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| 1 | Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes显示文摘 | Honghe Sun Shan WU Guoyu Zhang Chen Jiao Shaogui Guo Yi Ren Jie Zhang Haiying Zhang Guoyi Gong Zhangcai Jia Fan Zhang Jiaxing Tian William J. Lucas Jeff J. Doyle Haizhen Li Zhangjun Fei Yong Xu | 2017 | Molecular Plant2017，10，10： | 33 |
| 2 | Damage to DNA of effective microorganisms by heavy metals:Impact on wastewater treatment显示文摘The research is to test the damage to DNA of effective microorganisms(EMs)by heavy metal ions As3+,Cd2+,Cr3+,Cu2+,Hg2+, Pb2+,and Zn2+,as well as the effects of EM bacteria on wastewater treatment capability when their DNA is damaged.The approach applied in this study is to test with COMET assay the damage of EM DNA in wastewater with different concentrations of heavy metal ions As3+,Cd2+,Cr3+,Cu2+,Hg2+,Pb2+,Zn2+,as well as the effects of EM treated with As3+,Cd2+,Cr3+,Cu2+,Hg2+,Pb2+,and Zn2+ on COD degrading capability in wastewater.The results showed that the damage of the DNA of EM were negatively correlated with their treatment capability and that EM bacteria maximum tolerant concentrations of these heavy metal ions was at 0.05 mg/L for As3+, 0.2 mg/L for Hg2+,0.5 mg/L for Cd2+,Cr3+,and Cu2+,and 1 mg/L for Pb2+and Zn2+. | ZHOU, Sheng WEI, Chaohai LIAO, Chaodeng WU, Haizhen | 2008 | Journal of Environmental Sciences2008，20，12： | 9 |
| 3 | Degradation of o-chloronitrobenzene as the sole carbon and nitrogen sources by Pseudomonas putida OCNB-1显示文摘A bacterial strain that utilized o-chloronitrobenzene(o-CNB) as the sole carbon,nitrogen and energy sources was isolated from an activated sludge collected from an industrial waste treatment plant. It was identified as Pseudomonas putida based on its morphology,physiological,and biochemical characteristics with an automatic biometrical system and the 16S rRNA sequence analysis. Microcosm study showed that the biodegradation of o-CNB was optimized at culture medium pH 8.0 and 32°C. At these conditions,the strain degraded 85% of o-CNB at a starting concentration of 1.1 mmol/L in 42 h. o-Chloroaniline was identified as the major metabolite with high performance liquid chromatography(HPLC) and gas chromatography-mass spectrometry(GC-MS) . The study showed that o-CNB degradation by Pseudomonas putida OCNB-1 was initiated by aniline dioxyenase,nitrobenzene reductase and catechol-1,2dioxygenase. | WU Haizhen WEI Chaohai WANG Yaqin HE Qincong LIANG Shizhong | 2009 | Journal of Environmental Sciences2009，21，1： | 9 |
| 4 | Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma显示文摘Objective:This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes of primary liver malignancies to make better understanding of their clinical features.Methods:The clinicopathological data of 114 patients who were diagnosed with histologically proven four subtypes:clear cell carcinoma(CCC),giant cell carcinoma(GCC),sarcomatoid carcinoma(SC),and combined hepatocellular-cholangiocarcinoma(CHC)between October 1998 and August 2015 were reviewed.Their survival data were compared with those of 908 patients with histologically proven common hepatocellular carcinoma(HCC)(early-and advanced-stage HCC)during the same period.Results:The outcome of the CCC group was better than that of the other three subgroups,and was similar to that of the early-stage HCC group.Also,the smallest tumor size and the highest incidence of pseudocapsule formation were observed in the CCC group.The SC group had the worst outcome among these four subgroups;the prognosis was much poorer than that of any other subgroups,even poorer than that of the advanced-stage common HCC group.No statistical difference was observed between the GCC,CHC and advanced-stage HCC groups on survival analysis.The incidences of tumor vascular emboli,TNM staging and non-radical resection were three risk factors of the prognosis.Conclusions:CCC is a low-degree malignancy and relatively favorably prognostic subtype of HCC.However,GCC,SC,and CHC are three rare high-degree malignancy subtypes of HCC with poor prognosis. | Zhiyu Li Xiaolong Wu Xinyu Bi Yefan Zhang Zhen Huang Haizhen Lu Hong Zhao Jianjun Zhao Jianguo Zhou Muxing Li Jianming Ying Jianqiang Cai | 2018 | Chinese Journal of Cancer Research2018，30，3： | 6 |
| 5 | Adsorption characteristic of bensulfuron-methyl at variable added Pb^(2+) concentrations on paddy soils显示文摘The combined pollution of heavy metal Pb2+ and bensulfuron-methyl (BSM), originating from chemical herbicides, in agro- ecological environments has become commonplace in southern China. The adsorption of BSM on three paddy soils in the presence of Pb2+ was examined using high-performance liquid chromatograph (HPLC). Results indicated that adsorption of BSM could accurately be described by a Freundlich isotherm equation with correlation constant (R) > 0.98, irrespective of the presence of spiked Pb2+. Of the various factors influencing BSM sorption, soil pH appeared to be the most inffiuential. The constant Kf of Freundlich isotherm equation tended to increase with increasing Pb2+ concentration in soil which indicated that the spiked of Pb2+ in paddy soils would promote the sorption of BSM. △Gθ of BSM in three paddy soils was less than 40 kJ/mol in all treatments, indicating the adsorption of BSM is mainly physical in nature. The elution of soil dissolved organic matter (DOM) enhanced the adsorption of BSM in paddy soils. The mechanisms involved in the promotion effects of the spiked Pb2+ on BSM adsorption might be the modified surface characteristics of paddy soil solids due to the soil acidification and the increase of soil organic matter concentration because of DOM binding. | WU Weihong WANG Haizhen XU Jianming XIE Zhengmiao | 2009 | Journal of Environmental Sciences2009，21，8： | 4 |
| 6 | An efficient catalyst for the conversion of fructose into methyl levulinate 显示文摘 | Liu Yan Liu Chunling Wu Haizhen | 2013 | Catal Lett2013，143，12： | 1 |
| 7 | Angiotensin Type 1 Receptor Blocker Reduces Intimal Neovascularization and Plaque Growth in Apolipoprotein E–Deficient Mice显示文摘 | Xian Wu Cheng Haizhen Song Takeshi Sasaki Lina Hu Aiko Inoue Yasuko K. Bando Guo-Ping Shi Masafumi Kuzuya Kenji Okumura Toyoaki Murohara | 2011 | Hypertension2011，，5： | 1 |
| 8 | Improvement of biodegradability for coking wastewater by selective adsorption of hydrophobic organic pollutants显示文摘 | Yu Xubiao Wei Chaohai Wu Haizhen | 2015 | Separation and Purification Technology2015，151，： | 1 |
| 9 | Screening genetically modi- fied organisms using multiplex-PCR coupled with oligo nucleotide microarray显示文摘 | XU Jia MIAO Haizhen WU Houfei | 2006 | Biosensors and Bioelectronics2006，22，15： | 1 |
| 10 | Screening genetically modifiedorgan isms using multiplex--PeR coupled with oligonucleotide microar 显示文摘 | Jia Xu Haizhen Miao Houfei Wu | 2006 | Biosensors and Bioelectrenics2006，，1： | 1 |
| 11 | Complete sequence of virulence plasmid pEIB1 from the marine fish pathogen Vibrio anguillarum strain MVM425 and location of its replication region显示文摘 | Wu Haizhen Ma Yue Zhang Yuanxing | 2004 | Journal of Applied Microbiology2004，97，5： | 1 |
| 12 | Cloning, identification and expression of an entE homologue angE from Vibrio anguillarum serotype 01 显示文摘 | Liu Qin Ma Yue Wu Haizhen | 2004 | Archives of Microbiology2004，181，4： | 1 |
| 13 | Spatial distribution of heavy metals in soils: a case study of Changxing, China显示文摘 | Jiachun Shi Haizhen Wang Jianming Xu Jianjun Wu Xingmei Liu Haiping Zhu Chunlan Yu | 2007 | Environmental Geology2007，，1： | 1 |
| 14 | Cathepsin K Activity Controls Injury-Related Vascular Repair in Mice显示文摘 | Lina Hu Xian Wu Cheng Haizhen Song Aiko Inoue Haiying Jiang Xiang Li Guo-Ping Shi Eiji Kozawa Kenji Okumura Masafumi Kuzuya | 2014 | Hypertension2014，，： | 1 |
| 15 | Changes in microbial community structure due to biochars generated from different feedstocks and their relationships with soil chemical properties显示文摘 | Niaz Muhammad Zhongmin Dai Kongcao Xiao Jun Meng Philip C. Brookes Xingmei Liu Haizhen Wang Jianjun Wu Jianming Xu | 2014 | Geoderma2014，，： | 1 |
| 16 | A Detected Case of Avian Influenza H9N2 from Influenza-Like Illness Surveillance--Hunan Province, 2020显示文摘Jishou Municipal Center for Disease Control and Prevention(Jishou CDC)received a phone call at 7:30 a.m.on April 24,2020 from Xiangxi Tujia and Miao Autonomous Prefectural CDC(Xiangxi CDC)that avian influenza A/H9N2 virus was detected by quantitative reverse transcription-polymerase chain reaction(RT-PCR)from the throat swab sample of an influenza-like illness in an outpatient in the Xiangxi Traditional Chinese Medicine Hospital. | Siyu Zhang Chaoyang Huang Yingying Mo Zhoujian Wu Haizhen Li Yiwei Huang Fuqiang Liu Lidong Gao | 2020 | China CDC weekly2020，2，36： | 1 |
| 17 | Determination of Copper and Lead Contents in Soil of the Yellow River Wetland in Shaanxi Province by Flame Atomic Absorption Spectrometry显示文摘[Objectives] The contents of copper and lead in the soil of the Yellow River Wetland were determined by flame atomic absorption spectrometry, which provides a theoretical basis for the treatment of soil pollution. [Methods] The soil was digested with a concentrated nitric acid-hydrofluoric acid-perchloric acid system, and the contents of heavy metals such as copper and lead in the Yellow River Wetland of Shaanxi Province were determined by flame atomic absorption spectrometry. [Results] The correlation coefficients reached 0.999 5 in the range of 0.00-1.00 mg/L, indicating good linearity. [Conclusions] The method is simple in operation, good in reproducibility, high in sensitivity to most elements, and can be widely used. | Xiaoxiang QIU Fengfeng ZHANG Haizhen WU | 2019 | Agricultural Biotechnology2019，8，2： | 0 |
| 18 | An overview of kinase downregulators and recent advances in discovery approaches显示文摘Since the dinical approval of imatinib,the discovery of protein kinase downregulators entered a prosperous age.However,challenges still exist in the discovery of kinase downregulator drugs,such as the high failure rate during development,side effects,and drug-resistance problems.With the progress made through multidisciplinary efforts,an increasing number of new approaches have bee n applied to solve the above problems duri ng the discovery process of kin ase down regulators.In terms of in vitro and in vivo drug evaluation,progress was also made in cellular and animal model platforms for better and more clinically relevant drug assessme nt.Here,we review the adva nces in drug desig n strategies,drug property evaluatio n tech no logies,and efficacy evaluatio n models and tech no logies.Finally,we discuss the challenges and perspectives in the development of kin ase down regulator drugs. | Beilei Wang Hong Wu Chen Hu Haizhen Wang Jing Liu Wenchao Wang Qingsong Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 19 | GmYSL7 controls iron uptake,allocation,and cellular response of nodules in soybean显示文摘Iron(Fe)is essential for DNA synthesis,photosynthesis and respiration of plants.The demand for Fe substantially increases during legumesrhizobia symbiotic nitrogen fixation because of the synthesis of leghemoglobin in the host and Fecontaining proteins in bacteroids.However,the mechanism by which plant controls iron transport to nodules remains largely unknown.Here we demonstrate that GmYSL7 serves as a key regulator controlling Fe uptake from root to nodule and distribution in soybean nodules.GmYSL7 is Fe responsive and GmYSL7 transports iron across the membrane and into the infected cells of nodules.Alterations of GmYSL7 substantially affect iron distribution between root and nodule,resulting in defective growth of nodules and reduced nitrogenase activity.GmYSL7 knockout increases the expression of GmbHLH300,a transcription factor required for Fe response of nodules.Overexpression of GmbHLH300 decreases nodule number,nitrogenase activity and Fe content in nodules.Remarkably,GmbHLH300 directly binds to the promoters of ENOD93 and GmLbs,which regulate nodule number and nitrogenase activity,and represses their transcription.Our data reveal a new role of GmYSL7 in controlling Fe transport from host root to nodule and Fe distribution in nodule cells,and uncover a molecular mechanism by which Fe affects nodule number and nitrogenase activity. | Xinying Wu Yongliang Wang Qiaohan Ni Haizhen Li Xuesong Wu Zhanxin Yuan Renhao Xiao Ziyin Ren Jingjing Lu Jinxia Yun Zhijuan Wang Xia Li | 2023 | Journal of Integrative Plant Biology2023，65，1： | 0 |
| 20 | Primary Malignant Amelanotic Melanoma in the Female Genital Tract:A Report of Six Cases and a Review of the Literature显示文摘OBJECTIVE To analyze the clinical characteristics,pathologic diagnosis,treatment and prognosis of amelanotic melanoma in the female genital tract(AMFGT).METHODS The medical records of 6 patients with AMFGT between 1991 and 2006 in our hospital were reviewed.RESULTS Of these cases,4 were preliminarily misdiagnosed as chorioepithelioma,sarcoma,adenocarcinoma or lymphoma.Two patients were determined to have AMFGT preoperatively after positive immunohistochemical staining for both S-100 protein and HMB-45.Specimens removed from all 6 cases were tested for immunohistochemical staining,as well as H&E histochemical stains.S-100 and vimentin were both positive in all patients,and HMB-45 was positive in 3 out of 5 patients.Four patients recurred(at 6,6,12 and 19 months) a er primary treatments.Three patients died(at 13,18 and 19 months) a er the initial diagnosis.CONCLUSION Because of an absence of pigmentation AMFGT is extremely difficult to diagnose.Combined immunohistochemical staining,such as the S-100 protein,HMB-45 and vimentin etc,is important in the evaluation of AMFGT.Correct diagnosis plays a crucial role in the treatment of this disease. | Jusheng An Lingying Wu Bin Li Haizhen Lu Ning Li Shaokang Ma | 2008 | Chinese Journal of Clinical Oncology2008，5，5： | 0 |
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