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| 1 | A retrospective of knowledge graphs显示文摘 | Jihong YAN Chengyu WANG Wenliang CHENG Ming GAO Aoying ZHOU | 2018 | Frontiers of Computer Science2018，12，1： | 25 |
| 2 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 3 | Spatial patterns of ecosystem vulnerability changes during 2001–2011 in the three-river source region of the Qinghai-Tibetan Plateau, China显示文摘The three-river source region(TRSR, including Yangtze, Yellow and Lancang rivers), located in the Qinghai-Tibetan Plateau, China, is a typical alpine zone with apparent ecosystem vulnerability and sensitivity. In this paper, we introduced many interdisciplinary factors, such as landscape pattern indices(Shannon diversity index and Shannon evenness index) and extreme climate factors(number of extreme high temperature days, number of extreme low temperature days, and number of extreme precipitation days), to establish a new model for evaluating the spatial patterns of ecosystem vulnerability changes in the TRSR. The change intensity(CI) of ecosystem vulnerability was also analyzed. The results showed that the established evaluation model was effective and the ecosystem vulnerability in the whole study area was intensive. During the study period of 2001–2011, there was a slight degradation in the eco-environmental quality. The Yellow River source region had the best eco-environmental quality, while the Yangtze River source region had the worst one. In addition, the zones dominated by deserts were the most severely deteriorated areas and the eco-environmental quality of the zones occupied by evergreen coniferous forests showed a better change. Furthermore, the larger the change rates of the climate factors(accumulative temperature of ≥10°C and annual average precipitation) are, the more intensive the CI of ecosystem vulnerability is. This study would provide a scientific basis for the eco-environmental protection and restoration in the TRSR. | GUO Bing ZHOU Yi ZHU Jinfeng LIU Wenliang WANG Futao WANG Litao YAN Fuli WANG Feng YANG Guang LUO Wei JIANG Lin | 2016 | Journal of Arid Land2016，8，1： | 16 |
| 4 | Seasonal and reproductive variation in chemical constituents of scent signals in wild giant pandas显示文摘Seasonally reproducing animals show many behavioral and physiological changes during the mating period, including increased signaling for intrasexual competition and mate attraction. We collected 102 anogenital gland secretions(AGS) from marking trees in Foping Nature Reserve, and used gas chromatography mass spectrometry to analyze these chemical composition. Of these marks, all but one were from males, confirmed with DNA analysis. We found that several chemical constituents, especially volatile compounds, were present only during the mating season and that the relative abundance of many compounds changed as a function of breeding season, whereas nonvolatile compounds were lower in the mating season. This seasonal variation in chemical composition of AGS most likely plays an important role in governing giant panda reproduction, including mate location, attraction, and male-male competition. The chemical properties of many of these putative chemosignals—such as volatility and longevity—are suggestive of these roles, and undoubtedly contribute to successful reproduction for this species with a characteristically sophisticated chemical communication system. We also found a number of important differences between the chemical constituents of AGS from wild pandas and those found in previous studies with captive pandas, suggesting that inappropriate chemosignal composition may contribute to poor reproductive success in captive breeding programs. | Wenliang Zhou Yonggang Nie Yibo Hu Ronald R.Swaisgood Yaohua Zhang Dingzhen Liu Fuwen Wei | 2019 | Science China(Life Sciences)2019，62，5： | 6 |
| 5 | State Machine with Tracking Tree and Traffic Allocation Scheme Based on Cumulative Entropy for Satellite Network显示文摘SatelHte net work is regarded as an importan t componen t of 5th Generation(5G).New deployment scenarios have been designed in form of sat ellite net work fused 5G t erres trial network.Service requests in Non terrestrial networks(NTN)are non・centralized in the time and space domain,which cause services modelling uncertain and lack of balance between lat ency and bandwid th.Targe ted at t hose bot tienecks,a Satellite service model based on State machine with tracking tree(SM-SMTT)and trafRc allocation scheme base on cumulative entropy is proposed.Enhanced mobile broadband service,low latency service and massive machine type communications in satellite will be modelled by SM-SMTT.Cumulative entropy is introduced as the criterion to allocate traffic.According to the lower bound from cumulative entropy,the balance of latency and bandwidth is achieved in different deployment scenarios.The simulation in OPNET,demons trations the new scheme has promoted the performance of delay and bandwidth utilization by 37.8%and 12.0%. | LIN Wenliang WANG Huijun DENG Zhongliang WANG Ke ZHOU Xiaotian | 2020 | Chinese Journal of Electronics2020，29，1： | 4 |
| 6 | Systematics and Species Validity of the Dabieshan Pit Viper Protobothrops dabieshanensis Huang et al. 2012: Evidence from a Mitochondrial Gene Sequence Analysis显示文摘Aimed to evaluate the phylogenetic position of the recently described Protobothrops dabieshanensis Huang et al.(2012), phylogenic relationships of 12 species within Protobothrops based on four mtDNA gene fragments(12S RNA, 16S RNA, ND4 and Cyt b) were reconstructed in our study. The result indicates a clade composed of P. dabieshanensis, P. jerdonii and P. xiangchengsis with strong support. The genetic distance among P. dabieshanensis, P. jerdonii and P. xiangchengsis was much lower than other congeners. Based on the data from the phylogenetic analysis and previously described morphological differences, we conclude that P. dabieshanensis is a valid species with close affinities to P. jerdonii and P. xiangchengsis. | Baowei ZHANG Xin HUANG Tao PAN Liang ZHANG Wenliang ZHOU Tao SONG Demin HAN | 2013 | Asian Herpetological Research2013，4，4： | 4 |
| 7 | SIMS U-Pb dating of rutile within eclogitic xenoliths in the Early Cretaceous adakitic rocks of the Xuzhou-Huaibei area, China: Constraints on the timing of crustal thickening of the eastern North China Craton显示文摘This paper reports the results of secondary ion mass spectrometry(SIMS) U-Pb dating of rutile within eclogitic xenoliths from the Early Cretaceous adakitic rocks in the Xuzhou-Huaibei area of China and discusses the geological significance of these new dates. The dating of rutile from pargasite-bearing eclogite and garnet clinopyroxenite(retrograde eclogite) yielded ages of 209 ± 25 and 132 ± 7 Ma, respectively. The former is consistent with the timing of the first stage of exhumation of the Dabie-Sulu orogenic belt and provides evidence of crustal thickening within the southeastern margin of the North China Craton during the early Mesozoic, related to subduction and collision between the Yangtze and North China cratons. The latter age is similar to the timing of emplacement of the hosting intrusion and indicates that the rutile U-Pb system was triggered after uplifting by the intrusion of the hosting magmas. It implies that garnet clinopyroxenite was previously at the depth where the temperature was above the rutile U-Pb closure temperature. | XIONG BoQin XU WenLiang LI QiuLi YANG DeBin ZHOU QunJun | 2015 | Science China Earth Sciences2015，58，7： | 4 |
| 8 | 5-氟尿嘧啶和卡培他滨对中国患者的心脏毒性:一项前瞻性研究显示文摘背景与目的已有许多研究报道5-氟尿嘧啶(5-Fluorouracil,5-FU)和卡培他滨相关的心脏毒性,严重程度从无症状心电图(electrocardiography,ECG)异常到严重心肌梗塞而不同。目前为止,对中国恶性肿瘤患者的这种心脏毒性尚无研究。本研究旨在前瞻性地对多个中心招募的癌症患者进行5-FU和卡培他滨相关心脏毒性的发生率和临床表现进行评估。方法在完成研究的527例患者中,196例接受基于5-FU的化疗,331例接受基于卡培他滨的化疗并以其为一线或辅助治疗。在治疗期间和长达28 d的随访期间对所发生的不良反应进行记录。疗效测量指标包括心电图、心肌酶、心肌肌钙蛋白、脑钠肽和超声心动图。使用单因素分析和logistic回归方法进行亚组分析和鉴定与两种药物的心脏毒性相关的显著性独立变量。结果 527例患者中有161例(30.6%)出现心脏毒性。卡培他滨组的心脏毒性发生率为33.8%(112/331),显著高于5-FU组25%(49/196)的发生率(P=0.0042)。110/527患者(20.9%)发生心律失常,105/527(19.9%)发生缺血性改变,而只有20/527患者(3.8%)出现心力衰竭,6/527患者(1.1%)出现心肌梗塞。既往的心脏病、高血压、卡培他滨为基础的化疗和治疗时间被确定为与心脏毒性相关的显著风险因素。优势比分别为15.7(心脏病史vs.无病史)、1.86(卡培他滨vs. 5-FU)、1.06(5–8个化疗周期vs. 1–4个化疗周期)和1.58(高血压vs.无高血压)。结论氟嘧啶类药物在中国人群中引起的心脏毒性可能在临床实践中被低估。建议密切监测患者,尤其是对心脏毒性高风险的患者。可能的风险因素包括治疗持续时间、基于卡培他滨的化疗、既往心脏病史和高血压史。 | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | 癌症2018，37，10： | 3 |
| 9 | Analysis of changes in the structure of rural household energy consumption in northern China: A case study显示文摘 | Zhongren Zhou Wenliang Wu Xiaohua Wang Qun Chen Ou Wang | 2007 | Renewable and Sustainable Energy Reviews2007，，1： | 2 |
| 10 | Improved design of online fault diagnoser for partially observed Petri nets with generalized mutual exclusion constraints显示文摘This paper investigates the fault detection problem for discrete event systems(DESs) which can be modeled by partially observed Petri nets(POPNs). To overcome the problem of low diagnosability in the POPN online fault diagnoser in current use,an improved online fault diagnosis algorithm that integrates generalized mutual exclusion constraints(GMECs) and integer linear programming(ILP) is proposed. Assume that the POPN structure and its initial markings are known, and the faults are modeled as unobservable transitions. First, the event sequence is observed and recorded. GMEC is used for elementary diagnosis of the system behavior, then the ILP problem of POPN is solved for further diagnosis. Finally, an example of a real DES to test the new fault diagnoser is analyzed. The proposed algorithm increases the diagnosability of the DES remarkably, and the effectiveness of the new algorithm integrating GMEC and ILP is verified. | Jiufu Liu Wenliang Liu Jianyong Zhou Yan Sun Zhisheng Wang | 2017 | Journal of Systems Engineering and Electronics2017，28，5： | 2 |
| 11 | Validation of different personalized risk models of chemotherapy-induced nausea and vomiting:results of a randomized,double-blind,phase III trial of fosaprepitant for cancer patients treated with high-dose cisplatin显示文摘Background:Highly emetogenic chemotherapy induces emesis in cancer patients without prophylaxis.The purpose of this study was to evaluate the efficacy and safety of a fosaprepitant-based triple antiemetic regimen for the prevention of chemotherapy-induced nausea and vomiting(CINV)in patients with solid malignant tumors,determine risk factors and externally validate different personalized risk models for CINV.Methods:This phase III trial was designed to test the non-inferiority of fosaprepitant toward aprepitant in cancer patients who were to receive the first cycle of single-day cisplatin chemotherapy.The primary endpoint was complete response(CR)during the overall phase(OP)with a non-inferiority margin of 10.0%.Logistic regression modelswere used to assess the risk factors ofCRand no nausea.To validate the personalized risk models,the accuracy of the risk scoring systems was determined by measuring the specificity,sensitivity and area under the receiver operating characteristic(ROC)curve(AUC),while the predictive accuracy of the nomogram was measured using concordance index(C-index).Results:A total of 720 patients were randomly assigned.CR during the OP in the fosaprepitant group was not inferior to that in the aprepitant group(78.1%vs.77.7%,P=0.765)with a between-group difference of 0.4%(95%CI,-5.7%to 6.6%).Female sex,higher cisplatin dose(≥70 mg/m2),no history of drinking and larger body surface area(BSA)were significantly associated with nausea.The AUC for the acute and delayed CINV risk indexes was 0.68(95%CI:0.66-0.71)and 0.66(95%CI:0.61-0.70),respectively,and the C-index for nomogram CINV prediction was 0.59(95%CI,0.54-0.64).Using appropriate cutoff points,the three models could stratify patients with high-or low-risk CINV.No nausea and CR rate were significantly higher in the low-risk group than in the high-risk group(P<0.001).Conclusions:Fosaprepitant-based triple prophylaxis demonstrated non-inferior control for preventing CINV in patients treated with cisplatin-base chemotherapy.Female cancer patients without a history of alcohol consumption,with larger BSA and received high-dose cisplatin might be more vulnerable to CINV.Three personalized prediction models were well-validated and could be used to optimize antiemetic therapy for individual patients. | Yuanyuan Zhao Bing Zhao Gang Chen Yinlan Chen Zijun Liao Haiming Zhang Weineng Feng Yinyin Li Heng Weng Weidong Li Yuefen Zhou Biyong Ren Yanda Lu Jianhua Chen Zhenteng Liu Zhenzhong Su Wenliang Wang Li Zhang | 2023 | Cancer Communications2023，43，2： | 2 |
| 12 | Preparation of Exo-tetrahydrodicyclopentadiene Using SiW/Hβ Catalyst显示文摘Exo-tetrahydrodicyclopentadiene (exo-TCD) is an important high-energy fuel.Silicotungstic acid (SiW) immobilized on H-type β zeolite (Hβ) at room temperature were used to prepare the Hβ zeolite catalysts with different SiW contents.Catalytic performances of the catalysts were investigated during the preparation of exo-TCD via isomerization of endo-tetrahydrodicyclopentadiene (endo-TCD).The properties of catalysts were characterized by XRD,temperature pro-grammed desorption of ammonia (NH 3-TPD),FT-IR,and N 2-adsorption techniques.SiW was highly dispersed on the surface of Hβ zeolite,and the 10% SiW/Hβ zeolite catalyst had the highest amount of weak acidity among all SiW/Hβ zeolite catalysts.The influence of different factors on isomerization reaction was investigated.At a reaction temperature of 240 ℃,a n(cyclohexane) /n(endo-TCD) ratio of 10,a m(catalyst) /m(endo-TCD) ratio of 0.3,an initial pressure of 1.0 MPa,and a reaction time of 1.5 h in the presence of 10% SiW/Hβ catalyst calcined at 400 ℃,the conversion of endo-TCD reached up to 92.0%,with the yield of exo-TCD equating to 51.0%. | Kang Zhuozhuo Wu Wenliang Zhou Zhiwei (College of Chemistry and Chemical Engineering,Nanjing University of Technology,Nanjing 210009) | 2011 | China Petroleum Processing & Petrochemical Technology2011，13，3： | 2 |
| 13 | An efficient resin for solid-phase extraction and determination by UPLCMS/MS of 44 pharmaceutical personal care products in environmental waters显示文摘In this study,a hydrophilic resin named GCHM was fabricated based on poly(N-vinyl pyrrolidone-codivinylbenzene),characterized,and applied as a solid-phase extraction(SPE)material.Up to 44 pharmaceuticals and personal care products(PPCPs)belonging to 10 classes were recovered in environmental water samples.Different variables affecting extraction,such as adsorbent amount,sample pH,and loading speed,were optimized.Under optimal conditions,the average absolute recovgy of 44 PPCPs was 75.6%using GCHM,indicating a better performance than the commercial Oasis^HLB.SPE with home-made hydrophilic polymeric sorbent followed by ultra-performance liquid chromatography and tandem mass spectrometry was validated,and the method achieved good linearity(r2>0.991,for all analytes).In addition,the method detection limits of target compounds ranged from 0.03 to 0.6 ng/L.The developed method was applied to determine PPCPs in 10 environmental water samples taken from the Yangtze River,Huaihe River,and Taihu Lake,1 groundwater sample from Changzhou in Jiangsu Province,1 wastewater sample from Xiamen and 2 seawater samples from the Jiulong River in Fujian Province,China.In these samples,22 compounds were determined at levels ranging from 0.5 to 1590 ng/L. | Feng Zhu Zhijian Yao Wenliang Ji Deye Liu Hao Zhang Aimin Li Zongli Huo Qing Zhou | 2020 | Frontiers of Environmental Science & Engineering2020，14，3： | 1 |
| 14 | Blind Source Separation Based Vibration Mode Identification显示文摘 | Zhou Wenliang Chelidze D | 2007 | Mechanical Systems and Signal Processing2007，，21： | 1 |
| 15 | Analysis of changes in the structure of rural household energy consumption in northern China: A case study显示文摘 | Zhou Zhongren Wu Wenliang Wang Xiaohua | 2009 | Renewable and Sustainable Energy Reviews2009，13，1： | 1 |
| 16 | Blind source separation based vibration mode identification显示文摘 | Zhou Wenliang Chelidze D | 2007 | Mechanical Systems and Signal Processing2007，21，： | 1 |
| 17 | Blind source separation based vibration mode identification显示文摘 | ZHOU Wenliang CHELIDZE D | 2007 | Mechanical Systems and Signal Processing2007，21，8： | 1 |
| 18 | Study on sustainable development of rural household energy in northern China显示文摘 | ZHONGREN ZHOU WENLIANG WU QUN CHEN et a/ | 2008 | Renewable and Sustain- able Energy Reviews2008，，12： | 1 |
| 19 | 大熊猫保护区的生态系统服务价值显示文摘文章简介全球生态系统服务价值估计每年为125万亿美元,相似的国家和区域层面的评估也显示生态系统服务价值足以支撑我们的生活。所有的生态系统服务价值评估都肯定了生物多样性的重要作用. | 魏辅文 Robert Costanza Qiang Dai Natalie Stoeckl Xiaodong Gu Stephen Farber Yonggang Nie Ida Kubiszewski Yibo Hu Ronald Swaisgood Xuyu Yang Michael Bruford Youping Chen Alexey Voinov Dunwu Qi Megan Owen Li Yan Daniel C.Kenny Zejun Zhang Rong Hou Shiwei Jiang Hongbo Liu Xiangjiang Zhan Li Zhang Biao Yang Lianjun Zhao Xiaoguang Zheng Wenliang Zhou Yali Wen Heran Gao Wen Zhang | 2019 | 科学新闻2019，0，2： | 1 |
| 20 | A distal femoral supra-condylar plate: biomechanical comparison with condylar plate and first clinical application for treatment of supracondylar fracture显示文摘 | Bowei Liang Zhenqi Ding Junguo Shen Wenliang Zhai Liangqi Kang Liang Zhou Mo Sha Dongzhu Liang | 2012 | International Orthopaedics2012，，8： | 1 |
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