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| 1 | Puerarin reduces apoptosis in rat hippocampal neurons cultured in high glucose medium by modulating the p38 mitogen activated protein kinase and c-Jun N-terminal kinase signaling pathways显示文摘OBJECTIVE: To investigate the neuroprotective effect of puerarin on rat hippocampal neurons cultured in high glucose medium, and to examine the role of the p38 mitogen activated protein kinase(p38 MAPK) and c-Jun N-terminal kinase(JNK) signaling pathways in this effect.METHODS: Primary cultures of hippocampal neurons were prepared from newborn Sprague Dawley rats. Neuron-specific enolase immunocytochemistry was used to identify neurons. The neurons were cultured with normal medium(control group) or with high-glucose medium(high-glucose group),and puerarin(puerarin group), a p38 MAPK inhibitor(SB239063; p38 MAPK inhibitor group) or a JNK inhibitor(SP600125; JNK inhibitor group) were added. After 72 h of treatment, terminal deoxynucleotidyl transferase-mediated d UTP nick end labeling assay was performed to detect apoptosis, and western blotting was used to assess protein levels of p-p38, p38, p-JNK and JNK.RESULTS: In the high-glucose group, the neuronal apoptosis rate and the p-p38/p38 and p-JNK/JNK ratios were higher than in the control group. The p38 MAPK and JNK inhibitors prevented this increase in the apoptosis rate. The apoptosis rates in the puerarin group, the p38 MAPK inhibitor group and the JNK inhibitor group were significantly decreased compared with the high-glucose group.Moreover, protein levels of p-p38 and p-JNK were significantly reduced, and the p-p38/p38 and p-JNK/JNK ratios were decreased in the puerarin group compared with the high-glucose group. In addition, compared with the high-glucose group,p-p38 levels and the p-p38/p38 ratio were reduced in the p38 MAPK inhibitor group, and p-JNK levels and the p-JNK/JNK ratio were decreased in the JNK inhibitor group.CONCLUSION: Puerarin attenuates neuronal apoptosis induced by high glucose by reducing the phosphorylation of p38 and JNK. | Xu Xiaohan Wang Jingbo Zhang Hong Tian Guoqing Liu Yuqin | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 13 |
| 2 | Economic Optimization Dispatching Strategy of Microgrid for Promoting Photoelectric Consumption Considering Cogeneration and Demand Response显示文摘A system combining photovoltaic power generation and cogeneration is proposed to improve the photoelectric absorption capacity. First, a time-of-use price strategy is adopted to guide users to change their electricity consumption habits for participation in the demand response, and a demand response model is established. Then, particle swarm optimization(PSO)is used with the aim of minimizing the operation cost of the microgrid to achieve economic dispatching of the microgrid. This considers power balance equation constraints, unit operation constraints, energy storage constraints, and heat storage constraints. Finally, the simulation results show the improved level of photoelectric consumption using the proposed scheme and the economic benefits of the microgrid. | Chunxia Dou Xiaohan Zhou Tengfei Zhang Shiyun Xu | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，3： | 10 |
| 3 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 4 | Overview of China's Antarctic research progress 1984–2016显示文摘It is more than 30 years since the first Chinese National Antarctic Research Expedition(CHINARE) landed in Antarctica in 1984, representing China's initiation in polar research. This review briefly summarizes the Chinese Antarctic scientific research and output accomplished over the past 30 years. The developments and progress in Antarctic research and the enhancement of international scientific cooperation achieved through the implementation of the CHINARE program have been remarkable. Since the 1980 s, four permanent Chinese Antarctic research stations have been established successively and 33 CHINAREs have been completed. The research results have been derived from a series of spatiotemporal observations in association with various projects and multidisciplinary studies in the fields of oceanography, glaciology, geology, geophysics, geochemistry, atmospheric science, upper atmospheric physics, Antarctic astronomy, biology and ecology, human medicine, polar environment observation, and polar engineering. | CHEN Liqi LIU Xiaohan BIAN Lingen CHEN Bo HUANG Hongliang HU Hongqiao LUO Wei SHI Guitao SHI Jiuxin XU Chengli YANG Guang ZHAO Yue ZHANG Shaohua | 2017 | Advances in Polar Science2017，28，3： | 9 |
| 5 | Dichotomous roles of neutrophils in modulating pathogenic and repair processes of inflammatory bowel diseases显示文摘Neutrophils are considered as complex innate immune cells and play a critical role in maintaining intestinal mucosal homeostasis.They exert robust pro-inflammatory effects and recruit other immune cells in the acute phase of pathogen infection and intestinal inflammation,but paradoxically,they also limit exogenousmicrobial invasion and facilitate mucosal restoration.Hyperactivation or dysfunction of neutrophils results in abnormal immune responses,leading to multiple autoimmune and inflammatory diseases including systemic lupus erythematosus,rheumatoid arthritis,and inflammatory bowel diseases(IBD).As a refractory intestinal inflammatory disease,the pathogenesis and progression of IBD are associated with complicated immune response processes in which neutrophils are profoundly involved.However,the consensus on potential roles of neutrophils in modulating pathogenic and repair processes of IBD remains not fully understood.Accumulated infiltrating neutrophils cross the epithelial barrier and contribute to microbial dysbiosis,aggravated intestinal architectural damage,compromised resolution of intestinal inflammation and increased risk of thrombosis during IBD.Paradoxically,activated neutrophils are also associated with effective elimination of invaded microbiota,promoted angiogenesis and tissue restoration of gutmucosa in IBD.Here,we discuss the beneficial and detrimental roles of neutrophils in the onset and resolution of intestinalmucosal inflammation,hoping to provide a precise overview of neutrophil functions in the pathogenesis of IBD. | Huimin Chen Xiaohan Wu Chunjin Xu Jian Lin Zhanju Liu | 2021 | Precision Clinical Medicine2021，4，4： | 3 |
| 6 | Resource optimization in wireless powered cooperative mobile edge computing systems显示文摘Mobile edge computing(MEC)meets the high-bandwidth and ultra-low-latency requirements of mobile networks and improves communication reliability by reducing the networks’load.In this study,we study a wireless powered MEC system,which includes an access point(AP)and two mobile devices.The endurance of mobile devices can be effectively enhanced using the wireless power transfer technology and user cooperation.However,during user cooperation,a closer user assists a farther user with forwarding tasks by sharing the same bandwidth,which causes interference.To overcome the interference issue,the closer user can instead assist other users in forwarding tasks by using a different bandwidth.We aim to minimize the power of the AP by joint power and bandwidth optimization while satisfying the delay and users’computational tasks.Simulation results show that the proposed user collaboration method can overcome user interference,reduce energy consumption,and improve user performance compared with the baseline policies. | Qibin YE Weidang LU Su HU Xiaohan XU | 2021 | Science China(Information Sciences)2021，64，8： | 3 |
| 7 | UNIFORMIZATION OF MULTIGRANULAR LINGUISTIC LABELS AND THEIR APPLICATION TO GROUP DECISION MAKING显示文摘In multiple attribute group decision making(MAGDM) problems based on linguistic information,the granularities of linguistic label sets are usually different due to the differences of thinking modes and habits among decision makers.In order to deal with this inconvenience,the transformation relationships among multigranular linguistic labels(TRMLLs),which are applied to unify linguistic labels with different granularities into a certain linguistic label set with fixed granularity,are presented in this paper.Furthermore,the reference tables are made according to TRMLLs so that the interrelated calculation will be less complicated,and the method of how to use them is explained in detail.At length,the TRMLLs are illustrated through an application example. | Xiaohan YU Zeshui XU Xiumei ZHANG | 2010 | Journal of Systems Science and Systems Engineering2010，19，3： | 3 |
| 8 | Turbulent combustion modeling using a flamelet generated manifold approach——a validation study in Open FOAM显示文摘An OpenFOAM based turbulence combustion solver with flamelet generated manifolds (FGMs) is presented in this paper. A series of flamelets, representative for turbulent flames, are calculated first by a one-dimensional (1D) detailed chemistry solver with the consideration of both transport and stretch/curvature contributions. The flame structure is then parameterized as a function of multiple reaction control variables. A manifold, which collects the 1D flame properties, is built from the 1D flame solutions. The control variables of the mixture fraction and the progress variable are solved from the corresponding transport equations. During the calculation, the scalar variables, e.g., temperature and species concentration, are retrieved from the manifolds by interpolation. A transport equation for NO is solved to improve its prediction accuracy. To verify the ability to deal with the enthalpy loss effect, the temperature retrieved directly from the manifolds is compared with the temperature solved from a transport equation of absolute enthalpy. The resulting FGM-computational fluid dynamics (CFD) coupled code has three significant features, i.e., accurate NO prediction, the ability to treat the heat loss effect and the adoption at the turbulence level, and high quality prediction within practical industrial configurations. The proposed method is validated against the Sandia flame D, and good agreement with the experimental data is obtained. | Tao LI Fanfu KONG4 Baopeng XU Xiaohan WANG | 2019 | Applied Mathematics and Mechanics(English Edition)2019，40，8： | 2 |
| 9 | Fluorescence Sensing of Glutathione Thiyl Radical by BODIPY-Modified β-Cyclodextrin显示文摘Comprehensive Summary The fluorescence sensing of intracellular glutathione thiyl radical(GS·)is in great demand to seek the GS·-related pathophysiological events.Herein,boron-dipyrromethene(BODIPY)-modified β-cyclodextrin was developed for high-efficiency sensing of GS·,accompanied by a fast response time(t_(1/2)=218 s),with the detection limit of 468 nmol/L.Cell experiments indicated that the BODIPY-modified p-cyclodextrin could be applied to detect the GS· in live A549 cells. | Zhixue Liu Xianyin Dai Qiaoyan Xu Xiaohan Sun Yu Liu | 2022 | Chinese Journal of Chemistry2022，40，4： | 2 |
| 10 | Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling显示文摘The extracellular matrix(ECM)serves as signals that regulate specific cell states in tumor tissues.Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progression.In this study,we aimed to explore the influence of ECM-derived biomechanical force on breast cancer cell status.Experiments were conducted using 3D collagen,fibrinogen. | Cong Li Shi Qiu Xiaohan Liu Fengzhu Guo Jingtong Zhai Zhijun Li Linghui Deng Liming Ge Haili Qian Lu Yang Binghe Xu | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 2 |
| 11 | Nonvolatile reconfigurable dynamic Janus metasurfaces in the terahertz regime显示文摘Metasurfaces,especially tunable ones,have played a major role in controlling the amplitude,phase,and polarization of electromagnetic waves and attracted growing interest,with a view toward a new generation of miniaturized devices.However,to date,most existing reconfigurable devices are bounded in volatile nature with sustained external energy to maintain and single functionality,which restrict their further applications.Here,we demonstrate for the first time,to our knowledge,nonvolatile,reconfigurable,and dynamic Janus metasurfaces by incorporating phase-change material Ge_(2)Se_(2)Te_(5)(GST)in the terahertz(THz)regime.First,we experimentally show the reversible switching characteristic of GST on large areas by applying a single nanosecond laser pulse,which exhibits excellent contrast of THz properties in both states.Then,we present a multiplex metasurface scheme.In each metasurface,three sets of structures are adopted,in which two sets integrate GST.The effective structures can be reversely modulated by the amorphization and crystallization of GST.As a proof of concept,the dynamic beam splitter,bifocal metalens,dual-mode focusing optical vortex generators,and switchable metalens/focusing optical vortex generators are designed,fabricated,and experimentally characterized,and can be switched reversibly and repeatedly with the help of optical and thermal stimuli.Our scheme will pave the way toward the development of multifunctional and compact THz devices and may find use for applications in THz imaging,sensing,and communications. | SHOUJUN ZHANG XIEYU CHEN KUAN LIU HAIYANG LI YUEHONG XU XIAOHAN JIANG YIHAN XU QINGWEI WANG TUN CAO ZHEN TIAN | 2022 | Photonics Research2022，10，7： | 2 |
| 12 | METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis显示文摘The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic cells.How METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear.Here we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced keratinocytes.Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds.Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery.Mechanically,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and FZD7.Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation. | Qiuchan Xiong Caojie Liu Xin Zheng Xinyi Zhou Kexin Lei Xiaohan Zhang Qian Wang Weimin Lin Ruizhan Tong Ruoshi Xu Quan Yuan | 2022 | International Journal of Oral Science2022，14，3： | 2 |
| 13 | Targeted therapeutics and novel signaling pathways in nonalcohol-associated fatty liver/steatohepatitis(NAFL/NASH)显示文摘Non-alcohol-associated fatty liver/steatohepatitis(NAFL/NASH)has become the leading cause of liver disease worldwide.NASH,an advanced form of NAFL,can be progressive and more susceptible to developing cirrhosis and hepatocellular carcinoma.Currently,lifestyle interventions are the most essential and effective strategies for preventing and controlling NAFL without the development of fibrosis.While there are stll limited appropriate drugs specifically to treat NAFL/NASH,growing progress is being seen in elucidating the pathogenesis and identifying therapeutic targets.In this review,we discussed recent developments in etiology and prospective therapeutic targets,as well as pharmacological candidates in pre/clinical trials and patents,with a focus on diabetes,hepatic lipid metabolism,inflammation,and fibrosis.Importantly,growing evidence elucidates that the disruption of the gut-liver axis and microbederived metabolites drive the pathogenesis of NAFL/NASH.Extracellular vesicles(EVs)act as a signaling mediator,resulting in lipid accumulation,macrophage and hepatic stellate cell activation,further promoting inflammation and liver fibrosis progression during the development of NAFL/NASH.Targeting gut microbiota or EVs may serve as new strategies for the treatment of NAFL/NASH.Finally,other mechanisms,such as cell therapy and genetic approaches,also have enormous therapeutic potential.Incorporating drugs with different mechanisms and personalized medicine may improve the efficacy to better benefit patients with NAFL/NASH. | Xiaohan Xu Kyle L.Poulsen Ljuan Wu Shan Liu Tatsunori Miyata Qiaoling Song Qingda Wei Chenyang Zhao Chunhua Lin Jinbo Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 14 | Bacterial outer membrane vesicles-based therapeutic platform eradicates triple-negative breast tumor by combinational photodynamic/chemo-/immunotherapy显示文摘Bacterial outer membrane vesicles(OMVs)are potent immuno-stimulating agents and have the potentials to be bioengineered as platforms for antitumor nanomedicine.In this study,OMVs are demonstrated as promising antitumor therapeutics.OMVs can lead to beneficial M2-to-M1 polarization of macrophages and induce pyroptosis to enhance antitumor immunity,but the therapeutic window of OMVs is narrow for its toxicity.We propose a bioengineering strategy to enhance the tumor-targeting ability of OMVs by macrophage-mediated delivery and improve the antitumor efficacy by co-loading of photosensitizer chlorin e6(Ce6)and chemotherapeutic drug doxorubicin(DOX)into OMVs as a therapeutic platform.We demonstrate that systemic injection of the DOX/Ce6-OMVs@M therapeutic platform,providing combinational photodynamic/chemo-/immunotherapy,eradicates triple-negative breast tumors in mice without side effects.Importantly,this strategy also effectively prevents tumor metastasis to the lung.This OMVs-based strategy with bioengineering may serve as a powerful therapeutic platform for a synergic antitumor therapy. | Yongjiang Li Junyong Wu Xiaohan Qiu Suhe Dong Jun He Jihua Liu Wenjie Xu Si Huang Xiongbin Hu Da-Xiong Xiang | 2023 | Bioactive Materials2023，，2： | 2 |
| 15 | Iterative construction of low-altitude UAV air route network in urban areas:Case planning and assessment显示文摘With the rapid increase of Unmanned Aircraft Vehicle(UAV) numbers,the contradiction between extensive flight demands and limited low-altitude airspace resources has become increasingly prominent.To ensure the safety and efficiency of low-altitude UAV operations,the low-altitude UAV public air route creatively proposed by the Chinese Academy of Sciences(CAS) and supported by the Civil Aviation Administration of China(CAAC) has been gradually recognized.However,present planning research on UAV low-altitude air route is not enough to explore how to use the ground transportation infrastructure,how to closely combine the surface pattern characteristics,and how to form the mechanism of 'network'.Based on the solution proposed in the early stage and related researches,this paper further deepens the exploration of the low-altitude public air route network and the implementation of key technologies and steps with an actual case study in Tianjin,China.Firstly,a path-planning environment consisting of favorable spaces,obstacle spaces,and mobile communication spaces for UAV flights was pre-constructed.Subsequently,air routes were planned by using the conflict detection and path re-planning algorithm.Our study also assessed the network by computing the population exposure risk index(PERI) and found that the index value was greatly reduced after the construction of the network,indicating that the network can effectively reduce the operational risk.In this study,a low-altitude UAV air route network in an actual region was constructed using multidisciplinary approaches such as remote sensing,geographic information,aviation,and transportation;it indirectly verified the rationality of the outcomes.This can provide practical solutions to low-altitude traffic problems in urban areas. | XU Chenchen LIAO Xiaohan YE Huping YUE Huanyin | 2020 | Journal of Geographical Sciences2020，30，9： | 2 |
| 16 | Influence of the alkyl side chain length on the room-temperature phosphorescence of organic copolymers显示文摘Pure organic room-temperature phosphorescence(RTP)materials have attracted wide attention owing to their excellent luminescent properties and great potential in various applications.In this work,iminostilbene and its analogues are applied to realize RTP emission by copolymerizing with acrylamide.It can be concluded that the growth of alkane chain in monomers can enhance the lifetime and photoluminescence quantum yield of RTP emission,and polymers with the larger conjugated structure of the monomer show a longer RTP emission wavelength.This work provides a series of new pure organic RTP materials and might provide new thoughts for designing more advanced and superior RTP materials. | Qingyang Xu Liangwei Ma Xiaohan Lin Qiaochun Wang Xiang Ma | 2022 | Chinese Chemical Letters2022，33，6： | 2 |
| 17 | Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice显示文摘Circadian clocks are comprised of self-sustained transcriptional/translational feedback loops, which regulate the rhythms of physiology and behavior in mammals. CLOCK-interacting protein, Circadian(CIPC), has been indicated as an additional negative-feedback regulator of the circadian clock in vitro, although its physiological roles in circadian clock are unknown. Here, we generated Cipc homozygous knockout(Cipc-/-) mice and assessed the resultant circadian phenotypes. Surprisingly, the m RNA expression profiles of core clock genes in the liver of Cipc-/- mice showed no significant differences from that in wild-type mice except for Per1. Cipc-/- mice displayed normal locomotor rhythm and entrained activity pattern in both 12:12 light-dark cycle and constant dark cycle. Furthermore, deletion of Cipc in lungs and adipose tissues did not influence their peripheral clock. The results from this work provided more conclusive data suggesting that CIPC is not critically required for basic clock function. | QU ZhiPeng WANG XiaoHan LIU DongChuan GAO Xiang XU Ying | 2015 | Science China(Life Sciences)2015，58，4： | 2 |
| 18 | A method based on preference degrees for handling hybrid multiple attribute decision making problems显示文摘 | Xiaohan Yu Zeshui Xu Qi Chen | 2010 | Expert Systems With Applications2010，，4： | 2 |
| 19 | Reconfigurable and nonvolatile terahertz lithography-free photonic devices based on phase change films显示文摘High-performance terahertz(THz)devices with reconfigurable features are highly desirable in many promising THz applications.However,most of the existing reconfigurable THz elements are still limited to volatile responses,single functionality,and time-consuming multistep manufacturing procedures.In this paper,we report a lithography-free approach to create reconfigurable and nonvolatile THz components by exploring the reversible,nonvolatile,and continuous THz modulation capability of the phase change material Ge_(2)Sb_(2)Te_(5).As a proof of concept,THz gratings with significant Rayleigh anomalies and diffraction as well as ultrathin THz flat lenses with subwavelength and ultra-broadband focusing capabilities are designed and fabricated on ultrathin Ge_(2)Sb_(2)Te_(5)films using the presented photo-imprint strategy.Moreover,such a method can also be adopted to create more complex THz devices,such as Pancharatnam–Berry phase metasurfaces and grayscale holographic plates.With these findings,the proposed method will provide a promising solution to realize reconfigurable and nonvolatile THz elements. | XIEYU CHEN SHOUJUN ZHANG KUAN LIU YUEHONG XU XIAOHAN JIANG HAIYANG LI XI FENG QINGWEI WANG YONGCHANG LU KEMENG WANG TUN CAO ZHEN TIAN | 2023 | Photonics Research2023，11，4： | 1 |
| 20 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
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