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| 1 | Temporal variation of soil carbon stock and its controlling factors over the last two decades on the southern Song-nen Plain,Heilongjiang Province显示文摘对全球气候变化的当前的背景,在土壤碳水池和它的控制因素的变化的学习可以在温室气体的缓解或改进帮助土壤角色的评估。这份报纸在 Heilongjiang 省在南部的 Song-nen 平原在土壤碳水池和他们的控制因素学习空间、时间的变化,用在二个不同时期由上收集的土壤数据在 20052007 的多种用途的地区性的 Geochemical 调查,和另外一个玷污在 19821990 进行的调查。学习区域是 1479 t/km2 并且在过去的 20 年里的碳来源,从直到 2005 的 1980 年代,从土壤的实际的碳排放是 0.12 Gt。温度,被发现了线性地被相关玷污器官的碳,是控制器官的碳满足的土壤的主导的 climatologic 因素。我们的学习在器官的碳由升起的温度引起了的土壤的潜在的损失是的相关区域和时间时期显示出那 0.10 Gt ,源于陆地使用变化的潜在的土壤碳排放是 0.09 Gt ,并且温暖和陆地使用变化引起的土壤碳( 0.19 Gt )的联合潜在的损失比得上石块燃料燃烧( 0.21 Gt )的。由于在土壤碳水池变化的时间延期,仍然在温暖和以后将逐渐地被释放的陆地使用变化引起的潜在的排放有 0.07 Gt。 | Xueqi Xia Zhongfang Yang Yan Liao Yujun Cui Yansheng Li | 2010 | Geoscience Frontiers2010，1，1： | 19 |
| 2 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 3 | Mechanism and control technology of strong ground pressure behaviour induced by high-position hard roofs in extra-thick coal seam mining显示文摘This work aimed at revealing the mechanism of strong ground pressure behaviour(SGPB)induced by high-position hard roof(HHR).Based on the supporting structures model of HHR,a modified voussoir beam mechanical model for HHR was established by considering the gangue support coefficient,through which the modified expressions of limit breaking span and breaking energy of HHR were deduced.Combined with the relationship between the dynamic-static loading stress of supporting body(hydraulic support and coal wall)and its comprehensive supporting strength,the criteria of ground pressure behaviour(GPB)induced by HHR were discussed.The types of Ⅰ_(1),Ⅰ_(2),Ⅱ_(1),andⅡ_(2) of GPB were interpreted.Results showed that types Ⅰ_(1) and Ⅰ_(2) were the main forms of SGPB in extra-thick coal seam mining.The main manifestation of SGPB was static stress,which was mainly derived from the instability of HHR rather than fracture.Accordingly,an innovative control technology was proposed,which can weaken static load by vertical-well separated fracturing HHR.The research results have been successfully applied to the 8101 working face in Tashan coal mine,Shanxi Province,China.The results of a digital borehole camera observation and stress monitoring proved the rationality of the GPB criteria.The control technology was successful,paving the way for new possibilities to HHR control for safety mining. | Chao Pan Binwei Xia Yujun Zuo Bin Yu Changnan Ou | 2022 | International Journal of Mining Science and Technology2022，32，3： | 6 |
| 4 | PUM1 represses CDKN1B translation and contributes to prostate cancer progression显示文摘Posttranscriptional regulation of cancer gene expression programs plays a vital role in carcinogenesis;identifying the critical regulators of tumorigenesis and their molecular targets may provide novel strategies for cancer diagnosis and therapeutics.Highly conserved RNA-binding protein Pumilio-1(PUM1)regulates mouse growth and cell proliferation,propelling us to examine its role in cancer.We found human PUM1 is highly expressed in a diverse group of cancer,including prostate cancer;enhanced PUM1 expression is also correlated with reduced survival among prostate cancer patients.Detailed expression analysis in twenty prostate cancer tissues showed enhanced expression of PUM1 at mRNA and protein levels.Knockdown of PUM1 reduced prostate cancer cell proliferation and colony formation,and subcutaneous injection of PUM1 knockdown cells led to reduced tumor size.Downregulation of PUM1 in prostate cancer cells consistently elevated cyclin-dependent kinase inhibitor 1B(CDKN1B)protein expression through increased translation but did not impact its mRNA level,while overexpression of PUM1 reduced CDKN1B protein level.Our finding established a critical role of PUM1 mediated translational control,particularly the PUM1-CDKN1B axis,in prostate cancer cell growth and tumorigenesis.We proposed that PUM1-CDKN1B regulatory axis may represent a novel mechanism for the loss of CDKN1B protein expression in diverse cancers and potential targets for therapeutics development. | Xin Li Jian Yang Xia Chen Dandan Cao Eugene Yujun Xu | 2021 | The Journal of Biomedical Research2021，35，5： | 3 |
| 5 | Deletion of SMARCA4 impairs alveolar epithelial type II cells proliferation and aggravates pulmonary fibrosis in mice显示文摘Alveolar epithelial cells(AECs)injury and failed reconstitution of the AECs barrier are both integral to alveolar flooding and subsequent pulmonary fibrosis(PF).Nevertheless,the exact mechanisms regulating the regeneration of AECs post-injury still remain unclear.SMARCA4 is a part of the large ATP-dependent chromatin remodelling complex SWI/SNF,which is essential for kidney and heart fibrosis.We investigates SMARCA4 function in lung fibrosis by establishing PF mice model with bleomycin firstly and found that the expression of SMARCA4 was mainly enhanced in alveolar type II(ATII)cells.Moreover,we established an alveolar epithelium-specific SMARCA4-deleted SP-C-rtTA/(tetO)7-Cre/SMARCA4f/f mice(SOSM4D/D)model,as well as a new SMARCA4-deleted alveolar type II(ATII)-like mle-12 cell line.We found that the bleomycin-induced PF was more aggressive in SOSM4D/D mice.Also,the proliferation of ATII cells was decreased with the loss of SMARCA4 in vivo and in vitro.In addition,we observed increased proliferation of ATII cells accompanied by abnormally high expression of SMARCA4 in human PF lung sections.These data uncovered the indispensable role of SMARCA4 in the proliferation of ATII cells,which might affect the progression of PF. | Danyi Peng Daozhu Si Rong Zhang Jiang Liu Hao Gou Yunqiu Xia Daiyin Tian Jihong Dai Ke Yang Enmei Liu Yujun Shi Q.Richard Lu Lin Zou Zhou Fu | 2017 | Genes & Diseases2017，4，4： | 3 |
| 6 | 骨肉瘤中PTEN蛋白表达及临床意义的研究(英文)显示文摘调查癌症的表示和意义的目的在骨肉瘤的禁止的基因 PTEN 蛋白质。在骨肉瘤的不同组织学的分类分析它的表示的水平。决定为诊断骨肉瘤作为标记基因拿 PTEN 蛋白质的可能性。为了观察 PTEN 的临床的值,表达式为骨肉瘤分类作为一个引用索引铺平。43 个标本从骨肉瘤收集了切除的方法被学习。从操作作为控制组被拿的骨头(骨软骨瘤) 的良性的损害在一样的时期期间收集的 30 个标本。Immunohistochemistry 染色(Elivison™二个步骤方法) 被用来在骨肉瘤的 43 种情况中检测 PTEN 蛋白质的表示。社会科学统计套装软体 10.0 在统计分析被使用。染色的结果 Immunohistochemistry 证明 PTEN 蛋白质的阳性反应都对细胞质面向,它是棕色或微黄色褐的小粒。通过 χ
2 测试,在骨头之间的 PTEN 蛋白质的积极表情的有效差量良性的损害和骨肉瘤(χ
2= 7.976, P <
0.01 ) 被观察。有组织分化的不同的度的骨肉瘤显示出 PTEN 蛋白质的不同水平表示。在区分得好的骨肉瘤之间有有效差量(等级我 II ) 并且糟糕区分的骨肉瘤(等级 III ) 统计上(P <
0.01 ) 。PTEN 的表示的水平否定地被相关到骨肉瘤的组织学的等级。统计上有大意义(r s =−0.4922, P <
0.01 ) 。结论 PTEN 蛋白质可以被用作癌症的候选人基因禁止的基因:PTEN 蛋白质是癌症压制或在骨头肿瘤有表示的基因蛋白质。它可能不仅在肺的癌和神经胶质细胞瘤的学习,而且在骨头肿瘤的学习被使用;PTEN 的表示与骨头肿瘤的亲切和他们区别的度有关。PTEN 的表示断然与区别的度被相关。 | Yubin Wang Anmin Chen Fengjin Guo Yujun Xia | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 2 |
| 7 | REMOVAL OF ORGANIC POLLUTANTS USING TITANIUM DIOXIDE MEDIATED PHOTOCATALYTIC OXIDATION显示文摘A simple and effective method of removing polluted organics in water isreported here.Titanium dioxide is a catalyst in photo-oxidation of monocrotophos.Themechanism of photocatalytic oxidation and the kinetics of the reaction were studied.This same principle also leads to the construction of instrument of PTR-FIA analysisfor monitoring organic phosphorus and phosphate in water. | Manping ZHANG Zongfeng XIA Shinan XIE Peipei LI Junbo BAO Juying WANG Daiwen KANG (Department of Marine Chemistry,Ocean University of Qingdao,Qingdao.266003) Yujun WANG Nianhong CHEN Lidong YU (Institute of Oceanography,Academia Sinica,Oingdao,266003) G.K-C LOW (CSIRO Division of Feul Technology,Lucas Heights Research laboratories,PMB 7,M nai,2234 NSW,Australia) | 1990 | Chinese Chemical Letters1990，1，3： | 1 |
| 8 | Evolution of the Extensional Rifted Yunnan-Guizhou-Guangxi Oceanic Basin During the Late Hercynian to Middle Indosinian Stage显示文摘On the basis of exhaustive researches on the facies sequences and depositlonal evolutionary process of various depositional systems, the genetic stratigraphic framework of the extensional rifted oceanic basin, which has undergone strong structural destruction, has been reconstructed by means of dynamic genetic stratigraphic analysis. Five depositional episodes have been distinguished from various isochronous stratigraphic boundaries and stratigraphic sequences with the three-dimensional structure of each depositional episode analysed in detail. The tectonic paleogeographic environment corresponding to different stages of each depositional episode has been reconstructed for individual depositional system tracts. And the evolution history of this rifted basin has been divided into four stages’ initial rifting and oceanization of continental crust, stretching and spreading of the basin, subduction and basin differentiation, and convergence and collision. A NNE-trending intracontinental soft collision | Xia Wenchen, Zhou Jie, Lei Jianxi, Zhang Nianmao and Peng YangChina U niversity of Geoscience, W uhan, Hubei Wang Yujun | 1995 | Acta Geologica Sinica(English Edition)1995，69，4： | 1 |
| 9 | Simultaneous determination of melamine and related compounds by cap- illary zone electrophoresis 显示文摘 | Xia Jingen Zhou Naiyuan Liu Yujun | 2010 | Food Control2010，21，6： | 1 |
| 10 | Simultaneousdetermination of melamine and related compounds by capiuary zone electrophoresis显示文摘 | Xia Jingen Zhou Nalyuan Liu Yujun | 2010 | Food Control2010，21，6： | 1 |
| 11 | Relationship of recurrent laryngeal nerve with inferior horn of thyroid cartilage,inferior thyroid artery,berry's ligament and Zuckerkandl's tubercle:A study in corpses显示文摘The pivotal role of four anatomical landmarks:inferior horn of thyroid cartilage,inferior thyroid artery(ITA),Berry's ligament(BL)and Zuckerkandl's tubercle(ZT)on recurrent laryngeal nerve(RLN)protection has received more attention.In our study,anatomy of 14 specimens(28 sides in total)were dissected to investigate the relationship between RLN and these four landmarks. | Wang Changjing Xia Yujun Wang Shuangyan | 2021 | 解剖学杂志2021，44，S01： | 1 |
| 12 | State tracking model reference adaptive control for switched nonlinear systems with linear uncertain parameters显示文摘为适应控制(MRAC ) 为未知参数线性地在出现的交换非线性的系统的一个类被考虑的引用建模。当在不同分系统的向量和不明确的向量被不同向量变量个别地估计,在每个分系统的线性不明确的参数能被表示。更改法律被设计以便参数评价将结冰直到它的相应分系统是活跃的。为分系统的控制器被给保证在任意的切换下面追踪的 asymptotic 状态。二个例子被举验证建议方法。 | Xia WANG Jun ZHAO Yujun TANG | 2012 | 控制理论与应用(英文版)2012，10，3： | 1 |
| 13 | Simultaneous determination of melamine and related compounds by capillary zone electrophoresis显示文摘 | Xia Jingen Zhou Naiyuan Liu Yujun | | 0，，： | 1 |
| 14 | Novel biodegradable flocculating agents prepared by phosphate modification of Konjac显示文摘 | Chenxin Xie Yujun Feng Weiping Cao Yu Xia Zhiyong Lu | 2006 | Carbohydrate Polymers2006，，4： | 1 |
| 15 | Simultaneous determination of melamine and related compounds by capillary zone electrophoresis显示文摘 | XIA Jingen ZHOU Naiyuan LIU Yujun | 2010 | Food Control2010，21，6： | 1 |
| 16 | Photolu mineseenee properties and energy transfer in color tunable BaY2Si3O10 :Ce,Tb phosphors显示文摘 | Zhanggen Xia Yujun Liang Dongyan Yu | 2014 | Optics & Laser Tech- nology2014，5，： | 1 |
| 17 | Tunable ferromagnetic Weyl fermions from a hybrid nodal ring显示文摘Realization of nontrivial band topology in condensed matter systems is of great interest in recent years.Using first-principles calculations and symmetry analysis,we propose an exotic topological phase with tunable ferromagnetic Weyl fermions in a halfmetallic oxide CrP_(2)O_(7).In the absence of spin–orbit coupling(SOC),we reveal that CrP_(2)O_(7) possesses a hybrid nodal ring.When SOC is present,the spin-rotation symmetry is broken.As a result,the hybrid nodal ring shrinks to discrete nodal points and forms different types of Weyl points.The Fermi arcs projected on the(100)surface are clearly visible,which can contribute to the experimental study for the topological properties of CrP_(2)O_(7).In addition,the calculated quasiparticle interference patterns are also highly desirable for the experimental study of CrP_(2)O_(7).Our findings provide a good candidate of ferromagnetic Weyl semimetals,and are expected to realize related topological applications with their attracted features. | Baobing Zheng Bowen Xia Rui Wang Jinzhu Zhao Zhongjia Chen Yujun Zhao Hu Xu | 2019 | npj Computational Materials2019，，1： | 0 |
| 18 | Specific bFGF targeting of KIM-1 in ischemic kidneys protects against renal ischemia-reperfusion injury in rats显示文摘Renal ischemia-reperfusion(I/R)injury is one of the major causes of acute kidney injury.However,there is still no effective treatment for this disease.Basic fibroblast growth factor(bFGF)has been reported to be beneficial for recovery from ischemic diseases.It is vital to increase the local concentration and reduce the diffusion of bFGF in vivo for renal I/R injury therapy.A targeted growth factor delivery system that responds to specific biological signals in the regenerative environment to guide release has been highlighted in tissue repair.In the present study,a specific peptide was fused with bFGF and called bFGF-kidney injury targeting(KIT-bFGF),and this compound specifically targeted kidney injury molecule-1 both in hypoxic renal HK-2 cells in vitro and ischemic kidneys in vivo after intravenous injection.When administered to rat models of renal I/R injury,KIT-bFGF attenuated renal tubule damage and fibrosis,and promoted functional recovery compared to the effects of native bFGF and the control.We also investigated the mechanism by which KIT-bFGF activated the ERK1/2 and Akt signaling pathways to significantly reduce apoptosis and protect against ischemic injury in the kidney.These results demonstrated that targeted delivery of KIT-bFGF could be an effective strategy for the treatment of renal I/R injury. | Siqi Song Xianglin Hou Weiwei Zhang Xinyu Liu Wei Wang Xiaoya Wang Wenxuan Cao Yujun Xia Wei Chen Chunying Shi | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 19 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 20 | Tanshinone IIA protects intestinal epithelial cells from ferroptosis through the upregulation of GPX4 and SLC7A11显示文摘Background:Inflammatory bowel disease(IBD)is a chronic inflammatory disease of the gastrointestinal tract.The destruction of the intestinal epithelial barrier is one of the major pathological processes in IBD pathology.Growing evidence indicated that epithelial cell ferroptosis is linked to IBD and is considered a target process.Methods:RAS-selective lethal 3(RSL3)was used to induce ferroptosis in intestinal epithelial cell line No.6(IEC-6)cells,and cell ferroptosis and the effects of tanshinone IIA(Tan IIA)were determined by cell counting kit-8(CCK-8),reactive oxygen species(ROS)staining,Giemsa staining and transmission electron microscope(TEM).The cell viability of natural product library compounds was determined by CCK-8.The expression of ferroptosis-related genes were detected by real-time quantitative polymerase chain reaction(RT-qPCR)and western blot.Results:Treatment of IEC-6 cells results in the accumulation of ROS and typical morphological characteristics of ferroptosis.RSL3 treatment caused rapid cellular cytotoxicity which could be reversed by ferrostatin-1(Fer-1)in IEC-6 cells.Natural product library screening revealed that Tan IIA is a potent inhibitor of IEC-6 cell ferroptosis.Tan IIA could significantly protect the RSL3-induced ferroptosis of IEC-6 cells.Furthermore,the ferroptosis suppressors,glutathione peroxidase 4(GPX4),solute carrier family 7 member 11(SLC7A11),and miR-17-92 were found to be early response genes in RSL3-treated cells.Treatment of IEC-6 cells with Tan IIA resulted in upregulation of GPX4,SLC7A11,and miR-17-92.Conclusion:Our study demonstrated that Tan IIA protects IEC-6 cells from ferroptosis through the upregulation of GPX4,SLC7A11,and miR-17-92.The findings might provide a theoretical grounding for the future application of Tan IIA to treat or prevent IBD. | HAN WANG YANG SUN XIAOXU ZHANG XIAOYING WANG YUJUN XIA LISHENG WANG | 2023 | BIOCELL2023，47，5： | 0 |
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