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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | A study of support strategies in deep soft rock:The horsehead crossing roadway in Daqiang Coal Mine显示文摘Geomechanics in deep mines becomes more complex and structural support in soft rock can be very difficult.Highly stressed soft rock subject to expansion deformation is particularly difficult to control.The Tiefa Coal Industry Group Daqiang Coal Mine is used as an example.A ventilation shaft,à550 horsehead,is located in tertiary soft rock.Analysis of the reasons for deformation shows an intumescent rock,which is easily damaged.Field observations and theoretical analysis led to a design capable of stabilizing the rock.A combination of spray,anchors,anchor bolts,and soft corner coupled truss supports allowed the deformation to be controlled.This provides a model for similar designs when support of a horsehead roadway is required. | Guo Zhibiao Yang Xiaojie Bai Yunpeng Zhou Feng Li Erqiang | 2012 | International Journal of Mining Science and Technology2012，22，5： | 11 |
| 3 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 4 | The geochemical characteristics,geochronology and tectonic significance of the Carboniferous volcanic rocks of the Santanghu area in northeastern Xinjiang,China显示文摘The Santanghu area is located on the northeastern margin of the Junggar Basin,northern Xinjiang,Northwest China.The Carboniferous volcanic rocks in this area are widely distributed in Kaokesaiergaishan,Santanghu,Daheishan and Naomaohu districts,which are located to the north of the Kalameili Fault.These rocks,sourced from a cognate magma,consist of basic,intermediate,and acidic lavas,and pyroclastic rock.The basic volcanic rocks are enriched with large-ion lithophile elements(LILE),but are relatively depleted in high field strength elements(HFSE),and have an obvious negative Nb-Ta-Ti anomaly.They were most probably derived from a depleted mantle source,and during their ascent,these magmas were not contaminated by the crustal material as they underwent magma crystallization differentiation.Based on the Carboniferous volcanic assemblage and geochemical data,it is apparent that the early Carboniferous volcanism occurred in a subduction-related tectonic setting.New LA-ICP-MS zircon U-Pb analyses constrain the age of the andesite within the volcanic rocks as the early Carboniferous(328.9-331.3 Ma).Combined with the regional geological record,comprehensive analysis of the isotope geochronological data indicates that the subduction of the Junggar Ocean predates the early Carboniferous,and that the Santanghu island arc magmatism was induced by the subduction of the Junggar Ocean in the Carboniferous. | LI Wei LIU YiQun DONG YunPeng ZHOU XiaoHu LIU XiaoMing LI Hong FAN TingTing ZHOU DingWu XU XueYi CHEN JunLu | 2013 | Science China Earth Sciences2013，56，8： | 8 |
| 5 | Comprehensive Reliability Allocation Method for CNC Lathes Based on Cubic Transformed Functions of Failure Mode and Effects Analysis显示文摘Reliability allocation of computerized numerical controlled(CNC)lathes is very important in industry.Traditional allocation methods only focus on high-failure rate components rather than moderate failure rate components,which is not applicable in some conditions.Aiming at solving the problem of CNC lathes reliability allocating,a comprehensive reliability allocation method based on cubic transformed functions of failure modes and effects analysis(FMEA)is presented.Firstly,conventional reliability allocation methods are introduced.Then the limitations of direct combination of comprehensive allocation method with the exponential transformed FMEA method are investigated.Subsequently,a cubic transformed function is established in order to overcome these limitations.Properties of the new transformed functions are discussed by considering the failure severity and the failure occurrence.Designers can choose appropriate transform amplitudes according to their requirements.Finally,a CNC lathe and a spindle system are used as an example to verify the new allocation method.Seven criteria are considered to compare the results of the new method with traditional methods.The allocation results indicate that the new method is more flexible than traditional methods.By employing the new cubic transformed function,the method covers a wider range of problems in CNC reliability allocation without losing the advantages of traditional methods. | YANG Zhou ZHU Yunpeng REN Hongrui ZHANG Yimin | 2015 | Chinese Journal of Mechanical Engineering2015，28，2： | 8 |
| 6 | Growth, photosynthesis and podophyllotoxin accumulation of Dysosma versipellis in response to a light gradient and conservation implications显示文摘Dysosma versipellis (Hance) M. Cheng ex Ying (Berberidaceae) is a rare and vulnerable, perennial herb endemic to China with pharmaceutical significance. Increasing habitat loss and over-exploitation of the plant has severely affected the plant's in situ conservation, necessitating ex situ conservation and commercial cultivation. The light regime is a critical environmental factor contributing to successful ex situ conservation via efficient production of biomass and secondary metabolites. We investigated the responses of 2-year-old D. versipellis plants to a light gradient in terms of leaf morphology, growth, biomass production, photo- synthesis and podophyllotoxin (PTOX) accumulation. D. versipellis responded to the light gradient in terms of plant height, leaf size, leaf photosynthesis and PTOX accumulation. Plants demonstrated optimal vegetative growth, photosynthetic capability, and PTOX production, under a light intensity equal to 30% full sunlight. Half full sunlight led to the lowest production of PTOX despite having no obviously different effects on growth. Full sunlight was able to cause leaf death in mid-summer (July), although these plantlets did not significantly differ in growth or biomass production before July and new leaves emerged in August. D. versipellis is therefore proposed to be a shade-tolerant plant, well adapted to variations in irradiance. Irradiance of 10%-50%, particularly ca. 30% full sunlight is strongly recommended for ex situ conservation and commercial cultivation. | ZHAO YunPeng GONG HuaDong LU WeiQiang JIANG WeiMei ZHOU XiaoLong FU ChengXin | 2011 | Chinese Science Bulletin2011，56，24： | 6 |
| 7 | Compositions and sources of organic acids in fine particles(PM_(2.5)) over the Pearl River Delta region, south China显示文摘Organic acids as important constituents of organic aerosols not only influence the aerosols' hygroscopic property, but also enhance the formation of new particles and secondary organic aerosols. This study reported organic acids including C14–C32fatty acids, C4–C9dicarboxylic acids and aromatic acids in PM2.5collected during winter 2009 at six typical urban, suburban and rural sites in the Pearl River Delta region. Averaged concentrations of C14–C32fatty acids, aromatic acids and C4– C9 dicarboxylic acids were 157, 72.5 and 50.7 ng/m3, respectively. They totally accounted for 1.7% of measured organic carbon. C20–C32fatty acids mainly deriving from higher plant wax showed the highest concentration at the upwind rural site with more vegetation around, while C14–C18fatty acids were more abundant at urban and suburban sites, and dicarboxylic acids and aromatic acids except 1,4-phthalic acid peaked at the downwind rural site. Succinic and azelaic acid were the most abundant among C4–C9dicarboxylic acids, and 1,2-phthalic and 1,4-phthalic acid were dominant aromatic acids. Dicarboxylic acids and aromatic acids exhibited significant mutual correlations except for 1,4-phthalic acid, which was probably primarily emitted from combustion of solid wastes containing polyethylene terephthalate plastics. Spatial patterns and correlations with typical source tracers suggested that C14–C32fatty acids were mainly primary while dicarboxylic and aromatic acids were largely secondary. Principal component analysis resolved six sources including biomass burning, natural higher plant wax, two mixed anthropogenic and two secondary sources; further multiple linear regression revealed their contributions to individual organic acids. It turned out that more than 70% of C14–C18fatty acids were attributed to anthropogenic sources, about 50%–85% of the C20–C32fatty acids were attributed to natural sources, 80%–95% of dicarboxylic acids and 1,2-phthalic acid were secondary in contrast with that 81% of 1,4-phthalic acid was primary. | Xiuying Zhao Xinming Wang Xiang Ding Quanfu He Zhou Zhang Tengyu Liu Xiaoxin Fu Bo Gao Yunpeng Wang Yanli Zhang Xuejiao Deng Dui Wu | 2014 | Journal of Environmental Sciences2014，26，1： | 6 |
| 8 | The basic dyke swarms in the Wudang block and its geological significance显示文摘The basic dyke swarms, which have been deformed and metamorphosed, are widespread in the Wudang block. They are geochemically characterized by the continental tholeiites, and their Sm Nd isochron age is (782±164) Ma. All of these indicate that there was an ancient continental block in the Proterozoic and a rifting occurring on this continental block during ±800 Ma. | Dingwu Zhou Chengli Zhang Juli Wang Liang Liu Yunpeng Dong Yinyu Liu Song Han | 1998 | Chinese Science Bulletin1998，43，13： | 6 |
| 9 | Evolutionary trace analysis of eukaryotic DNA topoisomerase I superfamily: Identification of novel antitumor drug binding site显示文摘The studies of novel inhibitors of DNA topoisomerase I (Topo I) have already be-come very promising in cancer chemotherapy. Identifying the new drug-binding residues is playing an important role in the design and optimization of Topo I inhibitors. The designed com-pounds may have novel scaffolds, thus will be helpful to overcome the toxicities of current camptothecin (CPT) drugs and may provide a solution to cross resistance with these drugs. Mul-tiple sequence alignments were performed on eukaryotic DNA topoisomerase I superfamily and thus the evolutionary tree was constructed. The Evolutionary Trace method was applied to iden-tify functionally important residues of human Topo I. It has been demonstrated that class-specific hydrophobic residues Ala351, Met428, Pro431 are located around the 7,9-position of CPT, indi-cating suitable substitution of hydrophobic group on CPT will increase antitumor activity. The conservative residue Lys436 in the superfamily is of particular interest and new CPT derivatives designed based on this residue may greatly increase water solubility of such drugs. It has also been demonstrated that the residues Asn352 and Arg364 were conservative in the superfamily, whose mutation will render CPT resistance. As our molecular docking studies demonstrated they did not make any direct interaction with CPT, they are important drug-binding site residues for future design of novel non-camptothecin lead compounds. This work provided a strong basis for the design and synthesis of novel highly potent CPT derivatives and virtual screening for novel lead compounds. | SONG Yunlong QI Yunpeng ZHANG Wannian SHENG Chunquan ZHANG Min YAO Jianzhong YU Jianxin MIAO Zhenyuan ZHOU Youjun ZHU Ju L(U) Jiaguo | 2005 | Science China(Life Sciences)2005，48，4： | 5 |
| 10 | Geology and geochemistry of the Bingdaban ophiolitic mélange in the boundary fault zone on the northern Central Tianshan Belt,and its tectonic implications显示文摘The properties and tectonic significance of the fault bound zone on the northern margin of the Central Tianshan belt are key issues to understand the tectonic framework and evolutionary history of the Tianshan Orogenic Belt. Based on the geological and geochemical studies in the Tianshan orogenic belt, it is suggested that the ophiolitic slices found in the Bingdaban area represent the remaining oceanic crust of the Early Paleozoic ocean between the Hazakstan and Zhungaer blocks. Mainly com-posed of basalts, gabbros and diabases, the ophiolites were overthrust onto the boundary fault be-tween the Northern Tianshan and Central Tianshan belts. The major element geochemistry is charac-terized by high TiO2 (1.50%-2.25%) and MgO (6.64%-9.35%), low K2O (0.06%-0.41%) and P2O5 (0.1%-0.2%), and Na2O>K2O as well. Low ΣREE and depletion in LREE indicate that the original magma was derived from a depleted mantle source. Compared with a primitive mantle, the geochemistry of the basalts from the Bingdaban area is featureded by depletion in Th, U, Nb, La, Ce and Pr, and unfrac-tionated in HFS elements. The ratios of Zr/Nb, Nb/La, Hf/Ta, Th/Yb and Hf/Th are similar to those of the typical N-MORB. It can be interpreted that the basalts in the Bingdaban area were derived from a de-pleted mantle source, and formed in a matured mid-oceanic ridge setting during the matured evolu-tionary stage of the Northern Tianshan ocean. In comparison with the basalts, the diabases from the Bingdaban area show higher contents of Al2O3, ∑REE and HFS elements as well as unfractionated incompatible elements except Cs, Rb and Ba, and about 10 times the values of the primitive mantle. Thus, the diabases are thought to be derived from a primitive mantle and similar to the typical E-MORB. The diabases also have slight Nb depletion accompanying no apparent Th enrichment compared with N-MORB. From studies of the regional geology and all above evidence, it can be suggested that the diabases from the Bingdaban area were formed in the mid-oceanic ridge of the Northern Tianshan ocean during the initial spreading stage. | DONG YunPeng ZHANG GuoWei ZHOU DingWu LUO JinHai ZHANG ChengLi XIA LinQi XU XueYi LI XiangMin | 2007 | Science China Earth Sciences2007，50，1： | 5 |
| 11 | Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo- controlled trial显示文摘Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial haemorrhage.We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage expansion.Methods We did a prospective,double-blind,randomised,placebo-controlled trial at 10 stroke centres in China.Acute supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging(eg,spot sign,black hole sign or blend sign),and were treatable within 8 hours of symptom onset.Patients were randomly assigned(1:1)to receive either tranexamic acid or a matching placebo.The primary outcome was intracerebral haematoma growth(>33% relative or>6 mL absolute)at 24 hours.Clinical outcomes were assessed at 90 days.Results Of the 171 included patients,124(72.5%)were male,and the mean age was 55.9±11.6 years.89 patients received tranexamic acid and 82 received placebo.The primary outcome did not differ significantly between the groups:36(40.4%)patients in the tranexamic acid group and 34(41.5%)patients in the placebo group had intracranial haemorrhage growth(OR 0.96,95% CI 0.52 to 1.77,p=0.89).The proportion of death was lower in the tranexamic acid treatment group than placebo group(8.1%vs 10.0%),but there were no significant differences in secondary outcomes including absolute intracranial haemorrhage growth,death and dependency.Conclusions Among patients susceptible to haemorrhage expansion treated within 8 hours of stroke onset,tranexamic acid did not significantly prevent intracerebral haemorrhage growth.Larger studies are needed to assess safety and efficacy of tranexamic acid in intracerebral haemorrhage patients. | Jingyi Liu Ximing Nie Hongqiu Gu Qi Zhou Haixin Sun Ying Tan Dacheng Liu Lina Zheng Jiahui Zhao Yan Wang Yibin Cao Haomeng Zhu Yunpeng Zhang Lijin Yi Yuehua Pu Miao Wen Zhonghua Yang Shengjun Sun Wenzhi Wang Xingquan Zhao Liping Liu Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 12 | Syn- and post-collisional granitoids in the Central Tianshan orogen: Geochemistry, geochronology and implications for tectonic evolution显示文摘 | Yunpeng Dong Guowei Zhang Franz Neubauer Xiaoming Liu Christoph Hauzenberger Dingwu Zhou Wei Li | 2011 | Gondwana Research2011，，2： | 1 |
| 13 | Condition-based switching and replacement policies for a two-unit warm standby redundant system subject to non-instantaneous switchover显示文摘This study investigates condition-based switching and replacement policies for a two-unit warm standby redundant system subject to non-instantaneous switchover. The system consists of two identical units: one is operating unit, while the other is standby unit. Two units are under continuous monitoring and degradation described by Gamma processes. Both switching and replacement policies are based on the degradation level of the operating unit. The switching and replacement thresholds are decision variables decided by minimizing the long-run expected cost rate. We first setup the mathematical optimization model and then analyze the global optimal solution of replacement threshold, as well as the existence and uniqueness condition for the local optimal solution of switching threshold(STH). Finally, we find that the optimal replacement threshold is ‘‘the bigger the better'', but the optimal STH depends on some optimal conditions which can be easily computed. Numerical examples are provided to verify the policies, and the effects of noninstantaneous switchover and cost ratio on optimal STHs are numerically discussed. | Yunpeng Jiang Maoyin Chen Donghua Zhou | 2014 | Chinese Science Bulletin2014，59，33： | 1 |
| 14 | Crystal structure and optical performance analysis of a new type of persistent luminescence material with multi-functional application prospects显示文摘Persistent luminescence (PersL) materials,as environmentally friendly and energy-saving materials,have broad application prospects in many fields such as lighting,chemistry and even biomedicine.However,studies on the types,performances and mechanism of PersL materials are still insufficient,which significantly restricts their development and application.Under this consideration,we successfully synthesized a yellow PersL material CaSrGa_(4)O_(8)(CSG).The crystal structure was studied in detail through Rotation Electron Diffraction (RED) and Powder X-ray Diffraction (PXRD).What’s more,by co-doping Mn^(2+) and Yb^(3+),the afterglow brightness of CSG could be increased by nearly 20 times,and the afterglow duration could reach more than 6 h.It is worth mentioning that the samples also have excellent performances in mechanical luminescence (ML),photostimulated luminescence (PSL) and cathodoluminescence (CL),which was also investigated systematically.Finally,an anti-counterfeiting label was designed by the samples to reveal the potential of their application in anti-counterfeiting.The results showed that our research not only provided a new candidate PersL material for multifunctional applications,but also gave good help for studying the physical and chemical properties of CSG. | Songsong Ding Pohua Chen Haijie Guo Peng Feng Yunpeng Zhou Yuhua Wang Junliang Sun | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
| 15 | Joint optimization of preventive maintenance and inventory policies for multi-unit systems subject to deteriorating spare part inventory显示文摘 | Yunpeng Jiang Maoyin Chen Donghua Zhou | 2015 | Journal of Manufacturing Systems2015，，： | 1 |
| 16 | Joint optimization of preventive maintenance and inventory policies for multi-unit systems subject to deteriorating spare part inventory显示文摘 | Jiang Yunpeng Chen Maoyin Zhou Donghua | 2015 | Journal of ManufacturingSystems2015，35，： | 1 |
| 17 | An efficient chemical reduction-induced assembly of Fe_(3)O_(4)@graphene fiber for wire-shaped supercapacitors with ultrahigh volumetric energy density显示文摘Benefiting from high flexibility and weavability,the wire-shaped supercapacitors(SCs)arouse tremendous interests for the applications in wearable/portable electronics.Graphene fiber(GF)is considered as a promising linear electrode for wire-shaped SCs.However,the bottleneck is how to develop the GF-based linear electrode with facile fabrication process while wellmaintaining satisfactory electrochemical performance.Herein,a novel Fe_(3)O_(4)@GF composite linear electrode is proposed via a chemical reduction-induced assembly approach,in which the GO and Fe_(3)O_(4) nanoparticles(NPs)realize the efficient selfassembly owing to the electrostatic and van der Waals interactions,as well as the sufficient reduction of GO during the preparation process.The resultant fiber-shaped architecture shows boosted charge-transfer kinetics,high flexibility and structural integrity.Such Fe_(3)O_(4)@GF linear electrode exhibits excellent electrochemical behaviors including a large volumetric specific capacitance(~250.75 F cm^(−3)),remarkable rate capability and favorable electrochemical kinetics in aqueous electrolyte,superior than previously reported GF-based linear electrodes.For real application,a high-performance wire-shaped SC with excellent flexibility and weavability is fabricated based on such Fe_(3)O_(4)@GF linear electrode and gel electrolyte,demonstrating ultrahigh volumetric energy density(18.8 mWh cm^(−3)),power density(4000 mW cm^(−3))and strong durability(~93.5%retention after 10000 cycles).Prospectively,the fabricated wire-shaped SC can maintain reliable electrochemical behaviors in various deformation states,showing its potentials in future portable and wearable devices. | XIAO Peng SHI MinJie XU Li TAO FengBo LI Yu ZHU HangTian LIU YuTing LI ZhiMin ZHOU YunPeng FENG Wei | 2021 | Science China(Technological Sciences)2021，64，10： | 1 |
| 18 | Analysis and Calculation of Nonlinear Flow Fieldand Stator Temperature Field in Stator Radial Ventilating Grooves for Large Hydro-generator in the Case of Insulation Aging 显示文摘 | Hou Yunpeng Li Weili Zhou Feng Cheng Shukang | 2003 | Harbin Institute of Technology2003，，： | 1 |
| 19 | Optimization of urban bus operation frequency under common route condition with rail transit显示文摘The overlap of bus and rail transit routes is common in China. This overlap provides passengers multiple choices for one trip. However, the availability of multiple options would cause uncertainty in the travel distribution of passengers. Given that buses and rail transits are becoming increasingly common, this paper aims to present the overlapped operation condition of bus and rail transit using a bi-level model from the perspective of bus operators. Frequency optimization model is established in the upper-level model. A heuristic algorithm called shuffled complex evolution(SCE-UA) method is used to solve the established frequency optimization model, and three other heuristic methods are compared with SCE-UA. A lower-level Logit model based on Agent simulation is set for traffic mode split. Data on the transit system in Dalian city are chosen as an example to test the feasibility of the model and the algorithm. Results show that as the overlapped optimization of bus route and rail transit routes changed primary bus frequency, the use of SCE-UA to solve such problems has evident advantages and feasibility; furthermore, changed bus frequency would improve bus operations. | Bin YU Sijia REN Enze WU Yifan ZHOU Yunpeng WANG | 2017 | Frontiers of Engineering Management2017，4，4： | 1 |
| 20 | Pre-training with asynchronous supervised learning for reinforcement learning based autonomous driving显示文摘Rule-based autonomous driving systems may suffer from increased complexity with large-scale intercoupled rules,so many researchers are exploring learning-based approaches.Reinforcement learning(RL)has been applied in designing autonomous driving systems because of its outstanding performance on a wide variety of sequential control problems.However,poor initial performance is a major challenge to the practical implementation of an RL-based autonomous driving system.RL training requires extensive training data before the model achieves reasonable performance,making an RL-based model inapplicable in a real-world setting,particularly when data are expensive.We propose an asynchronous supervised learning(ASL)method for the RL-based end-to-end autonomous driving model to address the problem of poor initial performance before training this RL-based model in real-world settings.Specifically,prior knowledge is introduced in the ASL pre-training stage by asynchronously executing multiple supervised learning processes in parallel,on multiple driving demonstration data sets.After pre-training,the model is deployed on a real vehicle to be further trained by RL to adapt to the real environment and continuously break the performance limit.The presented pre-training method is evaluated on the race car simulator,TORCS(The Open Racing Car Simulator),to verify that it can be sufficiently reliable in improving the initial performance and convergence speed of an end-to-end autonomous driving model in the RL training stage.In addition,a real-vehicle verification system is built to verify the feasibility of the proposed pre-training method in a real-vehicle deployment.Simulations results show that using some demonstrations during a supervised pre-training stage allows significant improvements in initial performance and convergence speed in the RL training stage. | Yunpeng WANG Kunxian ZHENG Daxin TIAN Xuting DUAN Jianshan ZHOU | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，5： | 1 |
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