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| 1 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 2 | Charge storage mechanism of MOF-derived Mn2O3 as high performance cathode of aqueous zinc-ion batteries显示文摘Aqueous Zinc-ion batteries(ZIB) are attracting immense attention because of their merits of excellent safety and quite cheap properties compared with lithium-ion batteries(LIB).Manganese oxide is one of the most important cathode materials of ZIB.In this paper,α-Mn2O3 used as cathode of ZIB is synthesized via Metal-Organic Framework(MOF)-derived method,which delivers a high specific capacity of225 mAh g^(-1) at 0.05 A g^(-1) and 92.7 mAh g^(-1) after 1700 cycles at 2 A g^(-1).The charge storage mechanism of α-Mn2O3 cathode is found to greatly depend on the discharge current density.At lower current density discharging,the H+ and Zn2+ are successively intercalated into the α-Mn2O3 before and after the 'turning point' of discharge voltage and their discharging products present obviously different morphologies changing from flower-like to large plate-like products.At a higher current density,the low-voltage plateau after the turning point disappears due to the decrease of amount of Zn2+ intercalation and the H+intercalation is dominated in α-Mn2 O3.This study provides significant understanding for future design and research of high-performance Mn-based cathodes of ZIB. | Min Mao Xingxing Wu Yi Hu Qunhui Yuan Yan-Bing He Feiyu Kang | 2021 | Journal of Energy Chemistry2021，30，1： | 7 |
| 3 | GaN-based substrates and optoelectronic materials and devices显示文摘In order to solve the problems of GaN heteroepitaxy on sapphire substrate,some techniques were explored.Freestanding GaN substrates have been made by hydride vapor phase epitaxy(HVPE),laser lift-off(LLO),and chemical mechanical polishing techniques.Wafer bending and cracking in the HVPE growth were partly settled by pulsed flow modulation method.High-crystal quality was established for 1.2 mm thick GaN substrate by X-ray diffraction measurement,in which the full width of half maximum values were 72,110 arcsec for(102),(002)peaks.A novel micro-size patterned sapphire substrate(PSS)and a nano PSS were also fabricated.High-power vertical structure light emitting diodes(VSLEDs)have been developed by Au–Sn eutectic wafer bonding,homemade micro-area LLO,and light extraction structure preparation.The high-injection-level active region with low temperature GaN sandwiched layers was used for lowefficiency droop.The light output power of VSLED was achieved as 400 mW driven at 350 mA,and the dominant wavelength is about 460 nm.The structures and properties of strain modulated superlattices(SLs)and quantum wells as well as advanced simulation of carriers transport across the electron blocking layer were investigated in laser diodes.The hole concentration was achieved as high as1.6 9 1018cm-3in AlGaN/GaN SLs:Mg by inserting an AlN layer.High-quality AlGaN epilayers and structures were grown by MOCVD.Some device structures of UV LEDs and detectors were demonstrated.The emission wavelength of 262 nm UV LED has been successfully fabricated.At last,high-quality InN and InGaN materials for solar cell were grown by boundary-temperature-controlled epitaxy and growth-temperature-controlled epitaxy.Hall-effect measurement showed a recorded electron mobility of 3,280 cm2/(V s)and a residual electron concentration of 1.47 9 1017cm-3at 300 K. | Guoyi Zhang Bo Shen Zhizhong Chen Xiaodong Hu Zhixin Qin Xinqiang Wang Jiejun Wu Tongjun Yu Xiangning Kang Xingxing Fu Wei Yang Zhijian Yang Zhizhao Gan | 2014 | Chinese Science Bulletin2014，59，12： | 4 |
| 4 | Hybrid speciation via inheritance of alternate alleles of parental isolating genes显示文摘It is increasingly realized that homoploid hybrid speciation(HHS),which involves no change in chromosome number,is an important mechanism of speciation.HHS will likely increase in frequency as ecological and geographical barriers between species are continuing to be disrupted by human activities.HHS requires the establishment of reproductive isolation between a hybrid and its parents,but the underlying genes and genetic mechanisms remain largely unknown.In this study,we reveal by integrated approaches that reproductive isolation originates in one homoploid hybrid plant species through the inheritance of altemate alleles at genes that determine parental premating isolation.The parent species of this hybrid species are reproductively isolated by differences in flowering time and survivorship on soils containing high concentrations of iron.We found that the hybrid species inherits alleles of parental isolating major genes related to flowering time from one parent and alleles of major genes related to iron tolerance from the other parent.In this way,it became reproductively isolated from one parent by the difference in flowering time and from the other by habitat adaptation(iron tolerance).These findings and further modeling results suggest that HHS may occur relatively easily via the inheritance of alternate parental premating isolating genes and barriers. | Zefu Wang Yuanzhong Jiang Hao Bi Zhiqiang Lu Yazhen Ma Xiaoyue Yang Ningning Chen Bin Tian Bingbing Liu Xingxing Mao Tao Ma Stephen P.DiFazio Quanjun Hu Richard J.Abbott Jianquan Liu | 2021 | Molecular Plant2021，14，2： | 4 |
| 5 | A hierarchically structured tin-cobalt composite with an enhanced electronic effect for high-performance CO_(2) electroreduction in a wide potential range显示文摘Earth-abundant and nontoxic Sn-based materials have been regarded as promising catalysts for the electrochemical conversion of CO_(2)to C1 products,e.g.,CO and formate.However,it is still difficult for Snbased materials to obtain satisfactory performance at low-to-moderate overpotentials.Herein,a simple and facile electrospinning technique is utilized to prepare a composite of a bimetallic Sn-Co oxide/carbon matrix with a hollow nanotube structure(Sn Co-HNT).Sn Co-HNT can maintain>90%faradaic efficiencies for C1 products within a wide potential range from-0.6 VRHE to-1.2 VRHE,and a highest 94.1%selectivity towards CO in an H-type cell.Moreover,a 91.2%faradaic efficiency with a 241.3 m A cm^(-2)partial current density for C1 products could be achieved using a flow cell.According to theoretical calculations,the fusing of Sn/Co oxides on the carbon matrix accelerates electron transfer at the atomic level,causing electron deficiency of Sn centers and reversible variation between Co^(2+)and Co^(3+)centers.The synergistic effect of the Sn/Co composition improves the electron affinity of the catalyst surface,which is conducive to the adsorption and stabilization of key intermediates and eventually increases the catalytic activity in CO_(2)electroreduction.This study could provide a new strategy for the construction of oxide-derived catalysts for CO_(2)electroreduction. | Xingxing Jiang Xuan Li Yan Kong Chen Deng Xiaojie Li Qi Hu Hengpan Yang Chuanxin He | 2023 | Journal of Energy Chemistry2023，，1： | 1 |
| 6 | Pervasive hybridization during evolutionary radiation of Rhododendron subgenus Hymenanthes in mountains of southwest China显示文摘Radiations are especially important for generating species biodiversity in mountainous ecosystems.The contribution of hybridization to such radiations has rarely been examined.Here,we use extensive genomic data to test whether hybridization was involved in evolutionary radiation within Rhododendron subgenus Hymenanthes,whose members show strong geographic isolation in the mountains of southwest China.We sequenced genomes for 143 species of this subgenus and 93 species of four other subgenera,and found that Hymenanthes was monophyletic and radiated during the late Oligocene to middle Miocene.Widespread hybridization events were inferred within and between the identified clades and subclades.This suggests that hybridization occurred both early and late during diversification of subgenus Hymenan thes,although the extent to which hybridization,speciation through mixing-isolation-mixing or hybrid speciation,accelerated the diversification needs further exploration.Cycles of isolation and contact in such and other montane ecosystems may have together promoted species radiation through hybridization between diverging populations and species.Similar radiation processes may apply to other montane floras in this region and elsewhere. | Yazhen Ma Xingxing Mao Ji Wang Lei Zhang Yuanzhong Jiang Yuying Geng Tao Ma Liming Cai Shuangquan Huang Pete Hollingsworth Kangshan Mao Minghui Kang Yiling Li Wenlu Yang Haolin Wu Yang Chen Charles C.Davis Nawal Shrestha Richard H.Ree Zhenxiang Xi Quanjun Hu Richard I.Milne Jianquan Liu | 2022 | National Science Review2022，9，12： | 1 |
| 7 | Phylotranscriptomics of Swertiinae(Gentianaceae)reveals that key floral traits are not phylogenetically correlated显示文摘Establishing how lineages with similar traits are phylogenetically related remains critical for understanding the origin of biodiversity on Earth.Floral traits in plants are widely used to explore phylogenetic relationships and to delineate taxonomic groups.The subtribe Swertiinae(Gentianaceae)comprises more than 350 species with high floral diversity ranging from rotate to tubular corollas and possessing diverse nectaries.Here we performed phylogenetic analysis of 60 species from all 15 genera of the subtribe Swertiinae sensu Ho and Liu,representing the range of floral diversity,using data from the nuclear and plastid genomes.Extensive topological conflicts were present between the nuclear and plastome trees.Three of the 15 genera represented by multiple species are polyphyletic in both trees.Key floral traits including corolla type,absence or presence of lobe scales,nectary type,nectary position,and stigma type are randomly distributed in the nuclear and plastome trees without phylogenetic correlation.We also revealed the likely ancient hybrid origin of one large clade comprising 10 genera with diverse floral traits.These results highlight the complex evolutionary history of this subtribe.The phylogenies constructed here provide a basic framework for further exploring the ecological and genetic mechanisms underlying both species diversification and floral diversity. | Chunlin Chen Brad R.Ruhfel Jialiang Li Zefu Wang Lushui Zhang Lei Zhang Xingxing Mao Ji Wang Dashan He Yue Luo Quanjun Hu Yuanwen Duan Xiaoting Xu Zhenxiang Xi Jianquan Liu | 2023 | Journal of Integrative Plant Biology2023，65，6： | 1 |
| 8 | Early Cenozoic diorite and diabase from Doumer Island, Antarctic Peninsula: zircon U-Pb geochronology, petrogenesis and tectonic implications显示文摘In order to understand the petrogenesis and tectonic setting of diorite and diabase units on Doumer Island, Antarctic Peninsula, this paper reports new laser ablation-inductively coupled plasma-mass spectrometry(LA-ICP-MS) zircon U-Pb, geochemical, and Lu-Hf isotopic data for the magmatism. The diorite and diabase samples yielded zircon U-Pb ages of 55.4 ± 0.3 and 52.8 ± 0.4 Ma, respectively. These samples are enriched in the large ion lithophile elements and the light rare earth elements, and are depleted in the high field strength elements. The zircons in these samples yield eHf(t) values from 9.03 to 11.87 and model ages(TDM2) of 342–524 Ma. The major, trace, rare earth element(REE), and Hf isotopic data for the diorites indicate that these units were formed by the mixing of magmas generated by(a) the partial melting of mantle wedge material that experienced fluid-metasomatism in a subduction zone setting, and(b) the melting of juvenile crustal material induced by the upwelling of mantle-derived magmas in a subduction–collision setting. The diabase units contain higher total REE concentrations than the diorite, indicating they were derived from a different source region. These samples also have higher Mg~# values and contain lower concentrations of Cr and Ni than the diorites, and have weakly negative Nb and Ta anomalies with Nb/Ta values of <3. The zircons in these samples yield eHf(t) values from 9.08 to 11.11 and model ages(TDM2) of 389–503 Ma. The major, trace, REE, and Hf isotopic compositions of the diabase units indicate that that they were derived from the mixing of depleted mantle-derived magmas with magmas generated by the melting of juvenile crustal material which was induced by the upwelling of the mantle into the crust. Overall the Cenozoic diorite and diabase on Doumer Island is related to subduction environment. | CUI Jiawei HU Jianmin PEI Junling CHEN Hong DU Xingxing WEI Lijie | 2019 | Advances in Polar Science2019，30，2： | 1 |
| 9 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 10 | Vehicular mobility patterns and their applications to Internet-of-Vehicles:a comprehensive survey显示文摘With the growing popularity of the Internet-of-Vehicles(IoV),it is of pressing necessity to understand transportation traffic patterns and their impact on wireless network designs and operations.Vehicular mobility patterns and traffic models are the keys to assisting a wide range of analyses and simulations in these applications.This study surveys the status quo of vehicular mobility models,with a focus on recent advances in the last decade.To provide a comprehensive and systematic review,the study first puts forth a requirement-model-application framework in the IoV or general communication and transportation networks.Existing vehicular mobility models are categorized into vehicular distribution,vehicular traffic,and driving behavior models.Such categorization has a particular emphasis on the random patterns of vehicles in space,traffic flow models aligned to road maps,and individuals’driving behaviors(e.g.,lane-changing and car-following).The different categories of the models are applied to various application scenarios,including underlying network connectivity analysis,off-line network optimization,online network functionality,and real-time autonomous driving.Finally,several important research opportunities arise and deserve continuing research efforts,such as holistic designs of deep learning platforms which take the model parameters of vehicular mobility as input features,qualification of vehicular mobility models in terms of representativeness and completeness,and new hybrid models incorporating different categories of vehicular mobility models to improve the representativeness and completeness. | Qimei CUI Xingxing HU Wei NI Xiaofeng TAO Ping ZHANG Tao CHEN Kwang-Cheng CHEN Martin HAENGGI | 2022 | Science China(Information Sciences)2022，65，11： | 1 |
| 11 | Cardiomyocyte electrical-mechanical synchronized model for high-content, dose-quantitative and time-dependent drug assessment显示文摘Cardiovascular diseases have emerged as a significant threat to human health.However,drug development is a time-consuming and costly process,and few drugs pass the preclinical assessment of safety and efficacy.The existing patch-clamp,Ca2+imaging,and microelectrode array technologies in cardiomyocyte models for drug preclinical screening have suffered from issues of low throughput,limited long-term assessment,or inability to synchronously and correlatively analyze electrical and mechanical signals.Here,we develop a high-content,dose-quantitative and time-dependent drug assessment platform based on an electrical-mechanical synchronized(EMS)biosensing system.This microfabricated EMS can record both firing potential(FP)and mechanical beating(MB)signals from cardiomyocytes and extract a variety of characteristic parameters from these two signals(FP–MB)for further analysis.This system was applied to test typical ion channel drugs(lidocaine and isradipine),and the dynamic responses of cardiomyocytes to the tested drugs were recorded and analyzed.The high-throughput characteristics of the system can facilitate simultaneous experiments on a large number of samples.Furthermore,a database of various cardiac drugs can be established by heat map analysis for rapid and effective screening of drugs.The EMS biosensing system is highly promising as a powerful tool for the preclinical development of new medicines. | Jiaru Fang Xinwei Wei Hongbo Li Ning Hu Xingxing Liu Dongxin Xu Tao Zhang Hao Wan Ping Wang Xi Xie | 2021 | Microsystems & Nanoengineering2021，7，2： | 1 |
| 12 | An integrated front-end vertical hall magnetic sensor fabricated in 0.18μm low-voltage CMOS technology显示文摘An integrated front-end vertical CMOS Hall magnetic sensor is proposed for the in-plane magnetic field measure-ment.To improve the magnetic sensitivity and to obtain low offset,a fully symmetric vertical Hall device(FSVHD)has been op-timized with a minimum size design.A new four-phase spinning current modulation associated with a correlated double sampling(CDS)demodulation technique has been further applied to compensate for the offset and also to provide a linear Hall output voltage.The vertical Hall sensor chip has been manufactured in a 0.18μm low-voltage CMOS technology and it occu-pies an area of 1.54 mm2.The experimental results show in the magnetic field range from-200 to 200 mT,the entire vertical Hall sensor performs with the linearity of 99.9%and the system magnetic sensitivity of 1.22 V/T and the residual offset of 60μT.Meanwhile,it consumes 4.5 mW at a 3.3 V supply voltage.The proposed vertical Hall sensor is very suitable for the low-cost sys-tem-on-chip(SOC)implementation of 2D or 3D magnetic microsystems. | Zhengwu Shu Lei Jiang Xingxing Hu Yue Xu | 2022 | Journal of Semiconductors2022，43，3： | 0 |
| 13 | Tunable optical topological transition of Cherenkov radiation显示文摘Approaches to generate and manipulate Cherenkov radiation(CR)are challenging yet meaningful.Optical topological transition(OTT)in novel materials and metamaterials is also promising for modern photonics.We study the OTT of CR in graphene-based hyperbolic metamaterials(GHMs)for the first time.In GHMs,conventional and hyperbolic CR can be switched when crossing the topological transition frequency.This frequency can be altered by metamaterial components and external optical elements.For instance,external ultrafast optical pumps cause an ultrafast OTT from the elliptical to the hyperbolic state.Then,hyperbolic CR can be excited by lowenergy electrons by leveraging the excellent photothermal properties of graphene.Hyperbolic CR vanishes when the GHM returns to its original state.Furthermore,graphene nonlocality occurs when the electron velocity is low enough,corresponding to a large wave vector.Concretely,when the electron velocity approaches the Fermi velocity of graphene,a nonlocality-induced OTT modifies the plasmonic properties of the GHM and brings a new lower velocity threshold of hyperbolic CR.Therefore,hyperbolic CR can only be induced in a limited velocity range.These findings pave the way for understanding CR properties in active plasmonic metamaterials and may be applied to complex photonic and polaritonic systems. | TIANYU ZHANG XIAOQIUYAN ZHANG ZHUOCHENG ZHANG XINGXING XU YUEYING WANG ZHAOYUN DUAN YANYU WEI YUBIN GONG SHENGGANG LIU MIN HU TAO ZHAO | 2022 | Photonics Research2022，10，7： | 0 |
| 14 | Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity显示文摘Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical consequences.Here,we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive artificial amino acid fluorosulfate-L-tyrosine(FSY)into IL-2 for proximity-enabled covalent binding to IL-2Rαto selectively promote Treg activation.We found that FSY-bearing IL-2 variants,such as L72-FSY,covalently bound to IL-2Rαvia sulfur-fluoride exchange when in proximity,resulting in persistent recycling of IL-2 and selectively promoting the expansion of Tregs but not effector cells.Further assessment of L72-FSY-expanded Tregs demonstrated that L72-FSY maintained Tregs in a central memory phenotype without driving terminal differentiation,as demonstrated by simultaneously attenuated expression of lymphocyte activation gene-3(LAG-3)and enhanced expression of programmed cell death protein-1(PD-1).Subcutaneous administration of L72-FSY in murine models of pristane-induced lupus and graft-versus-host disease(GvHD)resulted in enhanced and sustained therapeutic efficacy compared with wild-type IL-2 treatment.The efficacy of L72-FSY was further improved by N-terminal PEGylation,which increased its circulatory retention for preferential and sustained effects.This proximity-enabled covalent binding strategy may accelerate the development of pleiotropic cytokines as a new class of immunomodulatory therapies. | Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu Boyang Cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 15 | Tumor-on-a-chip:from bioinspired design to biomedical application显示文摘Cancer is one of the leading causes of human death,despite enormous efforts to explore cancer biology and develop anticancer therapies.The main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring efficient means for screening anticancer drugs to reveal the nature of cancer and develop treatments.The tumor microenvironment possesses human-specific biophysical and biochemical factors that are difficult to recapitulate in conventional in vitro planar cell models and in vivo animal models.Therefore,model limitations have hindered the translation of basic research findings to clinical applications.In this review,we introduce the recent progress in tumor-on-a-chip devices for cancer biology research,medicine assessment,and biomedical applications in detail.The emerging tumor-on-a-chip platforms integrating 3D cell culture,microfluidic tech no logy,and tissue engineeri ng have successfully mimicked the pivotal structural and functional characteristics of the in vivo tumor microenvironment.The recent advances in tumor-on-a-chip platforms for cancer biology studies and biomedical applications are detailed and an a lyzed in this review.This review should be valuable for further understanding the mechanisms of the tumor evolution process,screening anticancer drugs,and developing cancer therapies,and it addresses the challenges and potential opportunities in predicting drug screening and cancer treatment. | Xingxing Liu Jiaru Fang Shuang Huang Xiaoxue Wu Xi Xie Ji Wang Fanmao Liu Meng Zhang Zhenwei Peng Ning Hu | 2021 | Microsystems & Nanoengineering2021，7，3： | 0 |
| 16 | Tumor-specific memory CD8^(+)T cells are strictly resident in draining lymph nodes during tumorigenesis显示文摘The functional exhaustion of CD8^(+)T cells represents a fundamental hallmark of chronic viral infection and cancer and,in both scenarios,is driven by prolonged exposure to persistent cognate antigens in the context of an immunoinhibitory microenvironment.Exhausted CD8^(+)T cells upregulate the expression of a wide diversity of coinhibitory immunoreceptors(also referred to as immune checkpoint receptors),such as PD-1,Tim-3,LAG-3,and TIGIT.Concomitantly,exhausted CD8^(+)T cells lose their potential to differentiate into functional memory cells and are characterized by hierarchical loss of effector function,leading to compromised tumor control and viral eradication[1,2]. | Qiao Liu Ling Ran Zhengliang Yue Xingxing Su Lisha Wang Shuqiong Wen Shun Lei Xiaofan Yang Yan Zhang Jianjun Hu Jianfang Tang Zhirong Li Li Hu Bo Zhu Lifan Xu Lilin Ye Qizhao Huang | 2023 | Cellular & Molecular Immunology2023，20，4： | 0 |
| 17 | Author Correction:Tumor-specific memory CD8^(+)T cells are strictly resident in draining lymph nodes during tumorigenesis显示文摘 | Qiao Liu Ling Ran Zhengliang Yue Xingxing Su Lisha Wang Shuqiong Wen Shun Lei Xiaofan Yang Yan Zhang Jianjun Hu Jianfang Tang Zhirong Li Li Hu Bo Zhu Lifan Xu Lilin Ye Qizhao Huang | 2023 | Cellular & Molecular Immunology2023，20，7： | 0 |
| 18 | Assembly and phylogenomic analysis of cotton mitochondrial genomes provide insights into the history of cotton evolution显示文摘Cotton is a major crop that provides the most important renewable textile fibers in the world.Studies of the taxonomy and evolution of cotton species have received wide attentions,not only due to cotton’s economic value but also due to the fact that Gossypium is an ideal model system to study the origin,evolution,and cultivation of polyploid species.Previous studies suggested the involvement of mitochondrial genome editing sites and copy number as well as mitochondrial functions in cotton fiber elongation.Whereas,with only a few mitogenomes assembled in the cotton genus Gossypium,our knowledge about their roles in cotton evolution and speciation is still scarce.To close this gap,here we assembled 20 mitogenomes from 15 cotton species spanning all the cotton clades(A–G,K,and AD genomes)and 5 cotton relatives using short and long sequencing reads.Systematic analyses uncovered a high level of mitochondrial gene sequence conservation,abundant sequence repeats and many insertions of foreign sequences,as well as extensive structural variations in cotton mitogenomes.The sequence repeats and foreign sequences caused significant mitogenome size inflation in Gossypium and its close relative Kokia in general,while there is no significant difference between the lint and fuzz cotton mitogenomes in terms of gene content,RNA editing,and gene expression level.Interestingly,we further revealed the specific presence and expression of two novel mitochondrial open reading frames(ORFs)in lint-fiber cotton species.Finally,these structural features and novel ORFs help us gain valuable insights into the history of cotton evolution and polyploidization and the origin of species producing long lint fibers from a mitogenomic perspective. | Yanlei Feng Yukang Wang Hejun Lu Jun Li Delara Akhter Fang Liu Ting Zhao Xingxing Shen Xiaobo Li James Whelan Tianzhen Zhang Jianping Hu Ronghui Pan | 2023 | The Crop Journal2023，11，6： | 0 |
| 19 | 肺上皮样血管内皮瘤伴肺门淋巴结转移的个案报道(英文)显示文摘Pulmonary epithelioid hemangioendothelioma (PEH) is a rare tumor that occurs among young women and typically presents as bilateral multiple nodules. In this report, we described an unusual case of PEH presented as a single mass in a 46-year-old man, with 6 positive pulmonary hilar lymph nodes. Histologic findings were compared with conventional PEH, except those features such as round to oval-shaped nodules, hypocellular/cellular peripheral zone, hyaline, myxomatous intercellular stroma and intracellular vacuoles, and we found the patient's pulmonary hilar lymph nodes were metastasis and cholesterol crystal were discovered in the focal infarction areas. Immunohistochemically, the tumor cells were strong positive for CD34, CD31, factor VIII related endothelial antigen and vimentin. The patient died 3 and half months after the surgery without receiving any radiotherapy or chemotherapy. This report may contribute to the data on clinical and histological finding of this rare tumour. | Xingxing Wang Xiangyang Hu Gang Meng | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，9： | 0 |
| 20 | Janus heterostructure of cobalt and iron oxide as dual-functional electrocatalysts for overall water splitting显示文摘In electrocatalytic water splitting,low-cost dual-functional catalysts can not only reduce costs but also avoid cross-contamination of cathode and anode.However,the orderly aggregation of active sites for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)into a specific catalyst is very challenging.In this study,a Co/Fe_(3)O_(4)Janus heterojunction supported on carbon fiber paper(J-CoFe-CFP)is designed and successfully synthesized.Generally,Co-Fe oxides have preferable OER activity but weak HER activity.However,in J-CoFe-CFP,due to the intense and special electronic interaction of different substances(Co and Fe3O4)in the Janus heterogeneous interface,a huge number of tidy high-quality HER and OER active sites are uniformly distributed on the interface simultaneously,which endows the catalyst with both excellent HER and OER performance.In HER,the overpotential@10 mA·cm^(−2)(ηHER)is only 53.9 mV,and the Tafel slope is 43.7 mV·dec^(−1).In OER,theηis 272 mV,and the Tafel slope is 50.2 mV·dec^(−1),much lower than those of RuO_(2)/CFP.In the J-CoFe-CFP||J-CoFe-CFP two-electrode system,the required voltage is only 1.26 V at the beginning and 1.56 V@10 mA·cm^(−2),much lower than those of RuO_(2)/CFP||20%Pt/C/CFP.This work provides a Janus heterojunction pathway for bifunctional water electrolysis catalysts. | Xiaojie Li Huike Zhang Xuan Li Qi Hu Chen Deng Xingxing Jiang Hengpan Yang Chuanxin He | 2023 | Nano Research2023，16，2： | 0 |
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