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| 1 | H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis显示文摘 | Xiaozhuan Dai Youhuang Bai Lihua Zhao Xianying DOU Yanhui Liu Lulu Wang Yi Li Weimin Li Yanan Hui Xinyu Huang Zonghua Wang Yuan Qin | 2017 | Molecular Plant2017，10，10： | 14 |
| 2 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 3 | Measurement-based Frequency Dynamic Response Estimation Using Geometric Template Matching and Recurrent Artificial Neural Network显示文摘Understanding power system dynamics after an event occurs is essential for the purpose of online stability assessment and control applications.Wide area measurement systems(WAMS)based on synchrophasors make power system dynamics visible to system operators,delivering an accurate picture of overall operating conditions.However,in actual field implementations,some measurements can be inaccessible for various reasons,e.g.,most notably communication failure.To reconstruct these inaccessible measurements,in this paper,the radial basis function artificial neural network(RBF-ANN)is used to estimate the system dynamics.In order to find the best input features of the RBF-ANN model,geometric template matching(GeTeM)and quality-threshold(QT)clustering are employed from the time series analysis to compute the similarity of frequency dynamic responses in different locations of the power system.The proposed method is tested and verified on the Eastern Interconnection(EI)transmission system in the United States.The results obtained indicate that the proposed approach provides a compact and efficient RBF-ANN model that accurately estimates the inaccessible frequency dynamic responses under different operating conditions and with fewer inputs. | Feifei Bai Xiaoru Wang Yilu Liu Xinyu Liu Yue Xiang Yong Liu | 2016 | CSEE Journal of Power and Energy Systems2016，2，3： | 8 |
| 4 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 5 | High-quality genome assembly of 'Cuiguan' pear (Pyrus pyrifolia) as a reference genome for identifying regulatory genes and epigenetic modifications responsible for bud dormancy显示文摘Dormancy-associated MADS-box(DAM)genes serve as crucial regulators of the endodormancy cycle in rosaceous plants.Although pear DAM genes have been identified previously,the lack of a high-quality reference genome and techniques to study gene function have prevented accurate genome-wide analysis and functional verification of such genes.Additionally,the contribution of other genes to the regulation of endodormancy release remains poorly understood.In this study,a high-quality genome assembly for'Cuiguan'pear(Pyrus pyrifolia),which is a leading cultivar with a low chilling requirement cultivated in China,was constructed using PacBio and Hi-C technologies.Using this genome sequence,we revealed that pear DAM genes were tandemly clustered on Chr8 and Chr15 and were differentially expressed in the buds between'Cuiguan'and the high-chilling-requirement cultivar'Suli'during the dormancy cycle.Using a virus-induced gene silencing system,we determined the repressive effects of DAM genes on bud break.Several novel genes potentially involved in the regulation of endodormancy release were identified by RNA sequencing and H3K4me3 chromatin immunoprecipitation sequencing analyses of‘Suli'buds during artificial chilling using the new reference genome.Our findings enrich the knowledge of the regulatory mechanism underlying endodormancy release and chilling requirements and provide a foundation for the practical regulation of dormancy release in fruit trees as an adaptation to climate change. | Yuhao Gao Qinsong Yang Xinhui Yan Xinyue Wu Feng Yang Jianzhao Li Jia Wei Junbei Ni Mudassar Ahmad Songling Bai Yuanwen Teng | 2021 | Horticulture Research2021，8，1： | 5 |
| 6 | Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications显示文摘Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer treatment, but the complex biological processes of cancer cells seriously limit the efficacy of various anticancer drugs. Autophagy, a self-degradative system that maintains cellular homeostasis, universally operates under normal and stress conditions in cancer cells. The roles of autophagy in cancer treatment are still controversial because both stimulation and inhibition of autophagy have been reported to enhance the effects of anticancer drugs. Thus, the important question arises as to whether we should try to strengthen or suppress autophagy during cancer therapy. Currently, autophagy can be divided into four main forms according to its different functions during cancer treatment: cytoprotective(cell survival), cytotoxic(cell death), cytostatic(growth arrest), and nonprotective(no contribution to cell death or survival). In addition, various cell death modes, such as apoptosis, necrosis, ferroptosis, senescence, and mitotic catastrophe, all contribute to the anticancer effects of drugs. The interaction between autophagy and these cell death modes is complex and can lead to anticancer drugs having different or even completely opposite effects on treatment. Therefore, it is important to understand the underlying contexts in which autophagy inhibition or activation will be beneficial or detrimental.That is, appropriate therapeutic strategies should be adopted in light of the different functions of autophagy. This review provides an overview of recent insights into the evolving relationship between autophagy and cancer treatment. | Zhaoshi BAI Yaling PENG Xinyue YE Zhixian LIU Yupeng LI Lingman MA | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，2： | 5 |
| 7 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 8 | Balancing the anionic framework polarity for enhanced thermoelectric performance in YbMg_(2)Sb_(2) Zintl compounds显示文摘1-2-2-type Zintl phase compound has aroused great interest for potential thermoelectric applications.However,YbMg_(2)Sb_(2) is seldom studied due to the very low electrical conductivity resulting from the large difference in the electronegativity between Mg and Sb.In this paper,we adjust the covalently bonded network of MgeSb by replacing part of the Mg with Zn which has the electronegativity closer to that of Sb.The decreased polarity in the anionic framework offers more free distance for electrons for the enhanced Hall mobility and electrical conductivity.Together with the increased point defect and the decreased lattice thermal conductivity by introduction of Zn,the maximum ZT value of ~0.8 at 773 K is achieved in YbMg_(0.9)Zn_(1.1)Sb_(2) which is~100% enhancement compared with that of YbMg_(2)Sb_(2). | Zongwei Zhang Xinyu Wang Yijie Liu Chen Chen Honghao Yao Li Yin Xiaofang Li Shan Li Fan Zhang Fengxian Bai Jiehe Sui Bo Yu Feng Cao Xingjun Liu Jun Mao Guoqiang Xie Qian Zhang | 2019 | Journal of Materiomics2019，5，4： | 3 |
| 9 | Pseudomonas sp.ZXY-1,a newly isolated and highly efficient atrazine-degrading bacterium,and optimization of biodegradation using response surface methodology显示文摘Atrazine, a widely used herbicide, is increasing the agricultural production effectively, while also causing great environmental concern. Efficient atrazine-degrading bacterium is necessary to removal atrazine rapidly to keep a safe environment. In the present study, a new atrazine-degrading strain ZXY-1, identified as Pseudomonas, was isolated. This new isolated strain has a strong ability to biodegrade atrazine with a high efficiency of 9.09 mg/L/hr.Temperature, p H, inoculum size and initial atrazine concentration were examined to further optimize the degradation of atrazine, and the synthetic effect of these factors were investigated by the response surface methodology. With a high quadratic polynomial mathematical model(R^2= 0.9821) being obtained, the highest biodegradation efficiency of 19.03 mg/L/hr was reached compared to previous reports under the optimal conditions(30.71°C, pH 7.14, 4.23%(V/V) inoculum size and 157.1 mg/L initial atrazine concentration).Overall, this study provided an efficient bacterium and approach that could be potentially useful for the bioremediation of wastewater containing atrazine. | Xinyue Zhao Li Wang Fang Ma Shunwen Bai Jixian Yang Shanshan Qi | 2017 | Journal of Environmental Sciences2017，29，4： | 3 |
| 10 | Bud endodormancy in deciduous fruit trees:advances and prospects显示文摘Bud endodormancy is a complex physiological process that is indispensable for the survival,growth,and development of deciduous perennial plants.The timely release of endodormancy is essential for flowering and fruit production of deciduous fruit trees.A better understanding of the mechanism of endodormancy will be of great help in the artificial regulation of endodormancy to cope with climate change and in creating new cultivars with different chilling requirements.Studies in poplar have clarified the mechanism of vegetative bud endodormancy,but the endodormancy of floral buds in fruit trees needs further study.In this review,we focus on the molecular regulation of endodormancy induction,maintenance and release in floral buds of deciduous fruit trees.We also describe recent advances in quantitative trait loci analysis of chilling requirements in fruit trees.We discuss phytohormones,epigenetic regulation,and the detailed molecular network controlling endodormancy,centered on SHORT VEGETATIVE PHASE(SVP)and Dormancy-associated MADS-box(DAM)genes during endodormancy maintenance and release.Combining previous studies and our observations,we propose a regulatory model for bud endodormancy and offer some perspectives for the future. | Qinsong Yang Yuhao Gao Xinyue Wu Takaya Moriguchi Songling Bai Yuanwen Teng | 2021 | Horticulture Research2021，8，1： | 2 |
| 11 | Comparative transcriptomics analysis of Zygosaccharomyces mellis under high-glucose stress显示文摘The high-glucose tolerance of yeast is the main factor determining the efficiency of high-density alcohol fermentation.Zygosaccharomyces mellis LGL-1 isolated from honey could survive under 700 g/L high-glucose stress and its tolerant characteristics were identified in our previous study.This study was performed to explore and clarify the high-glucose tolerance mechanism of Z.mellis LGL-1.Comparative transcriptomic analysis was used to analyze the genes with differential expression in Z.mellis under high-glucose conditions of 300,500 and 700 g/L.With 300 g/L samples as reference,there were 937 and 2380 differentially expressed genes(DEGs)in the 500 and 700 g/L samples,respectively.Meanwhile,there was 825 significant DEGs in the 700 g/L samples compared with that of the 500 g/L samples.The result revealed that transcriptional changes in multiple metabolic pathways occur in response to high-glucose stress.q-RT PCR analysis further confirmed that several stress response pathways,such as the high osmolarity glycerol mitogen-activated protein kinase(HOG-MAPK)signal transduction pathway,trehalose synthesis pathway and oxidative stress response are closely related to high-glucose tolerance in Z.mellis.This study clarifies mechanisms of Z.mellis in response to high-glucose osmotic stress,providing theoretical basis for the process control of high-density alcohol fermentation. | Gongliang Liu Xinyu Bi Changli Tao Yongtao Fei Sujuan Gao Jinglong Liang Weidong Bai | 2021 | Food Science and Human Wellness2021，10，1： | 2 |
| 12 | A novel classification method for aid decision of traditional Chinese patent medicines for stroke treatment显示文摘 | Yufeng Zhao Bo Liu Liyun He Wenjing Bai Xueyun Yu Xinyu Cao Lin Luo Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2017 | Frontiers of Medicine2017，11，3： | 2 |
| 13 | Evaluation on the natural gas hydrate formation process显示文摘Gas hydrates have endowed with great potential in gas storage,and rapid formation of gas hydrates is critical to use this novel technology.This work evaluated the natural gas hydrate formation process,which was compared from six parameters,including conversion of water to hydrate,storage capacity,the rate of hydrate formation,space velocity(SV)of hydrate reaction,energy consumption and hydrate removal.The literature was selected by analyzing and comparing these six parameters mentioned above,meanwhile placing emphasis on the three parameters of storage capacity,the rate of hydrate formation and space velocity of hydrate reaction.Through analysis and comparison,four conclusions could be obtained as follows.Firstly,the overall performance of the stirring process and the spraying process were better than other processes after analyzing the six parameters.Secondly,the additive types,the reactor structure and the reactor size had influence on the natural gas hydrate formation process.Thirdly,the energy consumption via reciprocating impact in the hydrate formation process was higher than that via stirring,spraying and static higee.Finally,it was one key for hydrate removal to realize the hydrate industrial production. | Shuqi Fang Xinyue Zhang Jingyi Zhang Chun Chang Pan Li Jing Bai | 2020 | Chinese Journal of Chemical Engineering2020，28，3： | 2 |
| 14 | Fluorescent probe gold nanodots to quick detect Cr(VI) via oxidoreduction quenching process显示文摘A method is described here for the quickly(<30 s) accurate determination of Cr(VI)(Cr_2O_7^(2-)), based on fluorescent probes gold nanodots(AuNDs, excitation/emission peaks at 395/604 nm) coated with glutathione(GSH). The fluorescence of the AuNDs responses linearly to Cr(VI) concentrations, ranging widely from 1 nM to 10 m M with detection limit as low as 0.35 nM. At the same time, the AuNDs is demonstrated highly selective for Cr(VI) detection over other acid group ions and metal ions without any masking reagent. These make probability for practical use. The quenching mechanism is investigated deeply via fluorescent lifetime, XPS and TEM analysis. Different from most reported quenching explanation of aggregation derived from charge attraction, these results verify the redox reaction between Cr_2O_7^(2-)and sulfhydryl(–S) of GSH. The Au(I)–S bonds of AuNDs broke, accompanies with the oxidation of –S to form S–S bonds. As a result, AuNDs cross linked to each other. In the end, the fluorescence quenched. Attractively, the present study provides a new strategy for pollutant detection, such as from harmful Cr(VI) of Cr_2O_7^(2-)to nontoxic Cr(III). | Yueqi Zhao Yuanqing Sun Yingnan Jiang Shanliang Song Tianxin Zhao Yue Zhao Xinyu Wang Baoquan Li Bai Yang Quan Lin | 2019 | Science China Chemistry2019，62，1： | 1 |
| 15 | Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens显示文摘Dear Editor,The global monkeypox(Mpox)outbreak leads to a surge in demand for vaccine.The Mpox vaccine in short supply is JYNNEOS(modified vaccinia ankara,MVA)due to less side effects,while ACAM2000 supply is abundant because of the strategic stockpile in U.s.1 The ACAM2000 replaced the first-generation smallpox vaccine Dryvax that has a questionable safety profile.However,the ACAM2000 is associated with high rate of myocarditis and pericarditis,and can cause severe illness in immunocompromised patients,foreshadowing the need to update the strategic stockpile. | Zhenhao Fang Valter S.Monteiro Paul A.Renauer Xingbo Shang Kazushi Suzuki Xinyu Ling Meizhu Bai Yan Xiang Andre Levchenko Carmen J.Booth Carolina Lucas Sidi Chen | 2023 | Cell Research2023，33，5： | 1 |
| 16 | Synergy between isolated Fe and Co sites accelerates oxygen evolution显示文摘Dual-metal catalysts with synergistic effect exhibit enormous potential for sustainable electrocatalytic applications and mechanism research.Compared with mono-metal-site catalysts,dual-metal-site catalysts exhibit higher efficiency for the oxygen evolution reaction(OER)due to reduced energy barrier of the process involving proton-coupled multi-electron transfer.Herein,we construct dual-metal Fe-Co sites coordinated with nitrogen in graphene(FeCo-NG),which exhibits high OER performance with onset overpotential of only 126 mV and Tafel slope of 120 mV·dec^(−1),showing that the rate-determining step is controlled by the single-electron transfer step.Theoretical calculations reveal that the FeN_(4)site exhibits lower OER overpotential than the CoN_(4)site due to appropriate adsorption energy of OOH*on the former,while the O^(*)adsorbed on the adjacent Co site could stabilize the OOH*on the FeN_(4)site through hydrogen bond interaction. | Tianmi Tang Zhiyao Duan Didar Baimanov Xue Bai Xinyu Liu Liming Wang Zhenlu Wang Jingqi Guan | 2023 | Nano Research2023，16，2： | 1 |
| 17 | Dry-etched ultrahigh-Q silica microdisk resonators on a silicon chip显示文摘We demonstrate the fabrication of ultrahigh quality(Q) factor silica microdisk resonators on a silicon chip by inductively coupled plasma(ICP) etching. We achieve a dry-etched optical microresonator with an intrinsic Q factor as high as 1.94×10^(8) from a 1-mm-diameter silica microdisk with a thickness of 4 μm. Our work provides a chip-based microresonator platform operating in the ultrahigh-Q region that will be useful in nonlinear photonics such as Brillouin lasers and Kerr microcombs. | JIAXIN GU JIE LIU ZIQI BAI HAN WANG XINYU CHENG GUANYU LI MENGHUA ZHANG XINXIN LI QI SHI MIN XIAO XIAOSHUN JIANG | 2021 | Photonics Research2021，9，5： | 1 |
| 18 | Solubility measurement and thermodynamic modeling of carbamazepine(form III)in five pure solvents at various temperatures显示文摘In this work,the solubilities of carbamazepine(CBZ)(form III)in ethyl acetate,methyl acetate,ethylene glycol,chloroform and cyclohexylamine were determined by laser monitoring techniques at pressure above sea level,and the solubility data of CBZ(form III)in different pure solvents were fitted by the Modified Apelblat model andλh model.The result shows that the solubility of CBZ(form III)in five solvents increases as temperature rises,and the solubility in chloroform was the largest.The experimental solubility values of CBZ(form III)in ethyl acetate,methyl acetate,chloroform and cyclohexylamine were in better agreement with the simulated fitting values of theλh model.For ethylene glycol,the r value was much larger than the other four solvents,and it can be seen from theλh model that ethylene glycol was closer to the ideal solution system than the other four solvents. | Wenju Liu Zehua Bao Yanmin Shen Tiantian Yao Hongjuan Bai Xinyu Jin | 2021 | Chinese Journal of Chemical Engineering2021，34，5： | 1 |
| 19 | Cu_(2−x)S derived copper nanoparticles:A platform for unraveling the role of surface reconstruction in efficient electrocatalytic CO_(2)-to-C_(2)H_(4)conversion显示文摘Cu-based electrocatalysts have provoked much attention for their high activity and selectivity in carbon dioxide(CO_(2))conversion into multi-carbon hydrocarbons.However,during the electrochemical reaction,Cu catalysts inevitably undergo surface reconstruction whose impact on CO_(2)conversion performance remains contentious.Here we report that polycrystalline Cu nanoparticles(denoted as Cu-s)with rich high-index facets,derived from Cu_(2−x)S through desulphurization and surface reconstruction,offer an excellent platform for investigating the role of surface reconstruction in electrocatalytic CO_(2)conversion.During the formation of Cu-s catalyst,the two stages of desulphurization and surface reconstruction can be clearly resolved by in situ X-ray absorption spectroscopy and OH−adsorption characterizations,which are well correlated with the changes in electrocatalytic performance.It turns out that the high CO_(2)conversion performance,achieved by the Cu-s catalyst(Faradic efficiency of 68.6%and partial current density of 40.8 mA/cm^(2)in H-cell toward C_(2)H_(4)production),is attributed to the increased percentage of high-index facets in Cu-s during the surface reconstruction.Furthermore,the operando electrochemical Raman spectroscopy further reveals that the conversion of the CO_(2)into the C_(2)H_(4)on Cu-s is intermediated by the production of*COCHO.Our findings manifest that the surface reconstruction is an effective method for tuning the reaction intermediate of the CO_(2)conversion toward high-value multicarbon(C2+)chemicals,and highlight the significance of in situ characterizations in enhancing the understanding of the surface structure and its role in electrocatalysis. | Chaohua He Delong Duan Jingxiang Low Yu Bai Yawen Jiang Xinyu Wang Shuangming Chen Ran Long Li Song Yujie Xiong | 2023 | Nano Research2023，16，4： | 1 |
| 20 | Discovery and bioassay of disubstituted β-elemene-NO donor conjugates:synergistic enhancement in the treatment of leukemia显示文摘Natural products are essential sources of antitumor drugs.One such molecule,β-elemene,is a potent antitumor compound extracted from Curcuma wenyujin.In the present investigation,a series of novel 13,14-disubstituted nitric oxide(NO)-donorβelemene derivatives were designed,withβ-elemene as the foundational compound,and subsequently synthesized to evaluate their therapeutic potential against leukemia.Notably,the derivative labeled as compound 13d demonstrated a potent anti-proliferative activity against the K562 cell line,with a high NO release.In vivo studies indicated that compound 13d could effectively inhibit tumor growth,exhibiting no discernible toxic manifestations.Specifically,a significant tumor growth inhibition rate of 62.9%was observed in the K562 xenograft tumor mouse model.The accumulated data propound the potential therapeutic application of compound 13d in the management of leukemia. | ZHU Junlong JIANG Xiaoying LUO Xinyu GAO Yuan ZHAO Rui LI Junjie CAI Hong DANG Xiawen YE Xiangyang BAI Renren XIE Tian | 2023 | Chinese Journal of Natural Medicines2023，21，12： | 1 |
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