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| 1 | Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease显示文摘煽动性的肠疾病(IBD ) 是包括中国在亚洲增加的流行的世界范围的肠的免疫者不正常的疾病。它是有未知原因的胃肠的道的长期的疾病。Exosomes 是在各种各样的身体液体的小泡。他们有 40-120 的直径 ? nm,并且他们的功能之一是各种各样的物质的长途的转移。在这研究,我们与 IBD 并且在健康控制在病人调查了唾液的 exosomes 的内容与 IBD 在病人探索新 biomarker。在这研究,整个口水与 IBD 从病人被获得(ulcerative 大肠炎(UC ) , n ?=? 37;Crohns 疾病(CD ) , n ?=? 11 ) 并且显然健康的个人(HC, n ?=? 10 ) 。唾液的 exosomes 从样品被提取,并且在 exosomes 以内的蛋白质被液体用色层法分离团分光计(LC-MS/MS ) 识别。结果证明超过 2000 蛋白质与 IBD 从病人在唾液的 exosomes 被检测。通过基因本体论分析,我们发现(PSMA7 ) proteasome 子单元 alpha 类型 7 与 IBD 和健康控制显示出病人之间的特别显著的差别,因为它的表达式水平在 CD 和 UC 组是高得多的。这 exosomal 蛋白质与 proteasome 活动和煽动性的回答有关。我们因此断定在这研究,唾液的 exosomal PSMA7 在在从有 IBD 的题目的唾液的 exosomes 的高水平是在场的。免除病人 colonoscopy 的疼痛能是很有希望的 biomarker。 | Xiaowen Zheng Feng Chen Qian Zhang Yulan Liu Peng You Shan Sun Jiuxiang Lin Ning Chen | 2017 | Protein & Cell2017，8，9： | 19 |
| 2 | Clinical and pathological features of miR-10b and RHOC gene expression in hepatocellular carcinoma显示文摘Aberrant expression of microRNAs(miRNAs)was reported frequently in different human cancers.The major role of miRNA is targeting 30-UTR of coding gene and causing translational repression or mRNA degradation.miR-10b overexpression was reported to promote breast cancer metastasis by up-regulating RHOC expression.But its expression in hepatocellular carcinoma(HCC)remains unclear.Our study indicated that the expression of miR-10b was different in HCC and adjacent tissue samples,and reduced expression of miR-10b in HCC was related tovein invasion.High-level expression of RHOC was also related to vein invasion in HCC.But no correlation was found between miR-10b and RHOC expression.These results suggest that miR-10b and RHOC are independent predictors of HCC invasion and metastasis. | Jingli Du Yulan Wang Hanjiang Fu Xiaofei Zheng Minggui Lin Mingzhou Guo Lixin Wei | 2014 | Chinese Science Bulletin2014，59，19： | 4 |
| 3 | 原煤成型特性研究(Ⅲ)煤的硬度和脆度与其成型效果的关系显示文摘利用HX-200型显微硬度计和哈氏可磨性指数仪等方法,研究了三种不同变质程度煤的硬度和脆度;采用重液分选法富集镜质组分,并分别进行成型试验,探讨了煤的硬度、脆度与其成型效果的关系.结果表明:在无粘结剂、冷压成型条件下,硬度小、脆度大的煤其成型性能好;硬度大、脆度小的煤其成型性能差. | Zhao Yulan Ji Denggao and Wang Lin(College of Mining Engineering, Taiyuan University of Technology, 030024 Taiyuan ) | 1999 | 煤炭转化1999，22，2： | 4 |
| 4 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 5 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 6 | Inferring user profiles in social media by joint modeling of text and networks显示文摘Dear editor,With the rapid growth of social media platforms such as Twit ter and Chinese Weibo,personalized services,such as recommendation and personalized advertising,provide more engaging experiences for the users.A prerequisite to personalized services is effective user profiling.However,many users do not want to share their profiles online due to the privacy concerns.To address this problem,automatic user profiling based on users5 posted contents and their social activities online has attracted many attentions in recent years[1-3]. | Ruifeng XU Jiachen DU Zhishan ZHAO Yulan HE Qinghong GAO Lin GUI | 2019 | Science China(Information Sciences)2019，62，11： | 3 |
| 7 | High-risk phenotypes of genetic disease in a Neonatal Intensive Care Unit population显示文摘To the Editor: Genetic diseases contribute to 35% of deaths during the first year of life and are a significant cause of intensive care.[1] A previous study based on the China Neonatal Genomes Project investigated the genetic causes of early infant deaths and found that >25% of deceased neonates with genetic diagnoses can be cured if diagnosed in time.[2] Therefore, it is crucial to target and diagnose neonates with genetic diseases as early as possible. According to our experience, the typical phenotypes, such as special facial features or multiple congenital anomalies (MCAs), indicate a high risk of genetic disease and lead physicians to perform genetic testing in neonates as early as possible. However, in practice, infants without typical phenotypes typically undergo a long and costly diagnostic process before genetic diagnoses are confirmed. Moreover, a recent survey by the American College of Medical Genetics and Genomics (ACMG) and other national professional organizations indicated that there are insufficient numbers of qualified geneticists to fulfil genetic service needs.[3] The ACMG published the general clinical features for genetic testing indications. For example, patients with phenotypes or family history data that strongly implicate a genetic cause may undergo genetic testing.[1] However, the study indicated that many genetic conditions arise de novo or are inherited with no family history.[1] A previous study attempted to apply the non-phenotype-driven panel approach in neonates admitted to the neonate intensive care unit (NICU).[4] However, at present, the diagnostic yield is only 3.45% (1/29).[4] In addition, the economic and ethical issues associated with genomic screening remain challenging. Therefore, the available indications for genetic testing may improve the management of genetic diseases. | Tiantian Xiao Qi Ni Huiyao Chen Huijun Wang Lin Yang Bingbing Wu Yun Cao Guoqiang Cheng Laishuan Wang Liyuan Hu Hongfang Mei Yulan Lu Mengchun Gong Xinran Dong Wenhao Zhou | 2022 | Chinese Medical Journal2022，，5： | 2 |
| 8 | The Study of Relationships between the Damage of Visual Function and Hemorrheology, Ocular Rheography, as well as Other Related Factors in Patients with Primary Open Angle Glaucoma (POAG)显示文摘Researches of glaucoma visual function damage, hemorrheololgy, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regresion analysis, indicate that the elevation of intraocular pressure (IOP) is not the only factor to induce visual impairment. POAG patients are shown to have markedly reduced diastolic purfussion pressure in ophthalmic artery, besides prolonged filling time of the retinal artery and vein, diminished erythrocyte deformability and increased platele... | Jian Ge, Wenbing Zhou National Ophthalmological Laboratories, Ministry of Public Health, China, Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences, Guangzhou 510060, China Jiancu Zhu, Anheng Cheng, Yulan Lin, Hongyan Tong, Lin Lian, Zhixing Chen Institute of Cardiovascular Diseases of Guangdong Province, Guangzhou 510080, China | 1993 | 眼科学报1993，9，1： | 1 |
| 9 | Evaluation of the structural integrity of the CPR1000 PWR containment under steam explosion accidents显示文摘 | Chunyu Zhang Peng Chen Juanhua Zhang Jiming Lin Yulan Liu Shishun Zhang Biao Wang | 2014 | Nuclear Engineering and Design2014，，： | 1 |
| 10 | Nuclear track anti-counterfeiting technique and its application in secure ID 显示文摘 | WANG Yulan XU Shiping LIN Jiangheng | 2008 | Radiation Measurements2008，43，： | 1 |
| 11 | Based on Multi-sensor Information Fusion Algorithm of TPMS Research 显示文摘 | Zhou Yulan Zang Yanhong Lin Y ahong | 2012 | International Conference on Solid State Devices and Materials Science2012，，： | 1 |
| 12 | Weakly Supervised Joint Sentiment-topic Detection from Text显示文摘 | Lin Chenghua He Yulan Richard Everson | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，6： | 1 |
| 13 | AEG -1 Overexpression: A Novel Indicator for Peritoneal Dissemination and Lymph Node Metastasis in Epithelial Ovarian Cancers显示文摘 | Cong Li Junjun Liu Renbo Lu Ge Yu Xiaochuan Wang Yulan Zhao Hongtao Song Ping Lin Xicai Sun Xiaoguang Yu Yuan Zhang Xiaoming Ning Jingshu Geng | 2011 | International Journal of Gynecological Cancer2011，，4： | 1 |
| 14 | Determination of Multiple Pesticide Residues in Honey Using Gas Chromatography-Electron Impact Ionization-Mass Spectrometry显示文摘 | Zhen JIN Zhuguang LIN Meiyu CHEN Yu MA Jun TAN Yulan FAN Jiachen WEN Zhaobin CHEN Fengzhang TU | 2006 | Chinese Journal of Chromatography2006，，5： | 1 |
| 15 | Fish Oil Alleviates Activation of the Hypothalamic-Pituitary-Adrenal Axis Associated with Inhibition of TLR4 and NOD Signaling Pathways in Weaned Piglets after a Lipopolysaccharide Challenge123显示文摘 | Yulan Liu Feng Chen Quan Li Jack Odle Xi Lin Huiling Zhu Dingan Pi Yongqing Hou Yu Hong Haifeng Shi | 2013 | Journal of Nutrition2013，，11： | 1 |
| 16 | Weakly supervised joint sentiment-topic detection from text显示文摘 | Lin Chenghua He Yulan Everson R | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，6： | 1 |
| 17 | Weakly supervised joint sentiment-topic detection from text显示文摘 | LIN Chenghua HE Yulan EVERSON R | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，6： | 1 |
| 18 | Surface characteristics of hydrous silica-coated TiO2 particles显示文摘 | Lin YuLan Wang TingJie Jin Yong | 2002 | Powder Technology2002，123，： | 1 |
| 19 | The Identification of Phenylalanine Ammonia-Lyase(PAL)Genes from Pinus yunnanensis and an Analysis of Enzyme Activity in vitro显示文摘Phenylalanine ammonia lyase(PAL)is the rate-limiting and pivotal enzyme of the general phenylpropanoid path-way,but few reports have been found on PAL genes in Pinus yunnanensis.In the present study,three PAL genes were cloned and identified from P.yunnanensis seedlings for thefirst time,namely,PyPAL-1,PyPAL-2,and PyPAL-3.Our results indicated that the open-reading frames of PyPAL genes were 2184,2157,and 2385 bp.Phylogenetic tree analysis revealed that PyPALs have high homology with other known PAL genes in other plants.In vitro enzymatic analysis showed that all three PyPAL recombinant proteins could catalyze the deamination of L-phenylalanine to form trans-cinnamic acid,but only PAL1 and PAL2 can catalyze the conversion of L-tyrosine toρ-coumaric acid.Three PyPAL genes were expressed in different tissues in 1-year-old P.yunnanensis,and such genes had different expression patterns.This study lays a foundation for further understanding of the biosynthesis of secondary metabolites in P.yunnanensis. | Dejin Mu Lin Chen Heze Wang Zhaoliu Hu Sihui Chen Shi Chen Nianhui Cai Yulan Xu Junrong Tang | 2024 | Phyton-International Journal of Experimental Botany2024，93，3： | 0 |
| 20 | COVID-19 vaccination intention and vaccine characteristics infuencing vaccination acceptance: a global survey of 17 countries显示文摘Background:The availability of various types of COVID-19 vaccines and diverse characteristics of the vaccines pre‑sent a dilemma in vaccination choices,which may result in individuals refusing a particular COVID-19 vaccine ofered,hence presenting a threat to immunisation coverage and reaching herd immunity.The study aimed to assess global COVID-19 vaccination intention,vaccine characteristics infuencing vaccination acceptance and desirable vaccine characteristics infuencing the choice of vaccines.Methods:An anonymous cross-sectional survey was conducted between 4 January and 5 March 2021 in 17 coun‑tries worldwide.Proportions and the corresponding 95%confdence intervals(CI)of COVID-19 vaccine acceptance and vaccine characteristics infuencing vaccination acceptance were generated and compared across countries and regions.Multivariable logistic regression analysis was used to determine the factors associated with COVID-19 vaccine hesitancy.Results:Of the 19,714 responses received,90.4%(95%CI 81.8–95.3)reported likely or extremely likely to receive COVID-19 vaccine.A high proportion of likely or extremely likely to receive the COVID-19 vaccine was reported in Australia(96.4%),China(95.3%)and Norway(95.3%),while a high proportion reported being unlikely or extremely unlikely to receive the vaccine in Japan(34.6%),the U.S.(29.4%)and Iran(27.9%).Males,those with a lower educational level and those of older age expressed a higher level of COVID-19 vaccine hesitancy.Less than two-thirds(59.7%;95%CI 58.4–61.0)reported only being willing to accept a vaccine with an efectiveness of more than 90%,and 74.5%(95%CI 73.4–75.5)said they would accept a COVID-19 vaccine with minor adverse reactions.A total of 21.0%(95%CI 20.0–22.0)reported not accepting an mRNA vaccine and 51.8%(95%CI 50.3–53.1)reported that they would only accept a COVID-19 vaccine from a specifc country‐of‐origin.Countries from the Southeast Asia region reported the highest proportion of not accepting mRNA technology.The highest proportion from Europe and the Americas would only accept a vaccine produced by certain countries.The foremost important vaccine characteristic infuencing vaccine choice is adverse reactions(40.6%;95%CI 39.3–41.9)of a vaccine and efectiveness threshold(35.1%;95%CI 33.9–36.4).Conclusions:The inter-regional and individual country disparities in COVID-19 vaccine hesitancy highlight the importance of designing an efcient plan for the delivery of interventions dynamically tailored to the local population. | Li Ping Wong Haridah Alias Mahmoud Danaee Jamil Ahmed Abhishek Lachyan Carla Zi Cai Yulan Lin Zhijian Hu Si Ying Tan Yixiao Lu Guoxi Cai Di Khanh Nguyen Farhana Nishat Seheli Fatma Alhammadi Milkar D.Madhale Muditha Atapattu Tasmi Quazi‑Bodhanya Samira Mohajer Gregory D.Zimet Qinjian Zhao | 2021 | Infectious Diseases of Poverty2021，10，5： | 0 |
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