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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | CTLA4 Silencing with siRNA Promotes Deviation of Th1/Th2 in Chronic Hepatitis B Patients显示文摘To determine whether RNA interference (RNAi) could block cytotoxic T-lymphocyte antigen 4 (CTLA4) in human lymphocytes in vitro and promote IFN-γ and IL-2 secretions, three small interfering RNAs (siRNAs) were selected based on target specificity sequences of human CTLA4 and transfected into human lymphocytes of chronic HBV patients. As a result, the expression of human CTLA4 mRNA was efficiently suppressed by all the three siRNAs. Compared with negative control (siRNA-co), siRNA-1 inhibited the expression of CTLA4 most efficiently and was used in the further study. The expressions of IFN-γ and IL-2 were upregulated and the level of IL-4 was almost unchanged in lymphocytes transfected with siRNA-1 compared with the blank control. These results indicated that siRNA-1 led to IFN-γ and IL-2 secretions, which is a main response of Th1/Th2. In a conclusion, RNAi significantly suppressed the expression of human CTLA4 mRNA in human lymphocytes in vitro, and could induce Th1/Th2 response. It could be a new therapeutic strategy for chronic HBV infection. | Yongsheng Yu Hao Wu Zhenghao Tang Guoqing Zang | 2009 | Cellular & Molecular Immunology2009，6，2： | 14 |
| 3 | Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan显示文摘Tremendous efforts have been devoted to the enhancement of drug solubility using nanotechnologies, but few of them are capable to produce drug particles with sizes less than a few nanometers. This challenge has been addressed here by using biocompatible versatile γ-cyclodextrin(γ-CD) metal-organic framework(CD-MOF) large molecular cages in which azilsartan(AZL) was successfully confined producing clusters in the nanometer range. This strategy allowed to improve the bioavailability of AZL in Sprague–Dawley rats by 9.7-fold after loading into CD-MOF. The apparent solubility of AZL/CD-MOF was enhanced by 340-fold when compared to the pure drug. Based on molecular modeling, a dual molecular mechanism of nanoclusterization and complexation of AZL inside the CD-MOF cages was proposed, which was confirmed by small angle X-ray scattering(SAXS) and synchrotron radiation-Fourier transform infrared spectroscopy(SR-FTIR) techniques. In a typical cage-like unit of CD-MOF, three molecules of AZL were included by the γ-CD pairs, whilst other three AZL molecules formed a nanocluster inside the 1.7 nm sized cavity surrounded by six γ-CDs. This research demonstrates a dual molecular mechanism of complexation and nanoclusterization in CD-MOF leading to significant improvement in the bioavailability of insoluble drugs. | Yuanzhi He Wei Zhang Tao Guo Guoqing Zhang Wei Qin Liu Zhang Caifen Wang Weifeng Zhu Ming Yang Xiaoxiao Hu Vikramjeet Singh Li Wu Ruxandra Gref Jiwen Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 13 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | The High Energy X-ray telescope (HE) onboard the Insight-HXMT astronomy satellite显示文摘The Insight-Hard X-ray Modulation Telescope(Insight-HXMT) is a broadband X-ray and γ-ray(1-3000 ke V) astronomy satellite. One of its three main telescopes is the High Energy X-ray telescope(HE). The main detector plane of HE comprises 18 Na I(Tl)/Cs I(Na) phoswich detectors, where Na I(Tl) is used as the primary detector to measure ~ 20-250 ke V photons incident from the field of view(FOV) defined by collimators, and Cs I(Na) is used as the active shielding detector to Na I(Tl) by pulse shape discrimination. Additionally, Cs I(Na) is used as an omnidirectional γ-ray monitor. The HE collimators have a diverse FOV,i.e. 1.1°×5.7°(15 units), 5.7°×5.7°(2 units), and blocked(1 unit). Therefore, the combined FOV of HE is approximately5.7°×5.7°. Each HE detector has a diameter of 190 mm resulting in a total geometrical area of approximately 5100 cm2, and the energy resolution is ~15% at 60 ke V. For each recorded X-ray event by HE, the timing accuracy is less than 10 μs and the deadtime is less than 10 μs. HE is used for observing spectra and temporal variability of X-ray sources in the 20-250 ke V band either by pointing observations for known sources or scanning observations to unveil new sources. Additionally, HE is used for monitoring the γ-ray burst in 0.2-3 Me V band. This paper not only presents the design and performance of HE instruments but also reports results of the on-ground calibration experiments. | CongZhan Liu YiFei Zhang XuFang Li XueFeng Lu Zhi Chang ZhengWei Li AiMei Zhang YongJie Jin HuiMing Yu Zhao Zhang MinXue Fu YiBao Chen JianFeng Ji YuPeng Xu JingKang Deng RenCheng Shang GuoQing Liu FangJun Lu ShuangNan Zhang YongWei Dong TiPei Li Mei Wu YanGuo Li HuanYu Wang BoBing Wu YongJie Zhang Zhi Zhang ShaoLin Xiong Yuan Liu Shu Zhang HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 9 |
| 6 | Leakage performance of floating ring seal in cold/hot state for aero-engine显示文摘Rotating experimental investigations were carried out to study the oil sealing capability of two different floating ring seals in cold/hot state for aero-engine. High-speed Floating Ring Seal(HFRS) is a seal with the inner diameter of 83.72 mm and maximum speed of 38000 r/min, and Low-speed Floating Ring Seal(LFRS) is another seal with the inner diameter of 40.01 mm and maximum speed of 18000 r/min. In hot state, sealing air with the temperature of 371 K and oil with the temperature of 343 K was employed to model the working conditions of an aero-engine. Comparisons between floating ring seal and labyrinth seal were done to inspect the leakage performance.More attention was paid to the critical pressure ratio where the oil leakage began. Results show that the critical pressure ratio in cold state is obviously larger than that in hot state for both seals. An underlying sealing mechanism for floating ring seal is clarified by the fluid film, which closely associates with the dimensionless parameter of clearance over rotating diameter(2 c/Dr). Another fantastic phenomenon is that the leakage coefficient in hot state, not the leakage magnitude, is unexpectedly larger than that in cold state. Overall, the leakage performance of the floating ring seal is better than the labyrinth seal. | Guoqing LI Qian ZHANG Enliang HUANG Zhijun LEI Hongwei WU Gang XU | 2019 | Chinese Journal of Aeronautics2019，32，9： | 9 |
| 7 | Plasma Nesfatin-1 concentration and its correlation with HPA axis in depression model rats显示文摘Objective To explore plasma Nesfatin-1 concentration and its correlation with hypothalamic pituitary adrenal(HPA) axis in depression model rats. Methods Twelve SD rats were randomly divided into normal control group(NCG) and depression model group(DMG). DMG received 5 consecutive weeks of 7 different chronic unpredictable mild stress(CUMS). The behavior of rats was evaluated by an open field test,sucrose preference test,and forced swimming test(FST). The concentration of plasma corticosterone and Nesfatin-1 were measured with an enzyme-linked immuno-sorbent assay(ELISA). Results Compared with NCG,DMG had a lower weight gain,lower index of sucrose preference and spent longer time being immobile in FST while all of these differences were statistically significant(P<0.05). The plasma concentrations of corticosterone and Nesfatin-1 were significantly higher in DMG than in theN CG(P<0.05). The plasma concentration of Nesfatin-1in DMG was positively correlated with the plasma corticosterone concentration. Conclusion CUMS could induce depression-like behavior in rats and increase the plasma concentration of Nesfatin-1 and corticosterone,while the HPA axis hyperactivity induced by CUMS may be associated with the increased concentration of Nesfatin-1. | WANG Gaohua WU Shengjuan WANG Huiling Wei Yanyan Gao Guoqing Li Jiangbo | 2016 | 国际精神病学杂志2016，43，3： | 6 |
| 8 | UAV cooperative air combat maneuver decision based on multi-agent reinforcement learning显示文摘In order to improve the autonomous ability of unmanned aerial vehicles(UAV)to implement air combat mission,many artificial intelligence-based autonomous air combat maneuver decision-making studies have been carried out,but these studies are often aimed at individual decision-making in 1 v1 scenarios which rarely happen in actual air combat.Based on the research of the 1 v1 autonomous air combat maneuver decision,this paper builds a multi-UAV cooperative air combat maneuver decision model based on multi-agent reinforcement learning.Firstly,a bidirectional recurrent neural network(BRNN)is used to achieve communication between UAV individuals,and the multi-UAV cooperative air combat maneuver decision model under the actor-critic architecture is established.Secondly,through combining with target allocation and air combat situation assessment,the tactical goal of the formation is merged with the reinforcement learning goal of every UAV,and a cooperative tactical maneuver policy is generated.The simulation results prove that the multi-UAV cooperative air combat maneuver decision model established in this paper can obtain the cooperative maneuver policy through reinforcement learning,the cooperative maneuver policy can guide UAVs to obtain the overall situational advantage and defeat the opponents under tactical cooperation. | ZHANG Jiandong YANG Qiming SHI Guoqing LU Yi WU Yong | 2021 | Journal of Systems Engineering and Electronics2021，32，6： | 6 |
| 9 | Delivery of Tapasin-modified CTL epitope peptide via cytoplasmic transduction peptide induces CTLs by JAK/STAT signaling pathway in vivo显示文摘特定的细胞毒素的 T 淋巴细胞(CTL ) 玩的肝炎 B 病毒(HBV ) 在病毒的控制和清理的一个重要角色。最近的研究阐明了那 Tapasin, endoplasmic 蜂窝胃女伴,是看起来在装载肽的过程必要的一个著名分子。Janus kinase/signal 变换器和小径玩的抄写(JAK/STAT ) 的使活跃之物在有免疫力的反应的一个重要角色规定和 cytokines 分泌物。我们以前证实了熔化蛋白质 CTP-HBcAg 18-27-Tapasin 能便于骨头髓的成熟导出的树枝状的房间并且在 vitro 提高特定的 CTL 回答,它可能与 JAK/STAT 发信号的激活被联系小径。为了进一步探索 JAK/STAT 发信号小径是否参予了特定的有免疫力的回答,由我们压制了的 CTP-HBcAg 18-27-Tapasin, 调停了有在 vivo 的药理学禁止者(AG490 ) 的 JAK/STAT 小径。我们的研究证明 IFN-+-CD8+ T 房间的数字在被 AG490 堵住以后与另外的组相比显著地被减少。IFN-+-CD4+ T 房间和 IL-2-CD4 + T 房间的百分比也被减少。而且, Jak2, Tyk2, STAT1,和 STAT4 的更低的表示层次在 AG490 被检测组。另外,象 Th1 一样 cytokines 的分泌物层次被减少,更弱的特定的 T 房间回答在 AG490 组被观察。而且,在这条小径在 HBV 转基因的老鼠被禁止以后,在浆液的 HBV DNA 和 HBsAg 的层次和在肝纸巾的 HBsAg 和 HBcAg 的表示层次被提高。这些结果证明表明小径的 JAK/STAT 参予 CTP-HBcAg 18-27-Tapasin 导致的 Th1 面向的有免疫力的反应,这可能为 HBV 免疫疗法提供一个理论基础。 | Shanshan Wu Xiaohua Chen Yuyan Tang Yi Zhang Dan Li Jie Chen Jieling Wang Zhenghao Tang Guoqing Zang Yongsheng Yu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 6 |
| 10 | Numerical prediction of envelope line-spectrum intensity in underwater acoustic waveguides显示文摘In order to predict the detectible range and region of passive sonar in underwater channel,the attenuation causes of envelope line-spectrum height during vessel noise propagation are analyzed and an approach of numerical prediction is proposed.In the paper a model for vessel radiated noise is established by a periodically locally stationary random process,two formulae of the envelope line-spectrum height with and without background-noise are deduced, therefore the attenuation rule of the envelope line-spectrum height is obtained.It is shown that the transmission loss of the sound level of the envelope line-spectrum is same as the sound level of the stationary spectrum,but the decrease of envelope line-spectrum height depends on a modified scale of amplitude modulation depth which is variable with the ratio of signal to noise. An approach of numerical prediction for envelope line-spectrum height is as follows:first,the transmission loss of the stationary radiated noise is derived using the numerical approaches of normal modes or wavenumber integration or PE etc.,then the ratio of signal to noise on sound field is calculated,finally the decrease of envelope line-spectrum height is obtained according to the modified scale,and the envelope line-spectrum height in sound field is predicted.The theory and the numerical prediction approach possess certain innovation,practicality,simplicity and suitability for engineering. | WU Guoqing WANG Meigang CHEN Yaoming | 2013 | Chinese Journal of Acoustics2013，32，3： | 6 |
| 11 | Effect of defect complex on magnetic properties of (Fe, Mn)-doped ZnO thin films显示文摘We have observed room temperature ferromagnetism in Mn-doped and (Fe, Mn)-codoped ZnO thin films grown under different oxygen partial pressures by pulsed laser deposition. The X-ray diffraction and optical transmission spectra studies demonstrate the natural incorporation of Fe and Mn cations into wurtzite ZnO lattices. The effects of transition metal doping and defects on the magnetic properties was investigated. It is found that room temperature ferromagnetism is sensitive to oxygen vacancy and Zn vacancy. The absence of ferromagnetism in pure ZnO films grown under different oxygen partial pressures reveals that the transition metal ions should also play an important role in inducing the ferromagnetism. | Yang, Hailing Xu, Xiaoguang Zhang, Guoqing Miao, Jun Zhang, Xin Wu, Shizhe Jiang, Yong | 2012 | Rare Metals2012，31，2： | 5 |
| 12 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 13 | Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis显示文摘Signal transduction between different organs is crucial in the normal development of the human body. As an important medium for signal communication, exosomes can transfer important information, such as microRNAs(miRNAs), from donors to receptors.MiRNAs are known to fine-tune a variety of biological processes, including maxillofacial development; however, the underlying mechanism remains largely unknown. In the present study, transient apoptosis was found to be due to the expression of a miniature swine maxillofacial-specific miRNA, ssc-mir-133b. Upregulation of ssc-mir-133b resulted in robust apoptosis in primary dental mesenchymal cells in the maxillofacial region. Cell leukemia myeloid 1(Mcl-1) was verified as the functional target, which triggered further downstream activation of endogenous mitochondria-related apoptotic processes during tooth development.More importantly, mandible exosomes were responsible for the initial apoptosis signal. An animal study demonstrated that ectopic expression of ssc-mir-133 b resulted in failed tooth formation after 12 weeks of subcutaneous transplantation in nude mice. The tooth germ developed abnormally without the indispensable exosomal signals from the mandible. | Ye Li Xinxin Wang Jiali Ren Xiaoshan Wu Guoqing Li Zhipeng Fan Chunmei Zhang Ang Li Songlin Wang | 2018 | Bone Research2018，6，4： | 5 |
| 14 | Beam pattern of sparse array for passive sonar显示文摘没有栅栏脑叶,这个工作为被动声纳瞄准稀少的数组,以便增加被动声纳和还原剂的频率乐队费用。根据传统的方法,在在声纳数组的二个连续传感器之间的距离应该是不到信号的最高的频率的波长;否则,栅栏脑叶出现在横梁模式上。纸认识到它是的栅栏脑叶出现的结论别在传统的方法由于正弦波浪信号模型适合到被动声纳,事实上被动声纳的输入是随机的信号。从计算机模拟,真实被动声纳信号和理论分析的三个方面,在在被动声纳数组的二个连续传感器之间的距离什么时候比最高的频率的波长长,被揭示栅栏脑叶不出现在横梁模式上。散发的噪音增白能拓宽频率乐队,到没有栅栏脑叶,保证横梁模式。纸的结论是:如果散发的噪音的乐队是足够宽的(比 1 八音度宽广) ,没有栅栏脑叶,信号的波长能是比在在被动声纳的二个连续传感器之间的距离短的。 | WU Guoqing WANG Meigang | 2007 | Chinese Journal of Acoustics2007，26，2： | 5 |
| 15 | An analytical study of unsteady heat transfer in the rock surrounding a deep airway显示文摘The heat transfer between an airway and the air flowing though it is an unsteady problem. The governing equation of unsteady heat transfer was solved using the method of separation of variables. The solution is an infinite series including Bessel functions. The theoretical solution was analyzed by solving for the positive roots of the transcendental equation by iteration. The dimensionless surface temperature of the sur- rounding rock is only affected by the Bi number but not by the thermo-physical coefficients of the rock. The dimensionless coefficient of heat transfer, k, decreases with the Fo number similarly to the influence of the Bi number on k. A formula for determining the fully developed stage (FDS) suitable for unsteady heat transfer in the airway is proposed. The FDS from theoretical analysis occurs with Fo from 1.6 to 2. The ratio of excess temperature in the surrounding rock is independent of the initial conditions and only dependent on the Bi number and the relative position in the airway, at the FDS. The calculation error is large when using just the first term from the complete series when Fo is from 2 to 12. Five terms give a solution approximately equal to that found using the complete series. The first term could replace the complete series only when Fo is greater than 12. The FDS plays an important role in predication of the temperature field of the surrounding rock and in simplified calculations. | Wang Yijiang | 2012 | International Journal of Mining Science and Technology2012，22，3： | 4 |
| 16 | Sensitivity analysis of the SWAP(Soil-Water-Atmosphere-Plant)model under different nitrogen applications and root distributions in saline soils显示文摘Sensitivity analysis is important for determining the parameters in the model calibration process.In our study,a variance-based global sensitivity analysis(extended Fourier amplitude sensitivity test,EFAST)was applied to an agro-hydrological model(the SWAP(Soil-Water-Atmosphere-Plant model)model).The sensitivities of 20 parameters belonging to 4 categories(soil hydraulics,solute transport,root water uptake,and environmental stresses)for the simulated accumulated transpiration,dry matter(DM),and yield of sunflowers were analyzed under three nitrogen application rates(N1,N2,and N3),four salinity levels(S1,S2,S3,and S4),and three root distributions(R1,R2,and R3).The results indicated that for predominantly loamy soils,the high-impact parameters for accumulated transpiration,DM,and yield were the soil hydraulic parameters(αand n),critical stress index for compensatory root water uptake(ωc),the salt level at which salt stress starts(Pi),the decline of root water uptake above Pi(SSF),residual water content(θr),saturated water content(θs),and relative uptake of solutes by roots(TSCF).We also found that nitrogen application did not change the order of the parameter impacts on accumulated transpiration,DM,and yield.However,TSCF replacedαas the highest-impact parameter for the accumulated transpiration,DM,and yield at high salinity levels(S2 and S3).Furthermore,αwas also the highest-impact parameter for DM and yield under different root distributions,but the highest-impact parameters for transpiration wereωc,α,andθs under R1,R2,and R3,respectively.Nitrogen application could be neglected when considering the interactive effects of nitrogen application,salinity level,and root distribution on the transpiration,DM,and yield.Additionally,the mean values and uncertainties of the transpiration,DM,and yield were similar in all scenarios,except S3,which showed a sharp decrease in the mean values.We suggest determining the above eight parameters(α,n,ωc,Pi,SSF,θr,θs,and TSCF)and the saturated vertical hydraulic conductivity(Ks)based on rigorous calibrations with direct or indirect local measurements using economical methods(e.g.,a literature review),with limited observations for other parameters when using the SWAP model and other similar agro-hydrological models. | Guoqing LEI Wenzhi ZENG Yonghua JIANG Chang AO Jingwei WU Jiesheng HUANG | 2021 | Pedosphere2021，31，5： | 4 |
| 17 | VOLUME DEFECT FATIGUE FAILURE OF CERAMIC BALLS UNDER ROLLING CONDITION显示文摘A newly developed pure rolling fatigue test rig with three contact points is used to test the rolling contact fatigue properties of silicon nitride ceramic balls. Ball surfaces are examined after failure with optical microscopy and scanning electron microscopy. The failure cause,fatigue phenomenon and mechanics are analyzed. The research shows that subsurface cracks play a dominant role in the formation of spalling failure. These cracks originated from volume defects of the material and propagate,to form elliptical fatigue spalls under the action of principal tensile stresses. The principal tensile stress increases with increasing contact load,causing spall formation and reduction of rolling contact life. The greater the principal tensile stress is,the more severe the peeling of near surface is. Under the same condition,the closer volume defects are to the surface,the more likely failure occurs,the shorter the rolling contact life is. | ZHOU Jingling WU Guoqing CHEN Xiaoyang | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 3 |
| 18 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 19 | Application and evaluation of Stanghellini model in the determination of crop evapotranspiration in a naturally ventilated greenhouse显示文摘Stanghellini model is one of the few models primarily developed to predict the evapotranspiration of crops(ET_(c))in naturally ventilated greenhouses.However,there are insufficient data on the model regarding its use,particularly in China where solar greenhouses without heating systems are fast spreading for vegetable growth and production.The application of Stanghellini model and the evaluation of its performance using meteorological and tomato plant data generated inside an unheated and naturally ventilated multi-span Venlo-type greenhouse is exploited in this study.Model capability was evaluated by utilizing data from sap flow measurements,meteorological and crop data.Measured meteorological data included solar radiation(R_(s)),air temperature(T_(a)),relative humidity(RH)and net radiation(Rn).Average leaf area index(LAI)values measured during the experimental period were 1.00,3.30,4.05 and 2.93;while determined crop coefficients(K_(c))changed from 0.40,0.62,1.12 to 0.83 for the initial stage,development stage,mid-season stage and late-season stage,respectively.Results from the study indicated that the average hourly ET_(c) values of tomato plants using sap flow measurements were 0.165 mm/h,0.148 mm/h,0.192 mm/h and 0.154 mm/h for the initial stage,development stage,mid-season stage and late-season stage,respectively.Meanwhile,the ET_(c) values obtained from calculation using Stanghellini model were 0.158 mm/h,0.152 mm/h,0.202 mm/h and 0.162 mm/h for the initial stage,development stage,mid-season stage and late-season stage,respectively.These ET_(c) values calculated by the Stanghellini model were close to the measured values within the same period.The coefficients of correlation(R^(2))based on hourly ET_(c) for the calibration data was 0.94 and that of the validation dataset was 0.90.Scatter plots of the estimated and measured hourly ET_(c) revealed that the R^(2) and the slope of the regression line for May,June and July were 0.94,0.90,0.96 and 1.15,0.97,1.10 respectively.These data were well represented around the 1:1 regression line.A model sensitivity analysis carried out illustrates how the changes in R_(s) and T_(a) affect greenhouse ET_(c).Stanghellini model was therefore proven to be suitable for ET_(c) estimation with acceptable accuracy in unheated and naturally ventilated greenhouses in the Northeast region of China. | Samuel Joe Acquah Haofang Yan Chuan Zhang Guoqing Wang Baoshan Zhao Haimei Wu Hengnian Zhang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 3 |
| 20 | A SMOOTHING CONJUGATE GRADIENT ALGORITHM FOR NONLINEAR COMPLEMENTARITY PROBLEMS显示文摘A PRP-type smoothing conjugate gradient method for solving large scale nonlinear complementarity problems(NCP(F)) is proposed.At each iteration,two Armijo line searches are performed,which guarantees the positive property of the smoothing parameter and minimizes the merit function formed by Fischer-Burmeister function,respectively.Global convergence is studied when F:R^n→R^n is a continuously differentiable P_0 + R_0 function.Numerical results show that the method is efficient. | Caiying WU Guoqing CHEN | 2008 | Journal of Systems Science and Systems Engineering2008，17，4： | 3 |
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