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| 1 | Structure and coalbed methane occurrence in tectonically deformed coals显示文摘Research on structure of tectonically deformed coals(TDC) is a key issue in coal and gas outburst prevention and coalbed methane(CBM) exploitation.This paper presents a summary on the research progress in TDC's structural-genetic classification,tectonic strain influence on coal microstructure,coal porosity system,coal chemical structure and constituents,and their relationship with the excess coalbed methane.Previous studies suggested that tectonic deformation had significant influence on coal microstructure,coal super microstructure,and even chemical macromolecular structure.The main mechanisms of coal deformation are the tectonic stress degradation and polycondensation metamorphism(dynamical metamorphism).Besides,under different deformation mechanisms,the ultra-and micro-structure and chemical constituents of TDC presented distinct characteristics.Based on these achievements,we propose one possible evolutionary trend of TDC with different deformation mechanisms,and suggest that the coal and gas outburst in the TDC,especially in the mylonitic coals,may be not only controlled by geological structure,but also influenced by the tectonic stress degradation of ductile deformation.Therefore,further study on TDC should be focused on the controlling mechanism of deformation on structure and composition of coal,generation conditions and occurrence state of excess coalbed methane from deformation mechanism of coal. | HOU QuanLin LI HuiJun FAN JunJia JU YiWen WANG TianKai LI XiaoShi WU YuDong | 2012 | Science China Earth Sciences2012，55，11： | 49 |
| 2 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
| 3 | Adaptive Robust Dead-Zone Compensation Control of Electro-Hydraulic Servo Systems with Load Disturbance Rejection显示文摘A backstepping method based adaptive robust dead-zone compensation controller is proposed for the electro-hydraulic servo systems(EHSSs) with unknown dead-zone and uncertain system parameters.Variable load is seen as a sum of a constant and a variable part.The constant part is regarded as a parameter of the system to be estimated real time.The variable part together with the friction are seen as disturbance so that a robust term in the controller can be adopted to reject them.Compared with the traditional dead-zone compensation method,a dead-zone compensator is incorporated in the EHSS without constructing a dead-zone inverse.Combining backstepping method,an adaptive robust controller(ARC) with dead-zone compensation is formed.An easy-to-use ARC tuning method is also proposed after a further analysis of the ARC structure.Simulations show that the proposed method has a splendid tracking performance,all the uncertain parameters can be estimated,and the disturbance has been rejected while the dead-zone term is well estimated and compensated. | HE Yudong WANG Junzheng HAO Renjian | 2015 | Journal of Systems Science & Complexity2015，28，2： | 14 |
| 4 | Color image enhancement based on HVS and PCNN显示文摘To enhance color images more effectively, a novel strategy is presented in this paper. We firstly translate the image to be enhanced from RGB space into HIS space, secondly keep its H component unchanged, and thirdly stretch its S component exponentially, and at last process its I component in the following manner: couple both the gray value and the spatial information into an inner activity item of corresponding neuron, integrate the human visual system into a dynamic component of corresponding neuron, and compare the inner activity item with dynamic component to obtain the enhanced image. Experiments demonstrate the effectiveness and validity of our strategy. | ZHANG YuDong, WU LeNan , WANG ShuiHua & WEI Geng School of Information Science & Engineering, Southeast University, Nanjing 210096, China | 2010 | Science China(Information Sciences)2010，53，10： | 12 |
| 5 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 6 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 7 | Dehydroepiandrosterone Inhibited the Bone Resorption through the Upregulation of OPG/RANKL显示文摘dehydroepiandrosterone (DHEA ) 的血浆水平与老化一起逐渐地是减少。DHEA 的有益的效果作为反老化类固醇,反糖尿病 mellitus,反动脉粥样硬化,反痴呆,反肥胖和反骨质疏松症例如免疫系统上的 stimulatory 效果,在 vitro 并且在 vivo 在实验被表明了。为绝经后的骨质疏松症在治疗学调查 DHEA 的有效机制是重要的。孤立并且有教养的造骨细胞( Obs )和骨破折( Ocs ),我们在 osteoblastic 生存能力上分析了 DHEA 的效果, osteoprotegerin ( OPG )的表示上的 DHEA 的规定 NF-B ligand ( RANKL )的 /receptor 使活跃之物在 Obs 的 mRNA ,然后当面在 Ocs 的骨头再吞上观察了 DHEA 的行动或 Obs 的缺席。结果证明 DHEA 在 10-8-10-6 M 的集中范围以内改进了 Obs 的生存能力,特别在 10-7 M 的集中。DHEA 能显然在 Obs 增加 OPG/RANKL mRNA 的比率。面对 Obs, DHEA 能减少 specula 的吸收空隙的数字和区域。因此,我们仅仅面对 Obs 得出结论, DHEA 能禁止 Ocs 的骨头再吞,它可以被 Obs 的 OPG/RANKL 调停。 | Yudong Wang Ling Wang Dajin Li Wenjun Wang | 2006 | Cellular & Molecular Immunology2006，3，1： | 11 |
| 8 | An overview of design for CSNS/RCS and beam transport显示文摘The China Spallation Neutron Source (CSNS) is the first accelerator-based pulsed neutron source in China. Its accelerators are made up of an 80 MeV H- linac, a Rapid Cycling Synchrotron (RCS) and two beam transport lines. RCS accumulates and accelerates protons to the design energy of 1.6 GeV, and extracts high energy beam to strike the target. The overview of RCS is presented, and the key problems of the physics design are discussed. The two beam transport lines, from linac to RCS and from RCS to the target, are also introduced. | WANG Sheng AN YuWen FANG ShouXian HUANG Nan LIU WeiBin LIU YuDong QIN Qing QIU Jing WANG Na XU Gang XU ShouYan YU ChengHui | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 11 |
| 9 | A telomere-to-telomere gap-free reference genome of watermelon and its mutation library provide important resources for gene discovery and breeding显示文摘Watermelon,Citrullus lanatus,is the world's third largest fruit crop.Reference genomes with gaps and a narrow genetic base hinder functional genomics and genetic improvement of watermelon.Here,we report the assembly of a telomere-to-telomere gap-free genome of the elite watermelon inbred line G42 by incorporating high-coverage and accurate long-read sequencing data with multiple assembly strategies.All 11 chromosomes have been assembled into single-contig pseudomolecules without gaps,representing the highest completeness and assembly quality to date.The G42 reference genome is 369321829 bp in length and contains 24205 predicted protein-coding genes,with all 22 telomeres and 11 centromeres characterized.Furthermore,we established a pollen-EMS mutagenesis protocol and obtained over 200000M1 seeds from G42.In a sampling pool,48 monogenic phenotypic mutations,selected from 223M1and 78 M2 mutants with morphological changes,were confirmed.The average mutation density was 1 SNP/1.69Mband1 indel/4.55 Mb per M1 plant and 1SNP/1.08Mb and 1 indel/6.25 Mb per M2 plant.Taking advantage of the gap-free G42 genome,8039 mutations from 32 plants sampled from M1 and M2 families were identified with 100%accuracy,whereas only 25% of the randomly selected mutations identified using the 97103v2 reference genome could be confirmed.Using this library and the gap-free genome,two genes responsible for elongated fruit shape and male sterility(CiMs1)were identified,both caused by a single basechange from G to A.The validated gap-free genome and its EMS mutation library provide invaluable resources for functional genomics and genetic improvement of watermelon. | Yun Deng Shoucheng Liu Yilin Zhang Jingsheng Tan Xiaopeng Li Xiao Chu Binghua Xu Yao Tian Yudong Sun Bosheng Li YunbiXu Xing Wang Deng Hang He Xingping Zhang | 2022 | Molecular Plant2022，15，8： | 9 |
| 10 | Distributed and Weighted Extreme Learning Machine for Imbalanced Big Data Learning显示文摘The Extreme Learning Machine(ELM) and its variants are effective in many machine learning applications such as Imbalanced Learning(IL) or Big Data(BD) learning. However, they are unable to solve both imbalanced and large-volume data learning problems. This study addresses the IL problem in BD applications. The Distributed and Weighted ELM(DW-ELM) algorithm is proposed, which is based on the Map Reduce framework. To confirm the feasibility of parallel computation, first, the fact that matrix multiplication operators are decomposable is illustrated.Then, to further improve the computational efficiency, an Improved DW-ELM algorithm(IDW-ELM) is developed using only one Map Reduce job. The successful operations of the proposed DW-ELM and IDW-ELM algorithms are finally validated through experiments. | Zhiqiong Wang Junchang Xin Hongxu Yang Shuo Tian Ge Yu Chenren Xu Yudong Yao | 2017 | Tsinghua Science and Technology2017，22，2： | 8 |
| 11 | Water demand for ecosystem protection in rivers with hyper-concentrated sediment-laden flow显示文摘Sediment transport is one of the main concerns in a river system with hyper-concentrated flows. Therefore, the water use for sediment transport must be considered in study on the water demand for river ecosystem. The conventional methods for calculating the Minimum Water Demand for River Ecosystem (MWDRE) are not appropriate for rivers with high sediment concentration. This paper studied the MWDRE in wet season, dry season and the whole year under different water-and-sediment conditions in the Lower Yellow River, which is regarded as a typical river with sediment-laden flows. The characteristics of MWDRE in the river are analyzed. Firstly, the water demand for sediment transport (WDST) is much larger than the demands for other riverine functions, the WDST accounts for the absolute majority of the MWDRE. Secondly, in wet season when the WDST is satisfied, not only most of the annual incoming sediment can be transported downstream, but also the water demands for other river functions can be satisfied automatically, so that the MWDRE in wet season is identical to the WDST. Thirdly, in dry season, when the WDST is satisfied, the water demands for other river functions can also be satisfied, but the low sediment transport efficiency results in significant waste of water resources. According to these characteristics and aiming at decreasing sediment deposition in the riverbed and improving the utilization efficiency of water resources, hydrological engineering works can be used to regulate or control flow and sediment so that the sediment incoming in dry season can be accumulated and be transported downstream intensively and thus efficiently in wet season. | LUO Huaming, LI Tianhong, NI Jinren & WANG Yudong Department of Environmental Engineering, Peking University, Beijing 100871, China The Key Laboratory of Water and Sediment Sciences, Ministry of Education, Beijing 100871, China | 2004 | Science China(Technological Sciences)2004，47，z1： | 8 |
| 12 | Enrichment of heavy metal elements and their adsorption on iron oxides during carbonate rock weathering process显示文摘Analysis of trace elements in the Lower Palaeozoic carbonate rock strata of the Beijing area shows that the Cr, Zn, Cd and Pb contents increase from primary carbonate rocks to weathered carbonate rocks and from primary carbonate rocks to the soil coexisting with carbonate rock. Distributions of Cr, Zn, Cd and Pb have the same trends as that of Fe2O3. Iron oxides play different roles at different stages of weathering of carbonate rock. The adsorption of Cr, Zn, Cd and Pb on Fe2O3 is greater than on FeO in soil. However, FeO, as a main component of clay mineral, is a better adsorbent of Cr, Zn, Cd and Pb than Fe2O3 in weathered and primary carbonate rocks. According to R-type clustering analysis, the main components of carbonate rock are divided into marine and continental sediments. Correlation analysis shows that heavy metal elements mainly exist in continental substances. | Shanqin Ni Yiwen Ju Quanlin Hou Shijie Wang Qing Liu Yudong Wu Lingling Xiao | 2009 | Progress in Natural Science:Materials International2009，19，9： | 8 |
| 13 | Building a sequence map of the pig pan-genome from multiple de novo assemblies and Hi-C data显示文摘Pigs were domesticated independently in the Near East and China,indicating that a single reference genome from one individual is unable to represent the full spectrum of divergent sequences in pigs worldwide.Therefore,12 de novo pig assemblies from Eurasia were compared in this study to identify the missing sequences from the reference genome.As a result,72.5 Mb of nonredundant sequences(~3% of the genome)were found to be absent from the reference genome(Sscrofa11.1)and were defined as pan-sequences.Of the pan-sequences,9.0 Mb were dominant in Chinese pigs,in contrast with their low frequency in European pigs.One sequence dominant in Chinese pigs contained the complete genic region of the tazarotene-induced gene 3(TIG3)gene which is involved in fatty acid metabolism.Using flanking sequences and Hi-C based methods,27.7% of the sequences could be anchored to the reference genome.The supplementation of these sequences could contribute to the accurate interpretation of the 3D chromatin structure.A web-based pan-genome database was further provided to serve as a primary resource for exploration of genetic diversity and promote pig breeding and biomedical research. | Xiaomeng Tian Ran Li Weiwei Fu Yan Li Xihong Wang Ming Li Duo Du Qianzi Tang Yudong Cai Yiming Long Yue Zhao Mingzhou Li Yu Jiang | 2020 | Science China(Life Sciences)2020，63，5： | 7 |
| 14 | A high-fiber diet synergizes with Prevotella copri and exacerbates rheumatoid arthritis显示文摘Both preclinical and established rheumatoid arthritis(RA)patients display alterations in the gut microbiome.Prevotella spp.are preferentially enriched in a subset of RA patients.Here,we isolated a Prevotella strain,P.copri RA,from the feces of RA patients and showed that colonization of P.copri RA exacerbated arthritis in a collagen-induced arthritis(CIA)model.With the presence of P.copri RA colonization,a high-fiber diet exacerbated arthritis via microbial alterations and intestinal inflammation.Colonization of P.copri together with a high-fiber diet enabled the digestion of complex fiber,which led to the overproduction of organic acids,including fumarate,succinate and short-chain fatty acids.Succinate promoted proinflammatory responses in macrophages,and supplementation with succinate exacerbated arthritis in the CIA model.Our findings highlight the importance of dysbiosis when evaluating the effects of dietary interventions on RA pathogenesis and provide new insight into dietary interventions or microbiome modifications to improve RA management. | Lingjuan Jiang Mengmeng Shang Shengnan Yu Yudong Liu Hui Zhang Yangzhong Zhou Min Wang Tingting Wang Hui Li Zhihua Liu Xuan Zhang | 2022 | Cellular & Molecular Immunology2022，19，12： | 6 |
| 15 | Cellulose fibers-reinforced self-expanding porous composite with multiple hemostatic efficacy and shape adaptability for uncontrollable massive hemorrhage treatment显示文摘Uncontrollable hemorrhage leads to high mortality and thus effective bleeding control becomes increasingly important in the military field and civilian trauma arena.However,current hemostats not only present limitation when treating major bleeding,but also have various side effects.Here we report a self-expanding porous composites(CMCP)based on novel carboxymethyl cellulose(CMC)fibers and acetalized polyvinyl alcohol(PVA)for lethal hemorrhage control.The CMC fibers with uniform fibrous structure,high liquid absorption and procoagulant ability,are evenly interspersed inside the composite matrix.The obtained composites possess unique fiber-porous network,excellent absorption capacity,fast liquid-triggered self-expanding ability and robust fatigue resistance,and their physicochemical performance can be fine-tuned through varying the CMC content.In vitro tests show that the porous composite exhibits strong blood clotting ability,high adhesion to blood cells and protein,and the ability to activate platelet and the coagulation system.In vivo hemostatic evaluation further confirms that the CMCP presents high hemostatic efficacy and multiple hemostatic effects in swine femoral artery major hemorrhage model.Additionally,the CMCP will not fall off from the injury site,and is also easy to surgically remove from the wound cavity after the hemostasis.Importantly,results of CT tomography and 3D reconstruction indicate that CMCP can achieve shape adaptation to the surrounding tissues and the wound cavities with different depths and shapes,to accelerate hemostasis while protecting wound tissue and preventing infection. | Yansen Wang Yifan Zhao Longxue Qiao Faxing Zou Yajie Xie Yudong Zheng Yong Chao Ying Yang Wei He Siming Yang | 2021 | Bioactive Materials2021，6，7： | 6 |
| 16 | In vitro and in vivo investigation of bacterial cellulose dressing containing uniform silver sulfadiazine nanoparticles for burn wound healing显示文摘Silver sulfadiazine(SSD) particles in homogeneous dispersion state were prepared by an ultrasonic method and then nano- and microparticles were separated using centrifugation. SSD particles with narrow size distribution were impregnated with bacterial cellulose(BC) to produce BC–SSD composite membrane used as burn wound dressing. A scanning electron microscope(SEM) was used to examine the surface morphology of BC–SSD membranes. The incorporation of SSD in BC–SSD was confirmed by X-ray diffraction(XRD). Antimicrobial tests in vitro indicated that BC–SSD showed excellent antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effects of BC–SSD on burn wound healing were assessed by rat models. The comparative study confirmed that the wound treated with BC–SSD showed high healing rate. The bacteria count in BC–SSD group was far less than control group. Histological analysis showed that epithelialization progressed better in wound treated with BC–SSD. These values demonstrated that the BC–SSD composite membrane could be a promising wound dressing for burn. | Xiaoxiao Wen Yudong Zheng Jian Wu Lina Yue Cai Wang Jiabin Luan Zhigu Wu Kaisheng Wang | 2015 | Progress in Natural Science:Materials International2015，25，3： | 6 |
| 17 | Gd-EOB-DTPA-enhanced MRI radiomic features for predicting histological grade of hepatocellular carcinoma显示文摘Background:Prediction models for the histological grade of hepatocellular carcinoma(HCC)remain unsatisfactory.The purpose of this study is to develop preoperative models to predict histological grade of HCC based on gadolinium-ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)-enhanced magnetic resonance imaging(MRI)radiomics.And to compare the performance between artificial neural network(ANN)and logistic regression model.Methods:A total of 122 HCCs were randomly assigned to the training set(n=85)and the test set(n=37).There were 242 radiomic features extracted from volumetric of interest(VOI)of arterial and hepatobiliary phases images.The radiomic features and clinical parameters[gender,age,alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),alanine aminotransferase(ALT),aspartate transaminase(AST)]were selected by permutation test and decision tree.ANN of arterial phase(ANN-AP),logistic regression model of arterial phase(LR-AP),ANN of hepatobiliary phase(ANN-HBP),logistic regression mode of hepatobiliary phase(LR-HBP),ANN of combined arterial and hepatobiliary phases(ANN-AP+HBP),and logistic regression model of combined arterial and hepatobiliary phases(LR-AP+HBP)were built to predict HCC histological grade.Those prediction models were assessed and compared.Results:ANN-AP and LR-AP were composed by AST and radiomic features based on arterial phase.ANN-HBP and LR-HBP were composed by AFP and radiomic features based on hepatobiliary phase.ANN-AP+HBP and LR-AP+HBP were composed by AST and radiomic features based on arterial and hepatobiliary phases.The prediction models could distinguish between high-grade tumors[Edmondson-Steiner(E-S)grade III and IV]and low-grade tumors(E-S grade I and II)in both training set and test set.In the test set,the AUCs of ANN-AP,LR-AP,ANN-HBP,LR-HBP,ANN-AP+HBP and LR-AP+HBP were 0.889,0.777,0.941,0.819,0.944 and 0.792 respectively.The ANN-HBP was significantly superior to LR-HBP(P=0.001).And the ANN-AP+HBP was significantly superior to LR-AP+HBP(P=0.007).Conclusions:Prediction models consisting of clinical parameters and Gd-EOB-DTPA-enhanced MRI radiomic features(based on arterial phase,hepatobiliary phase,and combined arterial and hepatobiliary phases)could distinguish between high-grade HCCs and low-grade HCCs.And the ANN was superior to logistic regression model in predicting histological grade of HCC. | Yingfan Mao Jincheng Wang Yong Zhu Jun Chen Liang Mao Weiwei Kong Yudong Qiu Xiaoyan Wu Yue Guan Jian He | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 6 |
| 18 | miR-27 inhibits adipocyte differentiation via suppressing CREB expression显示文摘miR-27 在 adipogenesis 的规定起一个否定作用。然而,分子的机制尚待是 clarified.In 现在的学习,我们发现 miR-27 由镇压部分禁止 adipogenesis 由直接指向它的 3 untranslated 区域的早 adipogenic transcriptionfactor 营地反应元素绑定蛋白质。另外,我们 demonstratedthat 肿瘤坏死因素 --(TNF-) 通过 NF-B 小径的处理起来调整 miR-27。而且, anti-miR-27 reducesthe TNF -- adipogenesis 的导致的抑制。同时, miR-27 表示的层次在成熟 adipocytesof 被减少肥胖的老鼠什么时候与瘦老鼠相比。我们的数据在 adipogenesis 的规定揭示了 miR-27 的新奇机制。 | Yingjie Zhu Xiaodong Zhang Xingpo Ding Huichao Wang Xiantao Chen Hanzheng Zhao Yudong Jia Sanhong Liu Youwen Liu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 5 |
| 19 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 20 | Social welfare maximization for SRSNs using bio-inspired communitycooperation mechanism显示文摘This paper considers social welfare maximization for spatial resource sharing networks(SRSNs),in which multiple autonomous users are spatially located and mutual influence only occurs between nearby users.To cope with a lack of central control and the restriction that only local information is available,a spatial resource sharing game is proposed.However,individual selfishness in traditional game models generally leads to inefficiency and dilemmas.Inspired by local cooperative behavior in biological sys- tems,a community cooperation mechanism(CCM)is proposed to improve the efficiency of the game.Specifically,when a user makes a decision,it maximizes the aggregate payoffs for its local community rather than selfishly consider itself.It is analytically shown that with the bio-inspired CCM,the social optimum of SRSNs is achieved with an exchange of local information.The proposed bio-inspired CCM is very general and can be applied to various communication networks. | XU YuHua WU QiHui WANG JinLong YAO YuDong | 2012 | Chinese Science Bulletin2012，57，1： | 5 |
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