline in serum GGT was greater in CR patients compared to non-CR patients after 24 wk and 48 wk of treatment(P = 0.012 and P = 0.008,respectively). The receiver operating characteristic curve yielded a sensitivity of 85.71% and a specificity of 61.54% at a threshold value of 0.89 times the upper limit of normal for baseline serum GGT in the prediction of CR following NA therapy. CONCLUSION:Serum GGT is significantly elevated in EPH and ENH patients and is a potential biomarker for the prediction of HBe Ag seroconversion following NA therapy. | Rui Huang Chen-Chen Yang Yong Liu Juan Xia Ran Su Ya-Li Xiong Gui-Yang Wang Zhen-Hua Sun Xiao-Min Yan Shan Lu Chao Wu | 2015 | World Journal of Gastroenterology2015，21，34： | 4 |
| 19 | Comparison of three remotely sensed drought indices for assessing the impact of drought on winter wheat yield显示文摘Agricultural drought threatens food security.Numerous remote-sensing drought indices have been developed,but their different principles,assumptions and physical quantities make it necessary to compare their suitability for drought monitoring over large areas.Here,we analyzed the performance of three typical remote sensing-based drought indices for monitoring agricultural drought in two major agricultural production regions in Shaanxi and Henan provinces,northern China(predominantly rain-fed and irrigated agriculture,respectively):vegetation health index(VHI),temperature vegetation dryness index(TVDI)and drought severity index(DSI).We compared the agreement between these indices and the standardized precipitation index(SPI),soil moisture,winter wheat yield and National Meteorological Drought Monitoring(NMDM)maps.On average,DSI outperformed the other indices,with stronger correlations with SPI and soil moisture.DSI also corresponded better with soil moisture and NMDM maps.The jointing and grain-filling stages of winter wheat are more sensitive to water stress,indicating that winter wheat required more water during these stages.Moreover,the correlations between the drought indices and SPI,soil moisture,and winter wheat yield were generally stronger in Shaanxi province than in Henan province,suggesting that remote-sensing drought indices provide more accurate predictions of the impacts of drought in predominantly rain-fed agricultural areas. | Jianxi Huang Wen Zhuo Ying Li Ran Huang Fernando Sedano Wei Su Jinwei Dong Liyan Tian Yanbo Huang Dehai Zhu Xiaodong Zhang | 2020 | International Journal of Digital Earth2020，13，4： | 4 |
| 20 | Milk production and composition and metabolic alterations in the mammary gland of heat-stressed lactating dairy cows显示文摘This experiment was conducted to investigate the effects of heat stress(HS) on the feed intake, milk production and composition and metabolic alterations in the mammary gland of dairy cows. Twenty Holstein cows were randomly assigned to one of two treatments according to a completely randomized design. Half of the cows were allocated to the HS group in August(summer season), and the other half were assigned to the HS-free group in November(autumn season). HS reduced(P<0.01) dry matter intake(DMI), milk yield, milk protein and milk urea nitrogen(MUN) of cows compared with HSfree control, but increased(P<0.01) milk somatic cell counts(SCC). We determined the HS-induced metabolic alterations and the relevant mechanisms in dairy cows using liquid chromatography mass spectrometry combined with multivariate analyses. Thirty-four metabolites were identified as potential biomarkers for the diagnosis of HS in dairy cows. Ten of these metabolites, glucose, lactate, pyruvate, lactose, β-hydroxybutyrate, citric acid, α-ketoglutarate, urea, creatine, and orotic acid, had high sensitivity and specificity for HS diagnoses, and seven metabolites were also identified as potential biomarkers of HS in plasma, milk, and liver. These substances are involved in glycolysis, lactose, ketone, tricarboxylic acid(TCA), amino acid and nucleotide metabolism, indicating that HS mainly affects lactose, energy and nucleotide metabolism in the mammary gland of lactating dairy cows. This study suggested that HS might affect milk production and composition by affecting the feed intake and substance metabolisms in the mammary gland tissue of lactating dairy cows. | FAN Cai-yun SU Di TIAN He HU Rui-ting RAN Lei YANG Ying SU Yan-jing CHENG Jian-bo | 2019 | Journal of Integrative Agriculture2019，18，12： | 4 |
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