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| 1 | Reversible Histone H2B Monoubiquitination Fine-Tunes Abscisic Acid Signaling and Drought Response in Rice显示文摘Histone H2B monoubiquitination (H2Bub1) plays important roles in several physiological and developmental processes, but its roles in the regulation of plant stress responses remain elusive. Here, we report that H2Bub1 is crucially involved in abscisic acid (ABA) signaling and drought response in rice. We found that rice HISTONE MONOUBIQUITINATION2 (OsHUB2), an E3 ligase for H2Bub1, in teracted with OsbZIP46, a key transcription factor regulating ABA signaling and drought response in rice. Genetic analyses suggest that OsHUB2, upregulated by drought and ABA, positively modulates ABA sensitivity and drought resistance. The H2Bub1 levels were in creased in the target genes of OsbZIP46 under the drought stress and ABA treat- merits, which were positively correlated with their increased expression levels. Interestingly, MODD, a reported suppressor of ABA signaling and drought resistance by mediating OsbZIP46 deactivation and degradation, could reduce the H2Bub1 levels in the target genes of OsbZIP46 by recruiting a putative deubiquitinase OsOTLD1 . Suppression of OsOTLD1in vivo resulted in increased H2Bub1 levels and expression of OsbZIP46 target genes. Collectively, these fin dings established an elaborate mecha nism of histone monoubiquitination in the fine-turning of ABA signaling and drought response by balancing H2Bub1 deposition and removal. | Siqi Ma Ning Tang Xu Li Yongjun Xie Denghao Xiang Jie Fu Jianqiang Shen Jun Yang Haifu Tu Xianghua Li Honghong Hu Lizhong Xiong | 2019 | Molecular Plant2019，12，2： | 7 |
| 2 | esveratrol inhibits necroptosis by mediating the TNF-α/RIP1/RIP3/MLKL pathway in myocardial hypoxia/reoxygenation injury显示文摘Resveratrol(RES)protects myocardial cells from hypoxia/reoxygenation(H/R)-caused injury.However,the mechanism of this effect has not been clarified.Thus,in this study,we aimed to determine whether RES attenuates H/R-induced cell necroptosis by inhibiting the tumor necrosis factor-alpha(TNF-α)/receptor-interacting protein kinase 1(RIP1)/RIP3/mixed-lineage kinase domain-like(MLKL)signaling pathway.Rat myocardial ischemia/reperfusion(I/R)models and H/R-injured cell models were constructed.Our study showed that myocardial H/R injury significantly increased the levels of TNF-α,RIP1,RIP3,and p-MLKL/MLKL by western blot analysis.Cell viability assay and 4,6-dianmidino-2-phenylindole(DAPI)-propidium iodide staining showed that the cell viability was decreased,and necroptosis was increased after myocardial H/R injury.The expressions of TNF-α,RIP1,RIP3,and p-MLKL/MLKL in H/R myocardial cells treated with different concentrations of RES were significantly downregulated.In addition,we also found that the cell viability was increased and necroptosis was decreased in dose-dependent manners when H/R-injured cells were treated with RES.In addition,the enhanced effect of TNF-αon necroptosis in myocardial H/R-injured cells was improved by RES,and the effect of RES was confirmed in vivo in I/R rats.This study also showed that RES suppresses necroptosis in H9c2 cells,which may occur through the inhibition of the TNF-α/RIP1/RIP3/MLKL signaling pathway.Our data suggest that necroptosis is a promising therapeutic target and may be a promising therapeutic target for the treatment of myocardial I/R injury. | Yongjun Hu Hongwei Pan Jianqiang Peng Jin He Mingxiang Tang Sulan Yan Jingjing Rong Junshan Li Zhaofen Zheng Haijun Wang Yanfu Liu Xin Zhong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 6 |
| 3 | Template-free synthesis of three-dimensional NiFe-LDH hollow microsphere with enhanced OER performance in alkaline media显示文摘Flower-like hierarchical three-dimensional Ni Fe layered double hydroxides hollow microspheres(3D NiFe-LDH HMS),as one kind of novel non-noble metal electrocatalysts,have been fabricated in a templatefree route for water oxidation.Both of the concentration of ammonium fluoride and the reaction time are adjusted to obtain a series of Ni Fe-LDH microspheres,with different internal structures from massive to hollow generated during the hydrothermal treatment,which improve the electrocatalytic activity of the Ni Fe-LDH catalysts towards the evolution reaction of oxygen.The optimized Ni Fe-LDH-0.4M HMS show the excellent OER performance in alkaline electrolyte withη=290 mV@10 mA cm^-2,and a Tafel slope of 51 mV dec-1,which outperforms the benchmark RuO2 catalyst.The possible reason is attributed to the more exposure of active sites,and fast ion transport resulting from the hierarchical hollow structure. | Haihong Zhong Tongyuan Liu Shuwei Zhang Dianqing Li Pinggui Tang Nicolas Alonso-Vante Yongjun Feng | 2019 | Journal of Energy Chemistry2019，28，6： | 5 |
| 4 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 5 | Emerging Variants of B.1.617 Lineage Identified Among Returning Chinese Employees Working in India—Chongqing Municipality,China,April 2021显示文摘On April 22 and 23,2021,3 confirmed COVID-19 cases in passengers on an arriving airplane from Nepal were reported by Chongqing Public Health Medical Center.Preliminary epidemiological investigation revealed these 3 patients,males aged 20-30 years,were coworkers of a cellphone company that has a manufacturing base in Noida,India,where they worked with their Indian colleagues since late 2019. | Sheng Ye Yongjun Zhang Xiang Zhao Zhen Yu Yang Song Zhangping Tan Yun Tang Shuang Chen Mingyue Wang Hua Ling | 2021 | China CDC weekly2021，3，19： | 4 |
| 6 | Two-factor ( biometric and password) authentication key exchange on lattice based on key consensus显示文摘In the post-quantum era,the password-based authentication key exchange(PAKE)protocol on lattice has the characteristics of convenience and high efficiency,however these protocols cannot resist online dictionary attack that is a common method used by attackers.A lattice-based two-factor(biometric and password)authentication key exchange(TFAKE)protocol based on key consensus(KC)is proposed.The protocol encapsulates the hash value of biometric information and password through a splittable encryption method,and compares the decapsulated information with the server's stored value to achieve the dual identity authentication.Then the protocol utilizes the asymmetric hash structure to simplify the calculation steps,which increases the calculation efficiency.Moreover,KC algorithm is employed in reducing data transmission overhead.Compared with the current PAKE protocol,the proposed protocol has the characteristics of hybrid authentication and resisting online dictionary attack.And it reduces the number of communication rounds and improves the efficiency and the security of protocol application. | Zhao Zongqu Ma Shaoti Wang Yongjun Tang Yongli Ye Qing | 2020 | The Journal of China Universities of Posts and Telecommunications2020，27，6： | 2 |
| 7 | Robust nonlinear control of spacecraft formation flying using constraint forces显示文摘A robust nonlinear control method is presented for spacecraft precise formation flying.With the constraint forces and consid-ering nonlinearity and perturbations,the problem of the formation keeping is changed to the Lagrange systems with the holonomic constraints and the differential algebraic equations (DAE).The nonlinear control laws are developed by solving the DAE.Because the traditional numerical solving methods of DAE are very sensitive to the various errors and the resulting con-trol laws are not robust in engineering application,the robust control law designed method is further developed by designing the correct coefficients to correct the errors of the formation array constraints.A numeral study simulated the robustness of this method for the various errors in the formation flying mission,including the initial errors of spacecraft formation,the reference satellite orbit determination errors,the relative perturbation forces model errors,and so on. | XING JianJun TANG GuoJin CHENG WenKe LEI YongJun | 2011 | Science China(Technological Sciences)2011，54，9： | 2 |
| 8 | A review of mechanical drilling for composite laminates显示文摘 | DeFu Liu YongJun Tang W.L. Cong | 2011 | Composite Structures2011，，4： | 2 |
| 9 | Autophagy regulates adipose mass and differentiation in mice显示文摘 | Singh Rajat Xiang Youqing Wang Yongjun Baikati Kiran Cuervo Ana Maria Luu Yen K Tang Yan Pessin Jeffrey E Schwartz Gary J Czaja Mark J | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 10 | Approximate analytical solution in slow-fast system based on modified multi-scale method显示文摘A simple,yet accurate modi?ed multi-scale method(MMSM)for an approximately analytical solution in nonlinear oscillators with two time scales under forced harmonic excitation is proposed.This method depends on the classical multi-scale method(MSM)and the method of variation of parameters.Assuming that the forced excitation is a constant,one could easily obtain the approximate analytical solution of the simpli?ed system based on the traditional MSM.Then,this solution for the oscillator under forced harmonic excitation could be established after replacing the harmonic excitation by the constant excitation.To certify the correctness and precision of the proposed analytical method,the van der Pol system with two scales subject to slowly periodic excitation is investigated;this system presents rich dynamical phenomena such as spiking(SP),spiking-quiescence(SP-QS),and quiescence(QS)responses.The approximate analytical expressions of the three types of responses are given by the MMSM,and it can be found that the precision of the new analytical method is higher than that of the classical MSM and better than that of the harmonic balance method(HBM).The results obtained by the present method are considerably better than those obtained by traditional methods,quantitatively and qualitatively,particularly when the excitation frequency is far less than the natural frequency of the system. | Xianghong LI Jianhua TANG Yanli WANG Yongjun SHEN | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，4： | 2 |
| 11 | The intervention effects of Lactobacillus casei LC2W on Escherichia coli O157:H7-induced mouse colitis显示文摘This study investigated the intervention effects of Lactobacillus casei LC2W in murine(SPF C57BL/c)challenge infection models induced by Escherichia coli O157:H7.Mice were fed streptomycin with water for 3 days prior to intragastric gavage by E.coli O157:H7(Control)or L.casei LC2W together with E.coli O157:H7(Intervention)to explore the role of L.casei LC2W by biochemical indicators,histological evaluation,expression of colonic pro-inflammatory and intestinal barrier factors related to enteritis.Results showed that the administration of L.casei LC2W was able to alleviate the symptoms of colitis induced by E.coli O157:H7,exhibiting lower weight loss as well as more intact colon tissue.Furthermore,L.casei LC2W could down-regulate the expression of pro-inflammatory cytokines(TNF-α,IL-6,and IL-1β)and protect the intestinal barrier function by improving the level of MUC2,ZO-1 and E-cadherin 1 compared to the control group.These results demonstrate that L.casei LC2W can reduce the severity of E.coli O157:H7 infection,and suggest L.casei LC2W may maintain the immune balance and intestinal barrier to reduce colitis.In addition,we found the effect of intervention is similar to that of prevention,which is better than that of treatment. | Guangqiang Wang Hongyu Tang Ying Zhang Xiang Xiao Yongjun Xia Lianzhong Ai | 2020 | Food Science and Human Wellness2020，9，3： | 2 |
| 12 | Nonlinear control of multiple spacecraft formation flying using the constraint forces in Lagrangian systems显示文摘Getting inspiration from the constraint forces in the classical mechanics, we presented the nonlinear control method of multiple spacecraft formation flying to accurately keep the desired formation arrays. Considering nonlinearity and perturbation, we changed the question of the formation array control to the Lagrange equations with the holonomic constraints and the differential algebraic equations (DAE), and developed the nonlinear control for design of the follower spacecraft tracking control laws by solving the DAE. Because of using the idea of the constraint forces, this approach can adequately utilize the characteristic of the dynamic equations, i.e., the space natural forces, and accurately keep the arbitrary formation array. Simulation results of the circular formation keeping with the linear and nonlinear dynamical equations were included to illuminate the control performance. | XING JianJun LEI YongJun CHENG WenKe TANG GuoJin | 2009 | Science China(Technological Sciences)2009，52，10： | 2 |
| 13 | Did Credit Rating Agencies Make Unbiased Assumptions on CDOs? 显示文摘 | Griffin John M Tang Dragon Yongjun | 2011 | American Economic Review2011，101，3： | 1 |
| 14 | Did Subjectivity Play a Role in CDO Credit Ratings? 显示文摘 | Griffin John M Tang Dragon Yongjun | 2012 | The Journal of Finance2012，，4： | 1 |
| 15 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
| 16 | Multiple Model Kalman Filter for Attitude Determination of Precision Pointing Spaceerat 显示文摘 | Kai Xiong Tang Liang Lei Yongjun | 2011 | Aeta Astro-Nautiea2011，，68： | 1 |
| 17 | A review of mechanical drilling for composite laminates显示文摘 | DeFu Liu YongJun Tang W.L. Cong | 2011 | Composite Structures2011，，4： | 1 |
| 18 | Biphasic calcium phosphate nano-composite scaffolds reinforced with bioglass provide a synthetic alternative to autografts in a canine tibiofibula defect model显示文摘 | Tang Dezhi Xu Guohua Yang Zhou Holz Jonathan Ye Xiaojian Cai Shu Yuan Wen Wang Yongjun | 2014 | Chinese Medical Journal2014，，7： | 1 |
| 19 | Depression after minor stroke: Prevalence and predictors显示文摘 | YuZhi Shi YuTao Xiang Yang Yang Ning Zhang Shuo Wang Gabor S. Ungvari Helen F.K. Chiu Wai Kwong Tang YiLong Wang XingQuan Zhao YongJun Wang ChunXue Wang | 2015 | Journal of Psychosomatic Research2015，，： | 1 |
| 20 | Multiple model Kalman filter for attitude determination of precision pointing spacecraft显示文摘 | Kai Xiong Tang Liang Lei Yongjun | 2010 | Acta Astronautica2010，，7： | 1 |
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