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| 1 | Fast cross validation for regularized extreme learning machine显示文摘A method for fast l-fold cross validation is proposed for the regularized extreme learning machine(RELM). The computational time of fast l-fold cross validation increases as the fold number decreases, which is opposite to that of naive l-fold cross validation. As opposed to naive l-fold cross validation, fast l-fold cross validation takes the advantage in terms of computational time, especially for the large fold number such as l > 20. To corroborate the efficacy and feasibility of fast l-fold cross validation,experiments on five benchmark regression data sets are evaluated. | Yongping Zhao Kangkang Wang | 2014 | Journal of Systems Engineering and Electronics2014，25，5： | 8 |
| 2 | Pitting corrosion of 2Cr13 stainless steel in deep-sea environment显示文摘Pitting corrosion of 2Cr13 stainless steel was investigated by deep-sea exposure test at various depths of 500 m,800 m and 1200 m in the South China Sea for 4 months.With the aid of electrochemical measurements in simulated deep-sea environments and grey relational analysis,the influence of deepsea environments on passive film and the mechanism of pitting corrosion were discussed.The results indicated that with the increase of sea depth,pitting depth of 2Cr13 stainless steel increased,which can be attributed to the change of chemical composition and the degradation of pitting resistance of passive film.Film growth was greatly retarded in the condition of low seawater temperature and low dissolved oxygen content of deep sea,resulting in an unstable and vulnerable film.Pitting depth was most influenced by hydrostatic pressure,which can increase the adsorption and penetration of Cl-ion,and promote the proliferation of point defects in passive film,leading to rapid deconstruction of protective oxides of the film.Pitting sensitivity of 2Cr13 stainless steel increased eventually with the combination of accelerated dissolution and suppressed self-healing of passive film in deep sea. | Xinhua Wang Lin Fan Kangkang Ding Likun Xu Weimin Guo Jian Hou Tigang Duan | 2021 | Journal of Materials Science & Technology2021，，5： | 6 |
| 3 | A Soft Robotic Fish with Variable-stiffness Decoupled Mechanisms显示文摘 | Kangkang Li Hongzhou Jiang Siyu Wang Jianmin Yu | 2018 | Journal of Bionic Engineering2018，15，4： | 5 |
| 4 | Single small molecule-assembled nanoparticles mediate efficient oral drug delivery显示文摘Oral drug delivery,which requires surviving the harsh environment in the gastrointestinal(Gl)tract and penetrating the intestinal epithelium,has not bee n achieved using simple formulatio n nan oparticles(NPs).Medici nal natural products(MNPs)have bee n widely used in traditi onal medicine for disease management through oral consumption.However,most pharmacologically active compounds within MNPs do not have the properties suitable for oral applicatio ns.We hypothesize that some MNPs contain n atural nano materials that can convert those compounds into oral formulations by forming NPs.After screening 66 MNPs,we identified five classes of small molecules that form NPs,many of which are capable of efficient drug encapsulation and Gl penetration.We show that one of them,dehydrotrametenolic acid(DTA),is capable of mediating oral delivery for effective disease treatment.We determined that DTA NPs assemble through hydrogen bonding and penetra怕the Gl tract via apical sodium-depe ndent bile acid tran sporter.Our study reveals a no vel class of single comp orient,small molecule-assembled NPs for oral drug delivery,and suggests a n ovel approach to modernizi ng MNPs through nano material discovery. | Xin Yang Chao Ma Zeming Chen Jun Liu Fuyao Liu Rongbin Xie Haitian Zhao Gang Deng Ann TChen Ningbo Gong Lei Yao Pengjian Zuo Kangkang Zhi Jiacheng Wang Xiaobin Gao Jing Wang Louzhen Fan Jiangbing Zhou | 2019 | Nano Research2019，12，10： | 4 |
| 5 | Relationship Between Economic Growth and Water Environmental Quality of Anshan City in Northeast China显示文摘Based on the decomposition model of environmental quality and univariate regression model,the relationships of industrial wastewater drainage with economic scale,economic structure,and technological level in Anshan,a mining city in Northeast China,were studied. The results showed that,due to scale effect,the drainage of three important industrial wastewater pollutants(COD,NH3-N and petroleum) increased 8505t,671t and 384t,respectively,and due to structure effect,those pollutants drainage increased 3996t,174t and 120t from 2001 to 2006. While due to technological effect,the drainage of COD,NH3-N and petroleum reduced 4452t,458t and 331t,and due to cross effect,those pollutants drainage reduced 7270t,575t and 476t simultaneously. Meantime,the relationships between household consumption structure and domestic sewage discharge were analyzed,and domestic sewage discharges in different income levels were also compared. The results showed that,the domestic sewage discharges would increase 376t with 1000 yuan(RMB) increased in the traffic and communication consumption,and they would be 344t,219t,428t,1873t,respectively,in housing consumption,food consumption,medical consumption,miscellaneous commodity consumption. The proportion of domestic sewage discharge increased for high income residents significantly,but reduced for lower income residents. The industrial wastewater pollutants drainage tends to be reduced by technical progress,while domestic sewage discharge will be a more important factor for urban water environment quality. | GU Kangkang LIU Jingshuang WANG Yang | 2009 | Chinese Geographical Science2009，19，1： | 4 |
| 6 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 7 | Parameter studies and evaluation principles of delamination damage in laminated composites显示文摘Delamination represents one of the most severe failure modes in composite laminates,especially when they are subjected to uniaxial compression loads.The evaluation of the delamination damage has always been an essential issue of composite laminates for durability and damage tolerance in engineering practice.Focusing on the most typical and representative elliptical delamination issue,an analytical model simultaneously considering the conservative buckling process and non-conservative delamination propagation process is implemented.Various computational cases considering different delamination depths,directions,aspect ratios,and areas are established,and the predicted results based on the analytical model are carefully compared.Effects of these geometrical delamination parameters on the buckling,delamination propagation,and failure behaviors of composite laminates are thoroughly analyzed,and innovative evaluation principles of the delamination damage have been concluded.It is found that the delamination area is the key factor that truly affecting the failure behaviors of delaminated composites,and the local/global buckling and failure loads show clear linearity with the delamination area,whilst the delamination depth and direction only have slight effects. | Kangkang WANG Libin ZHAO Haiming HONG Jianyu ZHANG Yu GONG | 2021 | Chinese Journal of Aeronautics2021，34，7： | 3 |
| 8 | Lamellar hafnium ditelluride as an ultrasensitive surface-enhanced Raman scattering platform for label-free detection of uric acid显示文摘The development of two-dimensional(2D)transition metal dichalcogenides has been in a rapid growth phase for the utilization in surface-enhanced Raman scattering(SERS)analysis.Here,we report a promising 2D transition metal tellurides(TMTs)material,hafnium ditelluride(HfTe2),as an ultrasensitive platform for Raman identification of trace molecules,which demonstrates extraordinary SERS activity in sensitivity,uniformity,and reproducibility.The highest Raman enhancement factor of 2.32×10^(6)is attained for a rhodamine 6G molecule through the highly efficient charge transfer process at the interface between the HfTe2 layered structure and the adsorbed molecules.At the same time,we provide an effective route for large-scale preparation of SERS substrates in practical applications via a facile stripping strategy.Further application of the nanosheets for reliable,rapid,and label-free SERS fingerprint analysis of uric acid molecules,one of the biomarkers associated with gout disease,is performed,which indicates arresting SERS signals with the limits of detection as low as 0.1 mmol/L.The study based on this type of 2D SERS substrate not only reveals the feasibility of applying TMTs to SERS analysis,but also paves the way for nanodiagnostics,especially early marker detection. | YANG LI HAOLIN CHEN YANXIAN GUO KANGKANG WANG YUE ZHANG PEILIN LAN JINHAO GUO WEN ZHANG HUIQING ZHONG ZHOUYI GUO ZHENGFEI ZHUANG ZHIMING LIU | 2021 | Photonics Research2021，9，6： | 2 |
| 9 | Microstructure and mechanical properties of cast Mg-15Al-xNd alloy by permanent mold显示文摘To improve the comprehensive mechanical properties of Mg-15Al magnesium alloy,different amounts(from 0 to 4.0wt.%)of Nd were added to the alloy and six Mg-15Al-xNd alloys were prepared by metal mould casting.The effect of Nd content on microstructure of the alloys was investigated by means of OM,SEM,EDS,TEM,and XRD.The tensile properties were tested at room temperature(RT)and high temperature(473 K).The results indicate that the primaryα-Mg dendrite is significantly refined with the addition of Nd.The best refinement is reached at 1.0wt.%Nd content and the average dendrite arm spacing decreases from 80-100μm(without Nd addition)to^20μm.A further increase in Nd content leads to the coarsening of the primaryα-Mg dendrite.The addition of Nd improves the tensile properties of Mg-15Al both at RT and 473 K.The Mg-15Al alloy containing 1.0wt.%Nd exhibits the best tensile properties.Compared with the alloy without Nd,the yield and ultimate tensile strength of the Mg-15Al-1.0Nd alloy at RT increase from 132.3 to 148.6 MPa and 152.3 to 189.6MPa,increase by 12.3%and 24.5%,respectively;and the elongation at RT increases from 0.05%to 1.24%.The yield and tensile strength of the alloy at 473 K increase from 97.9 to 115.3 MPa and 121.6 to 140.1 MPa,increase by 15.2%and 20%,respectively.Further increment of Nd content to 1.5wt.%degrades the tensile properties,which is ascribed to grain coarsening and growth of the Al-Nd phase. | Zhou Kangkang Wang Hongxia Liang Wei Zhang Jinshan Zhang Hongxia | 2013 | China Foundry2013，10，5： | 2 |
| 10 | Human activity during the late Pleistocene in the Lop Nur region, northwest China: Evidence from a buried stone artifact显示文摘The Lop Nur region, in the east part of Tarim Basin, was an important transportation junction between west and east,north and south Eurasia. However, previous studies on prehistoric human activity have concentrated mostly on the Bronze Age,whereas that during the Stone Age remains largely unresearched. Here, we present a new direct evidence of human activity in the late Pleistocene, recorded on a grinding stone buried in a lacustrine sediment section of the Lop Nur region. The grain size distribution of the sediment section indicates that the site was probably in the center of a lake with weak hydrodynamic environment. Therefore, the stone artifact can only be carried to here by people instead of river and it was never move as soon as left here. Results of radiocarbon dating, the evident stratigraphic relations between the stone artifact and the sedimentary formation, indicate that the human activity could extend to approximately 13 ka BP. Furthermore, the results of starch-grain and use-wear analyses suggest that ancient humans gathered seeds of Triticeae, roots, and tubers and used the grinding stone to simply process selected plant as plant foodstuffs during this period. It implies that the environmental conditions in the river delta of the Lop Nur were inhabitable during the late Pleistocene. | Kangkang LI Xiaoguang QIN Xiaoyan YANG Bing XU Lei ZHANG Guijin MU Dong WEI Chunxue WANG Yong WU Xiaohong TIAN Yongchong LIN Wen LI Jiaqi LIU Yinxin JIAO | 2018 | Science China Earth Sciences2018，61，11： | 1 |
| 11 | Hierarchical macro-microporous WPU-ECM scaffolds combined with Microfracture Promote in Situ Articular Cartilage Regeneration in Rabbits显示文摘Tissue engineering provides a promising avenue for treating cartilage defects.However,great challenges remain in the development of structurally and functionally optimized scaffolds for cartilage repair and regeneration.In this study,decellularized cartilage extracellular matrix(ECM)and waterborne polyurethane(WPU)were employed to construct WPU and WPU-ECM scaffolds by water-based 3D printing using low-temperature deposition manufacturing(LDM)system,which combines rapid deposition manufacturing with phase separation techniques.The scaffolds successfully achieved hierarchical macro-microporous structures.After adding ECM,WPU scaffolds were markedly optimized in terms of porosity,hydrophilia and bioactive components.Moreover,the optimized WPU-ECM scaffolds were found to be more suitable for cell distribution,adhesion,and proliferation than the WPU scaffolds.Most importantly,the WPU-ECM scaffold could facilitate the production of glycosaminoglycan(GAG)and collagen and the upregulation of cartilage-specific genes.These results indicated that the WPU-ECM scaffold with hierarchical macro-microporous structures could recreate a favorable microenvironment for cell adhesion,proliferation,differentiation,and ECM production.In vivo studies further revealed that the hierarchical macro-microporous WPU-ECM scaffold combined with the microfracture procedure successfully regenerated hyaline cartilage in a rabbit model.Six months after implantation,the repaired cartilage showed a similar histological structure and mechanical performance to that of normal cartilage.In conclusion,the hierarchical macro-microporous WPU-ECM scaffold may be a promising candidate for cartilage tissue engineering applications in the future. | Mingxue Chen YangYang Li Shuyun Liu Zhaoxuan Feng Hao Wang Dejin Yang Weimin Guo Zhiguo Yuan Shuang Gao Yu Zhang Kangkang Zha Bo Huang Fu Wei Xinyu Sang Qinyu Tian Xuan Yang Xiang sui Yixin Zhou Yufeng Zheng Quanyi Guo | 2021 | Bioactive Materials2021，6，7： | 1 |
| 12 | Single-atomic-site iron on N-doped carbon for chemoselective reduction of nitroarenes显示文摘A facile,gram-scale and sustainable approach has been established for the synthesis of single-atomic-site iron on N-doped carbon(Fe_(SA)@NC-20A)via the pyrolysis of aniline modified FeZn-ZIFs,in which the synthesis of zeolitic imidazolate frameworks(ZIFs)can be accomplished in water at room temperature,and no acid etching is required.The as-synthesized catalyst exhibits better performance on the chemoselective hydrogenation of nitroarenes with a broad substrate scope(turnover frequency(TOF)up to 1,727 h^(-1),23 examples)than most of previously reported works.Based on high-angle annular dark field scanning transmission microscopy(HAADF-STEM)images in combination with X-ray photoelectron spectroscopy(XPS),X-ray absorption spectroscopy(XAS),electron spin resonance(ESR),and Mossbauer spectroscopy,Fe is dispersed as single atoms via forming FeNx(x=4-6).This work not only determines the active sites of FesA@NC-20A for hydrogenation(FeN4),but also proposes tentative pathways for both N-H activation of hydrazine and the reduction of nitroarene on FeN4 site,both of which are the key steps for the hydrogenation of nitroarenes.In addition,this catalyst shows excellent stability,and no significant activity degradation is observed when recycling for 10 times or restoring in air for 2 months. | Guoping Lu Kangkang Sun Yamei Lin Qixuan Du Jiawei Zhang Kui Wang Pengcheng Wang | 2022 | Nano Research2022，15，1： | 1 |
| 13 | A Facile Route to Synthesize Sheet-like Na2Ti3O7 with Improved Sodium Storage Properties显示文摘 | XIE Man WANG Kangkang CHEN Renjie LI Li WU Feng | 2015 | Chemical Research in Chinese Universities2015，31，3： | 1 |
| 14 | A class of strong limit theorems for countable nonhomogeneous Markov chains on the generalized gambling system显示文摘 | Wang Kangkang | 2009 | Czechoslovak Mathematical Journal2009，59，134： | 1 |
| 15 | Inhibitory effects of mushroom tyrosinase by some alkyl benzaldehydes显示文摘 | CHEN Qingxi SONG Kangkang WANG Qin | 2003 | Journal of Enzyme Inhibition and Medicinal Chemistry2003，18，6： | 1 |
| 16 | An improved section- wise exploiting modification direction method 显示文摘 | WANG Jianjun SUN Yiting Xu Huan CHEN Kangkang KIM H J Joo S H | 2010 | Signal Processing2010，90，： | 1 |
| 17 | Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis显示文摘The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines has stimulated intensive efforts to expand nanoparticle strategies to treat various diseases.Numerous synthetic nanoparticles have been developed for pharmaceutical delivery and cancer treatment.However,only a limited number of nanotherapies have enter clinical trials or are clinically approved.Systemically administered nanotherapies are likely to be sequestered by host mononuclear phagocyte system(MPS),resulting in suboptimal pharmacokinetics and insufficient drug concentrations in tumors.Bioinspired drug-delivery formulations have emerged as an alternative approach to evade the MPS and show potential to improve drug therapeutic efficacy.Here we developed a biodegradable polymer-conjugated camptothecin prodrug encapsulated in the plasma membrane of lipopolysaccharide-stimulated macrophages.Polymer conjugation revived the parent camptothecin agent(e.g.,7-ethyl-10-hydroxy-camptothecin),enabling lipid nanoparticle encapsulation.Furthermore,macrophage membrane cloaking transformed the nonadhesive lipid nanoparticles into bioadhesive nanocamptothecin,increasing the cellular uptake and tumor-tropic effects of this biomimetic therapy.When tested in a preclinical murine model of breast cancer,macrophage-camouflaged nanocamptothecin exhibited a higher level of tumor accumulation than uncoated nanoparticles.Furthermore,intravenous administration of the therapy effectively suppressed tumor growth and the metastatic burden without causing systematic toxicity.Our study describes a combinatorial strategy that uses polymeric prodrug design and cell membrane cloaking to achieve therapeutics with high efficacy and low toxicity.This approach might also be generally applicable to formulate other therapeutic candidates that are not compatible or miscible with biomimetic delivery carriers. | Kangkang Ying Yifeng Zhu Jianqin Wan Chenyue Zhan Yuchen Wang Binbin Xie Peirong Xu Hongming Pan Hangxiang Wang | 2023 | Bioactive Materials2023，，2： | 1 |
| 18 | Microstructure and mechanical properties of an Mg–10Al alloy fabricated by Sb-alloying and ECAP processing显示文摘 | Hongxia Wang Kangkang Zhou Guoyin Xie Xingzhong Liang Wei Liang Yuantao Zhao | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 19 | SWOT Analysis of Information Technology Industry in Beijing,China Using Patent Data显示文摘 | Huang Lucheng Wang Kangkang Wu Feifei ect | | 0，，7333： | 1 |
| 20 | Adsorption of Pb2+on amino-functionalized core-shell magnetic mesoporous SBA-15 silica composite显示文摘 | Wang Shuguo Wang Kangkang Cong Dai | 2014 | Chemical Engineering Journal2014，262，： | 1 |
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