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| 1 | Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘 | Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao | 2017 | Frontiers of Medicine2017，11，4： | 37 |
| 2 | Promotion of spinosad biosynthesis by chromosomal integration of the Vitreoscilla hemoglobin gene in Saccharopolyspora spinosa显示文摘To promote spinosad biosynthesis by improving the limited oxygen supply during high-density fermentation of Saccharopolyspora spinosa, the open reading frame of the Vitreoscilla hemoglobin gene was placed under the control of the promoter for the erythromycin resistance gene by splicing using overlapping extension PCR. This was cloned into the integrating vector pSET152, yielding the Vitreoscilla hemoglobin gene expression plasmid pSET152EVHB. This was then introduced into S. spinosa SP06081 by conjugal transfer, and integrated into the chromosome by site-specific recombination at the integration site ΦC31 on pSET152EVHB. The resultant conjugant, S. spinosa S078-1101, was genetically stable. The integration was further confirmed by PCR and Southern blotting analysis. A carbon monoxide differential spectrum assay showed that active Vitreoscilla hemoglobin was successfully expressed in S. spinosa S078-1101. Fermentation results revealed that expression of the Vitreoscilla hemoglobin gene significantly promoted spinosad biosynthesis under normal oxygen and moderately oxygen-limiting conditions (P<0.01). These findings demonstrate that integrating expression of the Vitreoscilla hemoglobin gene improves oxygen uptake and is an effective means for the genetic improvement of S. spinosa fermentation. | LUO YuShuang KOU XiaoXiao DING XueZhi HU ShengBiao TANG Ying LI WenPing HUANG Fan YANG Qi CHEN HanNa XIA LiQiu | 2012 | Science China(Life Sciences)2012，55，2： | 14 |
| 3 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 4 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 5 | pH-sensitive polymeric micelles triggered drug release for extracellular and intracellular drug targeting delivery显示文摘Most of the conventional chemotherapeutic agents used for cancer chemotherapy suffer from multidrug resistance of tumor cells and poor antitumor efficacy.Based on physiological differences between the normal tissue and the tumor tissue,one effective approach to improve the efficacy of cancer chemotherapy is to develop pH-sensitive polymeric micellar delivery systems.The copolymers with reversible protonationedeprotonation core units or acid-liable bonds between the therapeutic agents and the micelle-forming copolymers can be used to form pH-sensitive polymeric micelles for extracellular and intracellular drug smart release.These systems can be triggered to release drug in response to the slightly acidic extracellular fluids of tumor tissue after accumulation in tumor tissues via the enhanced permeability and retention effect,or they can be triggered to release drug in endosomes or lysosomes by pH-controlled micelle hydrolysis or dissociation after uptake by cells via the endocytic pathway.The pH-sensitive micelles have been proved the specific tumor cell targeting,enhanced cellular internalization,rapid drug release,and multidrug resistance reversal.The multifunctional polymeric micelles combining extracellular pH-sensitivity with receptor-mediated active targeting strategies are of great interest for enhanced tumor targeting.The micelles with receptor-mediated and intracellular pH targeting functions are internalized via receptor-mediated endocytosis followed by endosomal-pH triggered drug release inside the cells,which reverses multidrug resistance.The pH sensitivity strategy of the polymeric micelles facilitates the specific drug delivery with reduced systemic side effects and improved chemotherapeutical efficacy,and is a novel promising platform for tumor-targeting drug delivery. | Yanhua Liu Wenping Wang Jianhong Yang Chengming Zhou Jin Sun | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，3： | 11 |
| 6 | SHRIMP U-Pb Zircon Age of the Ka'erjiao Intrusion in the Sawur Region in West Junggar,Xinjiang显示文摘摘要:酸侵入在 Sawur 区域是普遍的, Xinjiang。Ka'erjiao 侵入主要由钠长石花岗石斑岩, K 长石花岗石斑岩, ivernite 和花岗石斑岩组成。在 Sawur 区域是在岩浆侵入和爆发之间的一个过渡产品, Ka'erjiao 侵入在未期被形成对开始晚含碳作为早二叠由标明日期的 SHRIMP U-Pb 锆石决定了,与 302.6 | ZHOU Taofa TAN Lugui FAN Yu YUAN Feng YANG Wenping HE Lixin YUE Shucang | 2007 | Acta Geologica Sinica(English Edition)2007，81，2： | 9 |
| 7 | A Brief Introduction to BNU-HESM1.0 and Its Earth Surface Temperature Simulations显示文摘Integrated assessment models and coupled earth system models both have their limitations in understanding the interactions between human activity and the physical earth system. In this paper,a new human–earth system model,BNUHESM1.0,constructed by combining the economic and climate damage components of the Dynamic Integrated Model of Climate Change and Economy to the BNU-ESM model,is introduced. The ability of BNU-HESM1.0 in simulating the global CO2 concentration and surface temperature is also evaluated. We find that,compared to observation,BNU-HESM1.0underestimates the global CO2 concentration and its rising trend during 1965–2005,due to the uncertainty in the economic components. However,the surface temperature simulated by BNU-HESM1.0 is much closer to observation,resulting from the overestimates of surface temperature by the original BNU-ESM model. The uncertainty of BNU-ESM falls within the range of present earth system uncertainty,so it is the economic and climate damage component of BNU-HESM1.0 that needs to be improved through further study. However,the main purpose of this paper is to introduce a new approach to investigate the complex relationship between human activity and the earth system. It is hoped that it will inspire further ideas that prove valuable in guiding human activities appropriate for a sustainable future climate. | YANG Shili DONG Wenjie CHOU Jieming FENG Jinming YAN Xiaodong WEI Zhigang YUAN Wenping GUO Yan TANG Yanli HU Jiacong | 2015 | Advances in Atmospheric Sciences2015，32，12： | 8 |
| 8 | Aerodynamic performance enhancement forflapping airfoils by co-flow jet显示文摘Introducing active flow control into the design of flapping wing is an effective way to enhance its aerodynamic performance.In this paper,a novel active flow control technology called Co-Flow Jet(CFJ)is applied to flapping airfoils.The effect of CFJ on aerodynamic performance of flapping airfoils at low Reynolds number is numerically investigated using Unsteady Reynolds Averaged Navier-Stokes(URANS)simulation with Spalart-Allmaras(SA)turbulence model.Numerical methods are validated by a NACA6415-based CFJ airfoil case and a S809 pitching airfoil case.Then NACA6415 baseline airfoil and NACA6415-based CFJ airfoil with jet-off and jet-on are simulated in flapping motion,with Reynolds number 70,000 and reduced frequency 0.2.As a result,CFJ airfoils with jet-on generally have better lift and thrust characteristics than baseline airfoils and jet-off airfoil when Cμgreater than 0.04,which results from the CFJ effect of reducing flow separation by injecting high-energy fluid into boundary layer.Besides,typical kinematic and geometric parameters,including the reduced frequency and the positions of the suction and injection slot,are systematically studied to figure out their influence on aerodynamic performance of the CFJ airfoil.And a variable Cμjet control strategy is proposed to further improve effective propulsive efficiency.Compared with using constant Cμ,an increase of effective propulsive efficiency by22.6%has been achieved by using prescribed variable CμNACA6415-based CFJ airfoil at frequency 0.2.This study may provide some guidance to performance enhancement for Flapping wing Micro Air Vehicles(FMAV). | Tao WU Bifeng SONG Wenping SONG Wenqing YANG Zhonghua HAN | 2020 | Chinese Journal of Aeronautics2020，33，10： | 7 |
| 9 | The effects of span-wise and chord-wise flexibility on the aerodynamic performance of micro flapping-wing显示文摘The flexibility of flapping-wing strongly affects the aerodynamic performance of Flapping-wing Micro Air Vehicle (FMAV),and the deformations in span-wise and chord-wise directions are coupled together in flight.In this study,the flexible deformation is formulated in span-wise and chord-wise separately in order to analyze its effects on aerodynamic behavior.The preconditioned Navier-Stokes equations based on chimera grid are used in the computational fluid dynamics method to study the aerodynamic effects caused by flexible deformation,and the simulation results are compared with experimental test to illustrate the capability of above method.Based on our results,it is clearly showed that the span-wise flexible deformation should be limited in a small range to achieve higher aerodynamic performance and the chord-wise deformation could enhance the aerodynamic performance.The results also suggest that FMAV designers should design the flapping-wing with high stiffness leading edge to limit the span-wise deformation,and more flexible chord ribs to keep chord-wise deformation in suitable range. | YANG WenQing SONG BiFeng SONG WenPing WANG LiGuang | 2012 | Chinese Science Bulletin2012，57，22： | 6 |
| 10 | Short-term effects of biochar and gypsum on soil hydraulic properties and sodicity in a saline-alkali soil显示文摘Salt and sodicity of saline-alkali soil adversely affect the construction of ecological landscapes and negatively impact crop production.The reclamation potential of biochar(BC,wheat straw biochar applied at\%by weight),gypsum(G,0.4%by weight),and gypsum coupled with biochar(GBC)was examined in this laboratory-based study by evaluating their effects on a saline-alkali soil(silt loam)with no amendment as a control(CK).Saline ice and fresh water(simulated rainfall)were leached through soil columns to investigate changes in salt content,sodium adsorption ratio(SAR),alkalinity,and pH of the leachate and the soil.Results showed that saturated water content and field water capacity(FWC)significantly increased by 4.4%and 5.6%,respectively,in the BC treatment after a short incubation time.Co-application of biochar and gypsum(GBC)increased soil saturated hydraulic conductivity(Ks)by 58.4%,which was also significantly higher than the sole addition.Electrical conductivity(EC)of the leachate decreased sharply after saline ice leaching;subsequent freshwater leaching accelerated the removal of the rest of the salts,irrespective of the amendment application.However,the application of gypsum(G and GB)significantly enhanced the removal of exchangeable Na^+and reduced leachate SAR.After leaching,the soil salt content decreased significantly for all treatments.The application of gypsum resulted in a significantly lower soil pH,exchangeable sodium percentage(ESP),SAR,and alkalinity values than those recorded for the CK and BC treatments.These results demonstrated that the co-application of gypsum and biochar could improve saline-alkali soil hydraulic conductivity and decrease leaching-induced sodicity over a short period. | Yue ZHANG Jingsong YANG Rongjiang YAO Xiangping WANG Wenping XIE | 2020 | Pedosphere2020，30，5： | 6 |
| 11 | Human movement monitoring and behavior recognition for intelligent sports using customizable and flexible triboelectric nanogenerator显示文摘Effective collection,recognition,and analysis of sports information is the key to intelligent sports,which can help athletes to improve their skills and formulate scientific training plans and competition strategies.At present,wearable electronic devices used for movement monitoring still have some limitations,such as high cost and energy consumption,incompatibility of suitable flexibility and personalized spatial structure,dissatisfactory data analysis methods,etc.In this work,a novel three-dimensionalprinted thermoplastic polyurethane is introduced as the elastic shell and friction layer,and it endows the proposed customizable and flexible triboelectric nanogenerator(CF-TENG)with personalized spatial structure and robust correlation to external pressure.In practical application,it exhibits highly sensitive responses to the joint-bending motion of the finger,wrist,or elbow.Furthermore,a pressure-sensing insole and smart ski pole based on CF-TENG are manufactured to build a comprehensive sports monitoring system to transmit the athletes’motion information from feet and hands through the plantar pressure distribution and ski pole action.To recognize the movement status,the self-developed automatic peak recognition algorithm(P-Find)and machine learning algorithm(subspace K-Nearest Neighbors)were introduced to accurately distinguish the four typical motion behaviors and three primary sub-techniques of cross-country skiing,with accuracy rates of 98.2%and 100%.This work provides a novel strategy to promote the personalized applications of TENGs in intelligent sports. | YANG Yun HOU XiaoJuan GENG WenPing MU JiLiang ZHANG Le WANG XiangDong HE Jian XIONG Ji Jun CHOU XiuJian | 2022 | Science China(Technological Sciences)2022，65，4： | 6 |
| 12 | Vertical‐organic‐nanocrystal‐arrays for crossbar memristors with tuning switching dynamics toward neuromorphic computing显示文摘Memristors proposed by Leon Chua provide a new type of memory device for novel neuromorphic computing applications.However,the approaching of distinct multi‐intermediate states for tunable switching dynamics,the con-trolling of conducting filaments(CFs)toward high device repeatability and reproducibility,and the ability for large‐scale preparation devices,remain full of challenges.Here,we show that vertical‐organic‐nanocrystal‐arrays(VONAs)could make a way toward the challenges.The perfect one‐dimensional structure of the VONAs could confine the CFs accurately with fine‐tune resistance states in a broad range of 103 ratios.The availability of large‐area VONAs makes the fabrication of large‐area crossbar memristor arrays facilely,and the analog switching characteristic of the memristors is to effectively imitate different kinds of synaptic plasticity,indicating their great potential in future applications. | Fangxu Yang Lingjie Sun Qingxi Duan Huanli Dong Zhaokun Jing Yuchao Yang Rongjin Li Xiaotao Zhang Wenping Hu Leon Chua | 2021 | SmartMat2021，2，1： | 5 |
| 13 | Multi-infill strategy for kriging models used in variable fidelity optimization显示文摘In this paper, a computationally efficient optimization method for aerodynamic design has been developed. The low-fidelity model and the multi-infill strategy are utilized in this approach.Low-fidelity data is employed to provide a good global trend for model prediction, and multiple sample points chosen by different infill criteria in each updating cycle are used to enhance the exploitation and exploration ability of the optimization approach. Take the advantages of lowfidelity model and the multi-infill strategy, and no initial sample for the high-fidelity model is needed. This approach is applied to an airfoil design case and a high-dimensional wing design case.It saves a large number of high-fidelity function evaluations for initial model construction. What's more, faster reduction of an aerodynamic function is achieved, when compared to ordinary kriging using the multi-infill strategy and variable-fidelity model using single infill criterion. The results indicate that the developed approach has a promising application to efficient aerodynamic design when high-fidelity analyses are involved. | Chao SONG Xudong YANG Wenping SONG | 2018 | Chinese Journal of Aeronautics2018，31，3： | 5 |
| 14 | Zinc Anode for Mild Aqueous Zinc-Ion Batteries: Challenges, Strategies, and Perspectives显示文摘The rapid advance of mild aqueous zinc-ion batteries(ZIBs)is driving the development of the energy storage system market.But the thorny issues of Zn anodes,mainly including dendrite growth,hydrogen evolution,and corrosion,severely reduce the performance of ZIBs.To commercialize ZIBs,researchers must overcome formidable challenges.Research about mild aqueous ZIBs is still developing.Various technical and scientific obstacles to designing Zn anodes with high stripping efficiency and long cycling life have not been resolved.Moreover,the performance of Zn anodes is a complex scientific issue determined by various parameters,most of which are often ignored,failing to achieve the maximum performance of the cell.This review proposes a comprehensive overview of existing Zn anode issues and the corresponding strategies,frontiers,and development trends to deeply comprehend the essence and inner connection of degradation mechanism and performance.First,the formation mechanism of dendrite growth,hydrogen evolution,corrosion,and their influence on the anode are analyzed.Furthermore,various strategies for constructing stable Zn anodes are summarized and discussed in detail from multiple perspectives.These strategies are mainly divided into interface modification,structural anode,alloying anode,intercalation anode,liquid electrolyte,non-liquid electrolyte,separator design,and other strategies.Finally,research directions and prospects are put forward for Zn anodes.This contribution highlights the latest developments and provides new insights into the advanced Zn anode for future research. | Jinzhang Yang Bosi Yin Ying Sun Hongge Pan Wenping Sun Baohua Jia Siwen Zhang Tianyi Ma | 2022 | Nano-Micro Letters2022，14，3： | 5 |
| 15 | Interaction mechanism of the interface between a deep buried sand and a paleo-weathered rock mass using a high normal stress direct shear apparatus显示文摘In order to evaluate the feasibility of safe mining close to the contact zone under reduced security coal pillar conditions at a coal mine in eastern China, the interaction mechanism of the interface between deep buried sand and a paleo-weathered rock mass was investigated in the laboratory by direct shear testing. A DRS-1 high pressure soil shear testing machine and orthogonal design method were used in the direct shear tests. Variance and range methods were applied to analyze the sensitivity of each factor that has an influence on the mechanical characters of the interface. The test results show that the normal pressure is the main influencing factor for mechanical characteristics of the interface, while the lithological characters and roughness are minor factors; the shear stress against shear displacement curve for the interface shows an overall hyperbola relationship, no obvious peak stress and dilatancy was observed.When the normal pressure is 6 MPa, the shear strengths of interfaces with different roughness are basically the same, and when the normal pressure is more than 8 MPa, the larger the roughness of the interface, the larger will be the shear strength; the shear strength has a better linear relationship with the normal pressure, which can be described by a linear Mohr–Coulomb criterion. | Bai Hanying Li Wenping Ding Qingfeng Wang Qiqing Yang Dongdong | 2015 | International Journal of Mining Science and Technology2015，25，4： | 4 |
| 16 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 17 | Microsatellite variability reveals high genetic diversity and low genetic differentiation in a critical giant panda population显示文摘 | Jiandong YANG Zhihe ZHANG Fujun SHEN Xuyu YANG Liang ZHANG Limin CHEN Wenping ZHANG Qing ZHU Rong HOU | 2011 | Current Zoology2011，57，6： | 3 |
| 18 | High efficient acetalization of carbonyl compounds with diols catalyzed by novel carbon-based solid strong acid catalyst显示文摘The novel carbon-based acid catalyst has been applied to catalyzing the acetalization and ketalization. The results showed that the catalyst was very efficient with the average yield over 93%. The novel het- erogeneous catalyst has the advantages of high activity, wide applicability even to 7-membered ring acetals, strikingly simple workup procedure, non-pollution, and reusability, which will contribute to the green process greatly. | GAO Shan LIANG XueZheng WANG WenJuan CHENG WenPing YANG JianGuo | 2007 | Chinese Science Bulletin2007，52，21： | 3 |
| 19 | Aerodynamic performance of owl-like airfoil undergoing bio-inspired flapping kinematics显示文摘Natural flyers have extraordinary flight skills and their prominent aerodynamic performance has attracted a lot of attention.However,the aerodynamic mechanism of birds’flapping wing kinematics still lacks in-depth understanding.In this paper,the aerodynamic performance of owl-like airfoil undergoing bio-inspired flapping kinematics extracted from a free-flying owl wing has been numerically investigated.The overset mesh technique is used to deal with the large range movements of flapping airfoils.The bio-inspired kinematics consist of plunging and pitching movement.A pure sinusoidal motion and a defined motion composed of plunging of sinusoidal motion and pitching of the bio-inspired kinematics are selected for comparison.The other two NACA airfoils are also selected to figure out the advantages of the owl-like airfoil.It is found that the cambered owl-like airfoil can enhance lift during the downstroke.The bio-inspired kinematics have an obvious advantage in lift generation with a presence of higher peak lift and positive lift over a wider proportion of the flapping cycle.Meanwhile,the bio-inspired motion is more economical for a lower power consumption compared with the sinusoidal motion.The sinusoidal flapping motion is better for thrust generation for a higher peak thrust value in both upstroke and downstroke,while the bio-inspired kinematics mainly generate thrust during the downstroke but produce more drag during the upstroke.The defined motion has similar lift performance with the bio-inspired kinematics,while it consumes more energy and generates less thrust.The unsteady flow field around airfoils is also analyzed to explain the corresponding phenomenon.The research in this paper is helpful to understand the flight mechanism of birds and to design a micro air vehicle with higher performance. | Xinyu LANG Bifeng SONG Wenqing YANG Wenping SONG | 2021 | Chinese Journal of Aeronautics2021，34，5： | 2 |
| 20 | Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment显示文摘Hepatocellular carcinoma(HCC)is a malignancy with a poor prognosis.Surgery combined with chemotherapy has been recommended as a curative regimen for HCC.Nevertheless,the anticancer mechanisms of chemicals in hepatocellular carcinoma remain unclear.Pyroptosis is a type of programmed necrosis,and its mechanism in hepatocellular carcinoma is poorly understood.The efficacy and mechanism of arsenic trioxide nanoparticles in the treatment of HCC were explored in this research.Arsenic trioxide alone and arsenic trioxide nanoparticles were conveniently administered to mice intratumorally using a needle.Compared with As_(2)O_(3),As_(2)O_(3)nanoparticles(As_(2)O_(3)-NPs)showed better inhibition,promoted greater LDH release,and induced cell morphology indicative of pyroptosis in vitro.Compared with the free drug,As_(2)O_(3)-NPs increased GSDME-N expression and decreased Dnmt3a,Dnmt3b,and Dnmt1 expression in Huh7 cells.In vivo,As_(2)O_(3)-NPs induced a significant decrease in the expression of Dnmt3a,Dnmt3b and Dnmt1,but significantly upregulated the expression of GSDME-N(gasdermin E(GSDME)was originally found to be related to deafness;recently,it has been defined as a gasdermin family member associated with pyroptosis).As_(2)O_(3)-NPs inhibited tumor growth more strongly than As_(2)O_(3)or control,a finding likely attributed to the downregulation of PCNA and DNMT-related proteins and the upregulation of GSDME-N. | Jian Hu Yi Dong Li Ding Yang Dong Zhihua Wu Wenping Wang Ming Shen Yourong Duan | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
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