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| 1 | Terahertz metasurface zone plates with arbitrary polarizations to a fixed polarization conversion显示文摘Metasurfaces that can realize the polarization manipulation of electromagnetic waves on the sub-wavelength scale have become an emerging research field.Here,a novel strategy of combining the metasurface and Fresnel zone plate to form a metasurface zone plate is proposed to realize the conversion from nearly arbitrary polarizations to a fixed polarization.Specifically,when one polarized wave is incident on adjacent ring zones constructed by different types of meta-atoms,the transmitted waves generated by odd-numbered and even-numbered ring zones converge at the same focus and superimpose to generate a fixed polarized wave.As function demonstrations,we have designed two types of metasurface zone plates:one is a focused linear polarizer,and the other can convert nearly arbitrary polarized waves into focused circularly polarized waves.The simulated and measured results are consistent with theoretical expectations,suggesting that the proposed concept is flexible and feasible.Our work provides an alternative platform for polarization manipulation and may vigorously promote the development of polarization photonic devices. | Zhen Yue Jitao Li Jie Li Chenglong Zheng Jingyu Liu Guocui Wang Hang Xu Mingyang Chen Yating Zhang Yan Zhang Jianquan Yao | 2022 | Opto-Electronic Science2022，1，3： | 9 |
| 2 | Dynamic phase assembled terahertz metalens for reversible conversion between linear polarization and arbitrary circular polarization显示文摘If a metalens integrates the circular polarization(CP)conversion function,the focusing lens together with circular-polariz-ing lens(CPL)in traditional cameras may be replaced by a metalens.However,in terahertz(THz)band,the reported metalenses still do not obtain the perfect and strict single-handed CP,because they were constructed via Pancharatnam-Berry phase so that CP conversion contained both left-handed CP(LCP)and right-handed CP(RCP)components.In this paper,a silicon based THz metalens is constructed using dynamic phase to obtain single-handed CP conversion.Also,we can rotate the whole metalens at a certain angle to control the conversion of multi-polarization states,which can simply manipulate the focusing for incident linear polarization(LP)THz wave in three polarization conversion states,in-cluding LP without conversion,LCP and RCP.Moreover,the polarization conversion behavior is reversible,that is,the THz metalens can convert not only the LP into arbitrary single-handed CP,but also the LCP and RCP into two perpen-dicular LP,respectively.The metalens is expected to be used in advanced THz camera,as a great candidate for tradi-tional CPL and focusing lens group,and also shows potential application in polarization imaging with discriminating LCP and RCP. | Jitao Li Guocui Wang Zhen Yue Jingyu Liu Jie Li Chenglong Zheng Yating Zhang Yan Zhang Jianquan Yao | 2022 | Opto-Electronic Advances2022，5，1： | 9 |
| 3 | MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis显示文摘Current research indicates that beta cell loss in type 2 diabetes may be attributed to beta cell dedifferentiation rather than apoptosis;however,the mechanisms by which this occurs remain poorly understood.Our previous study demonstrated that elevation of microRNA-24(miR-24)in a diabetic setting caused beta cell dysfunction and replicative deficiency.In this study,we focused on the role of miR-24 in beta cell apoptosis and dedifferentiation under endoplasmic reticulum(ER)stress conditions.We found that miR-24 overabundance protected beta cells from thapsigargin-induced apoptosis at the cost of accelerating the impairment of glucosestimulated insulin secretion(GSIS)and enhancing the presence of dedifferentiation markers.Ingenuity?Pathway Analysis(IPA)revealed that elevation of miR-24 had an inhibitory effect on XBP1 and ATF4,which are downstream effectors of two key branches of ER stress,by inhibiting its direct target,Irela.Notably,elevated miR-24 initiated another pathway that targeted Mafa and decreased GSIS function in surviving beta cells,thus guiding their dedifferentiation under ER stress conditions.Our results demonstrated that the elevated miR-24,to the utmost extent,preserves beta cell mass by inhibiting apoptosis and inducing dedifFerentiation.This study not only provides a novel mechanism by which miR-24 dominates beta cell turnover under persistent metabolic stress but also offers a therapeutic consideration for treating diabetes by inducing dedifferentiated beta cells to re-differentiation. | Yunxia Zhu Yi Sun Yuncai Zhou Yan Zhang Tao Zhang Yating Li Weiyan You Xiaoai Chang Li Yuan Xiao Han | 2019 | Journal of Molecular Cell Biology2019，11，9： | 9 |
| 4 | Terahertz wavefront shaping with multi-channel polarization conversion based on all-dielectric metasurface显示文摘Polarization manipulation of electromagnetic wave or polarization multiplexed beam shaping based on metasurfaces has been reported in various frequency bands.However,it is difficult to shape the beam with multi-channel polarization conversion in a single metasurface.Here,we propose a new method for terahertz wavefront shaping with multi-channel polarization conversion via all-silicon metasurface,which is based on the linear shape birefringence effect in spatially interleaved anisotropic meta-atoms.By superimposing the eigen-and non-eigen-polarization responses of the two kinds of meta-atoms,we demonstrate the possibility for high-efficiency evolution of several typical polarization states with two independent channels for linearly polarized waves.The measured polarization conversion efficiency is higher than 70%in the range of 0.9–1.3 THz,with a peak value of 89.2%at 1.1 THz.In addition,when more other polarization states are incident,combined with the integration of sub-arrays,we can get more channels for both polarization conversion and beam shaping.Simulated and experimental results verify the feasibility of this method.The proposed method provides a new idea for the design of terahertz multi-functional metadevices. | JIE LI CHENGLONG ZHENG JITAO LI GUOCUI WANG JINGYU LIU ZHEN YUE XUANRUO HAO YUE YANG FUYU LI TINGTING TANG YATING ZHANG YAN ZHANG JIANQUAN YAO | 2021 | Photonics Research2021，9，10： | 5 |
| 5 | Ultraviolet-to-microwave room-temperature photodetectors based on three-dimensional graphene foams显示文摘Highly sensitive broadband photodetection is of critical importance for many applications.However,it is a great challenge to realize broadband photodetection by using a single device.Here we report photodetectors(PDs)based on three-dimensional(3 D)graphene foam(GF)photodiodes with asymmetric electrodes,which show an ultra-broadband photoresponse from ultraviolet to microwave for wavelengths ranging from 10~2 to 10~6 nm.Moreover,the devices exhibit a high photoresponsivity of 10~3 A·W^-1,short response time of 43 ms,and3 d B bandwidth of 80 Hz.The high performance of the devices can be attributed to the photothermoelectric(PTE,also known as the Seebeck)effect in 3 D GF photodiodes.The excellent optical,thermal,and electrical properties of 3 D GFs offer a superior basis for the fabrication of PTE-based PDs.This work paves the way to realize ultra-broadband and high-sensitivity PDs operated at room temperature. | YIFAN LI YATING ZHANG YU YU ZHILIANG CHEN QINGYAN LI TENGTENG LI JIE LI HONGLIANG ZHAO QUAN SHENG FENG YAN ZHEN GE YUXIN REN YONGSHENG CHEN JIANQUAN YAO | 2020 | Photonics Research2020，8，3： | 4 |
| 6 | Concentration of circulating microparticles:a new biomarker of acute heart failure after cardiac surgery with cardiopulmonary bypass显示文摘Acute heart failure(AHF)is a severe complication after cardiac surgery with cardiopulmonary bypass(CPB).Although some AHF biomarkers have been used in clinic,they have limitations when applied in the prediction and diagnosis of AHF after cardiac surgery with CPB,and there are still no effective and specific biomarkers.We and other researchers have shown that circulating microparticles(MPs)increased in a variety of cardiovascular diseases.However,whether the concentration of circulating MPs could be a new biomarker for AHF after cardiac surgery remains unknown.Here,90 patients undergoing cardiac surgery with CPB and 45 healthy subjects were enrolled.Patients were assigned into AHF(n=14)or non-AHF(n=76)group according to the diagnosis criteria of AHF.The concentrations of circulating MPs were determined before,as well as 12 h and 3 days after operation with nanoparticle tracking analysis technique.MPs concentrations in patients before surgery were significantly higher than those of healthy subjects.Plasma levels of MPs were significantly elevated at 12 h after surgery in patients with AHF,but not in those without AHF,and the circulating MPs concentrations at 12 h after surgery were higher in AHF group compared with non-AHF group.Logistic regression analysis indicated that MPs concentration at postoperative 12 h was an independent risk factor for AHF.The area under receiver operating characteristic curve for MPs concentration at postoperative 12 h was 0.87 and the best cut-off value is 5.20×10~8 particles mL~(–1)with a sensitivity of 93%and a specificity of 70%.These data suggested that the concentration of circulating MPs might be a new biomarker for the occurrence of AHF after cardiac surgery with CPB. | Yuquan Li Haoxiang Yuan Caiyun Chen Chao Chen Jian Ma Yating Chen Yan Li Yupeng Jian Donghong Liu Zhijun Ou Jingsong Ou | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 7 | Circular dichroism-like response of terahertz wave caused by phase manipulation via all-silicon metasurface显示文摘Chiral metasurfaces based on asymmetric meta-atoms have achieved artificial circular dichroism(CD),spin-dependent wavefront control,near-field imaging,and other spin-related electromagnetic control.In this paper,we propose and experimentally verify a scheme for achieving high-efficiency chiral response similar to CD of terahertz(THz)wave via phase manipulation.By introducing the geometric phase and dynamic phase in an all-silicon metasurface,the spin-decoupled terahertz transmission is obtained.The giant circular dichroism-like effect in the transmission spectrum is observed by using a random phase distribution for one of the circular polarization components.More importantly,the effect can be adjusted when we change the area of the metasurface illuminated by an incident terahertz beam.In addition,we also demonstrate the spin-dependent arbitrary wavefront control of the transmitted terahertz wave,in which one of the circularly polarized components is scattered,while the other forms a focused vortex beam.Simulated and experimental results show that this method provides a new idea for spin selective control of THz waves. | Jie Li Chenglong Zheng Guocui Wang Jitao Li Hongliang Zhao Yue Yang Zhang Zhang Maosheng Yang Liang Wu Jining Li Yating Zhang Yan Zhang Jianquan Yao | 2021 | Photonics Research2021，9，4： | 3 |
| 8 | IntegrinαEβ7^(+)T cells direct intestinal stem cell fate decisions via adhesion signaling显示文摘Intestinal stem cell(ISC)differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying(TA)cells.However,whether and how lymphocyte–stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell–stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrinαEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.BlockingαEβ7−E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7^(+)T cells regulate ISC differentiation at single-cell level through cell–cell contact-mediatedαEβ7−E-cadherin adhesion signaling,highlighting a critical role of the T cell–stem/TA cell contact in maintaining intestinal homeostasis. | Shiyang Chen Yajuan Zheng Xiaojuan Ran Hui Du Hua Feng Lei Yang Yating Wen Changdong Lin Shihui Wang Mengwen Huang Zhanjun Yan Dianqing Wu Hongyan Wang Gaoxiang Ge An Zeng Yi Arial Zeng Jianfeng Chen | 2021 | Cell Research2021，31，12： | 3 |
| 9 | Measurement of air exchange rates in different indoor environments using continuous CO_2 sensors显示文摘A new air exchange rate(AER) monitoring method using continuous CO 2 sensors was developed and validated through both laboratory experiments and field studies.Controlled laboratory simulation tests were conducted in a 1-m 3 environmental chamber at different AERs(0.1-10.0 hr 1).AERs were determined using the decay method based on box model assumptions.Field tests were conducted in classrooms,dormitories,meeting rooms and apartments during 2-5 weekdays using CO 2 sensors coupled with data loggers.Indoor temperature,relative humidity(RH),and CO 2 concentrations were continuously monitored while outdoor parameters combined with on-site climate conditions were recorded.Statistical results indicated that good laboratory performance was achieved:duplicate precision was within 10%,and the measured AERs were 90%-120% of the real AERs.Average AERs were 1.22,1.37,1.10,1.91 and 0.73 hr 1 in dormitories,air-conditioned classrooms,classrooms with an air circulation cooling system,reading rooms,and meeting rooms,respectively.In an elderly particulate matter exposure study,all the homes had AER values ranging from 0.29 to 3.46 hr 1 in fall,and 0.12 to 1.39 hr 1 in winter with a median AER of 1.15. | Yan You Can Niu Jian Zhou Yating Liu Zhipeng Bai Jiefeng Zhang Fei He Nan Zhang | 2012 | Journal of Environmental Sciences2012，24，4： | 2 |
| 10 | HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies显示文摘The hypoxic microenvironment is an essential characteristic of most malignant tu-mors.Notably,hypoxia-inducible factor-1 alpha(HIF-1a)is a key regulatory factor of cellular adaptation to hypoxia,and many critical pathways are correlated with the biological activity of organisms via HIF-1a.In the intra-tumoral hypoxic environment,HIF-1αis highly expressed and contributes to the malignant progression of tumors,which in turn results in a poor prog-nosis in patients.Recently,it has been indicated that HiF-1αinvolves in various critical pro-cesses of life events and tumor development via regulating the expression of HiF-1a target genes,such as cell proliferation and apoptosis,angiogenesis,glucose metabolism,immune response,therapeutic resistance,etc.Apart from solid tumors,accumulating evidence has re-vealed that HiF-1αis also closely associated with the development and progression of hemato-logical malignancies,such as leukemia,lymphoma,and multiple myeloma.Targeted inhibition of HiF-1a can facilitate an increased sensitivity of patients with malignancies to relevant ther-apeutic agents.In the review,we elaborated on the basic structure and biological functions of HIF-1a and summarized their current role in various malignancies.It is expected that they will have future potential fortargeted therapy. | Yan Zhao Cheng Xing Yating Deng Can Ye Hongling Peng | 2024 | Genes & Diseases2024，11，1： | 1 |
| 11 | Redirecting soluble antigen for MHC class I cross‐presentation during phagocytosis显示文摘 | Aswin Hari Anutosh Ganguly Libing Mu Shevaun P. Davis Melanie D. Stenner Raymond Lam Fay Munro Inana Namet Enaam Alghamdi Tobias Fürstenhaupt Wei Dong Pascal Detampel Lian Jun Shen Matthias W. Amrein Robin M. Yates Yan Shi | 2015 | Eur. J. Immunol2015，，： | 1 |
| 12 | Network analysis of eight industrial symbiosis systems显示文摘工业共生是一个 eco 工业的公园的精华的特征。把公园划分成不同类型,主要集中于质的判断,并且没能使用度量标准在一个公园的内部结构或功能的特征上进行量的研究的以前的研究。分析一公园结构的属性,从网络分析的度量标准的一个范围被使用了,但是很少研究人员比较了二或用多重度量标准的更多的 symbioses。在这研究,我们使用了二个度量标准(密度和网络度集中化) 比较完全性的度和八个多样却代表性的工业共生网络的依赖。通过二个度量标准的联合,我们把网络划分了成三种类型:强壮的完全性的弱完全性,和二种形式,也就是抛锚承租人互助论和面向平等的互助论。结果证明有完全性的弱度的网络是稀少的并且在节点之中有很少连接;为锚承租人互助论,完全性的度相对高,但是 affiliated members 太依赖于核心成员;并且在有的面向平等的互助论的成员等于角色,与多样、灵活的共生路径。这些结果揭示了一些系统内部结构并且不同结构怎么在一个系统的成员之中影响了材料,精力,和知识的交换,从而提供卓见进可以使动摇的威胁网络。把分析基于这,我们在一个典型中国 eco 工业的公园(山东 Lubei ) 里提供优点的例子和最近的改进工程的有效性。 | Yan ZHANG Hongmei ZHENG Han SHI Xiangyi YU Gengyuan LIU Meirong SU Yating LI Yingying CHAI | 2016 | Frontiers of Earth Science2016，10，2： | 1 |
| 13 | Diverse terahertz wavefront manipulations empowered by the spatially interleaved metasurfaces显示文摘Optical metasurfaces have advanced approaches for manipulating light information in the spatial domain,in which the spatially interleaved metasurfaces demonstrate the ability to manipulate a more complex wavefront of light than metasurfaces without the spatial interleaving.The potential of the spatially interleaved metasurfaces has not been fully exploited.In this paper,we design the spatially interleaved terahertz(THz)metasurfaces based on the ingenious spatial interleaving principles to develop the diverse THz wavefront manipulations.Four functions are performed,including the orbital angular momentum(OAM)superposition of single-frequency vortex beams,the separate vortex focusing of single-frequency dual beams,the different OAM manipulations of bifrequency beams in different planes,and achromatic focusing.The demonstrated functions prove that the spatially interleaved metasurface can manipulate THz wavefront at both single frequency and bifrequency,which traditional metasurfaces cannot.This work paves the way for diverse THz wavefront manipulations. | Jitao LI Zhen YUE Jie LI Chenglong ZHENG Silei WANG Mengyao LI Yating ZHANG Yan ZHANG Jianquan YAO | 2023 | Science China(Information Sciences)2023，66，3： | 1 |
| 14 | The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor显示文摘Cancer stem cells(CSCs)exhibit highly aggressive and metastatic features and resistance to chemotherapy and radiotherapy.Aryl hydrocarbon receptor(AhR)expression varies among non-small cell lung cancers(NSCLCs),and the mechanisms that support abnormal AhR expression in CSCs remain elusive.Here,we identified ubiquitin carboxyl terminal hydrolase L3(UCHL3),a DUB enzyme in the UCH protease family,as a bona fide deubiquitylase of the AhR in NSCLC.UCHL3 was shown to interact with,deubiquitylate,and stabilize AhR in a manner dependent on its deubiquitylation activity.Moreover,we showed that UCHL3 promotes the stem-like characteristics and potent tumorigenic capacity of NSCLC cells.UCHL3 increased AhR stability and the binding of AhR to the promoter regions of the“stemness”genes ATP-binding cassette subfamily G member 2(ABCG2),KLF4,and c-Myc.Depletion of UCHL3 markedly downregulated the“stemness”genes ABCG2,KLF4,and c-Myc,leading to the loss of selfrenewal and tumorigenesis in NSCLCs.Furthermore,the UCHL3 inhibitor TCID induced AhR degradation and exhibited significantly attenuated efficacy in NSCLC cells with stem cell-like properties.Additionally,UCHL3 was shown to indicate poor prognosis in patients with lung adenocarcinoma.In general,our results reveal that the UCHL3 deubiquitylase is pivotal for AhR protein stability and a potential target for NSCLC-targeted therapy. | Lianlian Ouyang Bin Yan Yating Liu Chao Mao Min Wang Na Liu Zuli Wang Shouping Liu Ying Shi Ling Chen Xiang Wang Yan Cheng Ya Cao Desheng Xiao Lingqiang Zhang Shuang Liu Yongguang Tao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 15 | Effectiveness of a multifaceted intervention for the improvement of nutritional status and nutrition knowledge of children in poverty-stricken areas in Shaanxi Province, China显示文摘Objectives:Compare the differences between the intervention and control groups in changes of primary outcomes(body mass index[BMI]and waist-to-height ratio[WHtR])and secondary outcomes(nutrition knowledge of children and parents),from baseline to the 6-and 12-month follow-ups;examine the associations of changes in nutrition knowledge of children and their parents with children’s changes in BMI and WHtR.Data sources:Data collected from four schools in two poverty-stricken counties in northern Shaanxi Province in 2020‒2021.Methods:A multifaced intervention program targeted children(promoting healthy diet and nutrition education)and their parents(promoting nutrition knowledge)was conducted in the interventional group.Four schools,with two in each group,were randomly allocated to the intervention or control group,with 814 eligible children aged 7.1 to 12.8 years.The control group conducted myopia promotion.Differences in changes of BMI and WHtR between groups were compared with t-test.Mixed-effects model was used to examine the associations between changes in nutrition knowledge of children and parents with changes in children’s BMI and WHtR.Results:At the 6-month follow-up,the difference in changes in BMI between the intervention and control groups was 0.4 kg/m 2(P<0.001).At the 12-month follow-up,the difference in changes in BMI and WHtR between intervention and control groups was 0.1 kg/m^(2)(P<0.001)and 0.01 kg/m^(2)(P<0.001).In the intervention group,the nutrition knowledge awareness rate of children increased from 16.9%(69/409)at baseline to 21.3%(87/409)at 6-month,and 22.7%(93/409)at 12-month.The awareness rate of nutrition knowledge of parents also fluctuated,from 5.6%(23/409)to 6.6%(27/409)and 5.4%(22/409).However,the difference in changes in nutrition knowledge between intervention and control groups was non-significant.The 6-month follow-up changes in children’s nutrition knowledge scores were negatively associated with changes in BMI in girls(β=−0.26,95%confidence interval[CI]:−0.38 to−0.14,P<0.001),while positively associated with changes in WHtR in boys(β=0.003,95%CI:−0.0002 to 0.005,P=0.035).The 12-month follow-up changes in children’s nutrition knowledge scores were positively associated with changes in children’s WHtR(β=0.003,95%CI:0.0004 to 0.01,P=0.018).Conclusions:The intervention strategies did not reduce the BMI and WHtR of children,and the nutrition knowledge of children and parents increased after the intervention in intervention group.Changes in nutrition knowledge of children and their parents are associated with changes in children’s BMI or WHtR.Interventions with a new focus on obesity are needed to help improve children’s nutritional status in poverty-stricken areas in Shaanxi Province of China. | Cai Zhao Lu Ma Liwang Gao Yan Wu Yating Yan Wen Peng Youfa Wang | 2022 | Global Health Journal2022，6，3： | 1 |
| 16 | Optimization and standardization of transient expression assays for gene functional analyses in strawberry fruits显示文摘Strawberry is increasingly used as a model plant for research on fruit growth and development.The transient gene manipulation(TGM)technique is widely used to determine the function of plant genes,including those in strawberry fruits.However,its reliable application for the precise identification of gene function has been difficult owing to the lack of conditional optimization.In this study,we found that successful transient gene manipulation requires optimization,with the vector type,temperature,and fruit developmental stage being three major factors determining success.Notably,we found that transient gene manipulation was feasible only from the large green fruit stage onwards,making it especially suitable for identifying genes involved in strawberry fruit ripening.Furthermore,we established a method called percentage difference of phenotype(PDP),in which the functional effect of a gene could be precisely and efficiently identified in strawberry fruits.This method can be used to estimate the functional effect of a gene as a value from 0 to 100%,such that different genes can be quantitatively compared for their relative abilities to regulate fruit ripening.This study provides a useful tool for accelerating research on the molecular basis of strawberry fruit ripening. | Yaoyao Zhao Wenwen Mao Yating Chen WeiWang Zhengrong Dai Zhechao Dou Kai Zhang Lingzhi Wei Tianyu Li Baozhen Zeng Ting Liu Yijuan Fan Jiaqi Yan Bingbing Li Wensuo Jia | 2019 | Horticulture Research2019，6，1： | 1 |
| 17 | Metal–ligand interfaces for well-defined gold nanoclusters显示文摘Ligand engineering for well-defined gold nanoclusters(Au NCs) is getting more extensive attention. Organizing the Au-ligand interfaces on gold NCs can achieve the structural and functional control. This review focuses on the Au-ligand interfaces including gold-phosphorus(Au-P), gold-sulfur(Au-S), gold-selenium(Au-Se), gold-carbon(Au-C), and gold-nitrogen(Au-N), derived from the bonding between Au atoms and the different ligands(e.g., organic phosphine, thiolate, selenolate, alkynyl,n-heterocyclic carbene and nitrogenous ligands). The formation mechanism of Au-ligand interfaces is well discussed. In addition, the effects of Au-ligand interfaces on the stability, optical property, and catalysis are also presented. We hope the advances in this research area can boost the development of Au NC sciences. | Dan Yang Yating Wu Zhaotong Yuan Chunmei Zhou Yihu Dai Xiaoyue Wan Yan Zhu Yanhui Yang | 2024 | Science China Chemistry2024，67，3： | 0 |
| 18 | Epidemiological survey and genetic characterization of type 3 vaccine-derived poliovirus isolated from a patient with four doses of inactivated polio vaccine in Henan Province,China显示文摘Background:Vaccine-derived poliovirus(VDPV)is a potential threat to polio eradication because they can reintroduce into the general population and cause paralytic polio outbreaks,a phenomenon that has recently emerged as a prominent public health concern at the end of global polio eradication.This study aimed to describe the epidemiology and genetic characteristics of the frst VDPV identifed from a patient with acute faccid paralysis(AFP),with four doses of inactivated polio vaccine immunization in Henan Province,China in 2017.Methods:The patient was diagnosed with type 3 VDPV.Subsequently,a series of epidemiological approaches was implemented,including a retrospective search of AFP cases,rate of vaccination assessment,study of contacts,and supplementary immunization activities.Fecal samples were collected,viral isolation was performed,and the viral isolates were characterized using full-length genomic sequencing and bioinformatic analysis.Results:Phylogenetic analysis showed that the viral isolates from the patient were diferent from other reported genetic clusters of type 3 VDPV worldwide.They were identifed as a Sabin 3/Sabin 1 recombinant VDPV with a crossover site in the P2 region.Nucleotide substitutions,including U→C(472)and C→U(2493),have been identifed,both of which are frequently observed as reversion mutations in neurovirulent type 3 poliovirus.A unique aspect of this case is that the patient had been vaccinated with four doses of inactive polio vaccine,and the serum neutralizing antibody for Sabin types 1 and 3 were 1∶16 and 1∶512,respectively.Thus,the patient was speculated to have been infected with type 3 VDPV,and the virus continued to replicate and be excreted for at least 41 d.Conclusions:The existence of this kind of virus in human population is a serious risk and poses a severe challenge in maintaining a polio-free status in China.To the best of our knowledge,this is the frst report of VDPV identifed in the Henan province of China.Our results highlight the importance of maintaining a high-level vaccination rate and highly sensitive AFP case surveillance system in intercepting VDPV transmission. | Mingyu Zhang Jianhui Yang Yiran Bai Hui Zhu Changshuang Wang Lu Zhang Jin Xu Mingxia Lu Xiaoxiao Zhang Zhanpei Xiao Yating Ma Yan Wang Xiaolei Li Dongyan Wang Shuangli Zhu Dongmei Yan Wenbo Xu Yong Zhang Yanyang Zhang | 2022 | Infectious Diseases of Poverty2022，11，6： | 0 |
| 19 | Analysis of urban metabolic processes based on input-output method: model development and a case study for Beijing显示文摘发现到增加,新陈代谢的过程的可持续性在都市化在包含了的方法在中国为城市的设计和管理成为了一项迫切任务。因为城市类似于生活有机体,他们的新陈代谢的过程的混乱能被认为是“城市的疾病”的原因。因此,这些的鉴定通过城市的生态系统的分隔空间通过新陈代谢的过程分析和生态的元素分发引起将有用。由把北京用作一个例子,我们从 1997, 2000, 2002, 2005,和 2007 编了钱的输入产量桌子并且计算了表达生态的元素的紧张编相应暗示物理输入产量桌子。我们然后把北京的经济划分了成 32 分隔空间并且分析了通过城市的新陈代谢的过程在生态的元素的流动表达的直接、间接的生态的紧张。基于输入产量桌子和生态的网络分析的联合,对在北京的工业分隔空间和他们的分发之中转移的多重生态的元素的描述被精制了。这条混合途径能为城市的资源流动的管理提供一个更科学的基础。另外,从生态的元素的分发特征获得的数据可以为探索北京的新陈代谢的机制提供一个基本数据平台[出版摘要] | Yan ZHANG Hong LIU Bin CHEN Hongmei ZHENG Yating LI | 2014 | Frontiers of Earth Science2014，8，2： | 0 |
| 20 | The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties显示文摘Posttranslational modifications(PTMs)of proteins,including chromatin modifiers,play crucial roles in the dynamic alteration of various protein properties and functions including stem-cell properties.However,the roles of Lymphoid-specific helicase(LSH),a DNA methylation modifier,in modulating stem-like properties in cancer are still not clearly clarified.Therefore,exploring PTMs modulation of LSH activity will be of great significance to further understand the function and activity of LSH.Here,we demonstrate that LSH is capable to undergo PTMs,including methylation and phosphorylation.The arginine methyltransferase PRMT5 can methylate LSH at R309 residue,meanwhile,LSH could as well be phosphorylated by MAPK1 kinase at S503 residue.We further show that the accumulation of phosphorylation of LSH at S503 site exhibits downregulation of LSH methylation at R309 residue,which eventually promoting stem-like properties in lung cancer.Whereas,phosphorylation-deficient LSH S503A mutant promotes the accumulation of LSH methylation at R309 residue and attenuates stem-like properties,indicating the critical roles of LSH PTMs in modulating stem-like properties.Thus,our study highlights the importance of the crosstalk between LSH PTMs in determining its activity and function in lung cancer stem-cell maintenance. | Na Liu Rui Yang Ying Shi Ling Chen Yating Liu Zuli Wang Shouping Liu Lianlian Ouyang Haiyan Wang Weiwei Lai Chao Mao Min Wang Yan Cheng Shuang Liu Xiang Wang Hu Zhou Ya Cao Desheng Xiao Yongguang Tao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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