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| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Sequence Thickness and its Response to Episodic Tectonic Evolution in Paleogene Qikou Sag, Bohaiwan Basin显示文摘The sequence stratigraphy framework of Paleogene of Qikou Sag has been built in this paper. The evolution law of episodic subsidence in Qikou Sag has been expounded, with the analysis of the characteristic of sequence thickness, as well as the study of consedimental tectonic activity, subsidence history, paleogeomorphology and the coupling relationship among them. The faults controlling action was the dominant mechanism during rifting stage I , as the depression was the dominant mechanism during rifting stage III, which embodies a process from intense disparity fault depression to integral subsidence. Meanwhile, under the control of regional faulting and later stage depression, subsidence rate centers and paleogeomorphic concave centers are always corresponding to the sequence thickness centers, and the changes of subsidence centers and paleogeomorphology concave centers are consistent with the migration of thickness centers, which presents the restriction, coupling and response among them and clarifies the law that tectonic activity controls the basin fill by means of controlling the subsidence rate and paleogeomorphology from contributing factor angle. On this basis, the dynamic evolution of the composite pattern of structure-subsidence-deposition in the fault controlling actic region during the three rifting stages and their petroleum geological significance has been discussed. | CHEN Si WANG Hua ZHOU Lihong HUANG Chuanyan WANG Jiahao REN Peigang XIANG Xuemei | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 11 |
| 3 | Impacts of algal blooms removal by chitosan-modified soils on zooplankton community in Taihu Lake,China显示文摘It is important to assess the eflect on zooplankton when perform the environmental protection or restoration technology,especially removing algal blooms,because algae were the major primary producer in algal lakes.The influence on zooplankton community after half a year of algal blooms removed by chitosan-modified soils in Taihu Lake was assessed and the rationality of carrying out the process semiannually was evaluated in the present study.Morphological composition and genetic diversity of zooplankton community were investigated by microscope checkup and polymerase chain reaction-denatured gradient gel electrophoresis(PCR-DGGE) .A total of 44 zooplankton taxa(23 protozoa,17 rotifers,3 copepoda and 1 cladocera) were detected by microscope checkup,and a total of 91 bands(28 bands amplified by primers F1427-GC and R1616,63 bands amplified by primers Fung-GC and NS1) were detected by PCR-DGGE.The results of cluster analysis or detrended correspondence analysis indicated that there was no considerable diflerence in morphological composition of zooplankton and DGGE profiles between experimental and control sites,and DGGE profiles could represent the biologic diversity.The study showed that zooplankton community could recover original condition after half year of algal blooms removed by chitosan-modified soils and it was acceptable to apply this process semiannually.In addition,the results revealed that PCR-DGGE could be applied to investigate the impacts of the environmental protection or restoration engineering on zooplankton community diversity. | Jiajia Ni Yuhe Yu Weisong Feng Qingyun Yan Gang Pan Bo Yang Xiang Zhang Xuemei Li | 2010 | Journal of Environmental Sciences2010，22，10： | 8 |
| 4 | Plankton Community Succession in Artificial Systems Subjected to Cyanobacterial Blooms Removal using Chitosan-Modified Soils显示文摘 | Qingyun Yan Yuhe Yu Weisong Feng Gang Pan Hao Chen Juan Chen Bo Yang Xuemei Li Xiang Zhang | 2009 | Microbial Ecology2009，，1： | 1 |
| 5 | Morpholo- gy observation of latex particles with scanning transmis- sion electron microscopy by a hydroxyethyl cellulose embedding combined with Ru04 staining method 显示文摘 | Geng Xiang Zhai Xuemei Sun Tong | 2013 | Microscopy and Microanalysis2013，19，2： | 1 |
| 6 | Hydrovoltaic energy from water droplets:Device configurations,mechanisms,and applications显示文摘Water,the source of life,contains immense energy and manifests in diverse forms.Hydrovoltaic technology enables the direct interaction between water and materials to generate electricity,a vital necessity for industry modernization.Due to the ubiquitous presence and easy availability of falling water,hydrovoltaic energy derived from water droplets has attracted considerable attention and shown great potential in raindrop energy harvesting.In this review,a comprehensive summary of the latest advancements in harvesting hydrovoltaic energy from water droplets is presented,with a focus on the configurations and underlying mechanisms of hydrovoltaic devices.Additionally,a brief discussion on the applications of dropletbased hydrovoltaic devices is presented,along with future prospects for this energyharvesting technology. | Luxian Li Xiang Wang Wei Deng Jun Yin Xuemei Li Wanlin Guo | 2023 | Droplet2023，2，4： | 1 |
| 7 | Practicing the concept of “structuring” processing in the manufacture of polymer films显示文摘Polymer processing is a technology used to transfer raw materials into products with different shapes and functionalities and is a key step for polymer application.After years of development,the polymer processing task has changed from traditional processing,which mainly addresses the specific shapes of articles and focuses on the effect of processing on the structures and properties of polymers,to modern processing,which directly transforms a“designed structure”into commercial products via processing.It is the so-called“structuring”processing.Owing to the unique long-chain nature and slow topological relaxation,polymers are always driven and frozen into different nonequilibrium conformations,providing an effective way to design a given polymer material with desired structure and tunable performances via processing.Among the endless number of processing techniques,film casting is a prototypical pathway involving high supercooling or/and a strong flow field,based on which diverse thin polymer films have been successfully developed.In this review,taking isotactic polypropylene(i PP)film as an example,we highlight the strategy of“structuring”processing,in which we transform various crystalline structures of i PP into diverse commercial film products. | Tong Wu Ke Wang Xiufeng Chen Xuemei Yang Ming Xiang Qiang Fu | 2023 | Science China Chemistry2023，66，4： | 0 |
| 8 | Comparative and population genomics of buckwheat species reveal key determinants of flavor and fertility显示文摘Common buckwheat(Fagopyrum esculentum)is an ancient crop with a world-wide distribution.Due to its excellent nutritional quality and high economic and ecological value,common buckwheat is becoming increasingly important throughout the world.The availability of a high-quality reference genome sequence and population genomic data will accelerate the breeding of common buckwheat,but the high heterozygosity due to the outcrossing nature has greatly hindered the genome assembly.Here we report the assembly of a chromosome-scale high-quality reference genome of F.esculentum var.homotropicum,a homozygous self-pollinating variant of common buckwheat.Comparative genomics revealed that two cultivated buckwheat species,common buckwheat(F.esculentum)and Tartary buckwheat(F.tataricum),underwent metabolomic divergence and ecotype differentiation.The expansion of several gene families in common buckwheat,including FhFAR genes,is associated with its wider distribution than Tartary buckwheat.Copy number variation of genes involved in the metabolism of flavonoids is associated with the difference of rutin content between common and Tartary buckwheat.Furthermore,we present a comprehensive atlas of genomic variation based on whole-genome resequencing of 572 accessions of common buckwheat.Population and evolutionary genomics reveal genetic variation associated with environmental adaptability and floral development between Chinese and non-Chinese cultivated groups.Genome-wide association analyses of multi-year agronomic traits with the content of flavonoids revealed that Fh05G014970 is a potential major regulator of flowering period,a key agronomic trait controlling the yield of outcrossing crops,and that Fh06G015130 is a crucial gene underlying flavor-associated flavonoids.Intriguingly,we found that the gene translocation and sequence variation of FhS-ELF3 contribute to the homomorphic self-compatibility of common buckwheat.Collectively,our results elucidate the genetic basis of speciation,ecological adaptation,fertility,and unique flavor of common buckwheat,and provide new resources for future genomics-assisted breeding of this economically important crop. | Kaixuan Zhang Yuqi He Xiang Lu Yaliang Shi Hui Zhao Xiaobo Li Jinlong Li Yang Liu Yinan Ouyang Yu Tang Xue Ren Xuemei Zhang Weifei Yang Zhaoxia Sun Chunhua Zhang Muriel Quinet Zlata Luthar Mateja Germ Ivan Kreft Dagmar Janovska Vladimir Meglic Barbara Pipan Milen I.Georgiev Bruno Studer Mark A.Chapman Meiliang Zhou | 2023 | Molecular Plant2023，16，9： | 0 |
| 9 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 10 | Coaxial fiber organic electrochemical transistor with high transconductance显示文摘Fiber organic electrochemical transistors(OECTs)have received extensive attention in wearable and implantable biosensors because of their high flexibility and low working voltage.However,the transconductance of fiber OECTs is much lower compared with the planar counterparts,leading to low sensitivity.Here,we developed fiber OECTs in a coaxial configuration with microscale channel length to achieve the highest transconductance of 135 mS,which is one to two orders of magnitude higher than that of the state-of-the-art fiber OECTs.Coaxial fiber OECT based sensors showed high sensitivities of 12.78,20.53 and 3.78 mA/decade to ascorbic acid,hydrogen peroxide and glucose,respectively.These fiber OECTs were woven into a fabric to monitor the glucose in sweat during exercise and implanted in mouse brain to detect ascorbic acid.This coaxial architectural design offers an effective way to promote the performance of fiber OECTs and realize highly sensitive detection of biochemicals. | Yuan Fang Jianyou Feng Xiang Shi Yiqing Yang Jiajia Wang Xiao Sun Wenjun Li Xuemei Sun Huisheng Peng | 2023 | Nano Research2023，16，9： | 0 |
| 11 | Preparation of Functionalized Fe304@SiO2 MagneticNanoparticles for Monoclonal Antibody Purification显示文摘Magnetic Fe304@SiO2 nanoparticles with superparamagnetic properties were prepared via a reverse mi-croemulsion method at room temperature. The as-prepared samples were characterized by transmission electron mi-croscopy(TEM), X-ray diffractometry(XRD), and vibrating sample magnetometry(VSM). The Fe304@SiO2 nanopar-ticles were modified by (3-aminopropyl)triethoxysilane(APTES) and subsequently activated by glutaraldehyde(Glu).Protein A was successfully immobilized covalently onto the Glu activated Fe304@SiO2 nanoparticles. The adsorptioncapacity of the nanoparticles was determined on an ultraviolet spectrophotometer(UV) and approximately up to 203mg/g of protein A could be uniformly immobilized onto the modified Fe304@SiO2 magnetic beads. The core-shell ofthe Fe304@SiO2 magnetic beads decorated with protein A showed a good binding capacity for the chime-ric anti-EGFR monoclonal antibody(anti-EGFR mAb). The purity of the anti-EGFR mAb was analyzed by virtue ofHPLC. The protein A immobilized affinity beads provided a purity of about 95.4%. | HOU Xuemei ZHAO Changjie TIAN Yanlong DOU Shuliang ZHANG Xiang ZHAO Jiupeng | 2016 | Chemical Research in Chinese Universities2016，32，6： | 0 |
| 12 | The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment显示文摘Lactate is an end product of glycolysis.Owing to the lactate shuttle concept introduced in the early 1980s,increasing researchers indicate lactate as a critical energy source for mitochondrial respiration and as a precursor of gluconeogenesis.Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells,resulting in diverse biological consequences including decreased lipolysis,immune regulation,and anti-inflammation wound healing,and enhanced exercise performance in association with the gut microbiome.Furthermore,increasing evidence reveals that lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones,which accounts for its key role in immune modulation and maintenance of homeostasis.Here,we summarize the function and mechanism of lactate and lactylation in tumor metabolism and microenvironment. | Yan Zhang Qiu Peng Jinhua Zheng Yuzhong Yang Xuemei Zhang Aiyu Ma Yuxia Qin Zailong Qin Xiang Zheng | 2023 | Genes & Diseases2023，10，5： | 0 |
| 13 | Cobalt valence modulating in CoO_(x) incorporated carbon nanofiber for enhanced glucose electrooxidation显示文摘Glucose fuel cells(GFCs)driven by abiotic catalysts are promising green power sources for portable or wearable devices.In this work,a CoO_(x)incorporated carbon nanofiber(CoO_(x)@CNF)catalyst with mixed valences cobalt oxides have been developed through partial oxidation of pyrolyzed electrospun Co^(2+)/poly acrylonitrile fibers.The cobalt valence modulating could be achieved via regulating the incorporation ratio of cobalt acetate in precursors or the oxidation temperature of the pyrolyzed fibers.Electrocatalytic analyses show that the presence of CoO in CoO_(x)@CNF will provide more active sites for glucose electrooxidation,and thus enhance the electrocatalytic performance significantly.As a result,the glucose fuel cell built with the CoO.@CNF anode containing both CoO and Co_(3)O_(4)delivered a maximum power density of 270μW cm^(-2),which is higher than that of other reported Co_(3)O_(4)based GFCs.This work provides a simple strategy to develop excellent transition metal catalysts for GFCs to expand their applications in portable and wearable energy devices. | Jiadong Hu Hao Lu Mingsong Li Gang Xiao Min Li Xuemei Xiang Zhisong Lu Yan Qiao | 2022 | Materials Reports(Energy)2022，2，2： | 0 |
| 14 | Global Solutions of Shock Reflection by Wedges for the Nonlinear Wave Equation显示文摘When a plane shock hits a wedge head on,it experiences a reflection-diffraction process and then a self-similar reflected shock moves outward as the original shock moves forward in time.In this paper,shock reflection by large-angle wedges for compressible flow modeled by the nonlinear wave equation is studied and a global theory of existence,stability and regularity is established.Moreover,0,1 is the optimal regularity for the solutions across the degenerate sonic boundary. | Xuemei DENG Wei XIANG | 2011 | Chinese Annals of Mathematics,Series B2011，32，5： | 0 |
| 15 | Image smoothing based on global sparsity decomposition and a variable parameter显示文摘Smoothing images,especially with rich texture,is an important problem in computer vision.Obtaining an ideal result is difficult due to complexity,irregularity,and anisotropicity of the texture.Besides,some properties are shared by the texture and the structure in an image.It is a hard compromise to retain structure and simultaneously remove texture.To create an ideal algorithm for image smoothing,we face three problems.For images with rich textures,the smoothing effect should be enhanced.We should overcome inconsistency of smoothing results in different parts of the image.It is necessary to create a method to evaluate the smoothing effect.We apply texture pre-removal based on global sparse decomposition with a variable smoothing parameter to solve the first two problems.A parametric surface constructed by an improved Bessel method is used to determine the smoothing parameter.Three evaluation measures:edge integrity rate,texture removal rate,and gradient value distribution are proposed to cope with the third problem.We use the alternating direction method of multipliers to complete the whole algorithm and obtain the results.Experiments show that our algorithm is better than existing algorithms both visually and quantitatively.We also demonstrate our method’s ability in other applications such as clip-art compression artifact removal and content-aware image manipulation. | Xiang Ma Xuemei Li Yuanfeng Zhou Caiming Zhang | 2021 | Computational Visual Media2021，7，4： | 0 |
| 16 | Landscape Architecture and Female Development Based on Questionnaire Survey显示文摘In view of gender difference in the development of landscape architecture, questionnaire survey and comparative analysis were applied to investigate landscape architecture students' studies and opinions on landscape architecture, and figure out differences between male and female students. By analyzing obstacles that female students and staffs encounter in this field, role of female in landscape architecture was explored, and strategies of developing female talents in landscape architecture were proposed. | ZHU Xuemei FAN Jianhong ZHOU Xiang | 2012 | Journal of Landscape Research2012，4，10： | 0 |
| 17 | SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection显示文摘A key question in the coronavirus disease 2019(COVID-19)pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)post primary infection,which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure to the virus.Here,we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in a unique cohort of convalescent individuals(CIs)that were among the first to be infected worldwide and without any possible antigen re-exposure since then.The magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs.The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82%and 76%,respectively,over the time period of ten months after infection.Accordingly,the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75%of CIs during the follow-up.Collectively,we provide a comprehensive characterization of the long-term memory T cell response in CIs,suggesting that robust SARS-CoV-2-specific T cell immunity post primary infection may be less durable than previously expected. | Ziwei Li Tiandan Xiang Boyun Liang Jing Liu Hui Deng Xuecheng Yang Hua Wang Xuemei Feng Gennadiy Zelinskyy Mirko Trilling Kathrin Sutter Mengji Lu Ulf Dittmer Baoju Wang Dongliang Yang Xin Zheng Jia Liu | 2023 | Virologica Sinica2023，38，4： | 0 |
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