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| 1 | A unifying approach in simulating the shot peening process using a 3D random representative volume finite element model显示文摘Using a modified 3D random representative volume(RV)finite element model,the effects of model dimensions(impact region and interval between impact and representative regions),model shapes(rectangular,square,and circular),and peening-induced thermal softening on resultant critical quantities(residual stress,Almen intensity,coverage,and arc height)after shot peening are systematically examined.A new quantity,i.e.,the interval between impact and representative regions,is introduced and its optimal value is first determined to eliminate any boundary effect on shot peening results.Then,model dimensions are respectively assessed for all model shapes to reflect the actual shot peening process,based on which shape-independent critical shot peening quantities are obtained.Further,it is found that thermal softening of the target material due to shot peening leads to variances of the surface residual stress and arc height,demonstrating the necessity of considering the thermal effect in a constitutive material model of shot peeing.Our study clarifies some of the finite element modeling aspects and lays the ground for accurate modeling of the SP process. | Dianyin HU Ye GAO Fanchao MENG Jun SONG Yanfei WANG Mengxi REN Rongqiao WANG | 2017 | Chinese Journal of Aeronautics2017，30，4： | 13 |
| 2 | Zircon U/Pb dating and Hf-O isotopes of the Zhouan ultramafic intrusion in the northern margin of the Yangtze Block,SW China:Constraints on the nature of mantle source and timing of the supercontinent Rodinia breakup显示文摘The Zhouan ultramafic intrusion in the northern margin of the Yangtze Block is mainly composed of lherzolite.Zircon grains selected from lherzolite are irregular in shape with distinct oscillatory and sector zoning and have Th/U ratios ranging from 0.8 to 10.6,indicating a magmatic origin.The weighted average 206 Pb/238 U age is 637±4 Ma (2σ,n=15),which can be considered as the crystallization age of the Zhouan intrusion.Zircon grains have δ18O values ranging from 5.2‰ to 7.0‰,with an averaged value of 5.8±0.4‰ (1σ,n=33),similar to the mantle δ18O value of zircon.Their 176Hf/177Hf(t) ratios range from 0.282410 to 0.282594 with εHf(t) values ranging from 1.3 to 7.6,lower than the corresponding value of the depleted mantle (~15),indicating an enriched mantle source.The enriched mantle source may have generated from a metasomatized lithospheric mantle with subducted slab.A number of ~635 Ma mafic-ultramafic intrusions in the Suizao basin are associated with coeval bimodal volcanics of the Yaolinghe Formation,indicating a continental rift setting.The ~635 Ma magmatic event in this region may represent the product of the last breakup of the Rodinia supercontinent in the northern margin of the Yangtze Block at Neoproterozoic. | WANG MengXi WANG ChristinaYan ZHAO JunHong | 2013 | Science China(Technological Sciences)2013，56，3： | 10 |
| 3 | Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2^(pos)subjects显示文摘Increasing numbers of SARS-CoV-2-positive(SARS-CoV-2^(pos))subjects are detected at silent SARS-CoV-2 infection stage(SSIS).Yet,SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination towards persistently asymptomatic or overt disease.Here,we retrieved blood samples from 19 asymptomatic and 12 presymptomatic SARS-COV-2^(pos)subjects,47 age/gender-matched patients with mild or moderate COVID-19 and 27 normal subjects,and interrogated them with combined assays of 44-plex CyTOF,RNA-seq and Olink.Notably,both asymptomatic and presymptomatic subjects exhibited numerous readily detectable immunological alterations,while certain parameters including more severely decreased frequencies of CD107a^(low)classical monocytes,intermediate monocytes,non-classical monocytes and CD62L^(hi)CD8^(+)Tnaive cells,reduced plasma STC1 level but an increased frequency of CD4^(+)NKT cells combined to distinguish the latter.Intercorrelation analyses revealed a particular presymptomatic immunotype mainly manifesting as monocytic overactivation and differentiation blockage,a likely lymphocyte exhaustion and immunosuppression,yielding mechanistic insights into SSIS fate determination,which could potentially improve 5ARS-CoV-2 management. | Shanhe Yu Caixia Di Shijun Chen Mingquan Guo Jiayang Yan Zhaoqin Zhu Li Liu Ruixue Feng Yinyin Xie Ruihong Zhang Juan Chen Mengxi Wang Dong Wei Hai Fang Tong Yin Jinyan Huang Saijuan Chen Hongzhou Lu Jiang Zhu Jieming Qu | 2021 | Cell Research2021，31，11： | 4 |
| 4 | Monitoring the Amery Ice Shelf front during 2004-2012 using ENVISAT ASAR data显示文摘The Amery Ice Shelf is the largest ice shelf in East Antarctica. It drains continental ice from an area of more than one million square kilometres through a section of coastline that represents approximately 2% of the total circumference of the Antarctic continent. In this study, we used a time series of ENVISAT ASAR images from 2004-2012 and flow lines derived from surface velocity data to monitor the changes in 12 tributaries of the Amery Ice Shelf front. The results show that the Amery Ice Shelf has been expanding and that the rates of expansion differ across the shelf. The highest average annual rate of advance from 2004-2012 was 3.36 m·d-1 and the lowest rate was 1.65 m·d-1 . The rates in 2009 and 2010 were generally lower than those in other years. There was a low correlation between the rate of expansion and the atmospheric temperature recorded at a nearby research station, however the mechanism of the relationship was complex. This study shows that the expansion of the Amery Ice Shelf is slowing down, reflecting a changing trend in climate and ice conditions in East Antarctica. | ZHAO Chen CHENG Xiao HUI Fengming KANG Jing LIU Yan WANG Xianwei WANG Fang CHENG Cheng FENG Zhunzhun CI Tianyu ZHAO Tiancheng ZHAI Mengxi | 2013 | Advances in Polar Science2013，24，2： | 4 |
| 5 | One-step ball milling-prepared nano Fe2O3 and nitrogendoped graphene with high oxygen reduction activity and its application in microbial fuel cells显示文摘Developing high activity,low-cost and long durability catalysts for oxygen reduction reaction is of great significance for the practical application of microbial fuel cells.The ftill exposure of active sites in catalysts can enhance catalytic activity dramatically.Here,novel Fe-N-doped graphene is successftilly synthesized via a one-step in situ ball milling method.Pristine graphite,ball milling graphene,N-doped graphene and Fe-N-doped graphene are applied in air cathodes,and enhanced performance is observed in microbial fuel cells with graphene-based catalysts.Particularly,Fe-Ndoped graphene achieves the highest oxygen reduction reaction activity,with a maximum power density of 1380±20 mW/m^2 in microbial fUel cells and a current density of 23.8 A/m^2 at-0.16 V in electrochemical tests,which are comparable to commercial Pt and 390%and 640%of those of pristine graphite.An investigation of the material characteristics reveals that the superior performance of Fe-Ndoped graphene results from the full exposure of Fe2O3 nanoparticles,pyrrolic N,pyridinic N and excellent Fe-N-G active sites on the graphene matrix.This work not only suggests the strategy of maximally exposing active sites to optimize the potential of catalysts but also provides promising catalysts for the use of microbial fuel cells in sustainable energy generation. | Xingguo Guo Qiuying Wang Ting Xu Kajia Wei Mengxi Yin Peng Liang Xia Huang Xiaoyuan Zhang | 2020 | Frontiers of Environmental Science & Engineering2020，14，2： | 3 |
| 6 | Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes显示文摘Traumatic brain injury(TBI)is a global cause of morbidity and mortality.Initial management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available,noninvasive diagnostic biomarker.In particular,a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI(mTBI).Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue injury.By applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after TBI.Acoustofluidic isolation eliminated interference from other blood components,making it possible to detect exosomal biomarkers for TBI via flow cytometry.Flow cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma,indicating the potential of using circulating exosomes for the rapid diagnosis of TBI.Elevated levels of TBI biomarkers were only detected in the samples separated via acoustofluidics;no changes were observed in the analysis of the raw plasma sample.This finding demonstrated the necessity of sample purification prior to exosomal biomarker analysis.Since acoustofluidic exosome separation can easily be integrated with downstream analysis methods,it shows great potential for improving early diagnosis and treatment decisions associated with TBI. | Zeyu Wang Haichen Wang Ryan Becker Joseph Rufo Shujie Yang Brian E.Mace Mengxi Wu Jun Zou Daniel T.Laskowitz Tony Jun Huang | 2021 | Microsystems & Nanoengineering2021，7，2： | 3 |
| 7 | Acoustofluidic separation of cells andparticles显示文摘Acoustofluidics,the integration of acoustics and microfluidics,is a rapidly growing research field that is addressing challenges in biology,medicine,chemistry,engineering,and physics.In particular,acoustofluidic separation of biological targets from complex fluids has proven to be a powerful tool due to the label-free,biocompatible,and contact-free nature of the technology.By carefully designing and tuning the applied acoustic field,cells and other bioparticles can be isolated with high yield,purity,and biocompatibility.Recent advances in acoustofluidics,such as the development of automated,point-of-care devices for isolating sub-micron bioparticles,address many of the limitations of conventional separation tools.More importantly,advances in the research lab are quickly being adopted to solve clinical problems.In this review article,we discuss working principles of acoustofluidic separation,compare different approaches of acoustofluidic separation,and provide a synopsis of how it is being applied in both traditional applications,such as blood component separation,cell washing,and fluorescence activated cell sorting,as well as emerging applications,including circulating tumor cell and exosome isolation. | Mengxi Wu Adem Ozcelik Joseph Rufo Zeyu Wang Rui Fang Tony Jun Huang | 2019 | Microsystems & Nanoengineering2019，5，1： | 2 |
| 8 | Production characteristics and drainage optimization of coalbed methane wells: A case study from low-permeability anthracite hosted reservoirs in southern Qinshui Basin, China显示文摘 | Huihu Liu Shuxun Sang Michael Formolo Mengxi Li Shiqi Liu Hongjie Xu Shikai An Junjun Li Xingzhen Wang | 2013 | Energy for Sustainable Development2013，，： | 2 |
| 9 | Climatic Change Characteristics of Sunshine Hours and Cause Analysis in Lianyungang City显示文摘[Objective]The research aimed to study climatic change characteristics of sunshine hours in Lianyungang and analyze its formation reason. [Method]Based on monthly sunshine hours,precipitation,cloudiness,haze days and vapor pressure from 7 stations of Lianyungang from 1961 to 2010,monthly,seasonal,annual and interdecadal change trends of the sunshine hours were analyzed by using MK test,linear trend analysis and Morlet wavelet. Meanwhile,the cause of change characteristics was analyzed. [Result] Monthly sunshine hours of Lianyungang showed bimodal distribution,and seasonal and annual sunshine hours had decreasing trend at different degrees. The interdecadal change of sunshine hours showed wave characteristics. The annual sunshine hours had multiple temporal-spatial scale features,and there was an obvious mutation in the late 1980s. Sunshine hours in Lianyungang was closely related to visibility,cloudiness,vapor pressure and haze,and they were important factors causing that sunshine hours significantly declined. [Conclusion]The research could provide reference basis for scientifically developing and using solar energy resource and reasonably adjusting industrial and agricultural structures. | Honghua Zhang Guichen Wang Mengxi Yang Peng Wang | 2013 | Meteorological and Environmental Research2013，4，12： | 1 |
| 10 | FoxM1 affects adhesive,migratory,and invasive abilities of human retinoblastoma Y-79 cells by targeting matrix metalloproteinase 2显示文摘Forkhead box protein M1(FoxM1)is an important transcription factor involved in various pathological processes including tumor metastasis.The changes of adhesive,migratory,and invasive abilities are considered as crucial events in tumor metastasis progression.In this study,we aimed to investigate the correlation between FoxM1 and retinoblastoma(Rb)metastasis and to explore the detailed mechanism.Wound healing,cell adhesion,and invasion assays showed that FoxM1 overexpression induced epithelial-mesenchymal transition in Y-79 cells and inhibited adhesion and subsequently promoted metastasis of Y-79 cells,while FoxM1 knockdown showed the opposite effects.A luciferase reporter assay and chromatin immunoprecipitation assay provided evidence that FoxM1 promoted matrix metalloproteinase 2(MMP2)transcription by directly binding to and promoting MMP2 promoter.MMP2 knockdown by siRNA transfection attenuated cell metastasis of Y-79 cells induced by FoxM1 overexpression.Furthermore,the FoxM1-binding site mapped between-1167 and-1161 bp of the MMP2 promoter was identified.Our results suggested that the FoxM1-MMP2 axis plays an important role in Rb metastasis,which may be a novel target for designing therapeutic regimen to control Rb metastasis. | Xue Zhu Mengxi Yu Ke Wang Wenjun Zou Ling Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 1 |
| 11 | Human mobility data in the COVID-19 pandemic:characteristics,applications,and challenges显示文摘The COVID-19 pandemic poses unprecedented challenges around the world.Many studies have applied mobility data to explore spatiotemporal trends over time,investigate associations with other variables,and predict or simulate the spread of COVID-19.Our objective was to provide a comprehensive overview of human mobility open data to guide researchers and policymakers in conducting data-driven evaluations and decision-making for the COVID-19 pandemic and other infectious disease outbreaks.We summarized the mobility data usage in COVID-19 studies by reviewing recent publications on COVID-19 and human mobility from a data-oriented perspective.We identified three major sources of mobility data:public transit systems,mobile operators,and mobile phone applications.Four approaches have been commonly used to estimate human mobility:public transit-based flow,social activity patterns,index-based mobility data,and social media-derived mobility data.We compared mobility datasets’characteristics by assessing data privacy,quality,space–time coverage,high-performance data storage and processing,and accessibility.We also present challenges and future directions of using mobility data.This review makes a pivotal contribution to understanding the use of and access to human mobility data in the COVID-19 pandemic and future disease outbreaks. | Tao Hu Siqin Wang Bing She Mengxi Zhang Xiao Huang Yunhe Cui Jacob Khuri Yaxin Hu Xiaokang Fu Xiaoyue Wang Peixiao Wang Xinyan Zhu Shuming Bao Wendy Guan Zhenlong Li | 2021 | International Journal of Digital Earth2021，14，9： | 1 |
| 12 | Evaluation of the synergetic gas-enrichment and higher-permeability regions for coalbed methane recovery with a fuzzy model显示文摘 | Huihu Liu Shuxun Sang Geoff G.X. Wang Yangmin Li Mengxi Li Shiqi Liu | 2012 | Energy2012，，1： | 1 |
| 13 | Strong Anti- Ice Ability of Nanohairs over Micro-Ratchet Structures显示文摘 | Peng Guo Mengxi Wen Lei Wang and Yongmei Zheng | 2014 | Nanoseale2014，6，： | 1 |
| 14 | Time domain approach for computing the mooring force of a mooring system subject to wind, waves and currents 显示文摘 | NIE Mengxi WANG Xusheng WANG Xiaoming | 2004 | Tsinghua Science and Technology2004，44，9： | 1 |
| 15 | Hydrodynamics in commercial-scale internally circulating fluidized beds with different central downcomer outlets显示文摘Standpipes,or downcomers,are commonly used in fluidized beds to transport particles.The outlet structure of the downcomer greatly affects the performance of flow from it and even overall reactor performance.In this study,the hydrodynamics in commercial-scale internally circulating fluidized beds(ICFBs)with central downcomers having different outlet structures was investigated using computational fluid dynamics simulations with an energy minimization multi-scale drag model.The predicted results closely agreed with experimental data.Results showed that in an ICFB with a downcomer outlet directly open to the bed(model A),nearly 12.7%to 5.4%of the gas in the draft tube bypasses into the downcomer.In the ICFB models B and C with a conic baffle below the downcomer,the gas bypass is significantly weakened or even eliminated when the diameter of the conic baffle is 1.1 times that of the downcomer(model C).In addition,the solids circulation mass flux in ICFBs increased by about 62.5%,from 126.8 kg/(m2 s)in model A to 206 kg/(m2 s)in model C. | Zhenliang Meng Mengxi Liu Nouman Ahmad Wei Wang Chunxi Lu | 2020 | Particuology2020，18，4： | 1 |
| 16 | New Results in Stabilization of Uncertain Nonholonomic Systems:An Event-Triggered Control Approach显示文摘This paper reports latest developments in event-triggered and self-triggered control of uncertain nonholonomic systems in the perturbed chained form.In order to tackle the effects of drift uncertain nonlinearities,nonholonomic constraints and nonsmooth aperiodic sampling in eventbased control,a novel systematic design scheme is proposed by integrating set-valued maps with stateseparation and state-scaling techniques.The stability analysis of the closed-loop event-triggered control system is based on the cyclic-small-gain techniques that overcome the limitation of Lyapunov theory in the construction of Lyapunov functions for nonsmooth dynamical systems and enjoy inherent robustness properties due to the use of gain-based characterization of robust stability.More specifically,the closed-loop event-triggered control system is transformed into an interconnection of multiple input-tostate stable systems,to which the cyclic-small-gain theorem is applied for robust stability analysis.New self-triggered mechanisms are also developed as natural extensions of the event-triggered control result.The proposed event-based control design approach is new and original even when the system model is reduced to the ideal unperturbed chained form.Interestingly,the proposed methodology is also applicable to a broader class of nonholonomic systems subject to state and input-dependent uncertainties.The efficacy of the obtained event-triggered controllers is validated by a benchmark example of mobile robots subject to parametric uncertainties and a measurement noise such as bias in the orientation. | LIU Tengfei ZHANG Pengpeng WANG Mengxi JIANG Zhong-Ping | 2021 | Journal of Systems Science & Complexity2021，34，5： | 0 |
| 17 | Research Progresses on QTLs for Main Grain Shape Genes in Rice显示文摘The performance of rice quality affects the market competitiveness of rice to a certain extent,and grain shape is an important factor for yield traits and appearance quality.The mapping and cloning of major rice grain type genes were briefly reviewed,and the utilization of related genes in breeding was prospected. | Mengxi ZHOU Diandong WANG Zhen'an BAI Ying PENG | 2021 | Agricultural Biotechnology2021，10，6： | 0 |
| 18 | Sealing functional ionic liquids in conjugated microporous polymer membrane by solvent-assisted micropore tightening显示文摘Porous organic polymers hold great promise for molecular sieving membrane separation.Although the inclusion of functional ionic liquid(IL)in the pores offers a facile way to manipulate their separation properties,the IL leaching during the separation process is difficult to avoid.Herein,we report a strategy to in-situ encapsulate ILs into the micropores of the conjugated microporous polymer membrane via a 6-min electropolymerization and further seal the aperture of the pores to prevent ILs leaching by solvent-assisted micropore tightening(SAMT).Upon screening the binding energy between different ILs and gas molecules,two ILs were selected to be incorporated into the membrane for CO_(2)/CH_(4) and O_(2)/N_(2) gas separations.The resultant separation performances surpass the 2008 Robeson upper bound.Notably,the ILs can be locked in the micropores by a facile high surface tension solvent treatment process to improve their separation stability,as evidenced by a 7-day continuous test.This simple and controllable process not only enables efficient and steady separation performance but also provides an effective strategy for confining and sealing functional guest molecules in the porous solids for various applications. | Mengxi Zhang Anke Yu Xiangyu Wu Pengpeng Shao Xin Huang Dou Ma Xianghao Han Jing Xie Xiao Feng Bo Wang | 2022 | Nano Research2022，15，3： | 0 |
| 19 | Perlecan/Hspg2 Deficiency Impairs Bone’s Calcium Signaling and Associated Transcriptome in Response to Mechanical Loading显示文摘Perlecan,a heparan sulfate proteoglycan,acts as a mechanical sensor for bone to detect external loading.Deficiency of perlecan increases the risk of osteoporosis in patients with Schwartz-Jampel Syndrome(SJS)and attenuates loading4nduced bone formation in perlecan deficient mice(Hypo).Considering that intracellular calcium[Ca2+]i is an ubiquitous messenger controlling numerous cellular processes including mechanotransduction,we hypothesized that perlecan deficiency impairs bone’s calcium signaling in response to loading.To test this,we performed real-time[Ca2+]i imaging on in situ osteocytes of adult murine tibiae under cyclic loading(8 N,Figure 1).Relative to wild type(WT),Hypo osteocytes showed decreases in the overall[Ca2+]i response rate(-58%),calcium peaks(-33%),cells with multiple peaks(-53%),peak magnitude(-6.8%),and recovery speed to baseline(-23%).RNA sequencing and pathway analysis of tibiae from mice subjected to one or seven days of unilateral loading demonstrated that perlecan deficiency significantly suppressed the calcium signaling,ECM-receptor interaction,and focal adhesion pathways following repetitive loading.Defects in the endoplasmic reticulum(ER)calcium cycling regulators such as Ryr1/ryanodine receptors and Atp2a1/Sercal calcium pumps were identified in Hypo bones.Taken together,impaired calcium signaling may contribute to bone’s reduced anabolic response to loading,underlying the osteoporosis risk for the SJS patients. | Shaopeng Pei Sucharitha Parthasarathy Ashutosh Parajuli Jerahme Martinez Mengxi Lv Sida Jiang Danielle Wu Shuo Wei XLucas Lu Mary CFarach-Carson Catherine BKirn-Safran Liyun Wang | 2019 | 医用生物力学2019，34，A01： | 0 |
| 20 | Combination of Solid-Phase Micro-Extraction and Direct Analysis in Real Time-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Sensitive and Rapid Analysis of 15 Phthalate Plasticizers in Beverages显示文摘A method for rapid identification and quantification of phthalate plasticizers in beverages was developed.A number of 15 phthalate plasticizers which covered all the phthalates concerned in the US Consumer Product Safety Improvement Act(CPSIA),European Union legislations and Chinese national standards(GB)were analyzed.By a combined solid-phase micro-extraction(SPME)and direct analysis in real time mass spectrometry(DART-MS)approach,phthalates at sub-ng•mL^(−1)levels can be qualitatively and quantitatively analyzed in a short time.The use of ultrahigh-resolving power and the accurate mass measurement capacity naturally provided by Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR-MS)minimizes the matrix interferences and thus enables the evaluation of phthalates in a complex matrix without extensive sample handlings or preparations.The limits of quantification(LOQs)were estimated to be at 0.3-5.0 ng•mL^(−1),lower than the Maximum Residue Limit(MRL)regulated by the European Union legislations(2007/19/EC)in foods,beverages,food packaging and toys(0.3-30 ng•mL^(−1)).This rapid and easy-to-use SPME-DART-FT-ICR-MS method provided a relatively high-throughput and powerful analytical approach for quick testing and screening phthalates in beverages and water samples to ensure food safety. | Mengxi Wu Haoyang Wang Guoqing Dong Brian D.Musselman Charles C.Liu Yinlong Guo | 2015 | Chinese Journal of Chemistry2015，33，2： | 0 |
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