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| 1 | Relative Contributions of Boundary-Layer Meteorological Factors to the Explosive Growth of PM2.5 during the Red-Alert Heavy Pollution Episodes in Beijing in December 2016显示文摘Based on observations of urban mass concentration of fine particulate matter smaller than 2.5 μm in diameter(PM_(2.5)), ground meteorological data, vertical measurements of winds, temperature, and relative humidity(RH), and ECMWF reanalysis data, the major changes in the vertical structures of meteorological factors in the boundary layer(BL) during the heavy aerosol pollution episodes(HPEs) that occurred in winter 2016 in the urban Beijing area were analyzed. The HPEs are divided into two stages: the transport of pollutants under prevailing southerly winds, known as the transport stage(TS), and the PM_(2.5) explosive growth and pollution accumulation period characterized by a temperature inversion with low winds and high RH in the lower BL, known as the cumulative stage(CS). During the TS, a surface high lies south of Beijing, and pollutants are transported northwards. During the CS, a stable BL forms and is characterized by weak winds, temperature inversion, and moisture accumulation. Stable atmospheric stratification featured with light/calm winds and accumulated moisture(RH > 80%) below 250 m at the beginning of the CS is closely associated with the inversion, which is strengthened by the considerable decrease in near-surface air temperature due to the interaction between aerosols and radiation after the aerosol pollution occurs. A significant increase in the PLAM(Parameter Linking Aerosol Pollution and Meteorological Elements) index is found, which is linearly related to PM mass change. During the first 10 h of the CS, the more stable BL contributes approximately 84% of the explosive growth of PM_(2.5) mass. Additional accumulated near-surface moisture caused by the ground temperature decrease, weak turbulent diffusion, low BL height, and inhibited vertical mixing of water vapor is conducive to the secondary aerosol formation through chemical reactions, including liquid phase and heterogeneous reactions, which further increases the PM_(2.5) concentration levels. The contribution of these reaction mechanisms to the explosive growth of PM_(2.5) mass during the early CS and subsequent pollution accumulation requires further investigation. | junting zhong xiaoye zhang yaqiang wang junying sun yangmei zhang jizhi wang kaiyan tan xiaojing shen haochi che lu zhang zhouxiang zhang xuefei qi huarong zhao sanxue ren yang li | 2017 | Journal of Meteorological Research2017，31，5： | 25 |
| 2 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 3 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 4 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 5 | Aerosol Hygroscopicity during the Haze Red-Alert Period in December 2016 at a Rural Site of the North China Plain显示文摘A humidification system was deployed to measure aerosol hygroscopicity at a rural site of the North China Plain during the haze red-alert period 17–22 December 2016. The aerosol scattering coefficients under dry [relative humidity(RH) < 30%] and wet(RH in the range of 40%–85%) conditions were simultaneously measured at wavelengths of450, 550, and 700 nm. It is found that the aerosol scattering coefficient and backscattering coefficient increased by only 29% and 10%, respectively when RH went up from 40% to 80%, while the hemispheric backscatter fraction went down by 14%, implying that the aerosol hygroscopicity represented by the aerosol scattering enhancement factor f(RH) is relatively low and RH exerted little effects on the aerosol light scattering in this case. The scattering enhancement factors do not show significant differences at the three wavelengths, only with an approximate 2% variation, suggesting that the aerosol hygroscopicity is independent of the wavelength. Aerosol hygroscopicity is highly dependent on the aerosol chemical composition. When there is a large mass fraction of inorganics and a small mass fraction of organic matter, f(RH) reaches a high value. The fraction of NO_3^- was strongly correlated with the aerosol scattering coefficient at RH = 80%, which suggests that NO_3^- played an important role in aerosol hygroscopic growth during the heavy pollution period. | Xuefei QI Junying SUN Lu ZHANG Xiaojing SHEN Xiaoye ZHANG Yangmei ZHANG Yaqiang WANG Haochi CHE Zhouxiang ZHANG Junting ZHONG Kaiyan TAN Huarong ZHAO Sanxue REN | 2018 | Journal of Meteorological Research2018，32，1： | 7 |
| 6 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 7 | Key features of new particle formation events at background sites in China and their influence on cloud condensation nuclei显示文摘 | Xiaojing SHEN Junying SUN Xiaoye ZHANG Yangmei ZHANG Lu ZHANG Ruxia FAN | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 5 |
| 8 | Tuning F-doped degree of rGO:Restraining corrosion-promotion activity of EP/rGO nanocomposite coating显示文摘Given that graphene features high electrical conductivity,it is a kind of material with corrosion-promotion activity.This study aimed to inhibit the corrosion-promotion activity of graphene in coatings.Here,we report an exciting application of epoxy matrix(EP)/F-doped reduced graphene oxide(rGO)coatings for the long-term corrosion protection of steel.The synthesized F-doped rGO(FG)did not reduce the utilization of rGO by a wide margin and possessed distinctive electrically insulating nature.The electrical conductivity of rGO was approximately 1500 S/m,whereas those of FG-1,FG-2 and FG-3 were 1.17,5.217×10^−2 and 3.643×10^-11 S/m,respectively.FG and rGO were then dispersed into epoxy coatings.The chemical structures of rGO and FG were investigated by transmission electron microscopy(TEM),scanning probe microscopy(SPM),X-ray photoelectron spectroscopy(XPS),Fourier-transform infrared spectroscopy(FTIR),and X-ray diffraction(XRD).EP/FG coatings exhibited outstanding corrosion protection in comparison with blank EP and EP/rGO coatings mainly because the corrosion-promotion effect of rGO was eliminated.The anticorrosion ability of EP/FG coatingswasimproved with increased F-doped degree of FG.In addition,electrochemical impendance spectroscopy(EIS)results indicated that the Rc values of EP/FG-2 and EP/FG-3 were four orders of magnitude higher than those of EP/rGO in diluent NaCl solution(3.5 wt.%)after immersion for 90 days. | Lu Shen Yong Li Wenjie Zhao Kui Wang Xiaojing Ci Yangmin Wu Gang Liu Chao Liu Zhiwen Fang | 2020 | Journal of Materials Science & Technology2020，44，9： | 5 |
| 9 | Myeloma cells resistance to NK cell lysis mainly involves an HLA class I-dependent mechanism显示文摘房间具有升起的生来的杀手(NK ) 的反多重的骨髓瘤(公里) 潜力对最近的年的兴趣。然而,到骨髓瘤房间的 NK 房间 cytotoxicity 的分子的机制仍然保持不清楚。在现在的学习,我们调查了人的白血球的 theexpressions 在耐心的骨髓瘤房间的抗原(HLA ) 一级和 HLA-G,并且决定了他们的关联住院病人肿瘤房间危险性到 NK 房间 cytotoxicity。我们的结果给那个病人看了骨髓瘤房间(n = 12 ) 对 NK-92 房间细胞溶解相对抵抗,与骨髓瘤房间线相比(n = 7, P < 0.01 ) 。基因表示介绍和流动 cytometry 分析证明 HLA 一级的 mRNA 和蛋白质是在 12 个耐心的骨髓瘤房间的 highlyexpressed。有趣地,没有或低 HLA-G 表面表示被检测,尽管多重 HLA-Gtranscripts 在这些骨髓瘤房间被检测。NK 房间功能试金证明由酸治疗的下面调整的 HLA 一级 expressionon 病人房间显著地增加了公里房间的危险性到调停 NK 的细胞溶解。而且,我们发现在骨髓瘤上用抗体堵住膜界限 HLA 一级而非 HLA-G 显著地取样 increasedtheir 危险性到调停 NK 的杀死。这些结果证明到 NK 的耐心的公里房间的抵抗 lysismainly 包含一个 HLA 班我依赖的机制,建议那 HLA 一级可以涉及保护公里房间调停 fromNK 在 vivo 攻击并且贡献他们的有免疫力的逃跑。 | Minjie Gao Lu Gao Guang Yang Yi Tao Jun Hou Hongwei Xu Xiaojing Hu Ying Han Qianqiao Zhang Xiaosong Wu Jumei Shi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 3 |
| 10 | Spatio-temporal characteristics and causes of changes in erosion-accretion in the Yangtze (Changjiang) submerged delta from 1982 to 2010显示文摘对加速河建水坝和灌溉的 Yangtze 三角洲反应是全球担心的一个话题。这研究分析了沉没三角洲前面,在不同分区的时间空间的变化模式,在典型剖面图的 geomorphological 变化,和四个主要分区的 geomorphological 原因的一般侵蚀生长(Chongming厘米的东方潮汐的沼泽地, Hengsha shoal-HS , Jiuduansha wetland-JDS ,并且 Nanhui-NH 的东方潮汐的沼泽地)。数据来源包括测量在的地志的数据高分辨率,在 Datong 车站的沉积负担,和相应河口构造信息。主要调查结果是:(1 ) 一般来说,学习区域稍微侵蚀了(侵蚀区域比率是 51.83% ,生长区域比率是 48.17%) 从 1982 ~ 2010,并且它经历了 erosion-accretion-erosion 的移动。地形学的时间空间的变化在八个分区也是重要的,排除在北方隧道的经常的侵蚀;( 2 )在在 NH 的 5 m 深线以内的东方、北的厘米和 HS ,北 JDS ,和这个区域的进化被垂直免职统治,它在南部的厘米和 HS 是那的反面,并且在东方、南部的 JDS 的 5 m 深线以内的区域;( 3 )总体上, 2 m 的包含的表面区域( ESA )和 5 m ,深线不停地增加,并且年度生长率在 19822010 期间分别地到达了 10.42 km 2/yr 和 7.99 km 2/yr (然而,四个分区展出了争论),并且在整个区域和所有分区, 10 m 深线的 ESA 减少了,当 15 m 深线的 ESA 在时期期间稍微变化了并且仍然保持稳定时;(4 ) 是更少由设计的河口影响了,厘米是深线的 ESA 根据沉积负担的衰落减少了的唯一的分区。主要结论是河口工程工程在对沉积负担, ESA 的变化和深线的分发的减小的宏背景影响沉没三角洲起一个日益重要的作用。与国际发货中心和开垦投射的上海的加速的构造一起,沉没三角洲的 geomorphological 进化将变得更复杂并且因此值得以后的经常的监视。 | SUN Xiaojing WANG Jun LI Mengya ZHENG Lu | 2015 | Journal of Geographical Sciences2015，25，8： | 3 |
| 11 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 12 | The genome of the recretohalophyte Limonium bicolor provides insights into salt gland development and salinity adaptation during terrestrial evolution显示文摘Halophytes have evolved specialized strategies to cope with high salinity.The extreme halophyte sea lavender(Limonium bicolor)lacks trichomes but possesses salt glands on its epidermis that can excrete harmful ions,such as sodium,to avoid salt damage.Here,we report a high-quality,2.92-Gb,chromosome-scale L.bicolor genome assembly based on a combination of Illumina short reads,single-molecule,real-time long reads,chromosome conformation capture(Hi-C)data,and Bionano genome maps,greatly enriching the genomic information on recretohalophytes with multicellular salt glands.Although the L.bicolor genome contains genes that show similarity to trichome fate genes from Arabidopsis thaliana,it lacks homologs of the decision fate genes GLABRA3,ENHANCER OF GLABRA3,GLABRA2,TRANSPARENT TESTA GLABRA2,and SIAMESE,providing a molecular explanation for the absence of trichomes in this species.We identified key genes(LbHLH and LbTTG1)controlling salt gland development among classical trichome homologous genes and confirmed their roles by showing that their mutations markedly disrupted salt gland initiation,salt secretion,and salt tolerance,thus offering genetic support for the long-standing hypothesis that salt glands and trichomes may share a common origin.In addition,a whole-genome duplication event occurred in the L.bicolor genome after its divergence from Tartary buckwheat and may have contributed to its adaptation to high salinity.The L.bicolor genome resource and genetic evidence reported in this study provide profound insights into plant salt tolerance mechanisms that may facilitate the engineering of salt-tolerant crops. | Fang Yuan Xi Wang Boqing Zhao Xiaojing Xu Miao Shi Bingying Leng Xinxiu Dong Chaoxia Lu Zhongtao Feng Jianrong Guo Guoliang Han Haikuan Zhang Jianwei Huang Min Chen Bao-Shan Wang | 2022 | Molecular Plant2022，15，6： | 3 |
| 13 | Genome-level diversification of eight ancient tea populations in the Guizhou and Yunnan regions identifies candidate genes for core agronomic traits显示文摘The ancient tea plant,as a precious natural resource and source of tea plant genetic diversity,is of great value for studying the evolutionary mechanism,diversification,and domestication of plants.The overall genetic diversity among ancient tea plants and the genetic changes that occurred during natural selection remain poorly understood.Here,we report the genome resequencing of eight different groups consisting of 120 ancient tea plants:six groups from Guizhou Province and two groups from Yunnan Province.Based on the 8,082,370 identified high-quality SNPs,we constructed phylogenetic relationships,assessed population structure,and performed genome-wide association studies(GWAS).Our phylogenetic analysis showed that the 120 ancient tea plants were mainly clustered into three groups and five single branches,which is consistent with the results of principal component analysis(PCA).Ancient tea plants were further divided into seven subpopulations based on genetic structure analysis.Moreover,it was found that the variation in ancient tea plants was not reduced by pressure from the external natural environment or artificial breeding(nonsynonymous/synonymous=1.05).By integrating GWAS,selection signals,and gene function prediction,four candidate genes were significantly associated with three leaf traits,and two candidate genes were significantly associated with plant type.These candidate genes can be used for further functional characterization and genetic improvement of tea plants. | Litang Lu Hufang Chen Xiaojing Wang Yichen Zhao Xinzhuan Yao Biao Xiong Yanli Deng Degang Zhao | 2021 | Horticulture Research2021，8，1： | 3 |
| 14 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 15 | Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery显示文摘Molecular self-assembly is crucially fundamental to nature.However,the aqueous self-assembly of polymers is still a challenge.To achieve self-assembly of block copolymers [(polyacrylic acid-block-polyethylene glycol-block-polyacrylic acid(PAA68-b-PEG86-b-PAA68)] in an aqueous phase,manganese oxide(MnO2) is first generated to drive phase separation of the PAA block to form the PAA68-b-PEG68-b-PAA68/MnO2 polymeric assembly that exhibits a stable structure in a physiological medium.The polymeric assembly exhibits vesicular morphology with a diameter of approximately 30 nm and high doxorubicin(DOX) loading capacity of approximately 94%.The transformation from MnO2 to Mn2+caused by endogenous glutathione(GSH)facilitates the disassembly of PAA68-b-PEG68-b-PAA68/MnO2 to enable its drug delivery at the tumor sites.The toxicity of DOXloaded PAA68-b-PEG68-b-PAA69/MnO2 to tumor cells has been verified in vitro and in vivo.Notably,drug-loaded polymeric vesicles have been demonstrated,especially in in vivo studies,to overcome the cardiotoxicity of DOX.We expect this work to encourage the potential application of polymer self-assembly. | Yalei Miao Yudian Qiu Mengna Zhang Ke Yan Panke Zhang Siyu Lu Zhongyi Liu Xiaojing Shi Xubo Zhao | 2020 | Nano-Micro Letters2020，12，9： | 2 |
| 16 | A selected population study reveals the biochemical mechanism of intramuscular fat deposition in chicken meat显示文摘Background:Increasing intramuscular fat(IMF)is an important strategy to improve meat quality,but the regulation mechanism of IMF deposition needs to be systematically clarified.Results:A total of 520 chickens from a selected line with improved IMF content and a control line were used to investigate the biochemical mechanism of IMF deposition in chickens.The results showed that the increased IMF would improve the flavor and tenderness quality of chicken meat.IMF content was mainly determined both by measuring triglyceride(TG)and phospholipid(PLIP)in muscle tissue,but only TG content was found to be decisive for IMF deposition.Furthermore,the increase in major fatty acid(FA)components in IMF is mainly derived from TGs(including C16:0,C16:1,C18:1n9c,and C18:2n6c,etc.),and the inhibition of certain very-long-chain FAs would help to IMF/TG deposition.Conclusions:Our study elucidated the underlying biochemical mechanism of IMF deposition in chicken:Prevalent accumulation of long-chain FAs and inhibitions of medium-chain FAs and very long chain FA would jointly result in the increase of TGs with the FA biosynthesis and cellular uptake ways.Our findings will guide the production of high-quality chicken meat. | Huanxian Cui Lu Liu Xiaojing Liu Yongli Wang Na Luo Xiaodong Tan Yuting Zhu Ranran Liu Guiping Zhao Jie Wen | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 2 |
| 17 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 18 | EXISTENCE OF PERIODIC SOLUTIONS TO A KIND OF HIGHER ORDER FUNCTIONAL DIFFERENTIAL EQUATION WITH TWO DEVIATING ARGUMENTS显示文摘In this paper, by the theory of Fourier series, Bernoulli number theory and continu-ation theorem of coincidence degree theory, we study a kind of higher order functional differential equation with two deviating arguments. Some new results on the existence of periodic solutions are obtained. | Li Xiaojing (College of Math. and Phy., Jiangsu Teachers University of Tech., Changzhou 213015, Jiangsu) Zhang Zhirong, Lu Shiping (Dept. of Math., Anhui Normal University, Wuhu 241000, Anhui) | 2008 | Annals of Differential Equations2008，24，3： | 2 |
| 19 | Analysis of the Genetic Diversity of Natural Populations of Alpinia oxyphylla Miquel Using Inter-Simple Sequence Repeat Markers显示文摘 | Wang Haiyan Liu Xiaojing Wen Mingfu Pan Kun Zou Meiling Lu Cheng Liu Shisheng Wang Wenquan | 2012 | EN2012，，4： | 2 |
| 20 | Heterogeneous photocatalytic treatment of wastewater in ultraviolet light irradiation photocatalyst Bi2WO6 microsphere with high repeatability显示文摘包括象染料, phenoaniline,酚和他们的衍生物那样的有毒的器官的污染物质的废水的处理仍然由于他们的 biorecalcitrant 和尖锐毒性是挑战到再循环的水的普遍接受。三维(3D ) Bi2WO6 microsphere 被热水的方法用双性人(NO3 ) 综合 3 并且 Na2WO4 作为原料。这结构为染料展出高 photocatalytic 活动,有毒的有机化合物。methlyene 蓝色的降级是在 30 min 的 100% , 4-nitrylphenol 在 60 min 是 95% , p-nitrylphenol 在 75 min 在是 95% 紫外(紫外) 轻照耀。3D Bi2WO6 microsphere 也是好光催化剂对待打印并且染的污水,并且展出高重覆性。在被使用第 20 次以后, Bi2WO6 仍然有高活动降级打印并且染污水,它为光催化剂到是很重要的在工业被使用。这研究将铺平一条新道路对待工业废水。 | Xiaojing Lu Yin PENG Zhengzheng HAN | 2012 | Frontiers of Optoelectronics2012，5，4： | 2 |
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