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| 1 | 活体肝移植术后胆管并发症的处理与预防显示文摘目的探讨活体肝移植术后胆管并发症的防治。方法84例活体肝移植,成人56例,小儿28例;良性终末期肝病66例,肝细胞肝癌18例。供受体胆管端端吻合重建50例,供体肝管与受体肝管端端和胆总管端侧吻合重建1例,供体肝管与受体肝管和胆囊管吻合1例,供体胆管与受体卒肠Roux—en-Y吻合重建32例,所有胆管重建后均置入4Fr或6Fr内支架管从受体胆总管前壁或空肠袢盲端侧肠壁引出体外。结果术后发生胆管并发症24例,发生率为28.5%,胆管胆管吻合与肝管宅肠Roux—en-Y吻合胆漏发生率差异显著(8.3%vs16.7%,P〈0.05)。胆管胆管吻合与肝管空肠Roux-en—Y吻合胆管狭窄发生率差异显著(50%vs16.7%,P〈0.05)。单支胆管与多支胆管发生胆管并发症差异娃著(20.8%vs79.2%,P〈0.05)。胆漏者保守治疗治愈4例,再次手术治疗治愈4例;胆管狭窄内镜下球囊扩张和鼻胆管引流治疗治愈4例,好转2例,再次手术胆管空肠Roux-en—Y吻合治疗治愈6例,经皮肝脏穿刺胆管狭窄球囊扩张治疗支架管引流治疗好转4例。该组资料无因胆管并发症死亡病例。结论良好的胆管血供和吻合技术,选择恰当的胆管重建方式,足降低活体肝移植术后胆管并发症的重要措施。 | 秦建民 Yasutsugu Takada Shinji Uemoto Koichi Tanaka | 2008 | 中华肝胆外科杂志2008，14，10： | 5 |
| 2 | 临床活体肝部分移植的适应证及手术时机——附1O例报告显示文摘本文报告10例临床活体肝部分移植术,9例为先天性胆道闭锁症,1例为暴发性肝炎。全组病例均为儿童,年龄:3个月~12岁,其中男3例,女7例。作者指出,现阶段临床活体肝部分移植的适应证多为先天性胆道闭锁症,移植对象多为儿童,手术时机应遵循不同适应证各自的发展规律,采取个体化的原则。但一旦确定了肝移植的方针后,则应尽早手术。 | 管文贤 李开宗 窦科峰 Tanaka Koichi Yamaoka Yoshio | 1997 | 中国微创外科杂志1997，，2： | 4 |
| 3 | 活体肝部分移植术供肝的处理显示文摘目的 探讨活体肝部分移植术供肝的处理方法。方法 以日本京都大学经治的9 例活体肝部分移植供者为对象, 对供肝的灌洗时机、方法和供肝的修整及保存等方面进行观察。结果 9 例供肝顺利切取, 肝切除量平均占全肝的20 % ~29% , 受肝者存活良好。结论 供肝的灌洗时机、方法和供肝的修整及保存都是活体肝部分移植术中应重视的问题。 | 管文贤 Tanaka Koichi | 1999 | 中华器官移植杂志1999，20，4： | 4 |
| 4 | Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal显示文摘 | Kazuichi Okazaki Shigeyuki Kawa Terumi Kamisawa Satoru Naruse Shigeki Tanaka Isao Nishimori Hirotaka Ohara Tetsuhide Ito Seiki Kiriyama Kazuro Inui Tooru Shimosegawa Masaru Koizumi Koichi Suda Keiko Shiratori Koji Yamaguchi Taketo Yamaguchi Masanori Sugiy | 2006 | Journal of Gastroenterology2006，，7： | 3 |
| 5 | Changes in portal venous pressure in the early phase after living donor liver transplantation: pathogenesis and clinical implications1,2显示文摘 | Takashi Ito Tetsuya Kiuchi Hidekazu Yamamoto Fumitaka Oike Yasuhiro Ogura Yasuhiro Fujimoto Kazuhiro Hirohashi and Koichi Tanaka | 2003 | Transplantation2003，，8： | 3 |
| 6 | Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver显示文摘AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more signif icantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreat-ment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver isch-emia-reperfusion injury. | Takayuki Takeichi Shinji Uemoto Sachiko Minamiguchi Izumi Takeyoshi Yukihiro Inomata Koichi Tanaka Eiji Kobayashi | 2009 | World Journal of Gastroenterology2009，15，45： | 3 |
| 7 | Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis显示文摘 | Shujiro Yazumi Takanobu Yoshimoto Hiroshi Hisatsune Kazunori Hasegawa Masaya Kida Shinsuke Tada Yoshito Uenoyama Junichi Yamauchi Seiji Shio Mureo Kasahara Kohei Ogawa Hiroto Egawa Koichi Tanaka Tsutomu Chiba | 2006 | Journal of Hepato-Biliary-Pancreatic Surgery2006，，6： | 2 |
| 8 | 临床活体肝部分移植术供肝的切取技巧显示文摘目的提高活体肝部分移植术供肝的切取技巧。方法介绍9例供体的临床资料及供肝切取过程,其中男4例,女5例,年龄25~38岁。8例切取肝左外侧叶,1例切取左肝叶,手术时间4~6h,出血量400~600ml。结果全组病例均顺利康复,所供肝脏全部存活。结论提高肝脏游离及肝门解剖技巧。 | 管文贤 李开宗 窦科峰 Yamaoka Yoshio Tanaka Koichi | 1999 | 中国普通外科杂志1999，8，2： | 2 |
| 9 | 临床活体肝部分移植术受体的手术技巧显示文摘目的探讨活体肝部分移植术受体手术技巧。方法以在京都大学留学时经治的10例患者为对象,介绍肝部分移植受体手术各个环节的操作方法及注意事项。结果10例中男3例,女7例。年龄3个月~12岁。9例施行肝左外叶移植术,1例施行肝左叶移植术。手术时间10~15h,出血量1000ml左右,无肝期90~120min。手术顺利,全部受体顺利康复。结论受体手术应从手术切口选择、肝脏游离、肝门显露及解剖、短肝静脉和肝静脉的处理、血管和胆管的重建、创面处理及引流等加以把握。 | 管文贤 李开宗 窦科峰 张新海 Tanaka Koichi | 1999 | 中国普通外科杂志1999，8，2： | 2 |
| 10 | Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma显示文摘AIM:To compare the clinicopathological characteristics of human epidermal growth factor receptor 2 (HER2)-positive and HER2-negative Barrett's adenocarcinoma in Japan. METHODS:We performed immunohistochemical analysis of HER2 in 30 samples taken from patients with Barrett's adenocarcinoma and dual color in situ hybridization in cases showing 2+ reactions. We compared the clinicopathological characteristics of HER2-positive and HER2-negative patients.RESULTS:HER2 positivity was identified in 8 (27%) carcinoma samples. We found that HER2 expression was associated with p53 overexpression (100% vs 52.6% in pT1 tumor; 100% vs 54.5% in all stage tumor, P < 0.05) and protruding lesions at the early disease stage. There was no association between the mucin phenotype of the carcinomas and prognosis. HER2 expression and low clinical stage were unexpectedly different between Barrett's adenocarcinoma patients and gastric cancer patients, but the macroscopic features may be associated with earlier diagnosis in these patients. CONCLUSION:Our results suggest that HER2-positive Barrett's adenocarcinomas are associated with p53 overexpression and lesion protrusion at the early disease stage. | Takehiro Tanaka Atsushi Fujimura Koichi Ichimura Hiroyuki Yanai Yasuharu Sato Katsuyohi Takata Hiroyuki Okada Seiji Kawano Shunsuke Tanabe Tadashi Yoshino | 2012 | World Journal of Gastroenterology2012，18，43： | 2 |
| 11 | The Presence of Foxp3 Expressing T Cells Within Grafts of Tolerant Human Liver Transplant Recipients显示文摘 | Ying Li Xiangdong Zhao Donghua Cheng Hironori Haga Tatsuaki Tsuruyama Kathryn Wood Shimon Sakaguchi Koichi Tanaka Shinji Uemoto Takaaki Koshiba | 2008 | Transplantation2008，，12： | 2 |
| 12 | The revised Japanese clinical diagnostic criteria for chronic pancreatitis显示文摘 | Tooru Shimosegawa Keisho Kataoka Terumi Kamisawa Hiroyuki Miyakawa Hirotaka Ohara Tetsuhide Ito Satoru Naruse Naohiro Sata Koichi Suda Morihisa Hirota Yoshifumi Takeyama Keiko Shiratori Takashi Hatori Makoto Otsuki Yutaka Atomi Kentaro Sugano Masao Tanaka | 2010 | Journal of Gastroenterology2010，，6： | 2 |
| 13 | Novel zinc alloys for biodegradable surgical staples显示文摘BACKGROUND The development of biodegradable surgical staples is desirable as non-biodegradable Ti alloy staples reside in the human body long after wound healing, which can cause allergic/foreign-body reactions, adhesion, or other adverse effects. In order to develop a biodegradable alloy suitable for the fabrication of surgical staples, we hypothesized that Zn, a known biodegradable metal, could be alloyed with various elements to improve the mechanical properties while retaining biodegradability and biocompatibility. Considering their biocompatibility, Mg, Ca, Mn, and Cu were selected as candidate alloying elements, alongside Ti, the main material of clinically available surgical staples.AIM To investigate the in vitro mechanical properties and degradation behavior and in vivo safety and feasibility of biodegradable Zn alloy staples.METHODS Tensile and bending tests were conducted to evaluate the mechanical properties of binary Zn alloys with 0.1–6 wt.% Mg, Ca, Mn, Cu, or Ti. Based on the results,three promising Zn alloy compositions were devised for staple applications(wt.%): Zn-1.0Cu-0.2Mn-0.1Ti(Zn alloy 1), Zn-1.0Mn-0.1Ti(Zn alloy 2), and Zn-1.0Cu-0.1Ti(Zn alloy 3). Immersion tests were performed at 37℃ for 4 wk using fed-state simulated intestinal fluid(Fe SSIF) and Hank’s balanced salt solution(HBSS). The corrosion rate was estimated from the weight loss of staples during immersion. Nine rabbits were subjected to gastric resection using each Zn alloy staple, and a clinically available Ti staple was used for another group of nine rabbits. Three in each group were sacrificed at 1, 4, and 12 wk post-operation.RESULTS Additions of ≤1 wt.% Mn or Cu and 0.1 wt.% Ti improved the yield strength without excessive deterioration of elongation or bendability. Immersion tests revealed no gas evolution or staple fracture in any of the Zn alloy staples. The corrosion rates of Zn alloy staples 1, 2, and 3 were 0.02 mm/year in HBSS and 0.12, 0.11, and 0.13 mm/year, respectively, in Fe SSIF. These degradation times are sufficient for wound healing. The degradation rate is notably increased under low pH conditions. Scanning electron microscopy and energy dispersive spectrometry surface analyses of the staples after immersion indicated that the component elements eluted as ions in Fe SSIF, whereas corrosion products were produced in HBSS, inhibiting Zn dissolution. In the animal study, none of the Zn alloy staples caused technical failure, and all rabbits survived without complications. Histopathological analysis revealed no severe inflammatory reaction around the Zn alloy staples.CONCLUSION Staples made of Zn-1.0Cu-0.2Mn-0.1Ti, Zn-1.0Mn-0.1Ti, and Zn-1.0Cu-0.1Ti exhibit acceptable in vitro mechanical properties, proper degradation behavior,and in vivo safety and feasibility. They are promising candidates for biodegradable staples. | Hizuru Amano Koichi Miyake Akinari Hinoki Kazuki Yokota Fumie Kinoshita Atsuko Nakazawa Yujiro Tanaka Yasuhiro Seto Hiroo Uchida | 2020 | World Journal of Clinical Cases2020，8，3： | 2 |
| 14 | Endoscopic management of biliary strictures after duct-to-duct biliary reconstruction in right-lobe living-donor liver transplantation显示文摘 | Hiroshi Hisatsune Shujiro Yazumi Hiroto Egawa Masanori Asada Kazunori Hasegawa Yuzo Kodama Kazuichi Okazaki Kyo Itoh Hiroshi Takakuwa Koichi Tanaka Tsutomu Chiba | 2003 | Transplantation2003，，5： | 2 |
| 15 | Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Yasuo Takahashi Hiroyuki Ohnuma Syunichi Okubo Naoaki Shintani Shingo Tanaka Masaya Kida Yasuhiro Sato Hidetoshi Ohta Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koji Yamaguchi Koichi Hirata Yos | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 2 |
| 16 | Outcomes of Adult-to-Adult Living Donor Liver Transplantation: A Single Institution?s Experience With 335 Consecutive Cases显示文摘 | Daisuke Morioka Hiroto Egawa Mureo Kasahara Takashi Ito Hironori Haga Yasutsugu Takada Hiroshi Shimada Koichi Tanaka | 2007 | Annals of Surgery2007，，2： | 2 |
| 17 | Requirement of Protocol Biopsy Before and After Complete Cessation of Immunosuppression After Liver Transplantation显示文摘 | Mami Yoshitomi Takaaki Koshiba Hironori Haga Ying Li Xiangdong Zhao Donghua Cheng Aya Miyagawa Hiromi Sakashita Tatsuaki Tsuruyama Hidenori Ohe Mikiko Ueda Shinya Okamoto Hiroto Egawa Kathryn Wood Shimon Sakaguchi Toshiaki Manabe Koichi Tanaka Shinji Uemo | 2009 | Transplantation2009，，4： | 2 |
| 18 | Jahn–Teller instability in spinel Li–Mn–O显示文摘 | Atsuo Yamada Masahiro Tanaka Koichi Tanaka Koji Sekai | 1999 | Journal of Power Sources1999，，： | 1 |
| 19 | MicroRNA-200b Regulates Cell Proliferation, Invasion, and Migration by Directly Targeting ZEB2 in Gastric Carcinoma显示文摘 | Junji Kurashige Hidenobu Kamohara Masayuki Watanabe Yukiharu Hiyoshi Masaaki Iwatsuki Youhei Tanaka Koichi Kinoshita Seiya Saito Yoshifumi Baba Hideo Baba | 2012 | Annals of Surgical Oncology2012，，3： | 1 |
| 20 | IMPACT OF GRAFT SIZE MISMATCHING ON GRAFT PROGNOSIS IN LIVER TRANSPLANTATION FROM LIVING DONORS1,2显示文摘 | Tetsuya Kiuchi Mureo Kasahara Kenji Uryuhara Yukihiro Inomata Shinji Uemoto Katsuhiro Asonuma Hiroto Egawa Shiro Fujita Michihiro Hayashi Koichi Tanaka | 1999 | Transplantation1999，，2： | 1 |
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