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| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | A real-time forecast of tunnel fire based on numerical database and artificial intelligence显示文摘The extreme temperature induced by fire and hot toxic smokes in tunnels threaten the trapped personnel and firefighters.To alleviate the potential casualties,fast while reasonable decisions should be made for rescuing,based on the timely prediction of fire development in tunnels.This paper targets to achieve a real-time prediction(within 1 s)of the spatial-temporal temperature distribution inside the numerical tunnel model by using artificial intelligence(Al)methods.A CFD database of 100 simulated tunnel fire scenarios under various fire location,fire size,and ventilation condition is established.The proposed Al model combines a Long Short-term Memory(LSTM)model and a Transpose Convolution Neural Network(TCNN).The real-time ceiling temperature profile and thousands of temperature-field images are used as the training input and output.Results show that the predicted temperature field 60 s in advance achieves a high accuracy of around 97%.Also,the Al model can quickly identify the critical temperature field for safe evacuation(i.e.,a critical event)and guide emergency responses and firefighting activities.This study demonstrates the promising prospects of Al-based fire forecasts and smart firefighting in tunnel spaces. | Xiqiang Wu Xiaoning Zhang Xinyan Huang Fu Xiao Asif Usmani | 2022 | Building Simulation2022，15，4： | 6 |
| 3 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 4 | Chitosan-Zn Chelate Increases Antioxidant Enzyme Activity and Improves Immune Function in Weaned Piglets显示文摘 | Yuanfei Ma Qichun Huang Mengyuan Lv Zhipeng Wu Zhengjun Xie Xinyan Han Yizhen Wang | 2014 | Biological Trace Element Research2014，，1： | 2 |
| 5 | Adverse associations of sedentary behavior with cancer incidence and all-cause mortality:A prospective cohort study显示文摘Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these relationships.Methods:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire.Cancer incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death certificates.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression models.Results:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were recorded.Sedentary behavior was associated with increased risk of developing cancer and deaths in a doseresponse manner.The multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary time.Sedentary populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 years.Failure to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of MVPA.Limitations of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient incident cases for the analysis of associations between sedentary behavior and site-specific cancers.Conclusion:Sedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults,especially for those with≥10 h/day of sedentary time.It is necessary to reduce sedentary time,in addition to increasing MVPA levels,for the prevention of cancer and premature death. | Yuan Lin Qiong Liu Fangchao Liu Keyong Huang Jianxin Li Xueli Yang Xinyan Wang Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Xiangfeng Lu Jianfeng Huang Dongfeng Gu | 2021 | Journal of Sport and Health Science2021，10，5： | 2 |
| 6 | Spontaneous movement of a retrotransposon generated genic dominant male sterility providing a useful tool for rice breeding显示文摘Male sterility in plants provides valuable breeding tools in germplasm innovation and hybrid crop production.However,genetic resources for dominant genic male sterility,which hold great promise to facilitate breeding processes,are extremely rare in natural germplasm.Here we characterized the Sanming Dominant Genic Male Sterility in rice and identified the gene SDGMS using a map-based cloning approach.We found that spontaneous movement of a 1978-bp long terminal repeat(LTR)retrotransposon into the promoter region of the SDGMS gene activates its expression in anther tapetum,which causes abnormal programmed cell death of tapetal cells resulting in dominant male sterility.SDGMS encodes a ribosome inactivating protein showing N-glycosidase activity.The activation of SDGMS triggers transcription reprogramming of genes responsive to biotic stress leading to a hypersensitive response which causes sterility.The results demonstrate that an ectopic gene activation by transposon movement can give birth to a novel trait which enriches phenotypic diversity with practical utility. | Conghao Xu Yifeng Xu Zhengji Wang Xiaoyu Zhang Yuying Wu Xinyan Lu Hongwei Sun Lei Wang Qinglu Zhang Qinghua Zhang Xianghua Li Jinghua Xiao Xu Li Mingfu Zhao Yidan Ouyang Xianbo Huang Qifa Zhang | 2023 | National Science Review2023，10，9： | 1 |
| 7 | The Value of c-TCD in the Diagnosis of Migraine and Cryptogenic Stroke Caused by PFO显示文摘Objective:To investigate the value of contrast-enhanced transcranial doppler(c-TCD)in the diagnosis of patent foramen ovale(PFO)of patients with migraine and cryptogenic stroke.Methods:A retrospective analysis of 160 patients undergoing c-TCD monitoring in our hospital from June 2014 to June 2019 was performed.Among them,there were 80 cases of patients with migraine(38 cases with aura and 42 cases without aura)in group A,and 80 cases of patients with cryptogenic stroke in group B.The positive detectable rate of PFO in the two groups were calculated and analyzed.Results:The detectable rate was 50.00%in group A,and 40.00%in group B.There was no statistical significance between the two groups(P>0.05).Among them,the detectable rate of PFO in migraine with aura in group A(62.50%)was higher than that in group B(37.50%).The difference was statistically significant(P<0.05);In the two groups of PFO-positive patients,the difference didn’t have statistical significance,comparing the proportion of the inherent type to that of potential type(P>0.05);There was no statistical significance of the difference between the RLS incidence of grade I and that of grade II among two groups of PFO-positive patients(P>0.05);the incidence of RLS in grade III in group B(50.00%)was higher than that in group A(25.00%),and the difference was statistically significant(P<0.05).Conclusion:c-TCD can accurately screen migraine and cryptogenic stroke caused by PFO,and grade and classify it as a clinical diagnosis of migraine and cryptogenic caused by PFO.It can also act as a objective reference of estimating the effect of treatment in different diseases and preventing cryptogenic stroke. | Xinyan Yu Jianyun Yang Dan Wu | 2020 | Journal of Clinical and Nursing Research2020，4，2： | 1 |
| 8 | Valine-- derived phos- phinothiourea as organocatalyst in enantioselective Morita- Baylis--Hillman reactions of acrylates with aromatic aldehydes 显示文摘 | Gong Jingjing Yuan Kui Wu Xinyan | 2009 | Tetrahedron: Asymmetry2009，20，： | 1 |
| 9 | Structural revolution of atomically dispersed Mn sites dictates oxygen reduction performance显示文摘An efficient preparation and local coordination environment regulation of isolated single-atom sites catalysts(ISASC)for improved activity is still challenging.Herein,we develop a solid phase thermal diffusion strategy to synthesize Mn ISASC on highly uniform nitrogen-doped carbon nanotubes by employing MnO_(2) nanowires@ZIF-8 core-shell structure.Under high-temperature,the Mn species break free from core-MnO_(2) lattice,which will be trapped by carbon defects derived from shell-ZIF-8 carbonization,and immobilized within carbon substrate.Furthermore,the poly-dispersed Mn sites with two nitrogen-coordinated centers can be controllably renovated into four-nitrogen-coordinated Mn sites using NH3 treatment technology.Both experimental and computational investigations indicate that the symmetric coordinated Mn sites manifest outstanding oxygen reduction activity and superior stability in alkaline and acidic solutions.This work not only provides efficient way to regulate the coordination structure of ISASC to improve catalytic performance but also paves the way to reveal its significant promise for commercial application. | Zhengkun Yang Xiaolin Wang Mengzhao Zhu Xinyan Leng Wenxing Chen Wenyu Wang Qian Xu Li-Ming Yang Yuen Wu | 2021 | Nano Research2021，14，12： | 1 |
| 10 | Post-stroke depression and lesion location: a systematic review显示文摘 | Na Wei Wu Yong Xinyan Li | 2015 | Journal o~ Neurology2015，26，21： | 1 |
| 11 | The epidemic status and genetic diversity of 14 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) isolates from China in 2009显示文摘 | Zhi Zhou Jianqiang Ni Zhen Cao Xue Han Yingju Xia Zhanchao Zi Kun Ning Qi Liu Lin Cai Peng Qiu Xiaoyu Deng Dongmei Hu Qian Zhang Yunfeng Fan Jiajun Wu Lilin Wang Miaojie Zhang Xiuling Yu Xinyan Zhai Kegong Tian | 2011 | Veterinary Microbiology2011，，3： | 1 |
| 12 | Post-transcriptional gene silencing in plants: a double-edged sword显示文摘In plants, post-transcriptional gene silencing(PTGS) protects the genome from foreign genes and restricts the expression of certain endogenous genes for proper development. Here, we review the recent progress about how the unwanted PTGS is avoided in plants. As a decision-making step of PTGS, aberrant transcripts from most endogenous coding genes are strictly sorted to the bidirectional RNA decay pathways in cytoplasm but not to the short interference RNA(si RNA)-mediated PTGS, with the exception of a few development-relevant endogenous si RNA-producing genes. We also discuss a finely balanced PTGS threshold model that plants fully take advantage of the power of PTGS without self-harm. | Xinyan Zhang Ying Zhu Huihui Wu Hongwei Guo | 2016 | Science China(Life Sciences)2016，59，3： | 1 |
| 13 | Performance Evaluation and Optimization of a Novel System Combining a Photovoltaic/Thermal Subsystem&an Organic Rankine Cycle Driven by Solar Parabolic Trough Collector显示文摘A novel coupling system that combines a photovoltaic/thermal(PV/T)subsystem and an Organic Rankine Cycle(ORC)driven by solar parabolic trough collector(PTC)is presented in this paper.The mathematical model is initially built.On the basis,the influence of area ratio of two collectors(PV/T and PTC)on the performance of system is discussed.The results show that the optimal area ratio of PV/T to PTC is 8:2,which can achieve the maximum energy output.Moreover,the performance of the coupling system and two independent systems(PV/T and ORC system)are compared and analyzed.The results show that the coupling system is more reliable and its total output energy(heat and electricity)is the highest,compared with the other two independent systems.The solar energy utilization efficiency of the coupling system is 40%higher than that of the other two independent systems in the steady-state simulation.Moreover,the annual output energy per unit area collector of the coupling system is 13%higher than that of the other two independent systems in the dynamic simulation.Furthermore,in the dynamic simulation of a typical day,the PV panels’temperature of the coupling system is 5℃–7℃ lower than that of the independent PV/T system.It means that the power generation efficiency of PV panels can be increased by 1.5%–3.5%.This study aims to explore the operation characteristics of the novel solar energy utilization coupling system and promote the development of renewable energy utilization models,which provides a reference for the design and optimization of related energy systems. | LIU Zhijian WEI Tianhe WU Di ZHANG Yulong LI Guiqiang YANG Xinyan | 2021 | Journal of Thermal Science2021，30，5： | 1 |
| 14 | Preparation and optical limiting properties of polyurethane containing long conjugated chromophores 显示文摘 | SU Xinyan WU Lei YIN Shouchun | 2007 | Journal of Maeromoleeular Science : Part A2007，44，7： | 1 |
| 15 | Highly Enantioselective Intramolecular Morita-Baylis-Hillman Reaction Catalyzed by Mannose-Based Thiourea-phosphine显示文摘基于糖类的 chiral bifunctional thiourea 磷化氢为 ω-formyl-enones 的 intramolecular Morita-Baylis-Hillman 反应作为 chiral organocatalysts 被开发。与仅仅 thiourea 磷化氢催化剂 3c 的 2 mol% , chiral functionalized cyclohexenes 与优秀收益和 enantioselectivities 在温和反应条件下面被完成。 | Weihong Yang Kui Yuan Hongliang Song Feng Sha Xinyan Wu | 2015 | Chinese Journal of Chemistry2015，33，10： | 1 |
| 16 | High-Dimensional Volatility Matrix Estimation with Cross-Sectional Dependent and Heavy-Tailed Microstructural Noise显示文摘The estimates of the high-dimensional volatility matrix based on high-frequency data play a pivotal role in many financial applications.However,most existing studies have been built on the sub-Gaussian and cross-sectional independence assumptions of microstructure noise,which are typically violated in the financial markets.In this paper,the authors proposed a new robust volatility matrix estimator,with very mild assumptions on the cross-sectional dependence and tail behaviors of the noises,and demonstrated that it can achieve the optimal convergence rate n-1/4.Furthermore,the proposed model offered better explanatory and predictive powers by decomposing the estimator into low-rank and sparse components,using an appropriate regularization procedure.Simulation studies demonstrated that the proposed estimator outperforms its competitors under various dependence structures of microstructure noise.Additionally,an extensive analysis of the high-frequency data for stocks in the Shenzhen Stock Exchange of China demonstrated the practical effectiveness of the estimator. | LIANG Wanwan WU Ben FAN Xinyan JING Bingyi ZHANG Bo | 2023 | Journal of Systems Science & Complexity2023，36，5： | 0 |
| 17 | Iron(Fe,Ni,Co)-based transition metal compounds for lithium-sulfur batteries:Mechanism,progress and prospects显示文摘Lithium-sulfur batteries(LSBs)have a high theoretical capacity,which is considered as one of the most promising high-energy-density secondary batteries due to the double electrons reaction of sulfur.However,the shuttle effects of lithium polysulfides(Li PSs)and sluggish redox kinetics lead to their materials capacity loss and cycle stability deterioration,which restrains LSBs commercialization.Metallic compounds as additions can improve the electrochemical performance of the Li-S system,through the trap of Li PSs and accelerate the conversion of the soluble Li PSs.Among of them,the iron group elements(Fe,Ni,Co)-based compounds are the promising materials for the LSBs,due to their unique outer electronic structure and its tunable properties,low cost,abundant in the earth,environmental benignity,controllable and scalable prepared,and so on.In this review,we have made a summary for iron-based compounds to capture Li PSs according to lithium bond,sulfur bond and magnetic force.The type of iron-based compound including oxides,sulfides,nitrides,phosphides,carbides,and so on,and we have investigated the electrocatalytic mechanism of these materials.Besides,some improvement strategies are proposed,such as the engineering of the special micro/nanostructure,defect concentrations,band structures,and heterostructures.We hope to shed an in-depth light on the rationally design and fabrication of robust,commercial and stable materials for high-performance LSBs. | Junhao Li Zhangshi Xiong Yujie Wu Hao Li Xinyan Liu Hongjie Peng Yuying Zheng Qiang Zhang Quanbing Liu | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 18 | Weakly Supervised Object Localization with Background Suppression Erasing for Art Authentication and Copyright Protection显示文摘The problem of art forgery and infringement is becoming increasingly prominent,since diverse self-media contents with all kinds of art pieces are released on the Internet every day.For art paintings,object detection and localization provide an efficient and ef-fective means of art authentication and copyright protection.However,the acquisition of a precise detector requires large amounts of ex-pensive pixel-level annotations.To alleviate this,we propose a novel weakly supervised object localization(WSOL)with background su-perposition erasing(BSE),which recognizes objects with inexpensive image-level labels.First,integrated adversarial erasing(IAE)for vanilla convolutional neural network(CNN)dropouts the most discriminative region by leveraging high-level semantic information.Second,a background suppression module(BSM)limits the activation area of the IAE to the object region through a self-guidance mechanism.Finally,in the inference phase,we utilize the refined importance map(RIM)of middle features to obtain class-agnostic loc-alization results.Extensive experiments are conducted on paintings,CUB-200-2011 and ILSVRC to validate the effectiveness of our BSE. | Chaojie Wu Mingyang Li Ying Gao Xinyan Xie Wing W.Y.Ng Ahmad Musyafa | 2024 | Machine Intelligence Research2024，21，1： | 0 |
| 19 | The Role of the National Significant Seismic Monitoring and Protection Regions Institution:From the Perspective of the RiskSociety Theory显示文摘Earthquake disaster risk,as a typical social disaster risk,is one of the most important risks in modern Chinese society.This study gives definitions of the institution,describes the formation history,the connotations and development and analyzes its role in the control of major social risks caused by earthquakes.Finally,the paper presents recommendations for continuous improvement of this institution under the guidance of risk society theory,and for its application to the government reform and social governance. | Gao Mengtan Wu Guochun Wu Xinyan Lang Cong | 2015 | Earthquake Research in China2015，29，1： | 0 |
| 20 | Conclusions on the Implementation of Regulation of the National Significant Seismic Monitoring and Protection Regions from 1996 to 2012 in the Chinese Mainland显示文摘The regulation of the National Significant Seismic Monitoring and Protection Regions(NSSMPR for short) is defined by the Law of the Peoples Republic of China on Protecting Against and Mitigating Earthquake Disasters.The first stage of implementation of the regulation of NSSMPR in the Chinese mainland was finished from 1996 to 2005.The second stage is being carried on from 2006 to 2020.With the support of the National Social Science Foundation,this paper follows up and evaluates the implementation of the regulation of NSSMPR from 1996 to 2012 in the Chinese mainland.Based on analysis of earthquake examples and investigation data,we find that the effect of disaster mitigation is good,and on this basis,some suggestions are proposed to improve the regulation of NSSMPR. | Chao Hongtai Gao Mengtan Li Bo Chen Shijun Liang Kaili Ma Yuxiang Wang Feng Wu Guochun Lang Cong Wu Xinyan | 2015 | Earthquake Research in China2015，29，1： | 0 |
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