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| 1 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 2 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 3 | Soluble CD40 ligand is associated with angiographic severity of coronary artery disease in patients with acute coronary syndrome显示文摘 | Zhao Wei | 2014 | Chinese Medical Journal2014，，12： | 11 |
| 4 | Generation of graphene-based aerogel microspheres for broadband and tunable high-performance microwave absorption by electrospinning-freeze drying process显示文摘 | Fanbin Meng Huagao Wang Wei Zijian Chen Tian Li Chunyuan Li Yu Xuan Zuowan Zhou | 2018 | Nano Research2018，11，5： | 9 |
| 5 | Site-Specifc Gene Targeting Using Transcription Activator-Like Effector(TALE)-Based Nuclease in Brassica oleracea显示文摘Site-specifc recognition modules with DNA nuclease have tremendous potential as molecular tools for genome targeting.The type III transcription activator-like effectors(TALEs)contain a DNA binding domain consisting of tandem repeats that can be engineered to bind user-defned specifc DNA sequences.We demonstrated that customized TALE-based nucleases(TALENs),constructed using a method called'unit assembly',specifcally target the endogenous FRIGIDA gene in Brassica oleracea L.var.capitata L.The results indicate that the TALENs bound to the target site and cleaved double-strand DNA in vitro and in vivo,whereas the effector binding elements have a 23 bp spacer.The T7 endonuclease I assay and sequencing data show that TALENs made double-strand breaks,which were repaired by a non-homologous end-joining pathway within the target sequence.These data show the feasibility of applying customized TALENs to target and modify the genome with deletions in those organisms that are still in lacking gene target methods to provide germplasms in breeding improvement. | Zijian Sun Nianzu Li Guodong Huang Junqiang Xu Yu Pan Zhimin Wang Qinglin Tang Ming Song Xiaojia Wang | 2013 | Journal of Integrative Plant Biology2013，55，11： | 3 |
| 6 | microRNA-18a Promotes Cell Migration and Invasion Through Inhibiting Dicer l Expression in Hepatocellular Carcinoma In Vitro显示文摘Objective To investigate the effects of microRNA-18a(miR-18a) on migration and invasion of hepatocellular carcinoma(HCC) cells,and its possible mechanism associated with Dicer l. Methods HepG 2 and HepG 2.2.15 cells were transfected with miR-18 a inhibitor using Lipofectamine. Cell invasion was evaluated by transwell invasion assay,and cell migration was detected by transwell migration and wound-healing assays. Moreover,luciferase reporter assay was used to identify whether Dicer expression was regulated by miR-18 a. Real-time RT-PCR and western blot were performed to analyze Dicer 1 expression. In addition,a functional restoration assay was performed to investigate whether miR-18 a promotes HCC cell migration and invasion by directly targeting Dicer 1. Results miR-18 a inhibitor can suppress the migration and invasion of HCC cells. Furthermore,suppression of Dicer l expression by small interfering RNA essentially abolished the inhibition of cell migration and invasion induced by miR-18 a inhibitor,restorating these activities to levels similar to the parental HCC cells. Interestingly,suppression of miR-18 a in HCC cells resulted in enhanced expression of Dicer l. In addition,the results of a luciferase assay demonstrated targeted regulation of Dicer l by miR-18 a. Conclusion Our findings suggest that miR-18 a promotes migration and invasion of HCC cells by inhibiting Dicer l expression. | Xiufen Zhang Bo Yu Fuzheng Zhang Zijian Guo Lihua Li | 2017 | Chinese Medical Sciences Journal2017，32，1： | 3 |
| 7 | A Two-Level Cross-Sectional Optimization Approach for Automotive Body Concept Design显示文摘Concept design is vital important in development of auto-body and it has great effects on later design work.In this paper,a twolevel cross-sectional optimization approach is presented to shorten concept design cycles.First,an exact structural analysis approach for spatial semi-rigid framed structures,i.e.,the transfer stiffness matrix method proposed in our previous study,is adopted for both static and dynamic analyses of body-in-white(BIW)structure.A two-level cross-sectional optimization approach is then proposed for an automotive BIW lightweight design,and genetic algorithm is used to solve the optimization models.Afterward,an object-oriented MATLAB toolbox,using distributed parallel computing techniques,is developed to promote the concept design of the BIW structure.Finally,relevant numerical examples demonstrate the validity and accuracy of the proposed method. | Huan Qin Zijian Liu Yu Liu Haolong Zhong | 2018 | Automotive Innovation2018，1，2： | 3 |
| 8 | Detection and Initial Response to a Type 2 Vaccine-Derived Poliovirus—Sichuan Province,China,2019显示文摘What is already known about this topic?After the type 2 strain of the live,attenuated poliovirus vaccine was withdrawn globally in 2016,any identification of a type 2 poliovirus is a Public Health Emergency of International Concern.A vaccinederived type 2 poliovirus(VDPV2)was identified in Sichuan,prompting an urgent,comprehensive investigation and response.What is added by this report?Type 2 monovalent,live,attenuated oral poliovirus vaccine(mOPV2)is being used to respond to the numerous VDPV2 outbreaks seen around the world.In contrast,the response in Sichuan used Sabin strain inactivated poliovirus(sIPV)to stop circulation of the VDPV2.In the 6 months following the vaccination response,there have been no VDPV2s detected in Sichuan,despite extensive search.What are the implications for public health practices?Further search for the VDPV2 must continue in order to determine whether transmission has been stopped.The ongoing investigation and response to the Sichuan VDPV2 is providing evidence to the Global Polio Eradication Initiative on managing VDPV2 outbreaks. | Jiushun Zhou Ning Wen Yong Zhang Qi Qi Chunxiang Fan Dongmei Yan Xiaoping Zhu Lixin Hao Shuangli Zhu Yu Liu Xiaozhen Ma Chao Ma Lei Nan Yong Chen Qianli Ma Cheng Wang Kun Deng Lei Cao Ge Shao Xianxiang Ding Hong Yang Zhijie An Lance ERodewald Aiqiang Xu Huaqing Wang Zijian Feng Zundong Yin Xianping Wu Wenbo Xu | 2020 | China CDC weekly2020，2，11： | 3 |
| 9 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 10 | Active Vaccine Safety Surveillance: Global Trends and Challenges in China显示文摘Importance.The great success in vaccine-preventable diseases has been accompanied by vaccine safety concerns.This has caused vaccine hesitancy to be the top 10 in threats to global health.The comprehensive understanding of adverse events following immunization should be entirely based on clinical trials and postapproval surveillance.It has increasingly been recognized worldwide that the active surveillance of vaccine safety should be an essential part of immunization programs due to its complementary advantages to passive surveillance and clinical trials.Highlights.In the present study,the framework of vaccine safety surveillance was summarized to illustrate the importance of active surveillance and address vaccine hesitancy or safety concerns.Then,the global progress of active surveillance systems was reviewed,mainly focusing on population-based or hospital-based active surveillance.With these successful paradigms,the practical and reliable ways to create robust and similar systems in China were discussed and presented from the perspective of available databases,methodology challenges,policy supports,and ethical considerations.Conclusion.In the inevitable trend of the global vaccine safety ecosystem,the establishment of an active surveillance system for vaccine safety in China is urgent and feasible.This process can be accelerated with the consensus and cooperation of regulatory departments,research institutions,and data owners. | Zhike Liu Ruogu Meng Yu Yang Keli Li Zundong Yin Jingtian Ren Chuanyong Shen Zijian Feng Siyan Zhan | 2021 | Health Data Science2021，，1： | 2 |
| 11 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 12 | High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells显示文摘在导致的 pluripotent 干细胞(iPSCs ) 积累的反常 epigenetic 修正是否能最终影响 iPSC pluripotency,仍然保持争论。为了探查这个问题,有一样的基因背景的 iPSC 线和 proviral 集成地点,被建立,并且每根 iPSC 线的 pluripotency 状态用 tetraploid (4N ) 被描绘互补试金。随后,基因表示和 “ 的全球 epigenetic 修正; 4N-ON ”并且相应 “ 4N-OFF ”iPSC 线通过深定序 mRNA 表示,小 RNA 侧面, histone 修正(H3K27me3, H3K4me3,和 H3K4me2 ) ,和 DNA methylation 的分析被比较。我们发现了印的基因的那 methylation, Zrsr1,一致地与减少的 pluripotency 在 iPSC 线被破坏。而且,破坏 methylation 不能被改进文化条件或 iPSCs 的 subcloning 救。而且,在 iPSCs 的 Zrsr1 和 pluripotency 状态的 hypomethylation 之间的关系进一步在线从另外的 reprogramming 系统导出的独立 iPSC 被验证。 | Gang Chang Shuai Gao Xinfeng Hou Zijian Xu Yanfeng Liu Lan Kang Yu Tao Wenqiang Liu Bo Huang Xiaochen Kou Jiayu Chen Lei An Kai Miao Keqian Di Zhilong Wang Kun Tan Tao Cheng Tao Cai Shaorong Gao Jianhui Tian | 2014 | Cell Research2014，24，3： | 2 |
| 13 | Vacuum-free fabrication of high-performance semitransparent perovskite solar cells via e-glue assisted lamination process显示文摘From a base material of conductive polymer(poly-(3,4-ethylenedioxythiophene):poly(styrenesulfonate),PEDOT:PSS),a flexible and high-conductivity(as low as 45Ω/sq)transparent electrode was fabricated on polydimethylsiloxane elastomer by an acid treatment and transfer process.Combined with the D-sorbitol-doped PEDOT:PSS electric glue,we successfully demonstrated a vacuum-free and ambient lamination fabrication process for semi-transparent perovskite solar cells using triple cation Cs0.05(MA0.17FA0.83)0.95Pb(I0.83Br0.17)3perovskite.By this manufacturing-friendly lamination process,we fabricated semitransparent perovskite solar cell devices with power conversion efficiencies up to 16.4%and variable transparencies. | Hengkai Zhang Yaokang Zhang Guang Yang Zhiwei Ren Wei Yu Dong Shen Chun-Shing Lee Zijian Zheng Gang Li | 2019 | Science China Chemistry2019，62，7： | 2 |
| 14 | Role of Heavy Metal Ions in the Formation of Oxyfluoride Glasses and Glass Ceramics显示文摘In order to investigate the influence of different heavy metal ions on the formation of the oxyfluoride glasses and glass ceramics, samples with different Pb F2/Cd F2 ratios have been prepared by the melting quenching and thermal treatment method. The different effects of Pb2 tand Cd2ton the glass network structure are investigated by FTIR and Raman spectra. During the formation of glass network structure, Pb2 tprefers to break the Sie Oe Si bond and subsequently bond to F for charge compensation, and Cd2 tprefers to break the SieO eA l bond and is surrounded by O2. Pb2 tand F gather together and form the fluoride nanocrystals,while Cd2 tremains in oxide matrix after thermal treatment. Introduction of proper Cd F2 is important to adjust and control the glass network structure and crystallization process in the fabrication of the transparent glass ceramics. | Min Liu Lijuan Zhao Yan Liu Zijian Lan Lifen Chang Yiming Li Hua Yu | 2014 | Journal of Materials Science & Technology2014，30，12： | 2 |
| 15 | Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis显示文摘Photodynamic Therapy(PDT)holds a great promise for cancer patients,however,due to the hypoxic characteristics of most solid tumors and the limited penetration depth of light in tissues,the extensive clinical application of PDT is limited.Herein,we report microwave induced copper-cysteamine(Cu-Cy)nanoparticles-based PDT as a promising cancer treatment to overcome cancer resistance in combination with ferroptosis.The treatment efficiency of Cu-Cy-mediated microwave dynamic therapy(MWDT)tested on HCT15 colorectal cancer(CRC)cells via cell titer-blue cell viability assay and live/dead assay reveal that Cu-Cy upon MW irradiation can effectively destroy HCT15 CRC cells with average IC-50 values of 20μg/mL.The cytotoxicity of Cu-Cy to tumor cells after MW stimulation can be alleviated by ferroptosis inhibitor.Furthermore,Cu-Cy mediated MWDT could deplete glutathione peroxide 4(GPX4)and enhance lipid peroxides(LPO)and malondialdehyde(MDA).Our findings demonstrate that MW-activated Cu-Cy killed CRC cells by inducing ferroptosis.The superior in vivo antitumor efficacy of the Cu-Cy was corroborated by a HCT15 tumor-bearing mice model.Immunohistochemical experiments showed that the GPX4 expression level in Cu-Cy+MW group was significantly lower than that in other groups.Overall,these findings demonstrate that Cu-Cy nanoparticles have a safe and promising clinical application prospect in MWDT for deep-seated tumors and effectively inhibit tumor cell proliferation by inducing ferroptosis,which provides a potential solution for cancer resistance. | Hui Zhou Zhongtao Liu Zijian Zhang Nil Kanatha Pandey Eric Amador William Nguyen Lalit Chudal Li Xiong Wei Chen Yu Wen | 2023 | Bioactive Materials2023，，6： | 1 |
| 16 | Recent progress in perovskite solar cells:from device to commercialization显示文摘Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization recently.In this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and industrialization.Last,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future. | Xinhui Luo Xuesong Lin Feng Gao Yang Zhao Xiaodong Li Liqing Zhan Zexiong Qiu Jin Wang Cong Chen Lei Meng Xiaofeng Gao Yu Zhang Zijian Huang Rundong Fan Huifen Liu Yanrun Chen Xiaoxue Ren Jiahong Tang Chun-Hao Chen Dong Yang Yongguang Tu Xiao Liu Dongxue Liu Qing Zhao Jingbi You Junfeng Fang Yongzhen Wu Hongwei Han Xiaodan Zhang Dewei Zhao Fuzhi Huang Huanping Zhou Yongbo Yuan Qi Chen Zhaokui Wang Shengzhong(Frank)Liu Rui Zhu Jotaro Nakazaki Yongfang Li Liyuan Han | 2022 | Science China Chemistry2022，65，12： | 1 |
| 17 | SPAC to improve port performance for seaports with very long one-way entrance channels显示文摘 | TANG Guolei GUO Zijian YU Xuhui | 2014 | Journal of Waterway Port Coastal and Ocean Engineering2014，140，04： | 1 |
| 18 | Human Influenza A (HSN1) Cases, Urban Areas of People's Republic of China, 2005-2006 显示文摘 | Yu Hongjie Feng Zijian Zhang Xianfeng | 2007 | Emerg Infect Dis2007，7，： | 1 |
| 19 | Hand, Foot, and Mouth Disease in China Patterns of Spread and Transmissibility显示文摘 | Yu Wang Zijian Feng Yang Yang | 2011 | Epidemiology2011，22，6： | 1 |
| 20 | Precipitate characteristics and their effects on the mechanical properties of as-extruded Mg-Gd-Li-Y-Zn alloy显示文摘In this work,a high-performance Mg-8.4 Gd-4.4 Li-3.5 Y-1.4 Zn(wt%)alloy was successfully prepared by low-temperature hot extrusion.The studied alloy has a TYS of 295±1 MPa and an EL of 2.5%±0.2%at room temperature,159±8 MPa and 15.9%±1.4%at 150℃,and 143±4 MPa and 19.8%±1.8%at200℃.The high performance at tempe ratures up to 200°is attributed to the dispersion strengthening of three Mg3 RE phase variants,the solid solution strengthening of alloying elements and the bimodal structure consisting of fine DRXed grains with random texture and coarse un-DRXed grains with basal texture.A novel island shapedβ_(1 R)phase(FCC,a=0.78 nm)with a size of 30 nm-100 nm is observed in the studied alloy.Theβ_(1 R)phase precipitates on the{1100}_(α)prismatic planes.The strain-induced,dislocationassisted dynamic precipitation during low-temperature hot extrusion is responsible for the formation of theβ_(1 R)phase.The growth of theβ_(1 R)phase is owing to the aid of the formation and transformation of zig-zag structures.The basal slip of dislocations is the dominate deformation mechanism of the studied alloy in the early stage of tensile deformation at room temperature,while non-basal slip of and dislocations at 200℃.Due to the strong interaction betweenβ_(1 R)precipitates and dislocations,the densely distributedβ_(1 R)precipitates significantly improve the mechanical properties via the Orowan strengthening both at room temperature and elevated temperatures. | Zijian Yu Xi Xu Adil Mansoor Baotian Du Kang Shi Ke Liu Shubo Li Wenbo Du | 2021 | Journal of Materials Science & Technology2021，，29： | 1 |
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