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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Design and Experiment of a Bionic Gannet for Plunge-Diving显示文摘 | Jianhong Liang Xingbang Yang Tianmiao Wang Guocai Yao Wendi Zhao | 2013 | Journal of Bionic Engineering2013，10，3： | 6 |
| 3 | Wing load investigation of the plunge-diving locomotion of a gannet Morus inspired submersible aircraft显示文摘In this paper,we studied the wing root pivot joint’s radial load of a submersible airplane which imitates the locomotion of gannet’s Morus plunge-diving,by implementing a test device name Mimic-Gannet.The housing of the device was designed by mimicking the morphology of a living gannet,and the folding wings were realized by the mechanism of variable swept back wing.Then,the radial loads of the wing root were obtained under the conditions of different dropping heights,different sweptback angles and different water-entry inclination angles(i.e.,the angle between the longitudinal body axis and the water surface),and the relationships between the peak radial load and the above three parameters were analyzed and discussed respectively.In the studied areas,the minimum peak radial load of the pivot joint is 50.93 N,while the maximum reaches up to1135.00 N.The largest peak load would be generated for the situation of vertical water entry and zero wing sweptback angle.And it is of great significance to choose the three parameters properly to reduce the pivot joint’s radial load,i.e.,larger wing sweptback angle,smaller dropping height and water-entry inclination angle.It is also concluded that the peak radial load on the wing root is closely linear with the water-entry dropping height and the wing sweptback angle with a significant correlation.Eventually,the relationship between the wing load and the dropping height,water-entry inclination angle or wing sweptback angle,could be used to calculate the wing load about plunge-diving of a submersible aircraft,and the conclusions reveal the wing load characteristic of the gannet’s plunge process for the biologists. | LIANG JianHong YAO GuoCai WANG TianMiao YANG XingBang ZHAO WenDi SONG Gang ZHANG YuCheng | 2014 | Science China(Technological Sciences)2014，57，2： | 5 |
| 4 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 5 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 6 | Postconditioning of stellate ganglion block improves intestinal barrier function by inhibiting autophagy in conscious rats following hemorrhagic shock and resuscitation显示文摘To the Editor:Hemorrhagic shock is a critical pathological process characterized by microcirculation dysfunction and hypoperfusion,with severe consequences of cell damage and organ dysfunction.Intestinal barrier dysfunction is a critical link of distant organ injury caused by hemorrhagic shock.Prophylactic treatment with stellate ganglion block(SGB)significantly reduces hemorrhagic shock-induced intestinal barrier damage. | Zhonghua Li Wendi Wang Qi Sun Tingjiao Suo Jiayi Zhai Huibo Du Zhen’ao Zhao Fulong Li Chunyu Niu Zigang Zhao | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 7 | EGFL7 Is Expressed in Bone Microenvironment and Promotes Angiogenesis via ERK, STAT3, and Integrin Signaling Cascades显示文摘 | Shek Man Chim Vincent Kuek Siu To Chow Bay Sie Lim Jennifer Tickner Jinmin Zhao Rosa Chung Yu‐Wen Su Ge Zhang Wendy Erber Cory J. Xian Vicki Rosen Jiake Xu | 2015 | Physiol2015，，1： | 1 |
| 8 | Inheritance of resis- tance to Bacillus thuringiensis the CrylAc toxin in Spodopera littoralis (Lepidoptera:Noctuidae)显示文摘 | WENDY C K ZHAO J Z ALIDA F J | 2004 | Journal of Economic Ento- mology2004，97，6： | 1 |
| 9 | Threshold Dynamics for Compartmental Epidemic Models in Periodic Environments显示文摘 | Wendi Wang Xiao-Qiang Zhao | 2008 | Journal of Dynamics and Differential Equations2008，，3： | 1 |
| 10 | Fisher waves in an epidemic model显示文摘 | Xiao-Qiang Zhao Wendi Wang | 2004 | Discrete and continuous dynamical systems-Section B2004，4，4： | 1 |
| 11 | Fisher waves in an epidemic model显示文摘 | Xiao-Qiang Zhao and Wendi Wang | 2004 | Discrete and continuous dynamical systems-Section B2004，4，4： | 1 |
| 12 | Determination of Carotid Artery Atherosclerotic Lesion Type and Distribution in Hypercholesterolemic Patients With Moderate Carotid Stenosis Using Noninvasive Magnetic Resonance Imaging显示文摘 | Baocheng Chu Thomas S. Hatsukami Nayak L. Polissar Xue-Qiao Zhao Lawrence W. Kraiss Dennis L. Parker John C. Waterton Joel S. Raichlen Wendy Hamar Chun Yuan | 2004 | Stroke2004，，11： | 1 |
| 13 | Fisher waves in an epidemic model显示文摘 | Zhao Xiaoqiang Wang Wendi | 2004 | Discrete and Continuous Dynamical Systems-Series B2004，4，4： | 1 |
| 14 | MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia显示文摘 | Chong Chen Yu Liu Amy R. Rappaport Thomas Kitzing Nikolaus Schultz Zhen Zhao Aditya S. Shroff Ross A. Dickins Christopher R. Vakoc James E. Bradner Wendy Stock Michelle M. LeBeau Kevin M. Shannon Scott Kogan Johannes Zuber Scott W. Lowe | 2014 | Cancer Cell2014，，5： | 1 |
| 15 | Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras -transformed fibroblasts显示文摘 | Pui Kei Wu William Chi Shing Tai Zhi-Tao Liang Zhong-Zhen Zhao Wen Luan Wendy Hsiao | 2009 | Life Sciences2009，，3： | 1 |
| 16 | Role of hypoxia inducible factor 1α in cobalt nanoparticle induced cytotoxicity of human THP-1 macrophages显示文摘Cobalt is one of the main components of metal hip prostheses and cobalt nanoparticles(CoNPs)produced from wear cause inflammation,bone lyses and cytotoxicity at high concentrations.Cobalt ions mimic hypoxia in the presence of normal oxygen levels,and activate hypoxic signalling by stabilising hypoxia inducible transcription factor 1α(HIF1α).This study aimed to assess in vitro the functional role of HIF1αin CoNP induced cellular cytotoxicity.HIF1α,lysosomal pH,tumour necrosis factorαand interleukin 1βexpression were analysed in THP-1 macrophages treated with CoNP(0,10 and 100μg/mL).HIF1αknock out assays were performed using small interfering RNA to assess the role of HIF1αin CoNP-induced cytotoxicity.Increasing CoNP concentration increased lysosomal activity and acidity in THP-1 macrophages.Higher doses of CoNP significantly reduced cell viability,stimulated caspase 3 activity and apoptosis.Reducing HIF1αactivity increased the pro-inflammatory activity of tumour necrosis factorαand interleukin 1β,but had no significant impact on cellular cytotoxicity.This suggests that whilst CoNP promotes cytotoxicity and cellular inflammation,the apoptotic mechanism is not dependent on HIF1α. | Wendy Rachel Francis Zhao Liu Sian E Owens Xiao Wang Huaming Xue Alex Lord Venkateswarlu Kanamarlapudi Zhidao Xia | 2021 | Biomaterials Translational2021，2，2： | 1 |
| 17 | An endemic model in a patchy environment显示文摘 | Wendi Wang Xiaogiang Zhao | 2004 | Math Biosci2004，190，： | 1 |
| 18 | Hydrogen clusters in clathrate hydrate science显示文摘 | Wendy I Mao H-kM Alexander F Goncharov Viktor V Struzhkin Guo Quanzhong Hu Jingzhu Shu Jinfu Russell J Hemley Maddury Somayazulu Zhao Yusheng | 2002 | Science2002，297，5590： | 1 |
| 19 | An Epidemic Model in a Patch Invironment 显示文摘 | Wang Wendi Zhao Xiaoqiang | 2004 | Math Bios2004，190，： | 1 |
| 20 | Corrosion mechanism of ceramic glaze from the Yangtze EstuaryⅡ显示文摘Ancient lead-glazed ceramics frequently corrode physically,chemically,and biologically when buried in soil,submerged in water,or exposed to air.In comparison to the other two environments,relatively little research has been conducted on how leadglazed ceramics deteriorate in the water environment.Four lead-glazed ceramic samples from the Yangtze EstuaryⅡwere examined for their micromorphology and structural composition using scanning electron microscopy-energy spectrum analysis,micro-area X-ray diffraction analysis,fluorescence microanalysis,and Fourier infrared spectroscopy analysis.The results demonstrate the formation of deposits of PbCO_(3),Pb(OH)Cl,and Cu FeS_(2)and corrosion pits and fractures on the glaze layer surfaces.According to the corrosion phenomenon,the lead glaze layers of ceramics mainly underwent chemical and microbial corrosion in water,and the corrosion process of the lead glaze was expounded and modeled.The research results deepen the understanding of the corrosion mechanism of lead-glazed ceramics,which is of great significance for the study of the conservation of lead-glazed ceramics and other types of ceramic relics and can also provide a reference for the long-term preservation of contemporary silicate products. | YU WenDi ZHAO Luo ZHAI Yang ZHAO Jing ZHANG KeXin GE Yan LI Qiang ZHAO Meng HUANG JiZhong LUO HongJie | 2023 | Science China(Technological Sciences)2023，66，8： | 0 |
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