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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens,a natural waste recycler显示文摘The black soldier fly(BSF),Hermetia illucens(Diptera:Stratiomyidae),is renowned for its bioconversion of organic waste into a sustainable source of animal feed.We report a high-quality genome of 1.1 Gb and a consensus set of 16,770 gene models for this beneficial species.Compared to those of other dipteran species,the BSF genome has undergone a substantial expansion in functional modules related to septic adaptation,including immune system factors,olfactory receptors,and cytochrome P450s.We further profiled midgut transcriptomes and associated microbiomes of BSF larvae fed with representative types of organic waste.We find that the pathways related to digestive system and fighting infection are commonly enriched and that Firmicutes bacteria dominate the microbial community in BSF across all diets.To extend its potential practical applications,we further developed an efficient CRISPR/Cas9-based gene editing approach and implemented this to yield flightless and enhanced feeding capacity phenotypes,both of which could expand BSF production capabilities.Our study provides valuable genomic and technical resources for optimizing BSF lines for industrialization. | Shuai Zhan Gangqi Fang Minmin Cai Zongqing Kou Jun Xu Yanghui Cao Liang Bai Yixiang Zhang Yongmao Jiang Xingyu Luo Jian Xu Xia Xu Longyu Zheng Ziniu Yu Hong Yang Zhijian Zhang Sibao Wang Jeffery K.Tomberlin Jibin Zhang Yongping Huang | 2020 | Cell Research2020，30，1： | 9 |
| 3 | High-throughput metagenomic analysis of petroleum-contaminated soil microbiome reveals the versatility in xenobiotic aromatics metabolism显示文摘The soil with petroleum contamination is one of the most studied soil ecosystems due to its rich microorganisms for hydrocarbon degradation and broad applications in bioremediation.However, our understanding of the genomic properties and functional traits of the soil microbiome is limited. In this study, we used high-throughput metagenomic sequencing to comprehensively study the microbial community from petroleum-contaminated soils near Tianjin Dagang oilfield in eastern China. The analysis reveals that the soil metagenome is characterized by high level of community diversity and metabolic versatility. The metageome community is predominated by γ-Proteobacteria and α-Proteobacteria, which are key players for petroleum hydrocarbon degradation. The functional study demonstrates over-represented enzyme groups and pathways involved in degradation of a broad set of xenobiotic aromatic compounds, including toluene, xylene, chlorobenzoate, aminobenzoate, DDT, methylnaphthalene, and bisphenol. A composite metabolic network is proposed for the identified pathways, thus consolidating our identification of the pathways. The overall data demonstrated the great potential of the studied soil microbiome in the xenobiotic aromatics degradation. The results not only establish a rich reservoir for novel enzyme discovery but also provide putative applications in bioremediation. | Yun-Juan Bao Zixiang Xu Yang Li Zhi Yao Jibin Sun Hui Song | 2017 | Journal of Environmental Sciences2017，29，6： | 5 |
| 4 | Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1显示文摘Background:Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion processes.Recently,abnormally increased mitochondrial fission has been observed in several types of can-cer.However,the functional roles of increased mitochondrial fission in lipid metabolism reprogramming in cancer cells remain unclear.This study aimed to explore the role of increased mitochondrial fission in lipid metabolism in hepa-tocellular carcinoma(HCC)cells.Methods:Lipid metabolism was determined by evaluating the changes in the expressions of core lipid metabolic enzymes and intracellular lipid content.The rate of fatty acid oxidation was evaluated by[PH]-labelled oleic acid.The mito-chondrial morphology in HCC cells was evaluated by fluorescent staining.The expression of protein was determined by real-time PCR,imnmunohistochemistry and Western blotting.Results:Activation of mitochondrial fission significantly promoted de novo fatty acid synthesis in HCC cells through upregulating the expression of lipogenic genes fatty acid synthase(FASN),acetyl-CoA carboxylasel(ACCI),and elonga-tion of very long chain fatty acid protein 6(ELOVL6),while suppressed fatty acid oxidation by downregulating carnitine palmitoyl transferase 1A(CPTIA)and acyl-CoA oxidase 1(ACOX1).Consistently,suppressed mitochondrial fission exhibited the opposite effects.Moreover,in vitro and in vivo studies revealed that mitochondrial fission-induced lipid metabolism reprogramming significantly promoted the proliferation and metastasis of HCC cells.Mechanistically,mito-chondrial fission increased the acetylation level of sterol regulatory element-binding protein 1(SREBPI)and peroxisome proliferator-activated receptor coaC-tivator 1 alpha(PGC-1a)by suppressing nicotinamide adenine dinucleotide(NAD+)/Sirtuin 1(SIRTI)signaling.The elevated SREBP1 then upregulated the expression of FASN,ACC1 and ELOVL6 in HCC cells,while PGC-1c/PPARa sup-pressed the expression of CPTIA and ACOXL Conclusions:Increased mitochondrial fission plays a crucial role in the repro-gramming of lipid metabolism in HCC cells,which provides strong evidence for the use of this process as a drug target in the treatment of this malignancy. | Dan Wu Yi Yang Yiran Hou Zifeng Zhao Ning Liang Peng Yuan Tao Yang Jinliang Xing Jibin Li | 2022 | Cancer Communications2022，42，1： | 4 |
| 5 | Dual activated NIR-Ⅱ fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies显示文摘Multimodal imaging in the second near-infrared window(NIR-II)guided cancer therapy is a highly precise and efficient cancer theranostic strategy.However,it is still a challenge to develop activated NIR-II optical imaging and therapy agents.In this study,we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod(AuNNR)and fluorescent down-conversion nanoparticles(DCNP)(AuNNR-DCNP Ve),showing remarkable and activated NIR-II fluorescence(FL)/NIR-II photoacoustic(PA)imaging performances.The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy.Interestingly,the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal.Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue. | Tao Chen Lichao Su Xiaoguang Ge Wenmin Zhang Qingqing Li Xuan Zhang Jiamin Ye Lisen Lin Jibin Song Huanghao Yang | 2020 | Nano Research2020，13，12： | 4 |
| 6 | Ultrasound-propelled Janus Au NR-mSiO_(2) nanomotor for NIR-II photoacoustic imaging guided sonodynamic-gas therapy of large tumors显示文摘Varieties of contrast agents have been developed for photoacoustic(PA)and ultrasound(US)imaging of cancers in vivo.However,access of traditional contrast agents into the sites of tumors has been principally through passive infiltration without any external force,preventing their deep penetration into the tissues of the tumors,and hindering the use of PA and US for deep tumor imaging.The concept of micro/nanomotors has been the focus of increasing attention as active theranostic agents due to their active movement in particular fluids,thereby conducting assigned tasks.Herein,US-propelled Janus mesoporous SiO_(2)partially coated gold nanorods(Au NR-mSiO_(2))were fabricated for deep tumor NIR-II PA imaging and synergistic sonodynamic-gas therapy.Following US irradiation,2,2-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride(AIPH)loaded in mSiO_(2)(Au NR-mSiO_(2)/AIPH)generated N_(2)microbubbles with high efficiency to achieve nanomotor drive.Due to the deep penetration of US,the nanomotors exhibited a capability to travel deep within sites of tumors,providing enhanced PA/US imaging inside the tumors.Furthermore,the nanomotor based cancer therapy was demonstrated through synergistic N_(2)gas and sonodynamic therapy.The US-propelled nanomotors demonstrated a novel strategy for the simultaneous PA/US dual imaging deep within tumor tissues and precise therapy of large tumors. | Jiamin Ye Qinrui Fu Luntao Liu Lanlan Chen Xuan Zhang Qingqing Li Zhi Li Lichao Su Rong Zhu Jibin Song Huanghao Yang | 2021 | Science China Chemistry2021，64，12： | 2 |
| 7 | Study and development of high peak power short pulse Nd:YAG laser for peening applications显示文摘Because short pulse Nd:YAG laser of nanosecond pulse-width and high peak power has a unique capability to improve the mechanical properties of metal parts,a study on the development of high peak power short pulse from Nd:YAG laser along with its peening application has been performed.The design scheme of laser and the characteristic of laser beam transmission are presented and discussed.A pulse energy of 25 J with 15 ns pulse-width and a maximum peak power of 1660 k W laser system which use one oscillation and eight amplifiers has been achieved.Laser beam has a max divergence angle of 0.03 mrad,a pulse-to-pulse pulse-width stability of±0.1 ns,and the pulse-to-pulse energy stability factors of less than±2.8%.A low value of divergence means an easier modification of a nearly hat-top laser beam intensity profile and an easier transmission of laser beam.To evaluate the performance of the laser system,several metal materials are processed.Laser peening quality and efficiency are analyzed by using an optical microscope,a transmission electron microscope,and an X-ray diffraction device.The processing results show that the performance of this laser system is excellent. | QIAO HongChao ZHAO JiBin YANG Hao | 2015 | Science China(Technological Sciences)2015，58，7： | 2 |
| 8 | Photocatalytic degradation kinetics and mechanism of antivirus drug-lamivudine in TiO2 dispersion显示文摘 | AN Taicheng AN Jibin YANG Hai | 2011 | J Hazard Mater2011，197，： | 1 |
| 9 | Potentially functional genetic variants in microRNA processing genes and risk of HBV‐related hepatocellular carcinoma显示文摘 | Li Liu Jiaze An Jibin Liu Juan Wen Xiangjun Zhai Yao Liu Shandong Pan Jie Jiang Yang Wen Zheng Liu Yixin Zhang Jianguo Chen Jinliang Xing Guozhong Ji Hongbing Shen Zhibin Hu Zhining Fan | 2013 | Mol Carcinog2013，，1： | 1 |
| 10 | Fabrication of polymerizable ZnS nanoparticles in N, N\'-dimethylacrylamide and the resulting high refractive index optical materials显示文摘 | Zhang Guoyan Zhang Jibin Yang Bai | 2013 | Polymer Chemistry2013，4，14： | 1 |
| 11 | Application progress of lymphography in oncology显示文摘 | Yang Yu Jibin Liu Lixue Yin | 2009 | Frontiers of Medicine in China2009，，1： | 1 |
| 12 | Study on speech segment algorithm for segment voceder 显示文摘 | Min gang Jiang Yongsheng Yang Jibin | 2007 | Signal Processing ( in chinese)2007，23，4： | 1 |
| 13 | Activatable nanoscale metal-organic framework for ratiometric photoacoustic imaging of hydrogen sulfide and orthotopic colorectal cancer in vivo显示文摘Nanoscale metal-organic frameworks(nano MOFs)have emerged as a promising biomedical nanoplatform because of their unique properties.However,the exploration of nano MOFs in photoacoustic(PA)imaging is still limited.Here,a novel hydrogen sulfide(H2 S)-activated nano copper-based MOF(Cu-MOF)was developed as a near-infrared(NIR)ratiometric PA probe for in vivo monitoring of endogenous H2 S level and orthotopic colorectal cancer imaging via in situ reaction of nano Cu-MOFs with endogenous H2 S that is closely associated with tumor growth and proliferation in colon cancer.The synthesized nano Cu-MOFs displayed excellent PA responsiveness towards tumor H2 S level with high selectivity and rapid kinetics.The result suggests the developed probe may provide a unique opportunity to investigate the malignant behaviors of H2 S-associated events in vivo. | Wenmin Zhang Jun Wang Lichao Su Hui Chen Lan Zhang Lisen Lin Xiaoyuan Chen Jibin Song Huanghao Yang | 2020 | Science China Chemistry2020，63，9： | 1 |
| 14 | Research Progress of Molecular Markers in Genetic Diversity of Rapeseed显示文摘In recent years,with the continuous improvement and development of molecular technology in the application process,different types of DNA molecular markers have made rapid progress in the study of genetic diversity of rapeseed. The study of genetic diversity is conducive to the correct formulation of the strategy of collecting and in situ preservation of genetic resources of rapeseed,and it is the genetic basis for the improvement of rapeseed varieties. This article mainly starts with the three DNA molecular markers( SSR,RAPD,AFLP) widely used in the study of genetic diversity of rapeseed. By introducing the application principles and characteristics of SSR,RFPD and AFLP molecular markers,research progress of these three marker technologies in genetic diversity of rapeseed is briefly described. | Guanghuan YANG Jibin NAN Suping GUO Yan YUAN Ba DAN | 2019 | Asian Agricultural Research2019，11，6： | 1 |
| 15 | Photocatalytic degradation kinetics and mechanism of antivirus drug-lamivudine in TiO 2 dispersion显示文摘 | Taicheng An Jibin An Hai Yang Guiying Li Huixia Feng Xiangping Nie | 2011 | Journal of Hazardous Materials2011，，： | 1 |
| 16 | Photocatalytic degradation kinetics and mechanism of antivirus drug-lamivudine in TiO 2 dispersion显示文摘 | Taicheng An Jibin An Hai Yang Guiying Li Huixia Feng Xiangping Nie | 2011 | Journal of Hazardous Materials2011，，： | 1 |
| 17 | The genetic association of adakites and Cu–Au ore deposits显示文摘 | Weidong Sun Hong Zhang Ming-Xing Ling Xing Ding Sun-Lin Chung Jibin Zhou Xiao-Yong Yang Weiming Fan | 2011 | International Geology Review (-)2011，，5： | 1 |
| 18 | GPR160 is a potential biomarker associated with prostate cancer显示文摘Dear Editor,Prostate cancer(PC)is one of the most common noncutaneous cancers among men worldwide with a relatively higher incidence and mortality rate.1 Conventional screening for prostate cancer relies on prostate-specific antigen(PSA),a valuable biomarker but has some deficiencies.Radical prostatectomy,androgen ablation,and radiotherapy are still commonly used treatments for localized prostate cancer. | Wanjing Guo Junyu Zhang Yan Zhou Caihong Zhou Yunjie Yang Zhaotong Cong Jibin Dong Dehua Yang Bo Dai Ming-Wei Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
| 19 | Changes of China’s Status in the Global System and Its Influencing Factors:A Multiple Contact Networks Perspective显示文摘Clarifying China’s position in the global system is an important logical basis for developing national diplomacy.Although much research has been done on China’s development status,most studies have been based on country comparisons or institutional en-vironment.In today’s networked era in which the global economy,trade,personnel,and information are closely connected,studies on China’s global position and its status changes and influencing factors in multiple contact networks are still insufficient.In this study,from the perspective of diverse global contact networks,we constructed economic,cultural,and political influence indices to explore the changes and influencing factors on China’s status in the global system from 2005 to 2018.The results show that during the study period,China’s global influence in the fields of economic ties,cultural exchanges,and political contacts increased significantly,but its influ-ence in the fields of cultural exchanges and political contacts lagged far economic ties.The pattern of China’s economic influence on various economies around the world has shown a transformation from an‘upright pyramid’to an‘inverted pyramid’structure.The proportion of these economies in low-influence zones has decreased from more than 60%in 2005 to less than 20%in 2018.China’s cultural and political influence on various economies around the world has increased significantly;however,for the former,the percentage of high-influence areas is still less than 20%,whereas for the latter the percentage of these economies in medium-and high-influence areas is still less than 50%.Analyses such as a scatter plot matrix show that geographical proximity,economic globalization,close cooperation with developing countries,and a proactive and peaceful foreign policy are important factors in improving China’s status in the diverse global network system. | LIU Jian LIU Jibin YANG Qingshan CAI Sikai LIU Jie | 2024 | Chinese Geographical Science2024，34，2： | 0 |
| 20 | Emerging low-dimensional black phosphorus:from physical-optical properties to biomedical applications显示文摘Low-dimensional black phosphorus(BP)is a class of nanomaterial derived from layered semiconductor BP which has gained tremendous attention in a variety of fields,owing to its uncommon structural features and appealing physical properties.More surprisingly,it has addressed current biomedical obstacles due to its orthorhombic puckered honeycomb crystal structure and unique properties such as tunable direct-bandgap,high carrier mobility,and exceptional photo-responsiveness.However,few reviews have focused on the interactions of low-dimensional BP’s physical properties with its biomedical performances.Herein,we discuss the physical properties of low-dimensional BP and potential biomedical applications associated with these physical properties.Moreover,different preparation methods,surface modification techniques,and future challenges,as well as future outlooks,are presented.This comprehensive review will provide a clear understanding of the relationship between lowdimensional BP’s physical properties and biomedical performances,with the ultimate goal of better knowledge of utilizing BP. | Zhi Li Jibin Song Huanghao Yang | 2023 | Science China Chemistry2023，66，2： | 0 |
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