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| 1 | Progress and perspectives of quantitative structure-activity relationships used for ecological risk assessment of toxic organic compounds显示文摘Structure-activity relationship (SAR) and quantitative structure-activity relationship (QSAR), collec- tively referred to as (Q)SARs, play an important role in ecological risk assessment (ERA) of organic chemicals. (Q)SARs can fill the data gap for physical-chemical, environmental behavioral and ecotoxicological parameters of organic compounds; they can decrease experimental expenses and reduce the extent of experimental testing (especially animal testing); they can also be used to assess the uncertainty of the experimental data. With the development for several decades, (Q)SARs in envi- ronmental sciences show three features: application orientation, multidisciplinary integration, and in- telligence. Progress of (Q)SAR technology for ERA of toxic organic compounds, including endpoint selection and mathematic methods for establishing simple, transparent, easily interpretable and portable (Q)SAR models, is reviewed. The recent development on defining application domains and diagnosing outliers is summarized. Model characterization with respect to goodness-of-fit, stability and predictive power is specially presented. The purpose of the review is to promote the development of (Q)SARs orientated to ERA of organic chemicals. | CHEN JingWen LI XueHua YU HaiYing | 2008 | Science China Chemistry2008，51，7： | 9 |
| 2 | The possible contribution of a mantle-derived fluid to the Ningwu porphyry iron deposits—Evidence from carbon and strontium isotopes of apatites显示文摘Apatite is a characteristic mineral for the iron deposits in the Ningwu region. Apatite shows a range of d13CPDB values from à9.6& to à0.6&,and most of them with the d13CPDB values distributed in a range of mantle carbon (i.e.,à2& to à9&),except for samples T-06-1 and J-06-3. Apatites in the Ningwu porphyry iron deposits yield a narrow variation range of 87Sr/86Sr values from 0.706326 to 0.707577,similar to those of the volcanic and subvolcanic rocks and higher than that of a typical mantle-derived magmatic apatite (i.e.,about 0.7040),indicating that formation of the apatites was involved with crust material contamination. d13CPDB and 87Sr/86Sr values of the apatite indicate a possible contribution of mantle-derived fluid and material to formation of the Ningwu porphyry iron deposits,supported by regional geology,regional gravities and geochemistry of the volcanic and subvolcanic rocks in the Ningwu region. | Jinjie Yu Jingwen Mao Changqing Zhang | 2008 | Progress in Natural Science:Materials International2008，18，2： | 7 |
| 3 | Geochemistry of Apatite from the Apatite-rich Iron Deposits in the Ningwu Region,East Central China显示文摘磷灰石的四种类型在 Ningwu 区域被识别了。磷灰石的第一种类型广泛地在中间的黑暗有颜色的地区被散布(即铁矿) 单个存款。集合包括磁铁矿,磷灰石和阳起石(或透辉石) 。Thesecond 类型在铁矿发生在磁铁矿磷灰石静脉以内。第三种类型是看见的 inmagnetite 磷灰石静脉并且(或) 在主人岩石中的小瘤(即斑粝岩闪长岩斑岩 orgabbro 闪长岩或辉石闪长岩) 。第四种类型在在 Xiangshan 组充满破裂的 apatite-pyrite-quartz 静脉以内发生。在斑岩铁矿床的四出现的磷灰石的稀土元素元素(REE ) 地球化学被介绍。磷灰石的 REE 分发模式通常类似于在 Kiruna 类型铁矿的磷灰石的那些, nelsonites。他们在轻 REE 被充实,与显著否定 Eu 异例。在从在在世界上的不同地点的各种各样的存款的磷灰石的 REE 分发模式的类似为各种各样的矿石类型显示形成的一个普通过程,例如 immiscibility。早 magmatic 磷灰石 contain3031.48-12080 x 10 ^(-6) REE。后来热水的磷灰石包含 1958 x10^(-6) REE,显示以后热水的形成矿石的答案包含降低 REE。尽管斑粝岩闪长岩斑岩和磷灰石显示出类似的 REE 模式,斑粝岩闪长岩斑岩没有铕异例或微弱的积极或微弱的否定的铕异例,在一个高氧易逃逸条件下面由披风源地的减小环境并且由分别和结晶化(immiscibility ) 引起了。磷灰石的否定 Eu 异例被更早的 diopsite 在矿石岩浆冷却期间由于 Eu^(2+) 的获得可能形成。在 Aoshan 和泰山铁矿床的磷灰石产出Sr/^( 86 ) Sr 从 0.7071~0.7073 珍视的^( 87 )的一个狭窄的变化范围,类似于那些暴烈并且潜水艇火山岩,显示磷灰石被液体 immiscibility 和中间、基本的岩浆的区别形成。 | YU Jinjie ZHANG Qi MAO Jingwen YAN Shenghao | 2007 | Acta Geologica Sinica(English Edition)2007，81，4： | 5 |
| 4 | Rational design for fungal laccase production in the model host Aspergillus nidulans显示文摘Laccases, multicopper oxidoreductases, are mainly produced in white-rot fungi and are considered as ideal green catalysts in industrial and biotechnological applications. However, the development of laccases is limited due to the slow growth of natural laccase producing strains and the low expression levels of laccases. In this study, we designed three regulation strategies for laccase gene expression in the model fungus Aspergillus nidulans. By introducing various promoters in front of the laccase gene pslcc from the white-rot fungus Pycnoporus sanguineus, we found that the laccase gene with the original promoter had effective expression in A. nidulans. Using the previously identified transcription factor RsmA regulatory mechanism, the aflR promoter was inserted into the pslcc expression vectors, and the laccase production was 15-fold higher in the strain overexpressing of RsmA compared to the control strain. To improve the laccase yield, the dipeptidyl-peptidase DppV, aspartic protease PepA and mannosyltransferase Mnn9 were successfully deleted in the A. nidulans host. The laccase activities were increased approximately 8-fold and 13-fold in the double deletions strains of Δmnn9ΔpepA and ΔdppVΔpepA over the control strains, respectively.Taken together, these results not only demonstrate an efficient system for heterologous protein production in the model fungus A.nidulans but also provide a general approach to applying regulatory methods to control gene expression. | Wei Li Jingwen Yu Zixin Li Wen-Bing Yin | 2019 | Science China(Life Sciences)2019，62，1： | 5 |
| 5 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 6 | Three-dimensional temperature reconstruction of diffusion flame from the light-field convolution imaging by the focused plenoptic camera显示文摘The plenoptic imaging technique provides a promising approach to the non-invasive three-dimensional measurement, especially for the high-temperature combustion diagnosis. We establish a light-field convolution imaging model for diffusion flame in this work, considering the radiation transfer process inside the diffusion flame and the light transfer process inside the focused plenoptic camera together. The radiation transfer process is described by the radiation transfer equation and solved by the generalized source multi-flux method. Wave optics theory is adopted to describe the light transfer process, combining Fresnel diffraction and the phase conversion of the lens. The flame light-field image is obtained by the light-field convolution imaging model and adopted as the measurement signal to reconstruct three-dimensional temperature field. The inverse problem of temperature reconstruction is solved by the least square QR decomposition method. The simulative temperature reconstruction work is conducted, including the inverse analysis, the uncertainty analysis, and the measurement noise influence. All the results show that the proposed measurement method is available to reconstruct three-dimensional temperature with satisfactory accuracy and acceptable uncertainty. Both symmetric and asymmetric distributed temperature fields are investigated, and the reconstructed results prove the validity and universality of the measurement method. | SHI JingWen QI Hong YU ZhiQiang AN XiangYang REN YaTao TAN HePing | 2022 | Science China(Technological Sciences)2022，65，2： | 4 |
| 7 | Identification of transporter proteins for PQQ-secretion pathways by transcriptomics and proteomics analysis in Gluconobacter oxydans WSH-003显示文摘Pyrroloquinoline quinone (PQQ ) 在细菌与脱氢酶在联合作为一个氧化还原作用余因子起一个重要作用。这些脱氢酶为生物工学工业在重要底层的氧化起关键作用,例如维生素 C 生产。当 PQQ 基因的生合成广泛地被学习了时, PQQ 运输机制仍然保持不清楚。此处,我们使用了定序在 Gluconobacter oxydans WSH-003 的工业紧张调查 pqqB overexpression 的效果的两二维的荧光差别胶化电气泳动双人脚踏车团 spectrometry 和 RNA。我们鉴别了 73 差别表示了蛋白质, 99 差别表示了基因,其一个多数与氧化减小有关并且由基因本体论分析搬运过程。我们也描述了对源于 pqqB overexpression 的增加的 PQQ 层次作出回应的几个通常认为的候选人受动器。而且,量的 PCR 被用来在生产紧张的不同 PQQ 之中验证五通常认为的 PQQ 运输基因,并且结果证明 ompW, B932_1930 和 B932_2186 是处于所有条件的 upregulated。当时,三基因在 G 是过去表示的。oxydans WSH-003 和 PQQ 生产被检测。结果显示出 B932_1930 (transporter ) 的那细胞外的 PQQ, overexpression 拉紧的 B932_2186 (ABC transporter permease ) 被 1.77 褶层和 1.67 褶层分别地提高。结果建议 PqqB, B932_1930 和 B932_2186 编码的蛋白质可能提高 PQQ 分泌物过程。 | Hui Wan Yu Xia Jianghua Li Zhen Kang Jingwen Zhou | 2017 | Frontiers of Chemical Science and Engineering2017，11，1： | 3 |
| 8 | Molybdenite Re–Os and albite 40 Ar/ 39 Ar dating of Cu–Au–Mo and magnetite porphyry systems in the Yangtze River valley and metallogenic implications显示文摘 | Jingwen Mao Yitian Wang Bernd Lehmann Jinjie Yu Andao Du Yanxiong Mei Yongfeng Li Wenshuan Zang Holly J. Stein Taofa Zhou | 2005 | Ore Geology Reviews2005，，3： | 2 |
| 9 | Oxidation reactivity of 1,2-bis(2,4,6-tribromophenoxy)ethane(BTBPE)by CompoundⅠmodel of cytochrome P450s显示文摘Alternative brominated flame retardants(BFRs) have become prevalent as a consequence of restrictions on the use of polybrominated diphenyl ethers(PBDEs). For risk assessment of these alternatives, knowledge of their metabolism via cytochrome P450 enzymes is needed.We have previously proved that density functional theory(DFT) is able to predict the metabolism of PBDEs by revealing the molecular mechanisms. In the current study, the reactivity of 1,2-bis(2,4,6-tribromophenoxy)ethane and structurally similar chemicals with the Compound I model representing the active site of P450 enzymes was investigated. The DFT calculations delineated reaction pathways which lead to reasonable explanations for products that were detected by wet experiments, meanwhile intermediates which cannot be determined were also proposed. Results showed that alkyl hydrogen abstraction will lead to bis(2,4,6-tribromophenoxy)ethanol, which may undergo hydrolysis yielding2,4,6-tribromophenol, a neurotoxic compound. In addition, a general pattern of oxidation reactivity regarding the 2,4,6-tribromophenyl moiety was observed among several model compounds. Our study has provided insights for convenient evaluation of the metabolism of other structurally similar BFRs. | Zhongyu Wang Zhiqiang Fu Qi Yu Jingwen Chen | 2017 | Journal of Environmental Sciences2017，29，12： | 2 |
| 10 | Innovations and challenges of polyphenol-based smart drug delivery systems显示文摘Polyphenols,as widely existing natural bioactive products,provide a vast array of advanced biomedical applications attributing to their potential health benefits that linked to antioxidant,anti-inflammatory,immunoregulatory,neuroprotective,cardioprotective function,etc.The polyphenol compounds could dynamically interact and bind with diverse species(such as polymers,metal ions,biomacromolecules,etc.)via multiple interactions,including hydrogen bond,hydrophobic,π–π,and cation–πinteractions due to their unique chemical polyphenolic structures,providing far-ranging strategies for designing of polyphenol-based vehicles.Natural polyphenols emerged as multifaceted players,acting either as inherent therapeutics delivered to combat diverse diseases or as pivotal assemblies of drug delivery vehicles.In this review,we focused on the rational design and application of metal-phenolic network(MPN)based delivery systems,polyphenol-based coating films,polyphenol hollow capsules,polyphenolincorporated hydrogels,and polymer-polyphenol-based nanoparticles(NPs)in various diseases therapeutic,including cancer,infection,cardiovascular disease,neurodegenerative disease,etc.Additionally.the versatility and mechanisms of polyphenols in the field of biomacromolecules(e.g.,protein,peptide,nucleic acid,etc.)delivery and cell therapy have been comprehensively summarized.Going through the literature review,the remaining challenges of polyphenol-containing nanosystems need to be addressed are involved,including long-term stability,biosafety in vivo,feasibility of scale-up,etc.,which may enlighten the further developments of this field.This review provides perspectives in utilizing natural polyphenol-based biomaterials to rationally design next generation versatile drug delivery system in the field of biomedicine,which eventually benefits public health. | Yanan Wang Jingwen Zhang Yi Zhao Minju Pu Xinyu Song Liangmin Yu Xuefeng Yan Jun Wu Zhiyu He | 2022 | Nano Research2022，15，9： | 2 |
| 11 | Multi-omics approach in tea polyphenol research regarding tea plant growth,development and tea processing:current technologies and perspectives显示文摘Polyphenols are one of the most important metabolites in tea due to their unique biological activities and health benefits,arousing great attention of researchers to investigate biochemical mechanisms of polyphenols during tea plant growth,development and tea processing.Although omics has been used as a major analytical platform for tea polyphenol research with some proven merits,a single-omics strategy remains a considerable challenge due to the complexity of biological system and functional processes of tea in each stage of tea production.Recent advances in multi-omics approaches and data analysis have enabled mining and mapping of enormous number of datasets at different biological scales from genotypes to phenotypes of living organisms.These new technologies combining genomics,metagenomics,transcriptomics,proteomics and/or metabolomics can pave a new avenue to address fundamental questions regarding polyphenol formation and changes in tea plants and products.Here,we review recent progresses in single-and multi-omics approaches that have been used in the field of tea polyphenol studies.The perspectives on future research and applications for improvement of tea polyphenols as well as current challenges of multi-omics studies for tea polyphenols are also discussed. | Jingwen Li Yu Wang Joon Hyuk Suh | 2022 | Food Science and Human Wellness2022，11，3： | 2 |
| 12 | Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants—China,2021显示文摘Introduction:Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in China.The study aims to estimate effectiveness of booster vaccines for high-risk populations(HRPs).Methods:A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed(SEIAR)model was developed to simulate scenarios of effective reproduction number(Reff)from 4 to 6.Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.Results:Our model showed that we could not prevent outbreaks when covering 80%of HRPs with booster unless Reff=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%.The results were consistent when the outcome index was confirmed cases or asymptomatic cases.Conclusions:An ideal coronavirus disease 2019(COVID-19)booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China.Accordingly,the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups. | Kangguo Li Zeyu Zhao Hongjie Wei Jia Rui Jiefeng Huang Xiaohao Guo Yichao Guo Shiting Yang Guzainuer Abudurusuli Li Luo Xingchun Liu Yao Wang Jingwen Xu Yuanzhao Zhu Meng Yang TianlongYang Weikang Liu Bin Deng Chan Liu Zhuoyang Li Peihua Li Shanshan Yu Zimei Yang Yanhua Su Benhua Zhao Yan Niu Tianmu Chen | 2021 | China CDC weekly2021，3，50： | 2 |
| 13 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 14 | Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages显示文摘Myocardial dysfunction is the most serious complication of sepsis.Sepsis-induced myocardial dysfunction(SMD)is often associated with gastrointestinal dysfunction,but its pathophysiological significance remains unclear.The present study found that patients with SMD had higher plasma gastrin concentrations than those without SMD.In mice,knockdown of the gastrin receptor,cholecystokinin B receptor(Cckbr),aggravated lipopolysaccharide(LPS)-induced cardiac dysfunction and increased inflammation in the heart,whereas the intravenous administration of gastrin ameliorated SMD and cardiac injury.Macrophage infiltration plays a significant role in SMD because depletion of macrophages by the intravenous injection of clodronate liposomes,48 h prior to LPS administration,alleviated LPSinduced cardiac injury in Cckbr-deficient mice.The intravenous injection of bone marrow macrophages(BMMs)overexpressing Cckbr reduced LPS-induced myocardial dysfunction.Furthermore,gastrin treatment inhibited toll-like receptor 4(TLR4)expression through the peroxisome proliferator-activated receptor a(PPAR-a)signaling pathway in BMMs.Thus,our findings provide insights into the mechanism of the protective role of gastrin/CCKBR in SMD,which could be used to develop new treatment modalities for SMD. | Dandong Fang Yu Li Bo He Daqian Gu Mingming Zhang Jingwen Guo Hongmei Ren Xinyue Li Ziyue Zhang Ming Tang Xingbing Li Donghai Yang Chunmei Xu Yijie Hu Hongyong Wang Pedro AJose Yu Han Chunyu Zeng | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 15 | Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice 显示文摘 | Yuexin Xu Jingwen Chen Xiao Yu | 2010 | Inflammation Research2010，59，10： | 1 |
| 16 | Oxygen vacancy promoting adsorption property of BiOI microspheres modified with SDS显示文摘BiOI microspheres were synthesized via a facile hydrolytic method with sodium dodecyl sulfate(SDS).The results showed that 8% SDS-BiOI microspheres possessed the homogeneous morphology, larger specific surface area and more oxygen vacancies compared with the pure BiOI. Moreover, the adsorption efficiency of rhodamine B(RhB) and methyl orange(MO) for 8% SDS-BiOI reached almost 96.4% and 79.4%,respectively. It was found that the oxygen vacancy induced by SDS improved adsorption performance of BiOI due to the enhanced electrostatic interaction. | Fenqiang Ma Jingwen Yao Yanfeng Zhang Yu Wei | 2018 | Chinese Chemical Letters2018，29，11： | 1 |
| 17 | Incorporating catechol into electroactive polypyrrole nanowires on titanium to promote hydroxyapatite formation显示文摘To improve the osteointegration property of biomedical titanium,nano-architectured electroactive coating was synthesized through the electrochemical polymerization of dopamine and pyrrole.The highly binding affinity of Ca2t to the catechol moiety of doped dopamine enabled efficient interaction between polypyrrole/polydopamine nanowires and mineral ions.The results indicate that the PPy/PDA nanowires preserved its efficient electro-activity and accelerated the hydroxyapatite deposition in a simulated body fluid.The PPy/PDA nanowires coating could be applied to promote the osteointegration of titanium implant. | Zhengao Wang Jinquan Zeng Guoxin Tan Jingwen Liao Lei Zhou Junqi Chen Peng Yu Qiyou Wang Chengyun Ning | 2018 | Bioactive Materials2018，3，1： | 1 |
| 18 | Protective effects of chlorogenic acid on acute hepatotoxieity induced by lipopolysac- charide in mice显示文摘 | Xu Yuexin Chen Jingwen Yu Xiao | 2010 | Inflamm Res2010，59，10： | 1 |
| 19 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 20 | 内侧缰核胆碱能神经元GABAB受体通过突触前兴奋作用调控动物恐惧记忆显示文摘动物的生存依赖于将预警信号和危险联系起来.对预警信号形成恐惧记忆,以便提前做出反应。当预警信号不再与危险相关时,动物逐渐解除这种联系,消退恐惧记忆,以适应新的生存环境。恐惧记忆消退缺陷被认为和人类创伤后应激障碍(PTSD)等精神障碍有紧密关系。目前关于动物恐惧记忆的研究主要集中在杏仁核及其相关脑区。 | 张举恩 Lubin Tan Yuqi Ren Jingwen Liang Rui Lin Qiru Feng Jingfeng Zhou Fei Hu Jing Ren Chao Wei Tao Yu Yinghua Zhuang Bernhard Bettler Fengchao Wang 罗敏敏 | 2017 | 科学新闻2017，19，4： | 1 |
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