|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 2 | Determining oil slick thickness using hyperspectral remote sensing in the Bohai Sea of China显示文摘Determining oil slick thickness plays an important role in assessing oil spill volume and its environmental impacts on the ocean.In this study,we used a Hyperion image of an oil spill accident area and seawater and fresh crude oil samples collected in the Bohai Sea of China.A well-controlled laboratory experiment was designed to simulate spectral responses to different oil slick thicknesses.Spectral resampling and normalization methods were used to reduce the differences in spectral reflectances between the experimental background seawater sample and real background seawater.Fitting the analysis with laboratory experimental data results showed a linear relationship between normalized oil slick reflectance and normalized oil slick thickness[20th band(R^(2)-0.92938,n=49,pB0.01),26th band(R^(2)=0.93806,n=49,pB0.01),29th band(R^(2)=0.93288,n=49,pB0.01)].By using these statistical models,we successfully determined the normalized oil slick thickness with the Hyperion image.Our results indicate that hyperspectral remote sensing technology is an effective method to monitor oil spills on water.The spectral ranges of visible green and red light were the optimal bands for estimating oil slick thickness in case 2 water.The high,stabilized spectral reflectance of background seawater will be helpful in oil slick thickness inversion. | Yingcheng Lu Qingjiu Tian Xinyuan Wang Guang Zheng Xiang Li | 2013 | International Journal of Digital Earth2013，6，1： | 2 |
| 3 | The formation mechanism of titania nanotube arrays in hydrofluoric acid electrolyte显示文摘 | Jing Bai Baoxue Zhou Longhai Li Yanbiao Liu Qing Zheng Jiahui Shao Xinyuan Zhu Weimin Cai Junsheng Liao Lexi Zou | 2008 | Journal of Materials Science2008，，6： | 1 |
| 4 | Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches显示文摘Artificial intelligence(AI)models usually require large amounts of high-quality training data,which is in striking contrast to the situation of small and biased data faced by current drug discovery pipelines.The concept of federated learning has been proposed to utilize distributed data from different sources without leaking sensitive information of the data.This emerging decentralized machine learning paradigm is expected to dramatically improve the success rate of AI-powered drug discovery.Here,we simulated the federated learning process with different property and activity datasets from different sources,among which overlapping molecules with high or low biases exist in the recorded values.Beyond the benefit of gaining more data,we also demonstrated that federated training has a regularization effect superior to centralized training on the pooled datasets with high biases.Moreover,different network architectures for clients and aggregation algorithms for coordinators have been compared on the performance of federated learning,where personalized federated learning shows promising results.Our work demonstrates the applicability of federated learning in predicting drug-related properties and highlights its promising role in addressing the small and biased data dilemma in drug discovery. | Zhaoping Xiong Ziqiang Cheng Xinyuan Lin Chi Xu Xiaohong Liu Dingyan Wang Xiaomin Luo Yong Zhang Hualiang Jiang Nan Qiao Mingyue Zheng | 2022 | Science China(Life Sciences)2022，65，3： | 1 |
| 5 | Investigating the function of Akt by tet-off inducible expression system显示文摘A tet-off inducible cell line named BBT derived from BA/F3β cell line was constructed and the effect of this inducible expression system was significant when detected by tet-off responded luciferase reporter gene assay. Then tet-off responded Akt expression plasmid was transfected into BBT cells, and the stable cell lines were screened. The result of Northern blot showed that the expression of akt was significantly inducible. The clone with the best inducible effect was selected and named BBA for investigating the function of Akt. We found that Akt could significantly inhibit zinc-induced decrease of cell viability when assayed by MTT method. And the flow cytometric analysis showed that Akt could markedly repress zinc-induced apoptosis. | Qiwei Zhai Hongbin Ji Zhongcheng Zheng Lanying Sun Xinyuan Liu | 2001 | Chinese Science Bulletin2001，46，3： | 1 |
| 6 | Cluster Randomization Trial of Sequence Mass Screening for Colorectal Cancer显示文摘 | Shu Zheng M.D. Kun Chen M.D. Xiyong Liu M.D. Xinyuan Ma M.D. Hai Yu Ph.D. Kang Chen Kaiyan Yao Lun Zhou M.D. Linbo Wang M.D. Peiling Qiu M.D. Yongchuan Deng M.D. Suzhan Zhang M.D | 2003 | Diseases of the Colon & Rectum2003，，1： | 1 |
| 7 | JAK3 mediates c-myc gene expression induced by interleukin-2显示文摘C myc gene expression can be rapidly induced by IL 2 through intracellular signal transduction which is triggered by the interaction between IL 2 and its receptor (IL 2R). JAK3 which associates to the intracellular domain of IL2R γ may play a critical role in this process. To reveal the action of JAK3 in c myc induction, a chimeric receptor gene IL2R α/γ/Δ NJAK3 is constructed which consists of extracellular domain derived from IL 2R α subunit (IL2R α), the transmembrane sequence derived from IL2R γ and the cytoplasmic domain derived from the catalytic domain of JAK3 (Δ NJAK3), and then transfected this chimeric gene into mouse fibroblast cell line L929 β which had been transfected with IL2R β gene and stably expressed IL2R β in high level. In the transfectants coexpressing IL2R β and α/γ/Δ NJAK3, the stimulation of IL2 could intensively induce c myc gene expression. Because the whole cytoplasmic domain of IL2R γ which could recruit signaling molecules was replaced by JAK3 and the c myc could be still induced by IL2 in this situation, the results here gave the direct evidence demonstrating that JAK3 plays an important role in c myc gene expression induced by IL2. | Zhu Jinfang Lu Linrong Ji Hongbin Zheng Zhongcheng J. Thèze Liu Xinyuan | 1998 | Chinese Science Bulletin1998，43，4： | 1 |
| 8 | The formation mechanism of titania nanotube arrays in hydrofluoric acid electrolyte显示文摘 | Jing Bai Baoxue Zhou Longhai Li Yanbiao Liu Qing Zheng Jiahui Shao Xinyuan Zhu Weimin Cai Junsheng Liao Lexi Zou | 2008 | Journal of Materials Science2008，，6： | 1 |
| 9 | The formation mechanism of titania nanotube arrays in hydrofluoric acid electrolyte显示文摘 | Jing Bai Baoxue Zhou Longhai Li Yanbiao Liu Qing Zheng Jiahui Shao Xinyuan Zhu Weimin Cai Junsheng Liao Lexi Zou | 2008 | Journal of Materials Science2008，，6： | 1 |
| 10 | Study on the interaction between Jak3 and IL-2R γ using the yeast two-hybrid system显示文摘Both interleukin-2 (IL-2) receptor y subunit and non-receptor tyrosine kinase Jak3 play important roles in IL-2 physiological functions. Jak3 has been known to bind IL-2Ry and the interaction is very important for IL-2 signaling. In order to find the domains directly involved in the interaction between IL-2Ry and Jak3, various deletion mutants have been constructed | Jinfang Zhu Wei Tang Hongbin Ji Zhongcheng Zheng Xinyuan Liu | 1999 | Chinese Science Bulletin1999，44，18： | 0 |
| 11 | Microstructure-dependent Band Gaps for Elastic Wave Propagation in a Periodic Microbeam Structure显示文摘A new model for producing band gaps for flexural elastic wave propagation in a periodic microbeam structure is developed using an extended transfer matrix method and a non-classical Bernoulli–Euler beam model that incorporates the strain gradient,couple stress and velocity gradient effects.The band gaps predicted by the new model depend on the three microstructure-dependent material parameters of each constituent material,the beam thickness,the unit cell length and the volume fraction.A parametric study is conducted to quantitatively illustrate these factors.The numerical results reveal that the first band gap frequency range increases with the increases of the three microstructure-dependent material parameters,respectively.In addition,the band gap size predicted by the current model is always larger than that predicted by the classical model,and the difference is large for very thin beams.Furthermore,both the unit cell length and volume fraction have significant effects on the band gap. | Gongye Zhang Chenyi Zheng Xinyuan Qiu Changwen Mi | 2021 | Acta Mechanica Solida Sinica2021，34，4： | 0 |
| 12 | Interleukin-2 mediates the peripheral analgesia of interferon alpha显示文摘Interferon-α (IFN-α) and interleukin-2 (IL-2) are crucial cytokines in immune system. They also play an important role in nerve system. It has been reported that IL-2 can induce the central analgesia. It is demonstrated that IFN-α also can induce the peripheral analgesia, which can be blocked by naloxone as IL-2. Furthermore, the analgesic effect of IFN-α is reversible by monoclonal anti-IL-2 antibody. In vitro experiments show that IFN-α significantly increases the production of IL-2 in a dose dependent manner. These data suggest that IL-2 mediates the peripheral analgesia of IFN-α. | Li Li Qiwei Zhai Wei Tang Tong Wu Zhongcheng Zheng Xinyuan Liu | 1999 | Chinese Science Bulletin1999，44，3： | 0 |
| 13 | Bioinspired mineral-in-shell nanoarchitectonics:Functional empowerment of mineral precursors for guiding intradentinal mineralization显示文摘Effective mineralization of biological structures poses a significant challenge in hard tissue engineering as it necessitates overcoming geometric complexities and multistep biomineralization processes.In this regard,we propose“mineral-in-shell nanoarchitectonics”,inspired by the nanostructure of matrix vesicles,which can influence multiple mineralization pathways.Our nanostructural design empowers mineral precursors with tailorable properties through encapsulating amorphous calcium phosphate within a multifunctional tannic acid(TA)and silk fibroin(SF)nanoshell.The bioinspired nanosystem facilitates efficient recruitment of mineral precursors throughout the dentin structures,followed by large-scale intradentinal mineralization both in vitro and in vivo,which provides persistent protection against external stimuli.Theoretical simulations combined with experimental studies attribute the success of intradentinal mineralization to the TA-SF nanoshell,which exhibits a strong affinity for the dentin structure,stabilizing amorphous precursors and thereby facilitating concomitant mineral formation.Overall,this bioinspired mineral-in-shell nanoarchitectonics shows a promising prospect for hard tissue repair and serves as a blueprint for next-generation biomineralization-associated materials. | Xiaoran Zheng Yang Liu Mingjing Li Yuyan Li Wanshan Gao Rongmin Qiu Jiaqi Xing Jiaojiao Yang Yantao Chen Xinyuan Xu Mingming Ding Jun Luo Jianshu Li | 2024 | Nano Research2024，17，5： | 0 |
| 14 | Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo显示文摘Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour metastasis.SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic cancer.However,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be discovered.Here,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/L.Moreover,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/L.The allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural analyses.Importantly,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver metastasis.To our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic cancer.It not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer. | Xinyuan Xu Qian Zhang Xufeng Wang Jing Jin Chengwei Wu Li Feng Xiuyan Yang Mingzhu Zhao Yingyi Chen Shaoyong Lu Zhen Zheng Xiaobing Lan Yi Wang Yan Zheng Xuefeng Lu Qiufen Zhang Jian Zhang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 15 | The genome of okra (Abelmoschus esculentus) provides insights into its genome evolution and high nutrient content显示文摘Okra(Abelmoschus esculentus)is an important vegetable crop with high nutritional value.However,the mechanism underlying its high nutrient content remains poorly understood.Here,we present a chromosome-scale genome of okra with a size of 1.19 Gb.Comparative genomics analysis revealed the phylogenetic status of A.esculentus,as well as whole-genome duplication(WGD)events that have occurred widely across the Malvaceae species.We found that okra has experienced three additional WGDs compared with the diploid cotton Gossypium raimondii,resulting in a large chromosome number(2n=130).After three WGDs,okra has undergone extensive genomic deletions and retained substantial numbers of genes related to secondary metabolite biosynthesis and environmental adaptation,resulting in significant differences between okra and G.raimondii in the gene families related to cellulose synthesis.Combining transcriptomic and metabolomic analysis,we revealed the relationship between gene expression and metabolite content change across different okra developmental stages.Furthermore,the sinapic acid/S-lignin biosynthesis-related gene families have experienced remarkable expansion in okra,and the expression of key enzymes involved in the sinapic acid/S-lignin biosynthesis pathway vary greatly across developmental periods,which partially explains the differences in metabolite content across the different stages.Our study gains insights into the comprehensive evolutionary history of Malvaceae species and the genetic basis that underlies the nutrient content changes in okra,which will facilitate the functional study and genetic improvement of okra varieties. | Ruyu Wang Wei Li Qiang He Hongyu Zhang Meijia Wang Xinyuan Zheng Ze Liu Yu Wang Cailian Du Huilong Du Longsheng Xing | 2023 | Horticulture Research2023，10，8： | 0 |
| 16 | A wide-field and high-resolution lensless compound eye microsystem for real-time target motion perception显示文摘Optical measurement systems suffer from a fundamental tradeoff between the field of view(FOV),the resolution and the update rate.A compound eye has the advantages of a wide FOV,high update rate and high sensitivity to motion,providing inspiration for breaking through the constraint and realizing high-performance optical systems.However,most existing studies on artificial compound eyes are limited by complex structure and low resolution,and they focus on imaging instead of precise measurement.Here,a high-performance lensless compound eye microsystem is developed to realize target motion perception through precise and fast orientation measurement.The microsystem splices multiple sub-FOVs formed by long-focal subeyes,images targets distributed in a panoramic range into a single multiplexing image sensor,and codes the subeye aperture array for distinguishing the targets from different sub-FOVs.A wide-field and high resolution are simultaneously realized in a simple and easy-to-manufacture microelectromechanical system(MEMS)aperture array.Moreover,based on the electronic rolling shutter technique of the image sensor,a hyperframe update rate is achieved by the precise measurement of multiple time-shifted spots of one target.The microsystem achieves an orientation measurement accuracy of 0.0023°(3σ)in the x direction and 0.0028°(3σ)in the y direction in a cone FOV of 120°with an update rate~20 times higher than the frame rate.This study provides a promising approach for achieving optical measurements with comprehensive high performance and may have great significance in various applications,such as vision-controlled directional navigation and high-dynamic target tracking,formation and obstacle avoidance of unmanned aerial vehicles. | Li Zhang Haiyang Zhan Xinyuan Liu Fei Xing Zheng You | 2022 | Microsystems & Nanoengineering2022，8，4： | 0 |
| 17 | PanGu Drug Model: learn a molecule like a human显示文摘Dear Editor,Recent achievements in large-scale pre-trained models like GPT-3 and PanGu-α have demonstrated astounding performances in many downstream tasks of natural language processing (NLP),confirming AI to be user-oriented for even industrial applications.Deep learning has been recognized as the most promising technology for pharmaceuticals,a powerful molecule pre-trained model that could economize researchers’tons of time.For the strategic application of AI capabilities to the drug discovery field,we pre-trained a model called PanGu Drug Model with 1.7 billion small molecules from ZINC20 (Irwin et al.,2020),DrugSpaceX(Yang et al.,2021),and UniChem (Chambers et al.,2013). | Xinyuan Lin Chi Xu Zhaoping Xiong Xinfeng Zhang Ningxi Ni Bolin Ni Jianlong Chang Ruiqing Pan Zidong Wang Fan Yu Qi Tian Hualiang Jiang Mingyue Zheng Nan Qiao | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 18 | Dark current modeling of thick perovskite X‑ray detectors显示文摘Metal halide perovskites(MHPs)have demonstrated excellent performances in detection of X-rays and gamma-rays.Most studies focus on improving the sensitivity of single-pixel MHP detectors.However,little work pays attention to the dark current,which is crucial for the back-end circuit integration.Herein,the requirement of dark current is quantitatively evaluated as low as 10^(−9)A/cm^(2)for X-ray imagers integrated on pixel circuits.Moreover,through the semiconductor device analysis and simulation,we reveal that the main current compositions of thick perovskite X-ray detectors are the thermionic-emission current(J_(T))and the generation-recombination current(J_(g-r)).The typical observed failures of p-n junctions in thick detectors are caused by the high generation-recombination current due to the band mismatch and interface defects.This work provides a deep insight into the design of high sensitivity and low dark current perovskite X-ray detectors. | Shan Zhao Xinyuan Du Jincong Pang Haodi Wu Zihao Song Zhiping Zheng Ling Xu Jiang Tang Guangda Niu | 2022 | Frontiers of Optoelectronics2022，15，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员