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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | The Genesis Mechanism of the Mantle Fluid Action and Evolution in the Ore-Forming Process: A Case Study of the Laowangzhai Gold Deposit in Yunnan, China显示文摘Based on petrological studies of the wall rocks, mineralizing rocks, ores and veins from the Laowangzhai gold deposit, it is discovered that along with the development of silication, carbonation and sulfidation, a kind of black opaque ultra-microlite material runs through the spaces between grains, fissures and cleavages. Under observations of the electron microprobe, scanning electronic microscopy and energy spectrum, this kind of ultra-microlite material is confirmed to consist of ultra microcrystalline quartz, silicate, sulfides and carbonates, as well as rutile, scheelite and specularite (magnetite), showing characters of liquation by the analyses of SEM and energy spectrum. The coexistence of immiscibility and precipitating co-crystallization strongly suggests that the mineralizing fluid changed from the melt to the hydrothermal fluid. Combined with the element geochemical researches, it is realized that the ultra-microlite aggregate is the direct relics of the mantle fluid behaving like a melt and supercritical fluid, which goes along with the mantle-derived magma and will escape from the magma body at a proper time. During the alteration process, the nature of the mantle fluid changed and it is mixed with the crustal fluid, which are favorable for mineralization in the Loawangzhai gold deposit. | LIU Xianfan LI Chunhui LU Qiuxia DENG Biping SONG Xiangfeng ZHAO Fufeng CHU Yating XIAO Jixiong YI Liwen HUANG Yupeng | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 13 |
| 3 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 6 | The High Energy X-ray telescope (HE) onboard the Insight-HXMT astronomy satellite显示文摘The Insight-Hard X-ray Modulation Telescope(Insight-HXMT) is a broadband X-ray and γ-ray(1-3000 ke V) astronomy satellite. One of its three main telescopes is the High Energy X-ray telescope(HE). The main detector plane of HE comprises 18 Na I(Tl)/Cs I(Na) phoswich detectors, where Na I(Tl) is used as the primary detector to measure ~ 20-250 ke V photons incident from the field of view(FOV) defined by collimators, and Cs I(Na) is used as the active shielding detector to Na I(Tl) by pulse shape discrimination. Additionally, Cs I(Na) is used as an omnidirectional γ-ray monitor. The HE collimators have a diverse FOV,i.e. 1.1°×5.7°(15 units), 5.7°×5.7°(2 units), and blocked(1 unit). Therefore, the combined FOV of HE is approximately5.7°×5.7°. Each HE detector has a diameter of 190 mm resulting in a total geometrical area of approximately 5100 cm2, and the energy resolution is ~15% at 60 ke V. For each recorded X-ray event by HE, the timing accuracy is less than 10 μs and the deadtime is less than 10 μs. HE is used for observing spectra and temporal variability of X-ray sources in the 20-250 ke V band either by pointing observations for known sources or scanning observations to unveil new sources. Additionally, HE is used for monitoring the γ-ray burst in 0.2-3 Me V band. This paper not only presents the design and performance of HE instruments but also reports results of the on-ground calibration experiments. | CongZhan Liu YiFei Zhang XuFang Li XueFeng Lu Zhi Chang ZhengWei Li AiMei Zhang YongJie Jin HuiMing Yu Zhao Zhang MinXue Fu YiBao Chen JianFeng Ji YuPeng Xu JingKang Deng RenCheng Shang GuoQing Liu FangJun Lu ShuangNan Zhang YongWei Dong TiPei Li Mei Wu YanGuo Li HuanYu Wang BoBing Wu YongJie Zhang Zhi Zhang ShaoLin Xiong Yuan Liu Shu Zhang HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 9 |
| 7 | Diffraction-limited imaging with monolayer 2D material-based ultrathin flat lenses显示文摘Ultrathin flat optics allow control of light at the subwavelength scale that is unmatched by traditional refractive optics.To approach the atomically thin limit,the use of 2D materials is an attractive possibility due to their high refractive indices.However,achievement of diffraction-limited focusing and imaging is challenged by their thickness-limited spatial resolution and focusing efficiency.Here we report a universal method to transform 2D monolayers into ultrathin flat lenses.Femtosecond laser direct writing was applied to generate local scattering media inside a monolayer,which overcomes the longstanding challenge of obtaining sufficient phase or amplitude modulation in atomically thin 2D materials.We achieved highly efficient 3D focusing with subwavelength resolution and diffractionlimited imaging.The high focusing performance even allows diffraction-limited imaging at different focal positions with varying magnifications.Our work paves the way for downscaling of optical devices using 2D materials and reports an unprecedented approach for fabricating ultrathin imaging devices. | Han Lin Zai-Quan Xu Guiyuan Cao Yupeng Zhang Jiadong Zhou Ziyu Wang Zhichen Wan Zheng Liu Kian Ping Loh Cheng-Wei Qiu Qiaoliang Bao Baohua Jia | 2020 | Light(Science & Applications)2020，9，1： | 9 |
| 8 | The Low Energy X-ray telescope (LE) onboard the Insight-HXMT astronomy satellite显示文摘The Low Energy X-ray telescope(LE) is one of the three main instruments of the Insight-Hard X-ray Modulation Telescope(Insight-HXMT). It is equipped with Swept Charge Device(SCD) sensor arrays with a total geometrical area of 384 cm^2 and an energy band from 0.7 to 13 ke V. In order to evaluate the particle induced X-ray background and the cosmic X-ray background simultaneously, LE adopts collimators to define four types of Field Of Views(FOVs), i.e., 1.6°×6°, 4°×6°, 50°-60°×2°-6 oand the blocked ones which block the X-ray by an aluminum cover. LE is constituted of three detector boxes(LEDs) and an electric control box(LEB) and achieves a good energy resolution of 140 e V@5.9 ke V, an excellent time resolution of 0.98 ms, as well as an extremely low pileup(<1%@18000 cts/s). Detailed performance tests and calibration on the ground have been performed,including energy-channel relation, energy response, detection efficiency and time response. | Yong Chen WeiWei Cui Wei Li Juan Wang YuPeng Xu FangJun Lul YuSa Wang TianXiang Chen DaWei Han Wei Hu Yi Zhang Jia Huo YanJi Yang MaoShun Li Bo Lu ZiLiang Zhang TiPei Li ShuangNan Zhang ShaoLin Xiong Shu Zhang RongFeng Xue XiaoFan Zhao Yue Zhu YuXuan Zhu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 8 |
| 9 | DDoS Attack Detection Scheme Based on Entropy and PSO-BP Neural Network in SDN显示文摘SDN (Software Defined Network) has many security problems, and DDoS attack is undoubtedly the most serious harm to SDN architecture network. How to accurately and effectively detect DDoS attacks has always been a difficult point and focus of SDN security research. Based on the characteristics of SDN, a DDoS attack detection method combining generalized entropy and PSOBP neural network is proposed. The traffic is pre-detected by the generalized entropy method deployed on the switch, and the detection result is divided into normal and abnormal. Locate the switch that issued the abnormal alarm. The controller uses the PSO-BP neural network to detect whether a DDoS attack occurs by further extracting the flow features of the abnormal switch. Experiments show that compared with other methods, the detection accurate rate is guaranteed while the CPU load of the controller is reduced, and the detection capability is better. | Zhenpeng Liu Yupeng He Wensheng Wang Bin Zhang | 2019 | China Communications2019，16，7： | 8 |
| 10 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 11 | Estimating biological reference points for Largehead hairtail(Trichiurus lepturus) fishery in the Yellow Sea and Bohai Sea显示文摘It is important to find a reliable method to estimate maximum sustainable yield(MSY)or total allowable catch(TAC)for fishery management,especially when the data availability is limited which is a case in China.A recently developed method(CMSY)is a data-poor method,which requires only catch data,resilience and exploitation history at the first and final years of the catch data.CMSY was used in this study to estimate the biological reference points for Largehead hairtail(Trichiurus lepturus,Temminck and Schlegel)in the Yellow Sea and Bohai Sea,based on the fishery data from China Fishery Statistical Year Books during 1986 to 2012.Additionally,Bayesian state-space Schaefer surplus production model(BSM)and the classical surplus production models(Schaefer and Fox)performed by software CEDA and ASPIC,were also projected in this study to compare with the performance of CMSY.The estimated MSYs from all models are about 19.7×104–27.0×104 t,while CMSY and BSM yielded more reasonable population parameter estimates(the intrinsic population growth rate and the carrying capacity).The biological reference points of B/BMSY smaller than 1.0,while F/FMSY higher than 1.0 revealed an over-exploitation of the fishery,indicating that more conservative management strategies are required for Largehead hairtail fishery. | Yupeng Ji Qun Liu Baochao Liao Qingqing Zhang Ya’nan Han | 2019 | Acta Oceanologica Sinica2019，38，10： | 5 |
| 12 | Flow behavior of liquid metal in the connected fascial space: Intervaginal space injection in the rat wrist and mice with tumor显示文摘扁带和 fascial 空格能帮助提供天体的更好的理解。intervaginal 空间注射(ISI ) 提供要求进一步的调查的唯一的优点。包括生理的条件和肿瘤过程的一个上面的手足模型被选择在 ISI 以后决定液体金属的流动行为。在正常老鼠,在直到 intervaginal 空间的液体金属的注射以后包括腱,容器,和神经,磁性的回声成像和一个解剖实验显示没有容器或淋巴节点,在 fascial 空间附近并且最后包的液体金属到达了下游的指尖和除了神经与血管的捆在上游的腋窝。用环境扫描,电子显微镜学(ESEM ) 想象,我们发现液体金属在扁带的纤维附近被包并且向前搬到 microscale 或 nanoscale 区域。这些数据证实了一条基于扁带的小径。在肿瘤,液体金属通过损坏的点搬到肿瘤囊,在癌症房间破坏在正常房间和癌症房间之间的扁带的完整的地方。部分在肿瘤附近包并且把肿瘤与包围正常肌肉分开了的液体金属。ESEM 图象证明扁带的纤维渗透了肿瘤,因此形成液体金属通过渗透了肿瘤的一个网络。我们的学习在 ISI 以后在上面的手足说明了液体金属的生理、病理学的流动行为并且在扁带表明了一条 nonvascular 小径。ISI 可能为在 fascial 小径的临床的治疗是有用的。 | Nan Hu Yupeng Cao Zhuo Ao Xinxiao Han Qiang Zhang Wentao Liu Sidi Liu Fulong Liao Dong Han | 2018 | Nano Research2018，11，4： | 5 |
| 13 | Lactobacillus reuteri-derived extracellular vesicles maintain intestinal immune homeostasis against lipopolysaccharideinduced inflammatory responses in broilers显示文摘Background:Lactobacillus reuteri strains are widely used as probiotics to prevent and treat inflammatory bowel disease by modulating the host’s immune system.However,the underlying mechanisms by which they communicate with the host have not been clearly understood.Bacterial extracellular vesicles(EVs)have been considered as important mediators of host-pathogen interactions,but their potential role in commensals-host crosstalk has not been widely studied.Here,we investigated the regulatory actions of EVs produced by L.reuteri BBC3,a gut-associated commensal bacterium of Black-Bone chicken,in the development of lipopolysaccharide(LPS)-induced intestinal inflammation in a chicken model using both in vivo and in vitro experiments.Results:L.reuteri BBC3 produced nano-scale membrane vesicles with the size range of 60-250 nm.Biochemical and proteomic analyses showed that L.reuteri BBC3-derived EVs(LrEVs)carried DNA,RNA and several bioactive proteins previously described as mediators of other probiotics’beneficial effects such as glucosyltransferase,serine protease and elongation factor Tu.In vivo broiler experiments showed that administration of LrEVs exerted similar effects as L.reuteri BBC3 in attenuating LPS-induced inflammation by improving growth performance,reducing mortality and decreasing intestinal injury.LrEVs suppressed the LPS-induced expression of pro-inflammatory genes(TNF-α,IL-1β,IL-6,IL-17 and IL-8),and improved the expression of anti-inflammatory genes(IL-10 and TGF-β)in the jejunum.LrEVs could be internalized by chicken macrophages.In vitro pretreatment with LrEVs reduced the gene expression of TNF-α,IL-1βand IL-6 by suppressing the NF-κB activity,and enhanced the gene expression of IL-10 and TGF-βin LPS-activated chicken macrophages.Additionally,LrEVs could inhibit Th1-and Th17-mediated inflammatory responses and enhance the immunoregulatory cells-mediated immunosuppression in splenic lymphocytes of LPS-challenged chickens through the activation of macrophages.Finally,we revealed that the reduced content of both vesicular proteins and nucleic acids attenuated the suppression of LrEVs on LPS-induced inflammatory responses in ex vivo experiments,suggesting that they are essential for the LrEVs-mediated immunoregulation.Conclusions:We revealed that LrEVs participated in maintaining intestinal immune homeostasis against LPSinduced inflammatory responses in a chicken model.Our findings provide mechanistic insight into how commensal and probiotic Lactobacillus species modulate the host’s immune system in pathogens-induced inflammation. | Rujiu Hu Hua Lin Mimi Wang Yuezhen Zhao Haojing Liu Yuna Min Xiaojun Yang Yupeng Gao Mingming Yang | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 5 |
| 14 | Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications显示文摘Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer treatment, but the complex biological processes of cancer cells seriously limit the efficacy of various anticancer drugs. Autophagy, a self-degradative system that maintains cellular homeostasis, universally operates under normal and stress conditions in cancer cells. The roles of autophagy in cancer treatment are still controversial because both stimulation and inhibition of autophagy have been reported to enhance the effects of anticancer drugs. Thus, the important question arises as to whether we should try to strengthen or suppress autophagy during cancer therapy. Currently, autophagy can be divided into four main forms according to its different functions during cancer treatment: cytoprotective(cell survival), cytotoxic(cell death), cytostatic(growth arrest), and nonprotective(no contribution to cell death or survival). In addition, various cell death modes, such as apoptosis, necrosis, ferroptosis, senescence, and mitotic catastrophe, all contribute to the anticancer effects of drugs. The interaction between autophagy and these cell death modes is complex and can lead to anticancer drugs having different or even completely opposite effects on treatment. Therefore, it is important to understand the underlying contexts in which autophagy inhibition or activation will be beneficial or detrimental.That is, appropriate therapeutic strategies should be adopted in light of the different functions of autophagy. This review provides an overview of recent insights into the evolving relationship between autophagy and cancer treatment. | Zhaoshi BAI Yaling PENG Xinyue YE Zhixian LIU Yupeng LI Lingman MA | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，2： | 5 |
| 15 | In situ growth of single-crystal TiO2 nanorod arrays on Ti substrate: Controllable synthesis and photoelectro- chemical water splitting显示文摘尽管有一个维(1D ) 半导体 nanostructure 数组吸引由于他们的许多增加注意有利,高度订的 TiO 2 nanorod 数组(TiO 2 NR ) 很少在 Ti 底层上在 situ 被种。此处,由使用一个通过面具阳极化过程在 Ti 底层上制作 TiO 2 NR 的一个可行方法被报导。在 Ti 底层上覆盖的自我命令的阳极的铝氧化物(AAO ) 被用作 nanotemplate 导致 TiO 2 NR 的生长。NR 长度和直径能被调整象电气化学的阳极化电压,阳极化时间和温度那样的阳极化参数控制,并且电解质作文。根据建议 NR 形成机制,而且,阳极化的 Ti 离子移居并且在 AAO nanochannels 扔形成 Ti (哦) 在电场下面的 4 或非结晶的 TiO 2 NR,由于模板的监禁效果。Photoelectrochemical 测试显示在加氢以后, TiO 2 NR 在模仿的日光和可见轻照明下面介绍了更高的光电流密度,建议他们在 photoelectrochemical 水切开,光催化,太阳能电池,和传感器的潜在的使用。 | Tingting Zhang Zia Ur Rahman Ning Wei Yupeng Liu Jun Liang Daoai Wang | 2017 | Nano Research2017，10，3： | 4 |
| 16 | Metabolic disorder in the progression of heart failure显示文摘Heart failure(HF) is a major clinical concern owing to its high prevalence and high mortality.Metabolomics,an effective approach to predict diagnostic biomarkers and to explore the altered metabolic pathways in pathogenesis,has been extensively applied in evaluating the course of diseases.In this study,we used this approach to analyse the abundance of metabolites,with liquid chromatograph-mass spectrometer,in plasma samples from rats with transverse aortic constriction(TAC) and patients at different stages of HF.We compared the metabolic parameters within and between TAC rats and patients.An apparent metabolic shift was observed in rats,from compensated hypertrophy stage to decompensated hypertrophy stage,and in patients with HF,from stage A to stage B and subsequently stage C.Diagnostic biomarkers were predicted by comparing the variable importance in the projection scores and fold change analysis within and between rats and patients.Enrichment pathway analysis and network analysis provided an overview of the largely disturbed metabolic pathways,and those interfered at different stages and across species were confirmed.The significantly changed metabolites and pathways revealed the underlying mechanisms of HF pathogenesis,hinted at novel potential biomarkers,and provided potential therapeutic intervention targets for HF. | Xiuxiu Zhang Huiying Liu Juan Gao Min Zhu Yupeng Wang Changtao Jiang Ming Xu | 2019 | Science China(Life Sciences)2019，62，9： | 4 |
| 17 | Enhanced voltage distribution and breakdown strength performances of oil‐paper composite insulation by adding TiO_(2)nanoparticles显示文摘Oil-paper composite insulation(OPCI)is used as the main insulation material in the converter transformer.However,the dielectric properties of insulating oil and oil‐impregnated paper are markedly mismatched under direct current(DC)voltage,resulting in an unbalanced distribution of voltage,which is considered to be a major cause of large insulation margin but frequent failures.Therefore,it is necessary to adjust the voltage distribution in OPCI to enhance its breakdown strength.In this work,surface‐treated TiO_(2) nanoparticles were employed to modify OPCI.The polarisation current tests revealed that by changing the additive amount of nano-particles,the polarisation intensities of both oil and oil‐impregnated paper could be adjusted.Based on this,a model taking relaxation polarisations into full consideration was established to analyse the voltage distribution in OPCI and predict the optimal concentration.The prepared OPCI with the concentration of 0.02 g/L has desired balanced voltage distribution due to the influence of nanoparticles on interface charge,and therefore high breakdown strengths under both DC voltage and polarity reversal voltage,which can be increased by 22.6%at most.This work puts forward a novel idea to improve insulation property of OPCI and provides a reference for broader application of nanomaterial in power equipment. | Meng Huang Yupeng Ying Baixin Liu Yuzhen Lv Bo Qi Chengrong Li | 2021 | High Voltage2021，6，1： | 4 |
| 18 | Soybean hairy roots produced in vitro by Agrobacterium rhizogenes-mediated transformation显示文摘Soybean is one of the world's most important oil and protein crops. Efficient transformation is a key factor for the improvement of soybean by genetic modification. We describe an optimized protocol for the Agrobacterium rhizogenes-mediated transformation of soybean and the induction of hairy root development in vitro. Cotyledons with 0.5-cm hypocotyls were cut from 5-day-old seedlings and used as explants. After infection and co-cultivation,hairy roots were produced in induction culture medium after 10–12 days. Using this method, 90%–99% of the infected explants of five different cultivars produced hairy roots within one month. Observations using reporter constructs showed that 30%–60% of the hairy roots induced were transformed. Based on high transformation efficiency and short transformation period, this method represents an efficient and rapid platform for study of soybean gene function. | Li Chen Yupeng Cai Xiujie Liu Chen Guo Shi Sun Cunxiang Wu Bingjun Jiang Tianfu Han Wensheng Hou | 2018 | The Crop Journal2018，6，2： | 4 |
| 19 | Novel coprecipitation-oxidation method for recovering iron from steel waste pickling liquor显示文摘 | Shejiang Liu Hongyang Yang Yongkui Yang Yupeng Guo Yun Qi | 2017 | Frontiers of Environmental Science & Engineering2017，11，1： | 4 |
| 20 | Multiple Spatial Scale Analysis of the Niche Characteristics of the Rhododendron dauricum Plant Communities in Northeast China显示文摘This study aims to verify the concept of niches at multiple spatial scales in plant communities.To this end,we analyzed the niche characteristic of Rhododendron dauricum plant communities in Northeast China at three spatial scales.At the local scale,we calculated the Importance Value(IV)of species in five communities in the north of the Da Hinggan Mountains.At the intermediate scale,we examined five communities in their entirety,calculated the niche breadth of the species,and integrated niche overlap and interspecific association to analyze interspecific relationships.Further,the generalized additive model(GAM)was used to analyze the impact of topography and soil factors on niche characteristics.At the regional scale,we analyzed the geographical distribution of dominant species of R.dauricum plant communities in Northeast China and used principal component analysis(PCA)to analyze the impact of geographical and climate factors on species distribution.The results show that at the local scale,the IV of the species in each community varies widely.At the intermediate scale,species with a wide niche breadth tend to have a high value for IV.Larix gmelinii,Betula platyphylla,R.dauricum,Ledum palustre,and Vaccinium vitis-idaea had a relatively wide niche breadth and a high niche overlap,and the interspecific associations were almost all positive.Elevation and soil nutrients were the most dominant environmental factors.At the regional scale,species with a wide niche breadth tend to have a wide range of distribution,and temperature and precipitation were the most dominant environmental factors.This study suggests that the niche characteristics at three scales are both related and different.Niche characteristics at the local scale were various and labile,and niche characteristics at the intermediate and regional scales were relatively regular.These results show some degree of consistency with previous studies from an evolutionary perspective.The action mechanisms of these communities are related to differences in the dominant environmental factors.In addition,the integration of niche overlap and interspecific association determine interspecific relationships more accurately. | LU Yupeng CHEN Wei YAO Jing HUANG Yanqing ZHANG Yue LIU Huanchu HE Xingyuan | 2020 | Chinese Geographical Science2020，30，4： | 4 |
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