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| 1 | EMT-associated microRNAs and their roles in cancer stemness and drug resistance显示文摘Epithelial-to-mesenchymal transition(EMT)is implicated in a wide array of malignant behaviors of cancers,including proliferation,invasion,and metastasis.Most notably,previou studies have indicated that both cancer stem-like properties and drug resistance were associated with EMT.Furthermore,microRNAs(miRNAs)play a pivotal role in the regulation of EMT phenotype,as a result,some miRNAs impact cancer stemness and drug resistance.Therefore,understanding the relationship between EMT-associated miRNAs and cancer stemness/drug resistance is beneficial to both basic research and clinical treatment.In this review,we preliminarily looked into the various roles that the EMT-associated miRNAs play in the stem-like nature of malignant cells.Then,we reviewed the interaction between EMT-associated miRNAs and the drugresistant complex signaling pathways of multiple cancers including lung cancer,gastric cancer,gynecologic cancer,breast cancer,liver cancer,colorectal cancer,pancreatic cancer,esophageal cancer,and nasopharyngeal cancer.We finally discussed the relationship between EMT,cancer stemness,and drug resistance,as well as looked forward to the potential applications of miRNA therapy for malignant tumors. | Guangtao Pan Yuhan Liu Luorui Shang Fangyuan Zhou Shenglan Yang | 2021 | Cancer Communications2021，41，3： | 46 |
| 2 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 3 | The telomere-to-telomere genome of Fragaria vesca reveals the genomic evolution of Fragaria and the origin of cultivated octoploid strawberry显示文摘Fragaria vesca,commonly known as wild or woodland strawberry,is the most widely distributed diploid Fragaria species and is native to Europe and Asia.Because of its small plant size,low heterozygosity,and relative ease of genetic transformation,F.vesca has been a model plant for fruit research since the publication of its Illumina-based genome in 2011.However,its genomic contribution to octoploid cultivated strawberry remains a long-standing question.Here,we de novo assembled and annotated a telomere-to-telomere,gap-free genome of F.vesca‘Hawaii 4’,with all seven chromosomes assembled into single contigs,providing the highest completeness and assembly quality to date.The gap-free genome is 220785082 bp in length and encodes 36173 protein-coding gene models,including 1153 newly annotated genes.All 14 telomeres and seven centromeres were annotated within the seven chromosomes.Among the three previously recognized wild diploid strawberry ancestors,F.vesca,F.iinumae,and F.viridis,phylogenomic analysis showed that F.vesca and F.viridis are the ancestors of the cultivated octoploid strawberry F.×ananassa,and F.vesca is its closest relative.Three subgenomes of F.×ananassa belong to the F.vesca group,and one is sister to F.viridis.We anticipate that this high-quality,telomere-to-telomere,gap-free F.vesca genome,combined with our phylogenomic inference of the origin of cultivated strawberry,will provide insight into the genomic evolution of Fragaria and facilitate strawberry genetics and molecular breeding. | Yuhan Zhou Jinsong Xiong Ziqiang Shu Chao Dong Tingting Gu Pengchuan Sun Shuang He Mian Jiang Zhiqiang Xia Jiayu Xue Wasi Ullah Khan Fei Chen Zong-Ming Cheng | 2023 | Horticulture Research2023，10，4： | 4 |
| 4 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 5 | Graphitic carbon nitride-based photocatalysts in the applications of environmental catalysis显示文摘Semiconductor photocatalytic technology has shown great prospects in converting solar energy into chemical energy to mitigate energy crisis and solve environmental pollution problems.The key issue is the development of high-efficiency photocatalysts.Various strategies in the state-of-the-art advancements,such as heterostructure construction,heteroatom doping,metal/single atom loading,and defect engineering,have been presented for the graphitic carbon nitride(g-C3N4)-based nanocomposite catalysts to design their surface chemical environments and internal electronic structures to make them more suitable for different photocatalytic applications.In this review,nanoarchitecture design,synthesis methods,photochemical properties,potential photocatalytic applications,and related reaction mechanisms of the modified high-efficiency carbon nitride-based photocatalysts were briefly summarized.The superior photocatalytic performance was identified to be associated with the enhanced visible-light response,fast photoinduced electron-hole separation,efficient charge migration,and increased unsaturated active sites.Moreover,the further advance of the visible-light harvesting and solar-to-energy conversions are proposed. | Hongxia Lin JinmoWu Fan Zhou Xiaolong Zhao Pengfei Lu Guanghui Sun Yuhan Song Yayun Li Xiaoyong Liu Hongxing Dai | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 6 | Hybrid spiking neural network for sleep electroencephalogram signals显示文摘Sleep staging is important for assessing sleep quality.So far,many scholars have tried to achieve automatic sleep staging by using neural networks.However,most researchers only perform sleep staging based on artificial neural networks and their variant models,which can not fully mine and model the bio-electrical signals.In this paper,we propose a new hybrid spiking neural network(HSNN)model for automatic sleep staging.Specifically,we use a spiking neural network to classify sleep EEG signals.In addition,we adopt a hybrid macro/micro back propagation algorithm,aiming to overcome the limitations of existing error back propagation methods for spiking neural network.In order to verify the effectiveness of HSNN,we evaluate it on the public sleep dataset ISRUC-SLEEP(Institute of Systems and Robotics,University of Coimbra-Sleep).The results show that the proposed method achieves satisfactory performance on ISRUC-SLEEP. | Ziyu JIA Junyu JI Xinliang ZHOU Yuhan ZHOU | 2022 | Science China(Information Sciences)2022，65，4： | 2 |
| 7 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 8 | Expression of HIF-1α and CAIX in nasopharyngeal carcinoma and their correlation with patients’ prognosis显示文摘 | Yuhan Chen Xianming Li Shihai Wu Gang Xu Yayan Zhou Long Gong Zihuang Li Dong Yang | 2014 | Medical Oncology2014，，12： | 1 |
| 9 | Vertical Profiles of Volatile Organic Compounds in Suburban Shanghai显示文摘As Volatile Organic Compounds(VOCs)are one of the precursors of ozone,their distribution and variable concentrations are highly related to local ozone pollution control.In this study,we obtained vertical profiles of VOCs in Shanghai’s Jinshan district on 8 September and 9 September in 2016 to investigate their distribution and impact on local atmospheric oxidation in the near surface layer.Vertical samples were collected from heights between 50 m and 400 m by summa canisters using an unmanned aerial vehicle(UAV).Concentrations of VOCs(VOCs refers to the 52 species measured in this study)varied minimally below 200 m,and decreased by 21.2%from 100 m to 400 m.The concentrations of VOCs above 200 m decreased significantly in comparison to those below 200 m.The proportions of alkanes and aromatics increased from 55.2%and 30.5%to 57.3%and 33.0%,respectively.Additionally,the proportion of alkenes decreased from 13.2%to 8.4%.Toluene and m/p-xylene were the key species in the formation of SOA and ozone.Principal component analysis(PCA)revealed that the VOCs measured in this study mainly originated from industrial emissions. | Yuhan LIU Hongli WANG Shengao JING Ming ZHOU Shenrong LOU Kun QU Wanyi QIU Qian WANG Shule LI Yaqin GAO Yusi LIU Xiaobing LI Zhong-Ren PENG Junhui CHEN Keding LU | 2021 | Advances in Atmospheric Sciences2021，38，7： | 1 |
| 10 | Optimized Backhaul Compression for Uplink Cloud Radio Access Network显示文摘 | ZHOU Yuhan YU Wei | 2014 | II::EI: Journal on Selected Areas in Communications2014，32，6： | 1 |
| 11 | Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances显示文摘Diabetes has become a global concern at present,among which type 2 diabetes mellitus(T2DM)accounts for approximately 90%-95%of patients.T2DM is a type of metabolic disorder syndrome that results from a genetic defect,and it is based on insulin resistance and an insulin secretion disorder.The occurrence of T2DM is usually the outcome of both genetic and environmental factors and their interactions.The etiology and pathogenesis of diabetes have not been fully elucidated,and no radical therapeutic cure has been found.Patients with T2DM suffer from complications such as the development of a chronic hyperglycemic condition and even serious metabolic disorders and organ damage in the body and depression and dementia,in addition to other chronic complications.Many studies have suggested that diet is crucial in the development of diabetes and the control of blood glucose.Natural substances have the characteristics of low toxicity and few side effects and may be key to the development of diabetic health products and preventive treatments.This paper reviews the etiology,pathogenesis,risks,treatments and diets related to T2DM to summarize the types of recently available natural products,from both local and foreign sources,for lowering blood glucose at home and their application in supplementary hypoglycemic foods.The key findings and conclusions suggest that there are various known T2DM-inducing factors,including genetic and environmental factors and three types of hybrid factors. | Chong Ning Yuhan Jiao Jiaqi Wang Weiwei Li Jingqiu Zhou Yi-Chieh Lee Dik-Lung Ma Chung-Hang Leung Rugang Zhu Hui-Min David Wang | 2022 | Food Science and Human Wellness2022，11，5： | 1 |
| 12 | TeaPGDB:Tea Plant Genome Database显示文摘As the most widely consumed beverage in the world,tea has various nutritional,economic,and global cultural values.With the development of the third-generation sequencing technology,several genome sequences of tea plants have been published.These genomic data have pivotal information that is of benefit to tea plant breeders and biologists in advancing tea plant improvement and the final quality of tea products.We hereby present the integrative online database,Tea Plant Genome Database(TeaPGDB;http://gffzz33ea8dac98494cc2hppof9b0fp0w96pwx.ffgz.tsg.suse.edu.cn/tea),which incorporates the published genome sequences of tea plants.The current release of TeaPGDB hosts published tea plant genome data with various online tools,including JBrowse,gene search,SSR search,BLAST.TeaPGDB also contains a download server,which provides access for the download of genome-related data and rich annotation files.TeaPGDB is committed to collecting,integrating,and annotating published tea plant genome data,providing data support for research on tea plant heredity,evolution,breeding for resistance,plant improvement,and facilitating the characterization of important traits or flavor related genes in the community.Compared with other tea plant databases,this database not only contains more complete genome data and gene annotation information,but also has a user-friendly interface for researchers in the field. | Xiaogang Lei Ya Wang Yuhan Zhou Yongzhong Chen Hongyuan Chen Zhongwei Zou Lin Zhou Yuanchun Ma Fei Chen Wanping Fang | 2021 | Beverage Plant Research2021，1，1： | 1 |
| 13 | Development of a Widely Applicable and Simple Prognostic Score for Patients with Acute-on-chronic Liver Failure显示文摘Background and Aims:Acute-on-chronic liver failure(ACLF)tends to progress rapidly with high short-term mortality.We aimed to create a widely applicable,simple prognostic(WASP)score for ACLF patients.Methods:A retrospective cohort of ACLF cases recruited from three centers in China were divided into training and validation sets to develop the new score.A prospective longitudinal cohort was recruited for further validation.Results:A total of 541 cases were included in the training set,and seven independent ACLF prognostic factors were screened to construct a new quantitative WASP-ACLF table.In the validation set of 671 cases,WASP-ACLF showed better predictive ability for 28-day and 90-day mortality than the currently used prognostic scores at baseline,day 3,week 1,and week 2.The predictive efficacy and clinical validity of the model improved over time.Patients were assigned to low-,intermediate-,and high-risk groups by their WASP-ACLF scores.Compared with the other two groups,intermediate-risk patients had a more uncertain prognosis,with a 90-day mortality of 44.4–50.6%.Sequential assessments at weeks 1 and 2 found the 90-day mortality of intermediate-risk groups was<20%forpatients with a≥2 point decrease in WASP-ACLF and was up to 56%for patients with a≥2 points increase.Similar results were observed in prospective data.Conclusions:The new ACLF prognostic score was simple,widely applicable,and had good predictive efficacy.Continuous assessments and trend of change in WASP-ACLF need to be considered,especially for intermediate-risk patients. | Zhenjun Yu Yu Zhang Yuhan Li Feng Zhou Manman Xu Shaoli You Yu Chen Bing Zhu Ming Kong Fangjiao Song Shaojie Xin Zhongping Duan Tao Han China Network for Severe Liver Diseases | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 14 | The tumor suppressor CYLD controls epithelial morphogenesis and homeostasis by regulating mitotic spindle behavior and adherens junction assembly显示文摘Epithelial morphogenesis and homeostasis are essential for animal development and tissue regeneration,and epithelial disorganization is associated with developmental disorders and tumorigenesis.However,the molecular mechanisms that contribute to the morphogenesis and homeostasis of the epithelium remain elusive.Herein,we report a novel role for the cylindromatosis(CYLD)tumor suppressor in these events.Our results show that CYLD depletion disrupts epithelial organization in both Drosophila egg chambers and mouse skin and intestinal epithelia.Microscopic analysis of proliferating cells in mouse epithelial tissues and cultured organoids reveals that loss of CYLD synergizes with tumor-promoting agents to cause the misorientation of the mitotic spindle.Mechanistic studies show that CYLD accu?mulates at the cell cortex in epithelial tissues and cultured cells,where it promotes the formation of epithelial adherens junctions through the modulation of microtubule dynamics.These data suggest that CYLD controls epithelial morphogenesis and homeostasis by modulating the assembly of adherens junctions and ensuring proper orientation of the mitotic spindle.Our findings thus provide novel insight into the role of CYLD in development,tissue homeostasis,and tumorigenesis. | Wei Xie Yunfan Yang Siqi Gao Ting Song Yuhan Wu Dengwen Li Min Liu Jun Zhou | 2017 | Journal of Genetics and Genomics2017，44，7： | 1 |
| 15 | Genetic Analysis and Improvement Strategies of Protein Content in Rice Seeds显示文摘Enhancing the nutritional quality of food crops is a way to improve human nutrition and health.Grain protein content(GPC)is an important nutritional quality trait for rice and many other crops.Therefore,it will be very significant to increase GPC and improve rice quality.This paper mainly reviewed the genetic studies GPC in rice,mapping and cloning of QTLs and genes associated with GPC.However,little is known about the molecular mechanism and gene function related to GPC in rice.Thus,here we put forward the genetic strategy by gene pyramiding or molecular marker assisted selection to improve GPC and nutritional quality in rice.This review could provide important information for genetic improvement of grain nutritional quality of rice. | Bo PENG Yanfang SUN Dongyan KONG Ruihua PANG Xiaohua SONG Huilong LI Lin LIU Xian-wen LI Jintao LI Qiying ZHOU Bin DUAN Huihui LIU Yuhan ZUO Yanlin HAO Shizhi SONG Hongyu YUAN | 2017 | Agricultural Biotechnology2017，6，4： | 1 |
| 16 | Drying kinetics and quality attributes of jujube ( Zizyphus jujuba Miller) slices dried by hot-air and short- and medium-wave infrared radiation显示文摘 | Qinqin Chen Jinfeng Bi Xinye Wu Jianyong Yi Linyan Zhou Yuhan Zhou | 2015 | LWT - Food Science and Technology2015，，2： | 1 |
| 17 | Interracial strength and mechanical properties of biocomposites based on ramie fibers and poly(butylene succinate)显示文摘 | Zhou Mi Yan Jiajie Li Yuhan | 2013 | RSCAdv2013，48，26： | 1 |
| 18 | Interfacial crystalli- zation enhanced interracial interaction of PBS/ramie fiber biocomposites using dopamine as a modifier显示文摘 | Zhou Mi Li Yuhan He Chao | 2014 | Compos ites Science and Technology2014，91，31： | 1 |
| 19 | Direct synthesis of 1,4-disubstituted-5-alumino-l,2,3-triazoles: copper-catalyzed cycloaddition of organic azides and mixed aluminum acetylides 显示文摘 | Zhou Yuhan Thomas Lecourt Laurent Micouin | 2010 | Angew Chem lnt Ed2010，49，26： | 1 |
| 20 | A convenient method to reduce hydroxyl-substituted aromatic carboxylic acid with NaBH4/Me2 SO4/B (OMe) 3显示文摘 | Zhou Yuhan Gao Guchao Li Hui | 2008 | Tetrahedron Letters2008，，49： | 1 |
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