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| 1 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 2 | Fault tolerant multivehicle formation control framework with applications in multiquadrotor systems显示文摘Compared with the traditional monolithic systems,a group of vehicles operating cooperatively in a formation can achieve greater efficiency and capability [1,2].However,faults may occur more frequently in multivehicle formations because a large number of controllers,sensors,and com- munication equipment exist [3].Occasionally,a fault occurring in one vehicle of the formation may deteriorate the system performance or even cause catastrophic accidents.Thus,fault-tolerant formation control schemes are indispensable to achieve a reliable and safe operation. | Jiantao SHI Donghua ZHOU Yuhao YANG Jun SUN | 2018 | Science China(Information Sciences)2018，61，12： | 4 |
| 3 | Erythromycin loaded by tetrahedral framework nucleic acids are more antimicrobial sensitive against Escherichia coli(E.coli)显示文摘Erythromycin is a commonly used broad-spectrum antibiotic,but resistance to this antibiotic makes its use less effective.Considerable efforts,beside finding alternatives,are needed to enhance its antimicrobial effect and stability against bacteria.Tetrahedral framework nucleic acids(tFNAs),a novel delivery vehicle with a three-dimensional nanostructure,have been studied as a carrying platform of antineoplastic drugs.In this study,the use of tFNAs in delivering erythromycin into Escherichia coli(E.coli)was investigated for the first time.The tFNAs vehicle increased the bacterial uptake of erythromycin and promoted membrane destabilization.Moreover,it increased the permeability of the bacterial cell wall,and reduced drug resistance by improving the movement of the drug across the membrane.The tFNAs-based delivery system enhanced the effects of erythromycin against E.coli.It may therefore provide an effective delivery vehicle for erythromycin in targeting antibiotic-resistant bacteria with thick cell wall. | Yue Sun Yuhao Liu Bowen Zhang Shirong Shi Tao Zhang Dan Zhao Taoran Tian Qirong Li Yunfeng Lin | 2021 | Bioactive Materials2021，6，8： | 4 |
| 4 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://gffzz4a3adbfa122d4a47houf5p95o55vv6fkw.ffgz.tsg.suse.edu.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 5 | Band structure engineering through van der Waals heterostructing superlattices of two-dimensional transition metal dichalcogenides显示文摘The indirect-to-direct band-gap transition in transition metal dichalcogenides(TMDCs)from bulk to monolayer,accompanying with other unique properties of two-dimensional materials,has endowed them great potential in optoelectronic devices.The easy transferability and feasible epitaxial growth pave a promising way to further tune the optical properties by constructing van der Waals heterostructures.Here,we performed a systematic high-throughput first-principles study of electronic structure and optical properties of the layerby-layer stacking TMDCs heterostructing superlattices,with the configuration space of[(MX2)n(M0X02)10−n](M/M0=Cr,Mo,W;X/X0=S,Se,Te;n=0-10).Our calculations involving long-range dispersive interaction show that the indirect-to-direct band-gap transition or even semiconductor-to-metal transition can be realized by changing component compositions of superlattices.Further analysis indicates that the indirect-to-direct band-gap transition can be ascribed to the in-plane strain induced by lattice mismatch.The semiconductor-to-metal transition may be attributed to the band offset among different components that is modified by the in-plane strain.The superlattices with direct band-gap show quite weak band-gap optical transition because of the spacial separation of the electronic states involved.In general,the layers stacking-order of superlattices results in a small up to 0.2 eV band gap fluctuation because of the built-in potential.Our results provide useful guidance for engineering band structure and optical properties in TMDCs heterostructing superlattices. | Xin-Gang Zhao Zhiming Shi Xinjiang Wang Hongshuai Zou Yuhao Fu Lijun Zhang | 2021 | InfoMat2021，3，2： | 2 |
| 6 | Systemic Infusion of FLK1+ Mesenchymal Stem Cells Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis in Mice显示文摘 | Baijun Fang Mingxia Shi Lianming Liao Shaoguang Yang Yuhao Liu Robert Chunhua Zhao | 2004 | Transplantation2004，，1： | 2 |
| 7 | Deep Reinforcement Learning Based Real-time AC Optimal Power Flow Considering Uncertainties显示文摘Modern power systems are experiencing larger fluctuations and more uncertainties caused by increased penetration of renewable energy sources(RESs) and power electronics equipment. Therefore, fast and accurate corrective control actions in real time are needed to ensure the system security and economics. This paper presents a novel method to derive realtime alternating current(AC) optimal power flow(OPF) solutions considering the uncertainties including varying renewable energy and topology changes by using state-of-the-art deep reinforcement learning(DRL) algorithm, which can effectively assist grid operators in making rapid and effective real-time decisions. The presented DRL-based approach first adopts a supervised-learning method from deep learning to generate good initial weights for neural networks, and then the proximal policy optimization(PPO) algorithm is applied to train and test the artificial intelligence(AI) agents for stable and robust performance. An ancillary classifier is designed to identify the feasibility of the AC OPF problem. Case studies conducted on the Illinois 200-bus system with wind generation variation and N-1 topology changes validate the effectiveness of the proposed method and demonstrate its great potential in promoting sustainable energy integration into the power system. | Yuhao Zhou Wei-Jen Lee Ruisheng Diao Di Shi | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，5： | 1 |
| 8 | StRAP2.3, an ERF-Ⅶ transcription factor, directly activates StInvInh2 to enhance cold-induced sweetening resistance in potato显示文摘Potato invertase inhibitor(StInvInh2)positively regulates cold-induced sweetening(CIS)resistance by inhibiting the activity of vacuolar invertase.The distinct expression patterns of StInvInh2 have been thoroughly characterized in different potato genotypes,but the related CIS ability has not been characterized.The understanding of the regulatory mechanisms that control StInvInh2 transcription is unclear.In this study,we identified an ERF‐Ⅶ transcription factor,StRAP2.3,that directly regulates StInvInh2 to positively modulate CIS resistance.Acting as a nuclear-localized transcriptional activator,StRAP2.3 directly binds the ACCGAC cis-element in the promoter region of StInvInh2,enabling promoter activity.Overexpression of StRAP2.3 in CIS-sensitive potato tubers induced StInvInh2 mRNA abundance and increased CIS resistance.In contrast,silencing StRAP2.3 in CIS-resistant potato tubers repressed the expression of StInvInh2 and decreased CIS resistance.We conclude that cold-responsive StInvInh2 is due to the binding of StRAP2.3 to the ACCGAC cis-element in the promoter region of StInvInh2.Overall,these findings indicate that StRAP2.3 directly regulates StInvInh2 to positively modulate CIS resistance,which may provide a strategy to improve the processing quality of potatoes. | Weiling Shi Yuhao Song Tiantian Liu Qiuqin Ma Wang Yin Yuchen Shen Tengfei Liu Chunyan Jiang Kai Zhang Dianqiu Lv Botao Song Jichun Wang Xun Liu | 2021 | Horticulture Research2021，8，1： | 1 |
| 9 | Scalable synthesis of macroscopic porous carbon sheet anode for potassium-ion capacitor显示文摘Carbon materials hold the great promise for application in energy storage devices owing to their low cost, high thermal/chemical stability, and high electrical conductivity. However, it remains challenging to synthesize high-performance carbon electrodes in a simple, scalable and sustainable way. Here, we report a facile method for scalable synthesis of porous carbon anode by using cheap and easily accessible zeolitic imidazolate framework-8 as a template and polyvinylpyrrolidone as an additional carbon source. The obtained porous carbon shows the macroscopic sheet-like morphology, which has the highly disordered structure, expanded interlayer spacing, abundant pore structure, and nitrogen doping properties. This porous carbon anode is demonstrated to have the excellent K^(+) charge storage properties in specific capacity, rate capability, and cycling stability. A potassium-ion capacitor assembled by using this porous carbon as the anode, delivers a maximum energy density of 85.12 Wh/kg and power density of 11860 W/kg as well as long cycle life exceeding 3000 cycles. This represents a critical advance in the design of low cost and scalable carbon material for applications in energy storage devices. | Yuying Qin Yuhao Xie Han Zhao Chunyan Zhu Tong Li Shuxian Zhang Rutao Wang Yuanchang Shi Longwei Yin | 2022 | Chinese Chemical Letters2022，33，3： | 1 |
| 10 | Influence of residual chirality on the conformation and enzymatic degradation of glycopolypeptide based biomaterials显示文摘Glycopolypeptides as analogs of glycoproteins or glycosaminoglycans represent attractive building blocks for the construction of biomimetic biomaterials.However,the effects of amino acid chirality on the conformation and enzymatic degradation of glycopolypeptides are often overlooked.Here,we synthesized and characterized a range of glycopolypeptides composed of galactosylated poly(γ-propargylglutamate)s containing L-and/or D-glutamate residues.Glycopolypeptides containing pure Lglutamate residues were predominantlyα-helical,and the helicity increased over the degree of polymerization of the polypeptide backbones(24 to 44).The glycopolypeptide with pure D-glutamate residues adopted a mirroredα-helical conformation,whilst apparent random coil conformation was observed for the glycopolypeptide with equally mixed enantiomeric residues.The enzymatic degradation rates of the glycopolypeptides were markedly reduced following the introduction of D-glutamate residues into backbones.Galactoside pendants on these glycopolypeptides maintained their binding to peanut agglutinin.These structureproperty relationships provide new insight for the design of biomimetic biomaterials containing glycopolypeptides. | SHI Shun WANG JiaYu WANG TianRan REN Hui ZHOU YuHao LI Gao HE ChaoLiang CHEN XueSi | 2021 | Science China(Technological Sciences)2021，64，3： | 1 |
| 11 | Antiferromagnetic spintronics: An overview and outlook显示文摘Over the pas few decades,the diversified development of antiferomagnetic spintronics has made antiferomagnets(AFMs)interesting and very useful.After tough challenges,the applications of AFMs in electronic devices have transitioned from focusing on the interface coupling features to achieving the manipulation and detection of AFMs.As AFMs are internally magnetic,taking full use of AFMs for information storage has been the main target of research.In this paper,we provide a comprehensive description of AFM spintronics applications from the interface coupling,read-out operations,and writing manipulations perspective.We examine the early use of AFMs in magnetic recordings and conventional magnetoresistive random-access memory(MRAM),and review the latest mechanisms of the manipulation and detection of AFMs.Finally,based on exchange bias(EB)manipulation,a high-performance EB-MRAM is introduced as the next generation of AFM-based memories,which provides an effective method for read-out and writing of AFMs and opens a new era for AFM spintronics. | Danrong Xionga Yuhao Jiang Kewen Shi Ao Du Yuxuan Yao Zongxia Guo Daoqian Zhu Kaihua Cao Shouzhong Peng Wenlong Cai Dapeng Zhu Weisheng Zhao | 2022 | Fundamental Research2022，2，4： | 1 |
| 12 | Distributed self-triggered formation control for multi-agent systems显示文摘Dear editor,Recently,the cooperative control of multi-agent systems(MASs)has stirred a significant amount of research effort[1,2].Within the realm of MASs,formation control is a very attractive topic with the aim of driving multiple agents to achieve prescribed constraints on their states/outputs. | Jiantao SHI Jun SUN Yuhao YANG Donghua ZHOU | 2020 | Science China(Information Sciences)2020，63，10： | 1 |
| 13 | A tetrahedral framework nucleic acid based multifunctional nanocapsule for tumor prophylactic mRNA vaccination显示文摘Synthetic antigen-encoding mRNA plays an increasingly significant role in tumor vaccine technology owing to its antigen-specific immune-activation. However, its immune efficacy is challenged by inferior delivery efficiency and demand for suitable adjuvants. Here, we develop a novel mRNA nanovaccine based on a multifunctional nanocapsule, which is a dual-adjuvant formulation composed of cytosine-phosphateguanine motifs loaded tetrahedral framework nucleic acid(CpG-tFNA) and an immunopeptide murine β-defensin 2(mDF2β). This m RNA nanovaccine successfully achieves intracellular delivery, antigen expression and presentation of dendritic cells, and proliferation of antigen-specific T cells. In a tumor prophylactic vaccination model, it exerts an excellent inhibitory effect on lymphoma occurrence through cellular immunity. This mRNA nanovaccine has promising prophylactic applications in tumors and many other diseases. | Yuhao Liu Songhang Li Shiyu Lin Sirong Shi Taoran Tian Bowen Zhang Tao Zhang Yunfeng Lin | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 14 | The Anneal Temperature Effect on the BTO and NZFO Films and Their Capacitance-Inductance Integrated Device显示文摘In this paper,a novel capacitor-inductor integrated structure was proposed.The dielectric material BaTiO3(BTO)and ferromagnetic material Ni0.5Zn0.5Fe2O4(NZFO)was prepared by sol-gel method.Phase composition and morphology of the thin films were characterized by XRD,SEM and AFM.The effect of annealing temperature on film crystallinity,surface morphology,dielectric properties and ferromagnetism was investigated.When the annealing temperature was 700°C,the BTO film and the NZFO film got the better dielectric properties and ferromagnetic properties.Then the BTO thin film was spin-coated on the substrate,and the NZFO thin film was in-situ sintered on the BTO thin film.The composite film possessed both ferromagnetism and dielectric properties.Finally,an inductive coil was fabricated on the BTO/NZFO composite film to produce a capacitance and inductance integrated device. | Zhen Zheng Yuhao Shi Chengjie Shi Chunqing Wang | 2019 | Semiconductor Science and Information Devices2019，1，1： | 0 |
| 15 | A self-powered piezoelectret sensor based on foamed plastic garbage for monitoring human motions显示文摘Constructing piezoelectret based on foamed plastic garbage is an advisable strategy for obtaining self-powered flexible electromechanical sensors with good performances.Herein,a self-powered piezoelectret sensor with basic material of low density polyethylene(LDPE)foamed plastic garbage is proposed,with characteristics of easy fabrication,excellent flexibility,and high equivalent piezoelectric coefficient d33 value up to~1,100 pC/N.The output stability is verified by continuously stimulating a sensor for~180,000 cycles under low and high applied pressure,and the variations of peak outputs are less than 5.5%.Applications for measuring low-and high-pressure signals from human body are achieved.Assembled with a wristband,a sensor is demonstrated for detecting the human pulse waves.Moreover,real time human sitting information is wirelessly monitored with a smart chair based on 4 pixels sensors array. | Yujun Shi Kaijun Zhang Sen Ding Zhaoyang Li Yuhao Huang Yucong Pi Dazhe Zhao Yaowen Zhang Renkun Wang Binpu Zhou Zhi-Xin Yang Junwen Zhong | 2023 | Nano Research2023，16，1： | 0 |
| 16 | Nanodiamonds decorated yolk-shell ZnFe_(2)O_(4) sphere as magnetically separable and recyclable composite for boosting antibiotic degradation performance显示文摘Photocatalysis is an environmentally friendly and energy-saving technology, which can effectively remove persistent dangerous pollutants in the water. Pitifully, optical absorption capacity and carrier separation have become major bottlenecks for marvelous photocatalytic performance of photocatalysts.Herein, to address these issue, Nanodiamonds/yolk-shell ZnFe_(2)O_(4) spheres(NDs/ZFO) nanocomposites were successfully constructed via a facile two-step of solvothermal and calcination methods. The synthesized optimal NDs/ZFO-10 nanocomposite exhibits superior photocatalytic degradation activity of antibiotic under visible light, approximately 85% of the total tetracycline(TC) is degraded, and this photocatalyst shows durable cycling stability. This stems from two aspects of refinement: improvement of light absorption capacity and photo-induced charges migration and separation. In addition, the NDs/ZFO composite photocatalyst features excellent magnetic recovery capability, facilitating the recovery of photocatalyst in industry. This study opens a new chapter in the combination of NDs with magnetic materials, and deepens the understanding of the application of NDs modified composite photocatalysts. | Jingjing Pan Haoran Sun Keyi Chen Yuhao Zhang Pengnian Shan Weilong Shi Feng Guo | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 0 |
| 17 | Efficient Evergreen Plant Regeneration of Cinnamomum japonicum Sieb.through in vitro Organogenesis显示文摘Cinnamomum japonicum Sieb.is an excellent roadside tree and medicinal tree species with considerable ornamental and economic value.In this study,we successfully developed a large-scale micropropagation protocol for C.japonicum for the first time.Sterilized shoots were excised and used as explants for shoot induction on several basal media,supplemented with different concentrations of plant growth regulators(PGRs),such as Thidiazuron(TDZ),N^(6)-Benzyladenine(6-benzylaminopurine)(BA),α-naphthaleneacetic acid(NAA)and Gibberellic acid(GA_(3)).After comparison,the most efficient medium for shoot regeneration was 1/2 Murashige and Skoog(MS)medium containing 0.5 mg L^(-1)BA,0.05 mg L^(-1)NAA and 0.2 mg L^(-1)GA_(3),which resulted in an average number of induced shoots per explant and shoot length of 5.2 and 1.62 cm at 28 d,respectively.Then,elongated adventitious shoots were transferred to induce roots.86.7%of shoots was able to root on 1/2 MS medium supplemented with 0.5 mg L^(-1)NAA and 0.1 mg L^(-1)BA.The earliest rooting time observed was after 21 d and the average root length was up to 3.3 cm after 28 d.Our study shows that C.japonicum can be successfully regenerated through de novo organogenesis,which lays a foundation for future transformation research on this tree. | Jiaji Zhang Xiaofei Long Yuhao Weng Tielong Cheng Jisen Shi Jinhui Chen | 2021 | Phyton-International Journal of Experimental Botany2021，90，2： | 0 |
| 18 | Hysteresis-Free, High-Performance Polymer-Dielectric Organic Field-Effect Transistors Enabled by Supercritical Fluid显示文摘Organic field-effect transistors(OFETs)are of the core units in organic electronic circuits,and the performance of OFETs replies critically on the properties of their dielectric layers.Owing to the intrinsic flexibility and natural compatibility with other organic components,organic polymers,such as poly(vinyl alcohol)(PVA),have emerged as highly interesting dielectric materials for OFETs.However,unsatisfactory issues,such as hysteresis,high subthreshold swing,and low effective carrier mobility,still considerably limit the practical applications of the polymer-dielectric OFETs for high-speed,low-voltage flexible organic circuits.This work develops a new approach of using supercritical CO_(2) fluid(SCCO_(2))treatment on PVA dielectrics to achieve remarkably high-performance polymer-dielectric OFETs.The SCCO_(2) treatment is able to completely eliminate the hysteresis in the transfer characteristics of OFETs,and it can also significantly reduce the device subthreshold slope to 0._(2)5 V/dec and enhance the saturation regime carrier mobility to 30.2 cm^(2) V^(-1) s^(-1),of which both the numbers are remarkable for flexible polymer-dielectric OFETs.It is further demonstrated that,coupling with an organic light-emitting diode(OLED),the SCCO_(2)-treated OFET is able to function very well under fast switching speed,which indicates that an excellent switching behavior of polymer-dielectric OFETs can be enabled by this SCCO_(2) approach.Considering the broad and essential applications of OFETs,we envision that this SCCO_(2) technology will have a very broad spectrum of applications for organic electronics,especially for high refresh rate and low-voltage flexible display devices. | Yuhao Shi Yingkai Zheng Jialiang Wang Ran Zhao Tao Wang Changbin Zhao Kuan-Chang Chang Hong Meng Xinwei Wang | 2020 | Research2020，，1： | 0 |
| 19 | White-light-driven fluorescence switch for super-resolution imaging guided photodynamic and photoacid therapy显示文摘Photocaged fluorophores with photoactivatable characteristics presented important applications in imaging the biological structures and processes.Taking advantage of their super-resolution imaging merits to manipulate and visualize anti-cancer treatment is always a goal of modern clinical medicine.Traditional photodynamic therapy(PDT) is a noninvasive treatment but limited in intracellular oxygen content.Type I PDT and photoacid therapy(PAT) are two effective supplements of traditional PDT especially in hypoxic condition.Herein,a novel white-light-driven fluorescence switch(7H-dibenzo[c,g]carbazol-7-yl)(2-iodophenyl)methanone(2IB) was designed and synthesized as an unprecedent “all in one” platform for stochastic optical reconstruction microscopy(STORM) imaging guided Type Ⅰ/Ⅱ PDT and PAT.The experimental and theoretical studies revealed that the working mechanism is based on two competing paths under excitation:photosensitization and photocyclization reaction.Efficient intersystem crossing(ISC) ensured the generation of reactive oxygen species(ROS) for PDT,while low energy barrier facilitated the photocyclization reaction that simultaneously yielded emissive fluorophores(2IBC) and H^(+) for super-resolution imaging and photoacid,respectively.Impressively,the fluorescent intensity of mitochondria-targeted 2IBC was positively correlated with treatment efficacy,which is beneficial to spatiotemporally visualized therapeutic process and outcome.As a result,superior anti-tumor performance was achieved in vitro and in vivo.This contribution provided a multifunctional nanodrug paradigm for multimode cancer diagnosis and treatment. | Hao Chen Kaikai Wen Yu Lu Xin Zhang Yuhao Shi Qinqin Shi Han Ma Qian Peng Hui Huang | 2022 | Science China Chemistry2022，65，12： | 0 |
| 20 | The Chloroplast Genome of Cerasus Campanulata Diverges from Other Prunoideae Genomes显示文摘Cerasus Campanulata is one of several species belonging to the Prunoideae focke,a subfamily of the flowering plant Rosaceae.We investigated the details of its chloroplast genome which may reveal its genus independent of morphological determination.Here,we determined the complete chloroplast(cp)genome sequence of C.campanulata and performed sequence analysis to reveal the presence of 18 forward repeats,20 palindrome repeats,2 complement repeats,4 reverse repeats and 93 simple sequence repeats(SSRs).We additionally performed a comparative study of C.campanulata and seven other Prunoideae focke species.Then,maximum parsimony(MP)and maximum likelihood(ML)phylogenetic analyses were carried out in the little part of Rosaceae,respectively.The results strongly support a position of C.campanulata as a member of the Cerasus in the Rosaceae family.Moreover,the complete cp genome can be used for plant phylogenetic and evolutionary studies that will provide insight into the degree of gene conservation. | Yuhao Weng Liming Zhu Yan Ma Hao Su Lu Lu Pengkai Wang Jinhui Chen Asif Ali Renhua Zheng Jisen Shi | 2020 | Phyton-International Journal of Experimental Botany2020，89，2： | 0 |
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