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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Characteristics of gas-solid micro fluidized beds for thermochemical reaction analysis显示文摘Fuel conversion and clean energy reaction systems involve a variety of catalytic and non-catalytic gas-solid thermochemical reactions.A good understanding of the correct reaction mechanism and kinetics,as well as the profiles of reaction products,is of great significance to the development,design,and operation of such reaction systems.The micro fluidized bed reaction analysis provides an efficient and reliable method to acquire this essential information with low capital and operating costs,low energy consumption and enhanced safety.This paper provides an overview of the system and its characteristics for the micro fluidized bed reaction analyzer that has been well proven to be a reliable new approach as well as an instrument for characterizing various gas-solid thermochemical reactions. | Zhennan Han Junrong Yue Xi Zeng Jian Yu Fang Wang Shaozeng Sun Hong Yao Guangqian Luo Xuejing Liu Yining Sun Fu Ding Liangliang Fu Lei Shi Kangjun Wang Jiebin Yang Shaonan Wang Xueqing Chen Dingrong Bai Guangwen Xu | 2020 | Carbon Resources Conversion2020，3，1： | 6 |
| 3 | Small GTPases:Structure,biological function and its interaction with nanoparticles显示文摘Small GTPase is a kind of GTP-binding protein commonly found in eukaryotic cells.It plays an important role in cytoskeletal reorganization,cell polarity,cell cycle progression,gene expression and many other significant events in cells,such as the interaction with foreign particles.Therefore,it is of great scientific significance to understand the biological properties of small GTPases as well as the GTPase-nano interplay,since more and more nanomedicine are supposed to be used in biomedical field.However,there is no review in this aspect.This review summarizes the small GTPases in terms of the structure,biological function and its interaction with nanoparticles.We briefly introduced the various nanoparticles such as gold/silver nanoparticles,SWCNT,polymeric micelles and other nano delivery systems that interacted with different GTPases.These current nanoparticles exhibited different pharmacological effect modes and various target design concepts in the small GTPases study.This will help to elucidate the conclusion that the therapeutic strategy targeting small GTPases might be a new research direction.It is believed that the in-depth study on the functional mechanism of GTPases can provide insights for the design and study of nanomedicines. | Siyang Song Wenshu Cong Shurong Zhou Yujie Shi Wenbing Dai Hua Zhang Xueqing Wang Bing He Qiang Zhang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 3 |
| 4 | The develop-ment of site-specific drug delivery nanocarriers based onreceptor mediation显示文摘 | Wang Xueqing Li Suxin Shi Yujie | 2014 | J Control Release2014，193，： | 1 |
| 5 | Accumulation of tissue advanced glycation end products correlated with glucose exposure dose and associated with cardiovascular morbidity in patients on peritoneal dialysis显示文摘 | Jianping Jiang Pingyan Chen Jianghua Chen Xueqing Yu Di Xie Changlin Mei Fei Xiong Wei Shi Wei Zhou Xusheng Liu Shiren Sun Ping Zhang Xiao Yang Yixiang Zhang Yanmin Zhang Xinling Liang Zhimin Zhang Qizhan Lin Yan Yu Toshio Miyata Jianwei Tian Min Liang We | 2012 | Atherosclerosis2012，，1： | 1 |
| 6 | Lead‑Carbon Batteries toward Future Energy Storage:From Mechanism and Materials to Applications显示文摘The lead acid battery has been a dominant device in large-scale energy storage systems since its invention in 1859.It has been the most successful commercialized aqueous electrochemical energy storage system ever since.In addition,this type of battery has witnessed the emergence and development of modern electricity-powered society.Nevertheless,lead acid batteries have technologically evolved since their invention.Over the past two decades,engineers and scientists have been exploring the applications of lead acid batteries in emerging devices such as hybrid electric vehicles and renewable energy storage;these applications necessitate operation under partial state of charge.Considerable endeavors have been devoted to the development of advanced carbon-enhanced lead acid battery(i.e.,lead-carbon battery)technologies.Achievements have been made in developing advanced lead-carbon negative electrodes.Additionally,there has been significant progress in developing commercially available lead-carbon battery products.Therefore,exploring a durable,long-life,corrosion-resistive lead dioxide positive electrode is of significance.In this review,the possible design strategies for advanced maintenance-free lead-carbon batteries and new rechargeable battery configurations based on lead acid battery technology are critically reviewed.Moreover,a synopsis of the lead-carbon battery is provided from the mechanism,additive manufacturing,electrode fabrication,and full cell evaluation to practical applications. | Jian Yin Haibo Lin Jun Shi Zheqi Lin Jinpeng Bao Yue Wang Xuliang Lin Yanlin Qin Xueqing Qiu Wenli Zhang | 2022 | Electrochemical Energy Reviews2022，5，3： | 1 |
| 7 | A Low Power, Fully Integrated SiGe BiCMOS Baseband Circuitry for a Direct Conversion CMMB Tuner IC显示文摘 | GONG Zheng CHEN Bei HU Xueqing SHI Yin Fa Foster Dai | 2012 | Chinese Journal of Electronics2012，21，2： | 1 |
| 8 | Biotoxicity dynamic change and key toxic organics identification of coal chemical wastewater along a novel full-scale treatment process显示文摘It is particularly important to comprehensively assess the biotoxicity variation of industrial wastewater along the treatment process for ensuring the water environment security.However,intensive studies on the biotoxicity reduction of industrial wastewater are still limited.In this study,the toxic organics removal and biotoxicity reduction of coal chemical wastewater(CCW)along a novel full-scale treatment process based on the pretreatment process-anaerobic process-biological enhanced(BE)process-anoxic/oxic(A/O)process-advanced treatment process was evaluated.This process performed great removal efficiency of COD,total phenol,NH_(4)^(+)-N and total nitrogen.And the biotoxicity variation along the treatment units was analyzed from the perspective of acute biotoxicity,genotixicity and oxidative damage.The results indicated that the effluent of pretreatment process presented relatively high acute biotoxicity to Tetrahymena thermophila.But the acute biotoxicity was significantly reduced in BE-A/O process.And the genotoxicity and oxidative damage to Tetrahymena thermophila were significantly decreased after advanced treatment.The polar organics in CCW were identified as the main biotoxicity contributors.Phenols were positively correlated with acute biotoxicity,while the nitrogenous heterocyclic compounds and polycyclic aromatic hydrocarbons were positively correlated with genotoxicity.Although the biotoxicity was effectively reduced in the novel full-scale treatment process,the effluent still performed potential biotoxicity,which need to be further explored in order to reduce environmental risk. | Weiwei Ma Xiaoqi Zhang Hongjun Han Xueqing Shi Qiaoping Kong Tong Yu Fei Zhao | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 9 | Analysis and Economic Evaluation of Hourly Operation Strategy Based on MSW Classification and LNG Multi-Generation System显示文摘In this study,a model of combined cooling,heating and power system with municipal solid waste(MSW)and liquefied natural gas(LNG)as energy sources was proposed and developed based on the energy demand of a large community,andMSW was classified and utilized.The systemoperated by determining power by heating load,and measures were taken to reduce operating costs by purchasing and selling LNG,natural gas(NG),cooling,heating,and power.Based on this system model,three operation strategies were proposed based on whether MSW was classified and the length of kitchen waste fermentation time,and each strategy was simulated hourly throughout the year.The results showed that the strategy of MSW classified and centralized fermentation of kitchen waste in summer(i.e.,strategy 3)required the least total amount of LNG for the whole year,which was 47701.77 t.In terms of total annual cost expenditure,strategy 3 had the best overall economy,with the lowest total annual expenditure of 2.7730×108 RMB at LNG and NG unit prices of 4 and 4.2 RMB/kg,respectively.The lower heating value of biogas produced by fermentation of kitchen waste from MSW being classified was higher than that of MSW before being classified,so the average annual thermal economy of the operating strategy of MSW being classified was better than that of MSW not being classified.Among the strategies in which MSW was classified and utilized,strategy 3 could better meet the load demand of users in the corresponding season,and thus this strategy had better thermal economy than the strategy of year-round fermentation of kitchen waste(i.e.,strategy 2).The hourly analysis data showed that the net electrical efficiency of the system varies in the same trend as the cooling,heating and power loads in all seasons,while the relationship between the energy utilization efficiency and load varied from season to season.This study can provide guidance for the practical application of MSW being classified in the system. | Xueqing Lu Yuetao Shi Jinsong Li | 2023 | Energy Engineering2023，120，6： | 0 |
| 10 | High-quality genome assembly and pan-genome studies facilitate genetic discovery in mung bean and its improvement显示文摘Mung bean is an economically important legume crop species that is used as a food,consumed as a vegetable,and used as an ingredient and even as a medicine.To explore the genomic diversity of mung bean,we assembled a high-quality reference genome(Vrad_JL7)that was479.35 Mb in size,with a contig N50 length of 10.34 Mb.A total of 40,125 protein-coding genes were annotated,representing96.9%of the genetic region.We also sequenced 217 accessions,mainly landraces and cultivars from China,and identified 2,229,343 high-quality single-nucleotide polymorphisms(SNPs).Population structure revealed that the Chinese accessions diverged into two groups and were distinct from non-Chinese lines.Genetic diversity analysis based on genomic data from 750 accessions in 23 countries supported the hypothesis that mung bean was first domesticated in south Asia and introduced to east Asia probably through the Silk Road.We constructed the first pan-genome of mung bean germplasm and assembled 287.73 Mb of non-reference sequences.Among the genes,83.1%were core genes and 16.9%were variable.Presence/absence variation(PAV)events of nine genes involved in the regulation of the photoperiodic flowering pathway were identified as being under selection during the adaptation process to promote early flowering in the spring.Genomewide association studies(GWASs)revealed 2,912 SNPs and 259 gene PAV events associated with 33 agronomic traits,including a SNP in the coding region of the SWEET10 homolog(jg24043)involved in crude starch content and a PAV event in a large fragment containing 11 genes for color-related traits.This high-quality reference genome and pan-genome will provide insights into mung bean breeding. | Changyou Liu Yan Wang Jianxiang Peng Baojie Fan Dongxu Xu Jing Wu Zhimin Cao Yunqing Gao Xueqing Wang Shutong Li Qiuzhu Su Zhixiao Zhang Shen Wang Xingbo Wu Qibing Shang Huiying Shi Yingchao Shen Bingbing Wang Jing Tian | 2022 | Plant Communications2022，3，6： | 0 |
| 11 | The Trend of Scientific and Refinement of Financial Management in Business Units显示文摘In the new era,financial management has become increasingly sophisticated and has had a significant impact and change on various industries and fields.This paper analyzes the key significance of performance appraisal in institutions and proposes ways to enhance performance appraisal innovation,which will prevail in financial management innovation in institutions and upgrade the value of its applications. | Zijun Shi Peng Yu Lin Lv Xueqing Liu Xiumao Li | 2022 | Journal of Economic Science Research2022，5，4： | 0 |
| 12 | Correction of a CADASIL point mutation using adenine base editors in hiPsCsandbloodvessel organoids显示文摘Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small vessel disease caused by mutations in the NOTCH3 gene. However, the pathogenesis of CADASIL remains unclear, and patients have limited treatment options. Here, we use human induced pluripotent stem cells (hiPSCs) generated from the peripheral blood mononuclear cells of a patient with CADASIL carrying a heterozygous NOTCH3 mutation (c.1261C>T, p.R421C) to develop a disease model. The correction efficiency of different adenine base editors (ABEs) is tested using the HEK293T-NOTCH3 reporter cell line. ABEmax is selected based on its higher efficiency and minimization of predicted off-target effects. Vascular smooth muscle cells (VSMCs) differentiated from CADASIL hiPSCs show NOTCH3 deposition and abnormal actin cytoskeleton structure, and the abnormalities are recovered in corrected hiPSC-derived VSMCs. Furthermore, CADASIL blood vessel organoids generated for in vivo modeling show altered expression of genes related to disease phenotypes, including the downregulation of cell adhesion, extracellular matrix organization, and vessel development. The dual adeno-associated virus (AAV) split-ABEmax system is applied to the genome editing of vascular organoids with an average editing efficiency of 8.82%. Collectively, we present potential genetic therapeutic strategies for patients with CADASIL using blood vessel organoids and the dual AAV split-ABEmax system. | Jingwen Wang Lei Zhang Guanglan Wu Jinni Wu Xinyao Zhou Xiaolin Chen Yongxia Niu Yiren Jiao Qianyi Liu Puping Liang Guang Shi Xueqing Wu Junjiu Huang | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
| 13 | Construction of the panoptosis-related gene model and characterization of tumor microenvironment infiltration in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common fatal cancer worldwide,patients with HCC have a high mortality rate and poor prognosis.PANoptosis is a novel discovery of programmed cell death associated with cancer development.However,the role of PANoptosis in HCC remains obscure.In this study,we enrolled 274 PANoptosisrelated genes(PANRGs)and screened 8 genes to set up a prognostic model.A previous scoring system calculated PANscore was utilized to quantify the individual risk level of each HCC patient,and the reliability of the prognostic model has been validated in an external cohort.Nomogram constructed with PANscore and clinical characteristics were used to optimize individualized treatment for each patient.Single-cell analysis revealed a PANoptosis model associated with tumor immune cell infiltration,particularly natural killer(NK)cells.Further exploration of hub genes and assessment of the prognostic role of these 4 hub genes in HCC by quantitative real-time PCR(qRT-PCR)and immunohistochemistry(IHC).In conclusion,we evaluated a PANoptosis-based prognostic model as a potential prognostic biomarker for HCC patients. | XINRUI SHI XIA GAO WENCONG LIU XUEJIAO TANG JIAYI LIU DONGCHEN PAN XUEQING DUAN YUQING JIN WEIYAN REN LEI YANG WENXUAN LIU | 2023 | Oncology Research2023，31，4： | 0 |
| 14 | Overview of enhancing biological treatment of coal chemical wastewater:New strategies and future directions显示文摘Coal chemical wastewater(CCW)is a type of refractory industrial wastewater,and its treatment has become the main bottleneck restricting the sustainable development of novel coal chemical industry.Biological treatment is considered as an economical,effective and environmentally friendly technology for CCW treatment.However,conventional biological process is difficult to achieve the efficient removal of refractory organics because of CCW with the characteristics of composition complexity and high toxicity.Therefore,seeking the novel enhancement strategy appears to be a favorable solution for enhancing biological treatment efficiency of CCW.This review focuses on presenting a comprehensive picture about the exogenous enhancement strategies for CCW biological treatment.The performance and potential application of exogenous enhancement strategies,including co-metabolic substrate enhancement,biofilm filler enhancement,adsorption material enhancement and conductive mediator enhancement,were expounded.Meanwhile,the enhancing mechanisms of different strategies were comprehensively discussed from a biological perspective.Furthermore,the prospects of enhancement strategies based on the engineering performance,economic cost and environmental impact(3E)evaluation were introduced.And novel enhancement strategy based on“low carbon emissions”,“resource recycling”and“water environment security”in the context of carbon neutrality was proposed.Taken together,this review provides technical reference and new direction to facilitate the regulation and optimization of typical industrial wastewater biological treatment. | Weiwei Ma Xiaoqi Zhang Hongjun Han Xueqing Shi Qiaoping Kong Tong Yu Fei Zhao | 2024 | Journal of Environmental Sciences2024，，1： | 0 |
| 15 | Natural variations of OsAUX5,a target gene of OsWRKY78,control the neutral essential amino acid content in rice grains显示文摘Grain essential amino acid(EAA)levels contribute to rice nutritional quality.However,the molecular mechanisms underlying EAA accumulation and natural variation in rice grains remain unclear.Here we report the identification of a previously unrecognized auxin influx carrier subfamily gene,OsAUX5,which encodes an amino acid transporter that functions in uptake of multiple amino acids.We identified an elite haplotype of Pro::OsAUX5^(Hap2) that enhances grain EAA accumulation without an apparent negative effect on agronomic traits.Natural variations of OsAUX5 occur in the cis elements of its promoter,which are differentially activated because of the different binding affinity between OsWRKY78 and the W-box,contributing to grain EAA variation among rice varieties.The two distinct haplotypes were shown to have originated from different Oryza rufipogon progenitors,which contributed to the divergence between japonica and indica.Introduction of the indica-type Pro::OsAUX5^(Hap2) genotype into japonica could significantly increase EAA levels,indicating that indica-type Pro::OsAUX5^(Hap2) can be utilized to increase grain EAAs of japonica varieties.Collectively,our study uncovers an WRKY78–OsAUX5-based regulatory mechanism controlling grain EAA accumulation and provides a potential target for breeding EAA-rich rice. | Yuheng Shi Yuanyuan Zhang Yangyang Sun Ziyang Xie Yu Luo Qiyuan Long Jiahui Feng Xueqing Liu Bi Wang Dujun He Junxia Ren Peizhen Guo Junwei Xing Liqiang He Alisdair RFernie Wei Chen Xianqing Liu Yuehua Luo Cheng Jin Jie Luo | 2023 | Molecular Plant2023，16，2： | 0 |
| 16 | Accelerate Fiscal Transformation, Actively Give Full Play to the Role of Financial Platforms显示文摘The 20th report puts forward more scientific and precise guidance for economic development,and makes a scientific direction for economic work at the overall height of the country.In recent years,with the rapid development of China’s economy and society,the financial situation has also changed to a large extent.Financial work is an important support for the current government work,and the quality of financial work is directly related to the harmony and stability of the whole society.Based on this,under the new situation,we will continue to deepen the research on financial transformation,fully stimulate the function of finance,let the financial platform play its function,and effectively provide a persistent guarantee for social and economic development. | Peng Yu Zijun Shi Lin Lv Xueqing Liu Xiumao Li | 2022 | Journal of Finance Research2022，6，2： | 0 |
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