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| 1 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 2 | Geo-engineered buffer capacity of two-layered absorbing system under the impact of rock avalanches based on Discrete Element Method显示文摘Many rock avalanches were triggered by the Wenchuan earthquake on May 12,2008 in southwest China.Protection galleries covered with a single soil layer are usually used to protect against rockfall.Since one-layer protection galleries do not have sufficient buffer capacity,a two-layered absorbing system has been designed.This study aims to find whether an expanded poly-styrol(EPS) cushion,which is used in the soil-covered protection galleries for shock absorption,could be positioned under dynamic loadings.The dynamic impacts of the two-layered absorbing system under the conditions ofrock avalanches are numerically simulated through a 2D discrete element method.By selecting reasonable parameters,a series of numerical experiments were conducted to find the best combination for the twolayered absorbing system.The values of the EPS layer area as a percentage of the total area were set as 0%(S1),22%(S2),and 70%(S3).22% of the area of the EPS layer was found to be a reasonable value,and experiments were conducted to find the best position of the EPS layer in the two-layered absorbing system.The numerical results yield useful conclusions regarding the interaction between the impacting avalanches and the two-layered absorbing system.The soil layer can absorb the shock energy effectively and S2(0.4-m thick EPS cushion covered with soillayer) is the most efficient combination,which can reduce the impact force,compared with the other combinations. | BI Yu-zhang HE Si-ming LI Xin-po WU Yong XU Qiang OUYANG Chao-jun SU Li-Jun WANG Hao | 2016 | Journal of Mountain Science2016，13，5： | 14 |
| 3 | Microstructure,mechanical and corrosion properties of Mg-2Dy-xZn(x=0,0.1,0.5 and 1 at.%)alloys显示文摘Microstructure,mechanical and corrosion properties of as-cast Mg-2Dy-xZn(x=0,0.1,0.5,and 1)(at.%)alloys were investigated.The microstructures of the as-cast Mg-2Dy and Mg-2Dy-0.1Zn alloys mainly consisted ofα-Mg phase and Mg_(24)Dy_(5)eutectic phase.With 0.5 at.%Zn addition,Mg_(12)ZnDy phase with 18R-type long period stacking ordered(LPSO)structure and Mg_(2)Dy phase precipitated at the grain boundaries.When the content of Zn is 1 at.%,only the Mg_(3)Zn_(3)Dy_(2)phase formed in theα-Mg matrix.The electrochemical measurements and immersion testing results indicated that the Mg-2Dy-0.1Zn alloy exhibited the best corrosion resistance.It revealed that the morphology,scale,amount and distribution of the second phase have a great effect on the corrosion resistance of alloy.Additionally,the tensile testing results showed that the Mg-2Dy-0.5Zn alloy exhibited the higher tensile strength and good elongation,especially at 200℃.The improvement of mechanical properties was mainly due to the strengthening of LPSO phase and grain refinement of α-Mg. | Guangli Bi Yuandong Li Shijun Zang Jianbin Zhang Ying Ma Yuan Hao | 2014 | Journal of Magnesium and Alloys2014，2，1： | 13 |
| 4 | Three-dimensional morphological characteristics measurement of ankle joint based on computed tomography image post-processing显示文摘脚关节X光线照相术的精确的放不是可能的背景,重复脚关节X光检查电影上的所有 syndesmotic 参数的量的测量可能具有这研究的小 value.The 目的是为由聪明的联合精确地并且可靠地估计脚关节破裂减小的质量提供一套科学、客观的评估标准三维的( 3-D )计算了断层摄影术( CT )测量从2008年6月的 model.Methods 到2011年3月,所有薄片的 CT | CHEN Yan-xi LU Xiao-ling BI Gang YU Xiao HAO Yi-li ZHANG Kun ZOU Li-ling MEI Jiong YU Guang-rong | 2011 | Chinese Medical Journal2011，，23： | 12 |
| 5 | Phosphorus oxoanion-intercalated layered double hydroxides for high-performance oxygen evolution显示文摘合理设计和为氧进化反应(OER ) 的有效、划算的电极的控制制造为探讨崭新的精力危机是批评的。有特定的夹层阴离子的镍铁分层的双氢氧化物(NiFe-LDHs )( 即磷酸盐,亚磷酸盐,和次磷酸盐) 被一个一起沉淀方法制作并且作为氧进化 electrocatalysts 调查了。磷 oxoanion 的置闰在一个碱的答案提高了 OER 活动;最佳的表演(即, 215 mV, 37.7 mV/dec 的一个小 Tafel 斜坡,和稳定的电气化学的行为的一个低发作潜力) 与设置次磷酸盐的 NiFe-LDH 催化剂被完成,在传统的设置碳酸盐的 NiFe-LDH 上的示威戏剧的改进以活动和耐久性。这提高的表演被归因于在设置的磷的 oxoanions 和分享边的瞬间 6 之间的相互作用(M = Ni, Fe ) 层,它修改表面 Ni 地点的电子结构。这个概念应该为更有效的基于 LDH 的氧进化 electrocatalysts 的设计是鼓舞人心的。 | Ma Luo Zhao Cai Cheng Wang Yongmin Bi Li Qian Yongchao Hao Li Li Yun Kuang Yaping Li Xiaodong Lei Ziyang HUO Wen Liu Hailiang Wang Xiaoming Sun Xue Duan | 2017 | Nano Research2017，10，5： | 12 |
| 6 | Bad Data Detection Algorithm for PMU Based on Spectral Clustering显示文摘Phasor measurement units(PMUs) can provide real-time measurement data to construct the ubiquitous electric of the Internet of Things. However, due to complex factors on site, PMU data can be easily compromised by interference or synchronization jitter. It will lead to various levels of PMU data quality issues, which can directly affect the PMU-based application and even threaten the safety of power systems. In order to improve the PMU data quality, a data-driven PMU bad data detection algorithm based on spectral clustering using single PMU data is proposed in this paper. The proposed algorithm does not require the system topology and parameters. Firstly, a data identification method based on a decision tree is proposed to distinguish event data and bad data by using the slope feature of each data. Then, a bad data detection method based on spectral clustering is developed. By analyzing the weighted relationships among all the data, this method can detect the bad data with a small deviation. Simulations and results of field recording data test illustrate that this data-driven method can achieve bad data identification and detection effectively. This technique can improve PMU data quality to guarantee its applications in the power systems. | Zhiwei Yang Hao Liu Tianshu Bi Qixun Yang | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，3： | 10 |
| 7 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 8 | Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury显示文摘Baicalin is a natural active ingredient isolated from Scutellariae Radix that can cross the blood-brain barrier and exhibits neuroprotective effects on multiple central nervous system diseases.However,the mechanism behind the neuroprotective effects remains unclear.In this study,rat models of spinal cord injury were established using a modified Allen's impact method and then treated with intraperitoneal injection of Baicalin.The results revealed that Baicalin greatly increased the Basso,Beattie,Bresnahan Locomotor Rating Scale score,reduced blood-spinal cord barrier permeability,decreased the expression of Bax,Caspase-3,and nuclear factorκB,increased the expression of Bcl-2,and reduced neuronal apoptosis and pathological spinal cord injury.SH-SY5 Y cell models of excitotoxicity were established by application of 10 m M glutamate for 12 hours and then treated with 40μM Baicalin for 48 hours to investigate the mechanism of action of Baicalin.The results showed that Baicalin reversed tight junction protein expression tendencies(occludin and ZO-1)and apoptosis-related protein expression(Bax,Bcl-2,Caspase-3,and nuclear factor-κB),and also led to up-regulation of PI3 K and Akt phosphorylation.These effects on Bax,Bcl-2,and Caspase-3 were blocked by pretreatment with the PI3 K inhibitor LY294002.These findings suggest that Baicalin can inhibit bloodspinal cord barrier permeability after spinal cord injury and reduce neuronal apoptosis,possibly by activating the PI3 K/Akt signaling pathway.This study was approved by Animal Ethics Committee of Xi'an Jiaotong University on March 6,2014. | Rui Zhao Xue Wu Xue-Yuan Bi Hao Yang Qian Zhang | 2022 | Neural Regeneration Research2022，17，5： | 9 |
| 9 | Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution显示文摘The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits,which is of fundamental importance for neuroscience research.Here,we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R)for high-throughput,high-quality brain mapping.Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion,the VISo R system effectively eliminates motion blur to obtain undistorted images.By continuously imaging moving samples without stopping,the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours,at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation,imaging,3D image reconstruction and quantification.Our approach is compatible with immunofluorescence methods,enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains.Using this system,we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming conditions.Our results indicate the involvement of multiple subcortical areas in stress response.Intriguingly,neuronal activation in these areas exhibits striking individual variability among different animals,suggesting the necessity of sufficient cohort size for such studies. | Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-Ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-Ning Zhou Fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi | 2019 | National Science Review2019，6，5： | 7 |
| 10 | Highly diversified Zika viruses imported to China, 2016显示文摘 | Yanjun Zhang Wenxian Chen Gary Wong Yuhai Bi Juying Yan Yi Sun Enfu Chen Hao Yan Xiuyu Lou Haiyan Mao Shichang Xia George F.Gao Weifeng Shi Zhiping Chen | 2016 | Protein & Cell2016，7，6： | 7 |
| 11 | Dry sliding wear behavior of an extruded Mg-Dy-Zn alloy with long period stacking ordered phase显示文摘The dry sliding wear behavior of extruded Mg-2Dy-0.5Zn alloy(at.%)was investigated using a pin-on-disk configuration.The friction coefficient and wear rate were measured within a load range 20-760 N at a sliding velocity of 0.785 m/s.Microstructure and wear surface of alloy were examined using scanning electron microscopy.The mechanical properties of alloy were tested at room and elevated temperatures.Five wear mechanisms,namely abrasion,oxidation,delamination,thermal softening and melting dominated the whole wear behavior with increasing applied load.The extruded Mg-2Dy-0.5Zn alloy exhibited the better wear resistance as compared with as-cast Mg_(97)Zn_(1)Y_(2) alloy under the given conditions through contact surface temperature analysis.The improved wear resistance was mainly related to fine grain size,good thermal stability of long period stacking order(LPSO)phase and excellent higher-temperature mechanical properties. | Guangli Bi Yuandong Li Xiaofeng Huang Tijun Chen Ying Ma Yuan Hao | 2015 | Journal of Magnesium and Alloys2015，3，1： | 6 |
| 12 | Simulation of multi-support depth-varying earthquake ground motions within heterogeneous onshore and offshore sites显示文摘This paper presents a novel approach to model and simulate the multi-support depth-varying seismic motions(MDSMs) within heterogeneous offshore and onshore sites.Based on 1 D wave propagation theory,the three-dimensional ground motion transfer functions on the surface or within an offshore or onshore site are derived by considering the effects of seawater and porous soils on the propagation of seismic P waves.Moreover,the depth-varying and spatial variation properties of seismic ground motions are considered in the ground motion simulation.Using the obtained transfer functions at any locations within a site,the offshore or onshore depth-varying seismic motions are stochastically simulated based on the spectral representation method(SRM).The traditional approaches for simulating spatially varying ground motions are improved and extended to generate MDSMs within multiple offshore and onshore sites.The simulation results show that the PSD functions and coherency losses of the generated MDSMs are compatible with respective target values,which fully validates the effectiveness of the proposed simulation method.The synthesized MDSMs can provide strong support for the precise seismic response prediction and performance-based design of both offshore and onshore large-span engineering structures. | Li Chao Li Hongnan Hao Hong Bi Kaiming Tian Li | 2018 | Earthquake Engineering and Engineering Vibration2018，17，3： | 6 |
| 13 | A new strategy for obtaining highly concentrated phosphorus recovery solution in biofilm phosphorus recovery process显示文摘Recovery of phosphorus(P)from wastewater is of great significance for alleviating the shortage of P resources.At present,the P recovery process is faced with the problem of excessive organic carbon consumption when obtaining a P-concentrated recovery solution.This study proposed a new strategy to obtain a more highly concentrated P recovery solution with minimal carbon consumption by strengthening the P storage capacity of the biofilm.A biofilm sequencing batch reactor(BSBR)process was modified to treat synthetic wastewater.The effect of the dissolved oxygen(DO)concentration on the P storage capacity of the biofilm was investigated at DO concentrations of DO 3.5 mg/L(P_(L))and DO 6.5 mg/L(P_(H)).The results showed a maximum P storage of 101.2 and 149.6 mg-P/g-mixed liquid suspended solids under the two conditions.Strengthening the P storage capacity of the biofilm resulted in a net increase in the P recovery rate,which was as high as 66.96%in a harvesting cycle,and total soluble P>220 mg/L in the P recovery solution was successfully achieved.Meanwhile,the carbon cost of P recovery in the BSBR was reduced to 41.57 g-chemical oxygen demand/gP,and the carbon utilization efficiency was enhanced.To highlight the new strategy,the P recovery performance of the BSBR was given and the relationship between P content and anaerobic P release was discussed.In addition,the changes in the microbial communities under P_(L) and P_(H) conditions were analyzed. | Wanjing Yang Jie Shan Yang Pan Zhen Bi Yong Huang Hao Zhang Min Ni | 2022 | Journal of Environmental Sciences2022，34，2： | 6 |
| 14 | Subsynchronous oscillation monitoring and alarm method based on phasor measurements显示文摘Owing to the large-scale grid connection of new energy sources, several installed power electronic devices introduce sub-/supersynchronous inter-harmonics into power signals, resulting in the frequent occurrence of subsynchronous oscillations(SSOs). The SSOs may cause significant harm to generator sets and power systems;thus, online monitoring and accurate alarms for power systems are crucial for their safe and stable operation. Phasor measurement units(PMUs) can realize the dynamic real-time monitoring of power systems. Based on PMU phasor measurements, this study proposes a method for SSO online monitoring and alarm implementation for the main station of a PMU. First, fast Fourier transform frequency spectrum analysis is performed on PMU current phasor amplitude data to obtain subsynchronous frequency components. Second, the support vector machine learning algorithm is trained to obtain the amplitude threshold and subsequently filter out safe components and retain harmful ones. Finally, the adaptive duration threshold is determined according to frequency susceptibility, amplitude attenuation, and energy accumulation to decide whether to transmit an alarm signal. Experiments based on field data verify the effectiveness of the proposed method. | Yuan Qi Jiaxian Li Hao Liu Tianshu Bi | 2020 | Global Energy Interconnection2020，3，5： | 5 |
| 15 | Atomistic Surface Passivation of CH_(3)NH_(3)PbI_(3) Perovskite Single Crystals for Highly Sensitive Coplanar-Structure X-Ray Detectors显示文摘Organic-inorganic halide perovskites(OIHPs)are recognized as the promising next-generation X-ray detection materials.However,the device performance is largely limited by the ion migration issue of OIHPs.Here,we reported a simple atomistic surface passivation strategy with methylammonium iodide(MAI)to remarkably increase the ion migration activation energy of CH_(3)NH_(3)PbI_(3)single crystals.The amount of MAI deposited on the crystal surface is finely regulated by a self-assemble process to effectively suppress the metallic lead defects,while not introducing extra mobile ions,which results in significantly improved dark current stability of the coplanar-structure devices under a large electric field of 100Vmm^(-1).The X-ray detectors hence exhibit a record-high sensitivity above 700,000μC Gy^(-1)_(air) cm^(-2)under continuum X-ray irradiation with energy up to 50 keV,which enables an ultralow X-ray detection limit down to 1.5 nGy_(air)s^(-1).Our findings will allow for the dramatically reduced X-ray exposure of human bodies in medical imaging applications. | Yilong Song Liqi Li Weihui Bi Mingwei Hao Yifei Kang Anran Wang Zisheng Wang Hanming Li Xiaohui Li Yanjun Fang Deren Yang Qingfeng Dong | 2020 | Research2020，，1： | 5 |
| 16 | Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer:a multicenter,randomized,double-blinded,placebo-controlled,phaseⅡclinical trial显示文摘Background: Metastatic colorectal cancer(mCRC) patients with progressive disease after all available standard therapies need new medication for further treatment. Famitinib is a small-molecule multikinase inhibitor, with promising anticancer activities. This multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial was designed to evaluate the safety and efficacy of famitinib in mCRC.Methods: Famitinib or placebo was administered orally once daily. The primary endpoint was progression-free survival(PFS). Secondary endpoints included objective response rate(ORR), disease control rate(DCR), overall survival(OS), quality-of-life(QoL), and safety.Results: Between July 18,2012 and Jan 22,2014, a total of 167 patients were screened, and 154 patients were randomized in a 2:1 ratio to receive either famitinib(n = 99) or placebo(n = 55). The median PFS was 2.8 and 1.5 months in the famitinib and placebo groups(hazard ratio = 0.60,95% confidence interval = 0.41-0.86, P = 0.004). The DCR was 59.8% and 31.4%(P = 0.002) and the ORR was 2.2% and 0.0%(P = 0.540) in the famitinib and placebo groups,respectively. The most frequent grade 3-4 adverse events were hypertension(11.1%), hand-foot syndrome(10.1%),thrombocytopenia(10.1%) and neutropenia(9.1%). Serious adverse events occurred in 11(11.1%) patients in the famitinib group and 5(9.1%) in the placebo group(P = 0.788). The median OS of the famitinib and placebo groups was 7.4 and 7.2 months(P = 0.657).Conclusion: Famitinib prolonged PFS in refractory mCRC patients with acceptable tolerability.Trial registration This study was registered on ClinicalTrials.gov(NCT01762293) and was orally presented in the 2015 ASCO-Gastrointestinal | Rui-Hua Xu Lin Shen Ke-Ming Wang Gang Wu Chun-Mei Shi Ke-Feng Ding Li-Zhu Lin Jin-Wan Wang Jian-Ping Xiong Chang-Ping Wu Jin Li Yun-Peng Liu Dong Wang Yi Ba Jue-Ping Feng Yu-Xian Bai Jing-Wang Bi Li-Wen Ma Jian Lei Qing Yang Hao Yu | 2017 | Chinese Journal of Cancer2017，36，12： | 4 |
| 17 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 18 | Hybrid speciation via inheritance of alternate alleles of parental isolating genes显示文摘It is increasingly realized that homoploid hybrid speciation(HHS),which involves no change in chromosome number,is an important mechanism of speciation.HHS will likely increase in frequency as ecological and geographical barriers between species are continuing to be disrupted by human activities.HHS requires the establishment of reproductive isolation between a hybrid and its parents,but the underlying genes and genetic mechanisms remain largely unknown.In this study,we reveal by integrated approaches that reproductive isolation originates in one homoploid hybrid plant species through the inheritance of altemate alleles at genes that determine parental premating isolation.The parent species of this hybrid species are reproductively isolated by differences in flowering time and survivorship on soils containing high concentrations of iron.We found that the hybrid species inherits alleles of parental isolating major genes related to flowering time from one parent and alleles of major genes related to iron tolerance from the other parent.In this way,it became reproductively isolated from one parent by the difference in flowering time and from the other by habitat adaptation(iron tolerance).These findings and further modeling results suggest that HHS may occur relatively easily via the inheritance of alternate parental premating isolating genes and barriers. | Zefu Wang Yuanzhong Jiang Hao Bi Zhiqiang Lu Yazhen Ma Xiaoyue Yang Ningning Chen Bin Tian Bingbing Liu Xingxing Mao Tao Ma Stephen P.DiFazio Quanjun Hu Richard J.Abbott Jianquan Liu | 2021 | Molecular Plant2021，14，2： | 4 |
| 19 | LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells显示文摘LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and metabolism.Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs,and few have addressed LIN28's role within the nucleus.Here,we show that LIN28 displays dynamic temporal and spatial expression during murine embryo development.Maternal LIN28 expression drops upon exit from the 2-cell stage,and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blas-tocyst stage development,to become dominantly expressed in the cytosol after implantation.In cultured pluripotent stem cells(PSCs),loss of LIN28 led to nucleolar stress and activation of a 2-cell/4-cell-like transcriptional program characterized by the expression of endogenous retrovirus genes.Mechanistically,LIN28 binds to small nucleolar RNAs and rRNA to maintain nucleolar integrity,and its loss leads to nucleolar phase separation defects,ribosomal stress and activation of P53 which in turn binds to and activates 2C transcription factor Dux.LIN28 also resides in a complex containing the nucleolar factor Nucleolin(NCL)and the transcrip-tional repressor TRIM28,and LIN28 loss leads to reduced occupancy of the NCL/TRIM28 complex on the Dux and rDNA loci,and thus de-repressed Dux and reduced rRNA expression.Lin28 knockout cells with nucleolar stress are more likely to assume a slowly cycling,translationally inert and anabolically inactive state,which is a part of previously unappreciated 2C-like transcriptional program.These findings elucidate novel roles for nucleolar LIN28 in PSCs,and a new mechanism linking 2C program and nucleolar functions in PSCs and early embryo development. | Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang Anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei Wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao Wu Jianlong Wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang | 2022 | Protein & Cell2022，13，7： | 4 |
| 20 | Genomic characterizations of H4 subtype avian influenza viruses from live poultry markets in Sichuan province of China, 2014–2015显示文摘Dear Editor,Avian influenza viruses (AIVs) have posed a serious threat to poultry production and public health. To date, more than fourteen AIV subtypes that are able to infect human beings have been documented. Also, it is suggested that new subtypes may be reported in the future, owing to the migration of wild birds and live poultry transportation (Gao, 2018).Poultry may act as a potential incubator for novel subtypes of avian influenza virus (Bi et al., 2016a; Bi et al., 2016b; Liu et al., 2014a; Su et al., 2017). Up to date, the H7N9 AIV emerged in February 2013 has caused 1,567 human cases,with a fatality rate of 39.2%(http://gffzz36b398b81f8a4a4chkknxbwubkov96pwx.ffgz.tsg.suse.edu.cn/influenza/ | Chuansong Quan Ting Huang Xiuwei Chen Jie Zhang Qianli Wang Cheng Zhang Tiyan Zhang Lijun Zhou Liumei Shu Chunrong Long Lei Yang Xunbo Du Yingze Zhao Peipei Liu Hao Song Weifeng Shi Yuhai Bi Qiang Lv William J.Liu George F.Gao | 2018 | Science China(Life Sciences)2018，61，9： | 4 |
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