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| 1 | Genetic diversity of rice cultivars (Oryza sativa L.) in China and the temporal trends in recent fifty years显示文摘To understand geographical distribution of the genetic diversity of rice cultivars {Oryza sativa L.) and its trends in recent fifty years in China, 453 ’ accessions were analyzed by 36 microsatellites loci and 42 phenotypic traits. Results revealed that the genetic diversity by SSRs is highly consistent with that by phenotypic traits and the genetic diversity of indica cultivars was higher than that of japonica cultivars; the genetic diversity of cultivars declined from 1950s to 1980s and then increased greatly; among the six rice ecological zones (REZs), genetic diversity of REZTl was the highest and those of REZV and REZVT were the lowest at both DNA and phenotypic level. Jiangsu and Jiangxi provinces in the middle and lower reaches of Yangtze River and Sichuan province in southwest of China were the areas with the highest genetic diversity. Breeders in REZV which is an important japonica rice area but with very low genetic diversity should explore more gene resources to widen the genetic backgrounds of cultivars. | QI Yonawen ZHANG Dongling ZHANG Hongliang WANG Meixing SUN Junli WEI Xinghua QIU Zongen TANG Shengxiang CAO Yongsheng WANG Xiangkun LI Zichao | 2006 | Chinese Science Bulletin2006，51，6： | 27 |
| 2 | CTLA4 Silencing with siRNA Promotes Deviation of Th1/Th2 in Chronic Hepatitis B Patients显示文摘To determine whether RNA interference (RNAi) could block cytotoxic T-lymphocyte antigen 4 (CTLA4) in human lymphocytes in vitro and promote IFN-γ and IL-2 secretions, three small interfering RNAs (siRNAs) were selected based on target specificity sequences of human CTLA4 and transfected into human lymphocytes of chronic HBV patients. As a result, the expression of human CTLA4 mRNA was efficiently suppressed by all the three siRNAs. Compared with negative control (siRNA-co), siRNA-1 inhibited the expression of CTLA4 most efficiently and was used in the further study. The expressions of IFN-γ and IL-2 were upregulated and the level of IL-4 was almost unchanged in lymphocytes transfected with siRNA-1 compared with the blank control. These results indicated that siRNA-1 led to IFN-γ and IL-2 secretions, which is a main response of Th1/Th2. In a conclusion, RNAi significantly suppressed the expression of human CTLA4 mRNA in human lymphocytes in vitro, and could induce Th1/Th2 response. It could be a new therapeutic strategy for chronic HBV infection. | Yongsheng Yu Hao Wu Zhenghao Tang Guoqing Zang | 2009 | Cellular & Molecular Immunology2009，6，2： | 14 |
| 3 | Dendritic cell-based vaccination with lentiviral vectors encoding ubiquitinated hepatitis B core antigen enhances hepatitis B virus-specific immune responses in vivo显示文摘肝炎 B 病毒(HBV ) 的活动特定的细胞毒素的 T 淋巴细胞(CTL ) 戏在 HBV 的清理的一个占优势的角色。树枝状的房间(DC ) 是关键介绍抗原的房间并且在有免疫力的回答的开始起一个重要作用。我们以前验证了有效地编码 ubiquitinated 肝炎 B 核心抗原(LV-Ub-HBcAg ) 的那 lentiviral 向量导致成熟的 transduced DC,和成熟 DC 高效地导致了 T 房间极化到 Th1 并且产生了 HBcAg 特定的 CTL 前 vivo。在这研究,在 BALB/c 老鼠的 LV-Ub-HBcAg 的 HBV 特定的有免疫力的回答(H-2K d ) 被评估。LV-Ub-HBcAg 的直接注射增加了 cytokines IL-2 和 IFN- 的生产,这被显示出,得到了强壮的抗体回答,并且显著地产生了 IFN-+ 有在 BALB/c 老鼠的 HBV 特定的 CTL 回答的 CD8 + T 房间。另外, LV-Ub-HBcAg 的直接注射导致了有势力 anti-HBV 免疫者回答,类似于得到由的那些在 vitro-transduced DC。在结论,基于 DC 的治疗学的疫苗的 LV-Ub-HBcAg 得到了特定的抗体免疫者回答并且在 vivo 导致了柔韧的特定的 CTL 活动。 | Shenglan Dai Meng Zhuo Linlin Song Xiaohua Chen Yongsheng Yu Zhenghao Tang Guoqing Zang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 9 |
| 4 | Classifying rheumatoid arthritis by Traditional Chinese Medicine Zheng: a multi-center cross-sectional study显示文摘OBJECTIVE:To assess the relationship between disease symptoms and traditional Chinese medicine (TCM) syndrome (Zheng) in rheumatoid arthritis (RA) patients.METHODS:RA Patients were recruited in Guang'anmen Hospital,China Academy of Chinese Medical Sciences and in the Second Affiliated Hospital of Zhejiang Chinese Medical University,and diagnosed with a particular RA Zheng from their symptoms.Demographic characteristics,self-reported symptoms,and blood samples were collected from patients.All data were input into EpiData and analyzed using SPSS software.RESULTS:The study included 302 RA patients (age range:18-86 years).All patients were Chinese,and 85.1% were women.Cold and fatigue triggers were reported by 8.6% of patients,followed by triggers such as childbirth (4.3%),cold (3.0%),dampness (2.0%),menopause (1.3%),and psychentonia (0.7%).The most prevalent Zheng was dampness and heat blockage (Shire Yuzu in Chinese,SRYZ),diagnosed in 39.4% of patients (119),followed by phlegm and stagnation blockage (Tanyu Bizu,TYBZ) in 21.5%,liver and kidney deficiency (Ganshen Buzu,GSBZ) in 18.5%,dual deficiency of Qi and blood (Qixue Liangxu,QXLX) in 9.6%,cold and dampness blockage (Hanshi Bizu,HSBZ) in 6%,and wind and dampness blockage (Fengshi Bizu,FSBZ) in 5%.Increased length of time since RA diagnosis was associated with the GSBZ group.Patients diagnosed with the SRYZ Zheng had the highest disease activity score.Patients diagnosed with the QXLX Zheng had the lowest blood platelet counts;patients diagnosed with the QXLX and HSBZ Zhengs had lower C-reactive protein levels and lower health assessment questionnaire scores.Patients diagnosed with the GSBZ and QXLX Zhengs had the highest health assessment questionnaire scores.CONCLUSION:The specific Zheng was related to RA characteristics.The findings suggest that eliminating dampness,cooling the patient,and promoting blood circulation may assist in treating severe RA. | Wang Weijie Tang Xiaopo Wang Xinchang Jiang Quan Fan Yongsheng | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 7 |
| 5 | Delivery of Tapasin-modified CTL epitope peptide via cytoplasmic transduction peptide induces CTLs by JAK/STAT signaling pathway in vivo显示文摘特定的细胞毒素的 T 淋巴细胞(CTL ) 玩的肝炎 B 病毒(HBV ) 在病毒的控制和清理的一个重要角色。最近的研究阐明了那 Tapasin, endoplasmic 蜂窝胃女伴,是看起来在装载肽的过程必要的一个著名分子。Janus kinase/signal 变换器和小径玩的抄写(JAK/STAT ) 的使活跃之物在有免疫力的反应的一个重要角色规定和 cytokines 分泌物。我们以前证实了熔化蛋白质 CTP-HBcAg 18-27-Tapasin 能便于骨头髓的成熟导出的树枝状的房间并且在 vitro 提高特定的 CTL 回答,它可能与 JAK/STAT 发信号的激活被联系小径。为了进一步探索 JAK/STAT 发信号小径是否参予了特定的有免疫力的回答,由我们压制了的 CTP-HBcAg 18-27-Tapasin, 调停了有在 vivo 的药理学禁止者(AG490 ) 的 JAK/STAT 小径。我们的研究证明 IFN-+-CD8+ T 房间的数字在被 AG490 堵住以后与另外的组相比显著地被减少。IFN-+-CD4+ T 房间和 IL-2-CD4 + T 房间的百分比也被减少。而且, Jak2, Tyk2, STAT1,和 STAT4 的更低的表示层次在 AG490 被检测组。另外,象 Th1 一样 cytokines 的分泌物层次被减少,更弱的特定的 T 房间回答在 AG490 组被观察。而且,在这条小径在 HBV 转基因的老鼠被禁止以后,在浆液的 HBV DNA 和 HBsAg 的层次和在肝纸巾的 HBsAg 和 HBcAg 的表示层次被提高。这些结果证明表明小径的 JAK/STAT 参予 CTP-HBcAg 18-27-Tapasin 导致的 Th1 面向的有免疫力的反应,这可能为 HBV 免疫疗法提供一个理论基础。 | Shanshan Wu Xiaohua Chen Yuyan Tang Yi Zhang Dan Li Jie Chen Jieling Wang Zhenghao Tang Guoqing Zang Yongsheng Yu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 6 |
| 6 | Kiwifruit Genome Database(KGD):a comprehensive resource for kiwifruit genomics显示文摘Kiwifruit(Actinidia spp.)plants produce economically important fruits containing abundant,balanced phytonutrients with extraordinarily high vitamin C contents.Since the release of the first kiwifruit reference genome sequence in 2013,large volumes of genome and transcriptome data have been rapidly accumulated for a handful of kiwifruit species.To efficiently store,analyze,integrate,and disseminate these large-scale datasets to the research community,we constructed the Kiwifruit Genome Database(KGD;http://gffzz6fc08c45f9754a68hnkwvqf6xpx9c6qfc.ffgz.tsg.suse.edu.cn/).The database currently contains all publicly available genome and gene sequences,gene annotations,biochemical pathways,transcriptome profiles derived from public RNA-Seq datasets,and comparative genomic analysis results such as syntenic blocks and homologous gene pairs between different kiwifruit genome assemblies.A set of user-friendly query interfaces,analysis tools and visualization modules have been implemented in KGD to facilitate translational and applied research in kiwifruit,which include JBrowse,a popular genome browser,and the NCBI BLAST sequence search tool.Other notable tools developed within KGD include a genome synteny viewer and tools for differential gene expression analysis as well as gene ontology(GO)term and pathway enrichment analysis. | Junyang Yue Jiacheng Liu Wei Tang Ya Qing Wu Xiaofeng Tang Wei Li Ying Yang Lihuan Wang Shengxiong Huang Congbing Fang Kun Zhao Zhangjun Fei Yongsheng Liu Yi Zheng | 2020 | Horticulture Research2020，7，1： | 6 |
| 7 | The modification of Tapasin enhances cytotoxic T lymphocyte activity of intracellularly delivered CTL epitopes via cytoplasmic transduction peptide显示文摘以前的研究证明了基于肝炎 B 病毒(HBV ) 的改进,特定的细胞毒素的 T 淋巴细胞(CTL ) 活动可以导致的治疗学的疫苗在感染 HBV 的个人的病毒的清理。endoplasmic 蜂窝胃(嗯) 女伴 Tapasin 在主要 histocompatibility 起一个重要作用建筑群(MHC ) 一级汇编并且由允许更多的肽是进 ER 的 translocated 提高特定的 MHC 班我限制 CTL 活动。联合核心抗原(HBcAg ) CTL epitope,细胞质的 transduction 肽(CTP ) 的渗透房间的性质,和女伴 Tapasin 可以得到的肝炎 B 的特性柔韧的特定的 HBV 有免疫力的回答。在现在的学习,我们在 vitro 证实了 CTP-HBcAg1827-Tapasin 熔化蛋白质的细胞质的本地化偏爱并且在支持骨头上评估了效果导出髓的树枝状的房间(BMDC ) 成熟和提高的 T 房间反应到产生特定的 CTL。我们的结果证明那 CTP-HBcAg1827-Tapasin 熔化蛋白质不能仅仅确切并且有效地渗透进细胞质提高 Tapasin 表示,而且增加表面分子(CD80, CD83, CD86,和 MHC-I ) 和 DC 的 cytokine (IL-12p70 ) 的分泌物的表示。而且,与上述熔化蛋白质对待的 DC 显著地与控制组相比在 vitro, IFN-+CD8+ T 房间的百分比和特定的 CTL 回答增加了增殖的 T 房间的 cytokine 分泌物。在结论, Tapasin 的修正能提高经由细胞内部的交货指向抗原到 DC 的演讲并且高效地得到特定的 CTL 有免疫力的回答。 | Xiaohua Chen Honghong Liu Zhenghao Tang Yongsheng Yu Guoqing Zang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 6 |
| 8 | Recent progress in organic solar cells(PartⅠmaterial science)显示文摘During past several years,the photovoltaic performances of organic solar cells(OSCs)have achieved rapid progress with power conversion efficiencies(PCEs)over 18%,demonstrating a great practical application prospect.The development of material science including conjugated polymer donors,oligomer-like organic molecule donors,fused and nonfused ring acceptors,polymer acceptors,single-component organic solar cells and water/alcohol soluble interface materials are the key research topics in OSC field.Herein,the recent progress of these aspects is systematically summarized.Meanwhile,the current problems and future development are also discussed. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，2： | 5 |
| 9 | Genetic structure and diversity of Oryza sativa L. in Guizhou,China显示文摘Preserving many kinds of rice resources and rich variations, Guizhou Province is one of the districts with the highest genetic diversity of cultivated rice (Oryza sativa L.) in China. In the current research, genetic diversity and structure of 537 accessions of cultivated rice from Guizhou were studied using 36 microsatellite markers and 39 phenotypic characters. The results showed that the model-based genetic structure was the same as genetic-distance-based one using SSRs but somewhat different from the documented classification (mainly based on phenotype) of two subspecies. The accessions being classified into indica by phenotype but japonica by genetic structure were much more than that being classified into japonica by phenotype but indica by genetic structure. Like Ding Ying’s taxonomic sys- tem of cultivated rice, the subspecific differentiation was the most distinct differentiation within culti- vated rice. But the differentiation within indica or japonica population was different: japonica presented clearer differentiation between soil-watery ecotypes than indica, and indica presented clearer differen- tiation between seasonal ecotypes than japonica. Cultivated rices in Guizhou revealed high genetic diversity at both DNA and phenotypic levels. Possessing the highest genetic diversity and all the nec- essary conditions as a center of genetic diversity, region Southwestern of Guizhou was suggested as the center of genetic diversity of O. sativa L. from Guizhou. | ZHANG DongLing ZHANG HongLiang WEI XingHua QI YongWen WANG Meixing SUN JunLi DING Li TANG ShengXiang QIU Zong'En CAO YongSheng WANG XiangKun LI ZiChao | 2007 | Chinese Science Bulletin2007，52，3： | 5 |
| 10 | Enhancement of cytotoxic T lymphocyte activity by dendritic cells loaded with Tat-protein transduction domain-fused hepatitis B virus core antigen显示文摘人的免疫不全 virus-1-Tat 蛋白质的蛋白质 transduction 领域(PTD ) 有唯一的力量渗透细胞的膜。综合 Tat-PTD 47 的顺序 57 和肝炎 B 病毒核心抗原(HBcAg ) ,我们拼接这些序列并且连接了熔化基因进 pMAL-c2x 向量。熔化蛋白质被亲密关系层析净化并且与骨头搏动了导出髓的树枝状的房间(DC ) ,和 recombinant 蛋白质的 transduction 被免疫检测荧光抗体试金。当 recombinant HBcAg 在房间的表面上被检测时,结果证明 recombinant PTD-HBcAg 能渗透细胞质进 DC。DC 表面分子的百分比 CD86 和主要 histocompatibility 建筑群 II,和 recombinant PTD-HBcAg 导致的 cytokine (IL-12p70 ) 的生产例如 CD80,比 recombinant HBcAg 或肿瘤坏死 factor-α 导致的那些显著地高。与 PTD-HBcAg 对待的 DC 导致了 T 房间区分进特定的细胞毒素的 T 淋巴细胞(CTL ) 并且提高了杀死反应的 CTL。在结论,表示并且净化的 PTD-HBcAg 熔化蛋白质能通过血浆膜渗透进房间,支持 DC 成熟,并且提高 T 房间反应高效地产生 HBcAg 特定的 CTL。 | Xiaohua Chen Yongsheng Yu Qingchun Pan Zhenghao Tang Jinchao Han Guoqing Zang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 4 |
| 11 | A MACWILLIAMS TYPE IDENTITY ON LEE WEIGHT FOR LINEAR CODES OVER F_2+uF_2显示文摘在这份报纸,为 m 厚度李重量的 MacWilliams 类型身份在 \mathbbF2 + u\mathbbF2\mathbb 上为线性代码枚举符 { F }_2 + u\mathbb { F }_2 被决定。作为这身份的一个应用程序,作者在 \mathbbF2m + u\mathbbF2m \mathbb 上为线性代码在李重量上获得 MacWilliams 类型身份 { F }_{ 2 ^ m }+ u\mathbb { F }_{ 2 ^ m } 。而且,作者由利用 Krawtchouk 多项式为 m 厚度李重量分布证明两重性。 | Shixin ZHU Yongsheng TANG | 2012 | Journal of Systems Science & Complexity2012，25，1： | 3 |
| 12 | Recent progress in organic solar cells(PartⅡdevice engineering)显示文摘1 Introduction Organic solar cells(OSCs)belong to a multidisciplinary field composed of chemistry,materials science,physics,engineering,etc.For a better reviewing of this field,we briefly divide the research field of OSCs into two parts:material science and device engineering.In our previous review,the material science part of OSCs,including conjugated polymer donors and acceptors,small molecular donors and acceptors. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yuqiang Liu Lei Meng Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，8： | 3 |
| 13 | Reprogramming donor cells with oocyte extracts improves in vitro development of nuclear transfer embryos显示文摘 | Shuang Tang Yongsheng Wang Dong Zhang Yajun Gao Yefei Ma Baoying Yin Jianhong Sun Jun Liu Yong Zhang | 2008 | Animal Reproduction Science2008，，1： | 1 |
| 14 | Study on the all position automatic pipeline backing weld machine显示文摘As a result of the lower backing weld efficiency, the applying of automatic welding is seriously limited. So a kind of special automatic welder is designed and manufactured for backing weld. This paper introduces the character of the assembled pulse CO2 arc welding machine which has strong penetrability. It specifies the technology of controlling the parameters of all position automatic welding by computer and multi-axis controller. Moreover typical welding procedure parameters are provided. It is proved by examination that the economical and practical equipment and technology are suitable for the long-distance transmission pipeline, and it has a good foreground of spreading and applying. | Tang Deyu Feng Biao Li Chunrun Niu Huli Zhang Yongsheng Zhang Jianhu | 2008 | Engineering Sciences2008，6，2： | 1 |
| 15 | Capacitive properties of PANI/MnO 2 synthesized via simultaneous-oxidation route显示文摘 | Jie Zhang Dong Shu Tianren Zhang Hongyu Chen Haimin Zhao Yongsheng Wang Zhenjie Sun Shaoqing Tang Xueming Fang Xiufang Cao | 2012 | Journal of Alloys and Compounds2012，，： | 1 |
| 16 | 9/11 and Global Strategic Stability显示文摘In the past ten years since 9/11, terrorism has become a growing threat to international security, and to people's lives and property. Increasing incidents of terrorism have underlined the fundamental structural flaws in the international system, showing that American hegemony has reached a certain limit. Not only have the major security concerns of the United States changed, but existing international strategic relations have also been shaken. This has directly affected global strategic stability. | Tang Yongsheng,Deputy Director of the Institute for Strategic Studies of National Defense University in China. Professor Tang’s main research focuses on international strategy and national security strategy. He Nan | 2011 | Contemporary International Relations2011，21，5： | 1 |
| 17 | Thermodynamic descriptions of quaternary Mg-Al-Zn-Bi system supported by experiments and their application in descriptions of solidification behavior in Bi-additional AZ casting alloys显示文摘16 Mg-Al-Zn-Bi quaternary alloys were utilized to measure the phase equilibria and transformation temperatures in the Mg-rich Mg-Al-Zn-Bi quaternary system by means of the X-ray diffraction,electron probe micro-analysis and differential scanning calorimetry techniques.The isothermal section at 400℃and three vertical sections along Mg-8 wt%Al-0.75 wt%Zn-vBi,Mg-3.4 wt%Al-0.5 wt%Zn-ABi and Mg-6.9 wt%Al-2.3 wt%Zn-xBi in the Mg-Al-Zn-Bi quaternary system were constructed.Based on the literature data,the ternary Mg-Al-Bi and Mg-Bi-Zn systems were re-assessed using the CALculaiton of PHAse Diagram(CALPHAD)approach.The calculated phase equilibria agree well with the measured data.By directly extrapolating the constituent sub-ternary systems,the thermodynamic database for the Mg-Al-Zn-Bi quaternary system was developed.The remarkable consistency between the predicted phase equilibria and the presently measured data in Mg-Al-Zn-Bi quaternary system further demonstrated the accuracy and reliability of the established thermodynamic database.After that,by using the newly developed thermodynamic database,the growth restrict factors and the solidification curves in Bi-containing AZ series magnesium alloys were calculated and analyzed.It was confirmed that the grain size of AZ alloys can be refined with the addition of Bi,and the comp on ent Al had larger grain refinement effect than Bi.Besides,the amount of Bi had also no ticeable effect on the solidification sequence of the AZ alloys. | Ying Tang Yongsheng Li Weimin Zhao Irina Roslyakova Lijun Zhang | 2020 | Journal of Magnesium and Alloys2020，8，4： | 1 |
| 18 | A clinical analysis of percutaneous coronary intervention in 65 patients with coronary chronic total occlusions显示文摘 | Ke Yongsheng Jia Liangliang Tang Jun et al | 2014 | Chin J Cardiovasc Rehabil Med2014，23，2： | 1 |
| 19 | Determination of cut-off wavelength and composition distribution in Hg1-xCdxTe显示文摘 | Junhao Chu Yongsheng Gui Biao Li Dingyuan Tang | 1998 | Journal of Electronic Materials1998，，6： | 1 |
| 20 | The delivery of HBcAg via Tat-PTD enhances specific immune response and inhibits Hepatitis B virus replication in transgenic mice显示文摘 | Xiaohua Chen Jinglan Lai Qingchun Pan Zhenghao Tang Yongsheng Yu Guoqing Zang | 2010 | Vaccine2010，，23： | 1 |
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