|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interface issues of lithium metal anode for high-energy batteries: Challenges, strategies, and perspectives显示文摘Lithium(Li)metal is considered as one of the most promising anode materials for next-generation high-energy-density storage systems.However,the practical application of Li metal anode is hindered by interfacial instability and air instability due to the highly reactivity of Li metal.Unstable interface in Li metal batteries(LMBs)directly dictates Li dendrite growth,“dead Li”and low Coulombic efficiency,resulting in inferior electrochemical performance of LMBs and even safety issues.In addition,its sensitivity to ambient air leads to the severe corrosion of Li metal anode,high requirements of production and storage,and increased manufacturing cost.Plenty of efforts in recent years have overcome many bottlenecks in these fields and hastened the practical applications of high-energy-density LMBs.In this review,we focus on emerging methods of these two aspects to fulfill a stable and low cost electrode.In this perspective,design artificial solid electrolyte interphase(SEI)layers,construct three-dimensional conductive current collectors,optimize electrolytes,employ solid-state electrolytes,and modify separators are summarized to be propitious to ameliorate interfacial stability.Meanwhile,ex situ/in situ formed protective layers are highlighted in favor of heightening air stability.Finally,several possible directions for the future research on advanced Li metal anode are addressed. | Yiyao Han Bo Liu Zhen Xiao Wenkui Zhang Xiuli Wang Guoxiang Pan Yang Xia Xinhui Xia Jiangping Tu | 2021 | InfoMat2021，3，2： | 11 |
| 2 | Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner显示文摘As one of the hallmarks of cancer,metabolic reprogramming leads to cancer progression,and targeting glycolytic enzymes could be useful strategies for cancer therapy.By screening a small molecule library consisting of 1320 FDA-approved drugs,we found that penfluridol,an antipsychotic drug used to treat schizophrenia,could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma(ESCC).Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of penfluridol.By using drug affinity responsive target stability(DARTS)technology and proteomics,we identified phosphofructokinase,liver type(PFKL),a key enzyme in glycolysis,as a direct target of penfluridol.Penfluridol could not exhibit its anticancer property in PFKL-deficient cancer cells,illustrating that PFKL is essential for the bioactivity of penfluridol.High PFKL expression is correlated with advanced stages and poor survival of ESCC patients,and silencing of PFKL significantly suppressed tumor growth.Mechanistically,direct binding of penfluridol and PFKL inhibits glucose consumption,lactate and ATP production,leads to nuclear translocation of FOXO3a and subsequent transcriptional activation of BIM in an AMPK-dependent manner.Taken together,PFKL is a potential prognostic biomarker and therapeutic target in ESCC,and penfluridol may be a new therapeutic option for management of this lethal disease. | Cancan Zheng Xiaomei Yu Yiyao Liang Yidong Zhu Yan He Long Liao Dingkang Wang Yanming Yang Xingfeng Yin Ang Li Qingyu He Bin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 3 | Functions and clinical significance of mechanical tumor microenvironment:cancer cell sensing,mechanobiology and metastasis显示文摘Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence,progression,invasion,and metastasis of solid tumors.In this process,the tumormicroenvironment(TME)fractures cellular and matrix architecture normality through biochemical and mechanical means,abetting tumorigenesis and treatment resistance.Tumor cells sense and respond to the strength,direction,and duration of mechanical cues in the TME by various mechanotransduction pathways.However,far less understood is the comprehensive perspective of the functions and mechanisms of mechanotransduction.Due to the great therapeutic difficulties brought by the mechanical changes in the TME,emerging studies have focused on targeting the adverse mechanical factors in the TME to attenuate disease rather than conventionally targeting tumor cells themselves,which has been proven to be a potential therapeutic approach.In this review,we discussed the origins and roles ofmechanical factors in the TME,cell sensing,mechano-biological coupling and signal transduction,in vitro construction of the tumormechanicalmicroenvironment,applications and clinical significance in the TME. | Hanying Zhou Meng Wang Yixi Zhang Qingqing Su Zhengxin Xie Xiangyan Chen Ran Yan Ping Li Tingting Li Xiang Qin Hong Yang ChunhuiWu Fengming You Shun Li Yiyao Liu | 2022 | Cancer Communications2022，42，5： | 3 |
| 4 | BmCH25H,a vertebrate interferon-stimulated gene(ISG)homolog,inhibits BmNPV infection dependent on its hydroxylase activity in Bombyx mori显示文摘Cholesterol-25-hydroxylase(CH25H)has been identified as an interferon-stimulated gene(ISG)in mammals that exerts its antiviral effects by catalyzing the conversion of cholesterol to 25-hydroxycholesterol(25HC).However,invertebrates lack an antiviral system homologous to vertebrate interferons(IFNs)because the genomes of invertebrates do not encode IFN-like cytokines.Nevertheless,CH25H is present in insect genomes and it therefore deserves further study of whether and by which mechanism it could exert an antiviral effect in invertebrates.In this study,the Bombyx mori CH25H(BmCH25H)gene,of which the encoded protein has high homology with other lepidopteran species,was identified and located on chromosome 9.Interestingly,we found that the expression of BmCH25H was significantly upregulated in B.mori nucleopolyhedrovirus(BmNPV)-infected BmN cells and silkworm(B.mori)larvae at the early infection stage.The inhibitory effect of BmCH25H on BmNPV replication was further demonstrated to depend on its catalytic residues to convert cholesterol to 25HC.More importantly,we demonstrated that during BmNPV infection,BmCH25H expression was increased through the Janus kinase–signal transducer and activator of transcription(JAK–STAT)pathway,similar to the induction of ISGs following virus infection in vertebrates.This is the first report that CH25H has antiviral effects in insects;the study also elucidates the regulation of its expression and its mechanism of action. | Hongyun Wu Junming Xia Shigang Fei Yeyuan Wang Mengmeng Zhang Yiyao Guo Xian Li Luc Swevers Jingchen Sun Min Feng | 2023 | Insect Science2023，30，2： | 2 |
| 5 | Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy显示文摘The clinical outcomes of cancer nanovaccine have been largely impeded owing to the low antigen-specific T cell response rate and acquired resistance caused by the immunosuppressive tumor microenvironment(TME).Here,we reported a tumor acidity-responsive nanovaccine to remodel the immunosuppressive TME and expand the recruitment of tumor infiltrating lymphocytes(TILs)using hybrid micelles(HM),which encapsulated colony stimulating factor 1 receptor(CSF1-R)inhibitor BLZ-945 and indoleamine 2,3-dioxygenase(IDO)inhibitor NLG-919 in its core and displayed a model antigen ovalbumin(OVA)on its surface(denoted as BN@HM-OVA).The bioactive nanovaccine is coated with a polyethylene glycol(PEG)shell for extending nanoparticle circulation.The shell can be shed in response to the weakly acidic tumor microenvironment.The decrease in size and the increase in positive charge may cause the deep tumor penetration of drugs.We demonstrated that the bioactive nanovaccine dramatically enhance antigen presentation by dendritic cells(DCs)and drugs transportation into M1-like tumor-associated macrophages(TAMs)and tumor cells via size reduction and increasing positive charge caused by the weakly acidic TME.Such bioactive nanovaccine could remodel the immunosuppressive TME into an effector T cells favorable environment,leading to tumor growth inhibition in prophylactic and therapeutic E.G7-OVA tumor models.Furthermore,combining the bioactive nanovaccine with simultaneous anti-PD-1 antibody treatment leads to a long-term tumor inhibition,based on the optimal timing and sequence of PD-1 blockade against T cell receptor.This research provides a new strategy for the development of efficient cancer immunotherapy. | Xiaoxue Xie Yi Feng Hanxi Zhang Qingqing Su Ting Song Geng Yang Ningxi Li Xiaodan Wei Tingting Li Xiang Qin Shun Li Chunhui Wu Xiaojuan Zhang Guixue Wang Yiyao Liu Hong Yang | 2022 | Bioactive Materials2022，7，10： | 1 |
| 6 | Effects of ultrasound on the growth and vacuolar H+-ATPase activity of aloe arborescens callus cells显示文摘 | Liu Yiyao Takatsuki Hideyo Yoshikoshi Akio Wang Bochu Sakanishi Akio | 2003 | Colloids and surfaces B: Biointerfaces2003，32，： | 1 |
| 7 | Adaptive evolution and structure modeling of rbcL gene in Ephedra显示文摘The adaptive evolution of the rbcL gene in 14 species of Ephedra and 9 other gymnosperms was tested by the PAML program. Three large-scale selections were found in the catalytic region of the RbcL protein by branch model. Species in Ephedra with positive selection at the 365th codon site in rbcL gene were detected by branch-site model. 3D structure modeling showed that the 365th codon could change the spatial structure of the β-sheet (βG, βH, or βE) of the RbcL protein. These changes may be associated with the adaptation of the protein in Ephedra to the environment. | LIU Nian WANG QingBiao CHEN Jie ZHU Yong TASHI Tsering HU YiYao CHEN Fan ZHONG Yang | 2010 | Chinese Science Bulletin2010，55，22： | 1 |
| 8 | Influence of ultrasonic stimulation on the growth and proliferation of Oryza sativa Nipponbare callus cells 显示文摘 | Liu Yiyao Yoshikoshi Akio Wang Bochu Sakanishi Akio | 2003 | Colloids and Surfaces B: Biointerfaces2003，27，： | 1 |
| 9 | Effects of sound field on the growth of Chrysanthemum callus 显示文摘 | Li Yiyao Wang Bochu Long Xuefeng | 2002 | Colloids and Surfaces B: Biointerfaces2002，24，34： | 1 |
| 10 | Influence of ultrasonic stimulation on the growth and proliferation of Oryza sativa Nipponbare callus cells显示文摘 | Liu Yiyao Akio Y Wang BC | 2003 | Colloids Surfaces B:Biointerfaces2003，27，： | 1 |
| 11 | Influence of ultrasonic stimulation on the growth and proliferation of Oryza sativa Nipponbare callus cells显示文摘 | Liu Yiyao Akio Y Wang BC | 2003 | Colloids Surfaces B:Biointerfaces2003，27，： | 1 |
| 12 | Effects of sound field on the growth of Chrysanthemum callus 显示文摘 | Li Yiyao Wang Bochu Long Xuefeng | 2002 | Colloids and Surfaces B: Biointerfaces2002，24，34： | 1 |
| 13 | Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration显示文摘Diabetes mellitus(DM)aggravates periodontitis,resulting in accelerated periodontal bone resorption.Disordered glucose metabolism in DM causes reactive oxygen species(ROS)overproduction resulting in compromised bone healing,which makes diabetic periodontal bone regeneration a major challenge.Inspired by the natural bone healing cascade,a mesoporous silica nanoparticle(MSN)-incorporated PDLLA(poly(DL-lactide))-PEG-PDLLA(PPP)thermosensitive hydrogel with stepwise cargo release is designed to emulate the mesenchymal stem cell“recruitment-osteogenesis”cascade for diabetic periodontal bone regeneration.During therapy,SDF-1 quickly escapes from the hydrogel due to diffusion for early rat bone marrow stem cell(rBMSC)recruitment.Simulta-neously,slow degradation of the hydrogel starts to gradually expose the MSNs for sustained release of metformin,which can scavenge the overproduced ROS under high glucose conditions to reverse the inhibited osteogenesis of rBMSCs by reactivating the AMPK/β-catenin pathway,resulting in regulation of the diabetic microenvironment and facilitation of osteogenesis.In vitro experiments indicate that the hydrogel markedly restores the inhibited migration and osteogenic capacities of rBMSCs under high glucose conditions.In vivo results suggest that it can effectively recruit rBMSCs to the periodontal defect and significantly promote periodontal bone regeneration under type 2 DM.In conclusion,our work provides a novel therapeutic strategy of a bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration. | He Wang Xiaowei Chang Qian Ma Boyang Sun Han Li Jinmin Zhou Yiyao Hu Xiaoyu Yang Jie Li Xin Chen Jinlin Song | 2023 | Bioactive Materials2023，，3： | 1 |
| 14 | Oxygen-assisted preparation of mechanoluminescent ZnS:Mn for dynamic pressure mapping显示文摘变换机械刺激点亮排放的 Mechanoluminescent 材料在人机器的相互作用为潜在的应用吸引了广泛的注意。这里,我们为 ZnS 的帮助氧的准备报导一条简单、可得到的新奇途径: Mn 粒子由固态在没有相应氧化物的形成的气压的反应。O 2 的存在在 wurtzite 阶段 ZnS 在 S 空缺的形成上有积极影响,导致 Mn 2+ 离子的介绍光中心和浅施主铺平,它能改进电子洞再结合率。O 2 比率和 Mn 2+ 离子做集中在发光效率上有重要效果,它分别地在 1%-20% 和 1 at.%-2 at.% 是最佳的。另外,一台设备基于有 0.032 MPa 1 的优秀压力敏感的 piezo-photonic 效果被制作,它能印射在 situ 从 2.2 ~ 40.6 MPa 的二维的压力分发。这台设备能被用于即时压力印射,聪明的传感器网络,高级安全系统,人机器的接口,和人工的皮肤。 | Xiandi Wang Rui Ling Yufei Zhang Miaoling Que Yiyao Peng Caofeng Pan | 2018 | Nano Research2018，11，4： | 1 |
| 15 | Influence of ultrasonic stimulation on growth and proliferation of Oryza sativa Nipponbare callus显示文摘 | LIU Yiyao Yoshikoshi akio WANG Bochu sakanishi Akio | 2003 | Colloids and Surfaces B: Biointerfaces2003，27，： | 1 |
| 16 | Varying water column stability controls the denitrification process in a subtropical reservoir,Southwest China显示文摘Reservoirs are regarded as hotspots of nitrogen transformation and potential sources of nitrous oxide(N_(2)O).However,it remains unclear how the hydrological conditions due to dam construction control the processes of nitrogen transformation in reservoir waters.To address this issue,we examined the spatial-temporal characteristics of nitrate concentrations,δ^(15)N-NO_(3)^(-),δ^(18)O-NO_(3)^(-),δ^(18)O-H_(2)O,relative water column stability(RWCS),and related environmental factors in a subtropical eutrophic reservoir(Hongfeng Reservoir,HFR),Southwest China.We found that denitrification was the most important nitrogen transformation process in the HFR and that higher denitrification intensity was associated with increased RWCS in summer,which suggested hydrological control of the denitrification process.In contrast,low RWCS conditions favored the nitrification process in the HFR in winter.Additionally,dissolved oxygen(DO;p<0.05)and nitrate concentrations(p<0.01)had significant impacts on the denitrification rate.We also found that the spatiotemporal RWCS variations were a prerequisite for regulating DO/nitrate stratification and the coupling/decoupling of nitrification-denitrification at the local and global scales.This study would advances our knowledge of the impacts of RWCS and thermal stratification on nitrogen transformation processes in reservoirs. | Gaoyang Cui Xiao-Dong Li Siqi Li Shiyuan Ding Qinkai Li Mengdi Yang Hong Lv Yiyao Wang | 2022 | Journal of Environmental Sciences2022，34，1： | 0 |
| 17 | Infl uences of aeration induced turbulence on growth and competition of Microcystis and Scenedesmus in the presence of sediments with varying particle sizes显示文摘Aeration is an important measure to prevent cyanobacterial growth in eutrophic lakes and reservoirs.The purpose of this study is to clarify the infl uence of aeration induced turbulence on growth and competition of Microcystis and Scenedesmus in the presence of sediments with varying particle sizes.Microcystis aeruginosa and Scenedesmus obliquus were selected as the model organisms.Sediments with varying particle sizes were added into mono and mixed cultures of the organisms.In the absence of sediment,both low-and high-intensity aerations(the turbulent dissipation rates were 1.60×10^(-6)and 1.16×10^(-5)m^(2)/s^(3),respectively)promoted the growth of Scenedesmus,but the growth of Microcystis was inhibited particularly obvious under the high-intensity aeration conditions.In the presence of sediment,Scenedesmus was promoted under all aeration conditions,while Microcystis was inhibited.The inhibition rate of Microcystis decreased with the increase of sediment size when treated with low-intensity aeration in the nighttime.The highest inhibition rate of M.aeruginosa(89.2%)was identifi ed under the condition of low-intensity aeration in the nighttime with small sediment addition.Furthermore,our results indicated that the impacts of sediment-induced light intensity reduction on algal growth were insignifi cant.In the mixed culture,the growth of Microcystis was inhibited by Scenedesmus in all treatments with aeration.Our results provided a theoretical basis for the practice in controlling cyanobacteria by aeration. | Qiang HE Yiyao WANG Ming LI | 2022 | Journal of Oceanology and Limnology2022，40，1： | 0 |
| 18 | Synthesis of amorphous Pd-based nanocatalysts for efficient alcoholysis of styrene oxide and electrochemical hydrogen evolution显示文摘Amorphous nanomaterials with long-range disordered structures could possess distinct properties and promising applications,especially in catalysis,as compared with their conventional crystalline counterparts.It is imperative to achieve the controlled preparation of amorphous noble metal-based nanomaterials for the exploration of their phase-dependent applications.Here,we report a facile wet-chemical reduction strategy to synthesize various amorphous multimetallic Pd-based nanomaterials,including PdRu,PdRh,and PdRuRh.The phase-dependent catalytic performances of distinct Pd-based nanomaterials towards diverse catalytic applications have been demonstrated.Specifically,the usage of PdRu nanocatalysts with amorphous and crystalline face-centered cubic(fcc)phases can efficiently switch the ring-opening route of styrene oxide to obtain different products with high selectivity through alcoholysis reaction and hydrogenation reaction,respectively.Moreover,when used as an electrocatalyst for hydrogen evolution reaction(HER),the synthesized amorphous PdRh nanocatalyst exhibits low overpotential and high turnover frequency values,outperforming its crystalline fcc counterpart and most of the reported Pd-based HER electrocatalysts. | Yiyao Ge Jingjie Ge Biao Huang Xixi Wang Guigao Liu Xiang-Huan Shan Lu Ma Bo Chen Guanghua Liu Songmo Du An Zhang Hongfei Cheng Qingbo Wa Shiyao Lu Lujiang Li Qinbai Yun Kuo Yuan Qinxin Luo Zhichuan J.Xu Yonghua Du Hua Zhang | 2023 | Nano Research2023，16，4： | 0 |
| 19 | Hard nanocrystalline gold materials prepared via high-pressure phase transformation显示文摘As one of the important materials,nanocrystalline Au(n-Au)has gained numerous interests in recent decades owing to its unique properties and promising applications.However,most of the current n-Au thin films are supported on substrates,limiting the study on their mechanical properties and applications.Therefore,it is urgently desired to develop a new strategy to prepare nAu materials with superior mechanical strength and hardness.Here,a hard n-Au material with an average grain size of~40 nm is prepared by cold-forging of the unique Au nanoribbons(NRBs)with unconventional 4H phase under high pressure.Systematic characterizations reveal the phase transformation from 4H to face-centered cubic(fcc)phase during the cold compression.Impressively,the compressive yield strength and Vickers hardness(HV)of the prepared n-Au material reach~140.2 MPa and~1.0 GPa,which are 4.2 and 2.2 times of the microcrystalline Au foil,respectively.This work demonstrates that the combination of high-pressure cold-forging and the in-situ 4H-to-fcc phase transformation can effectively inhibit the grain growth in the obtained n-Au materials,leading to the formation of novel hard n-Au materials.Our strategy opens up a new avenue for the preparation of nanocrystalline metals with superior mechanical property. | Chenlong Xie Wenxin Niu Penghui Li Yiyao Ge Jiawei Liu Zhanxi Fan Xiaoxiao Liu Ye Chen Ming Zhou Zihe Li Mengdong Ma Yonghai Yue Jing Wang Li Zhu Kun Luo Yang Zhang Yingju Wu Lin Wang Bo Xu Hua Zhang Zhisheng Zhao Yongjun Tian | 2022 | Nano Research2022，15，7： | 0 |
| 20 | Corrigendum to “Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy” [Bioactive Mater. 16 107-119]显示文摘The authors regret that the published version of the above article contained two errors which were not identified during the proofing stage.Also,Figure 2A and 6C have been replaced.The authors apologize for these errors and state that these corrections do not change the scientific conclusions of the article in any way. | Xiaoxue Xie Yi Feng Hanxi Zhang Qingqing Su Ting Song Geng Yang Ningxi Li Xiaodan Wei Tingting Li Xiang Qin Shun Li Chunhui Wu Xiaojuan Zhang Guixue Wang Yiyao Liu Hong Yang | 2023 | Bioactive Materials2023，，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员