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| 1 | A pilot phase Ⅱ study of neoadjuvant triplet chemotherapy regimen in patients with locally advanced resectable colon cancer显示文摘Objective: This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer.Methods: Patients with clinical stage IIIb colon cancer received a perioperative triple chemotherapy regimen(oxaliplatin 85 mg/m2 and irinotecan 150 mg/m2, combined with folinic acid 200 mg, 5-fluorouracil 500 mg bolus and then 2,400 mg/m2 by 44 h infusion or capecitabine 1 g/m2 or S-1 40–60 mg b.i.d orally d 1–10, repeated at 2-week intervals) for 4 cycles. Complete mesocolic excision was scheduled 2–6 weeks after completion of neoadjuvant treatment and followed by a further 6 cycles of FOLFOXIRI or XELOX. Primary outcome measures of this stage II trial were feasibility, safety, tolerance and efficacy of neoadjuvant treatment.Results: All 23 patients received neoadjuvant chemotherapy and underwent surgery. Twenty-one patients(91.3%) had reductions in tumor volume after neoadjuvant treatment, and 13 patients(56.5%) had grade 3–4toxicity. No patients had severe complications from surgery. Preoperative therapy resulted in significant downstaging of T-stage and N-stage compared with the baseline clinical stage including one pathological complete response.Conclusions: Neoadjuvant triple chemotherapy has high activity and acceptable toxicity and perioperative morbidity, and is feasible, tolerable and effective for locally advanced resectable colon cancer. | Haitao Zhou Yan Song Jun Jiang Haitao Niu Hong Zhao Jianwei Liang Hao Su Zheng Wang Zhixiang Zhou Jing Huang | 2016 | Chinese Journal of Cancer Research2016，28，6： | 18 |
| 2 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 3 | AMPK activation by peri-sciatic nerve administration of ozone attenuates CCl-induced neuropathic pain in rats显示文摘 | Lijuan Lu Cailong Pan Lu Chen Liang Hu Chaoyu Wang Yuan Han Yanjing Yang Zhixiang Cheng Wen-Tao Liu | 2017 | Journal of Molecular Cell Biology2017，9，2： | 14 |
| 4 | Cenozoic tectonic and geomorphic evolution of the Longxi region in northeastern Tibetan Plateau interpreted from detrital zircon显示文摘The Longxi region contains different kinds of Cenozoic sediments,including eolian deposits,reworked loess,fluvial and lacustrine deposits.The provenance evolution of these sediments is of great significance in exploring the uplift,tectonic deformation and associated with geomorphic evolution of the Northeastern Tibetan Plateau.In this paper,we used the single-grain zircon provenance analysis to constrain the provenances for the Paleogene alluvial conglomerates and for the Neogene fluvial-lacustrine sediments,and compared them with results from the loess deposits since the Miocene.The results show that:(1)the Paleogene alluvial conglomerates contain a large number of detrital zircons ranging from 560 to 1100 Ma that were derived from the Yangzi Block.However,the sediments of early Miocene have much fewer zircons of this age span,which are characterized by an abundance of zircon ages in the ranges of 200-360 Ma.This indicates that the Paleogene alluvial conglomerates mainly come from the middle and/or southern West Qinling,and the early Miocene sediments are primarily from the northern West Qinling;(2)Late Neogene fluvial sediments(11.5 Ma onward)in Tianshui-Qinan region are dominated by zircon ages of 3 80-450 Ma.This zircon population is similar to that of the exposed intrusive rocks of southern part of the Liupan Mountains,implying that the southern part of Liupan Mountains probably had already uplifted by 11.5 Ma;(3)Late Miocene lacustrine sediments in Tianshui region have a zircon age spectra that is remarkably different from coeval fluvial deposits,but is similar to the zircon age distributions of the Miocene loess in Qinan region,late Miocene-Pliocene Hipparion red clay and Quaternary loess.This indicates that fine particles within these Miocene lacustrine sediments in Tianshui region may be dominated by aeolian materials.This study reveals that provenance changes of Cenozoic sediments in Tianshui-Qinan region and its geomorphic evolution are closely related to the multi-stage uplift of the Northeastern Tibetan Plateau.In particular,the major uplift of the Northern Tibetan Plateau during late Oligocene-early Miocene may have not only provided the source areas and wind dynamic conditions for the deposits of the Miocene loess,but also provided the geomorphic conditions for its accumulation. | WANG ZhiXiang LIANG MeiYan SUN YuQi DAI GaoWen | 2017 | Science China Earth Sciences2017，60，2： | 4 |
| 5 | The provenance of Gansu Group in Longxi region and implications for tectonics and paleoclimate显示文摘The Neogene sediments of Gansu Group from northwestern China contain eolian and fluvial deposits.The origins of these sediments are very important for exploring the onset of Asian inland aridification,the pattern of paleo-atmospheric circulation,and the regional tectonics and geomorphic evolution during the Miocene.Here we present detrital-zircon age spectra of typical eolian and fluvial deposits from highlands and subsidence basin,and compare them with those of surrounding eroded mountain(such as the West Qinling Mountains and Liupan Mountains)materials and Quaternary loess derived from the Asian inlands.The results reveal that(1)the detrital-zircon age spectrum of the Miocene eolian sample is remarkably different from the eroded materials of the West Qinling Mountains and the Miocene fluvial deposits from Tianshui region,but very similar to the Quaternary loess deposits.This indicates that the provenance of Miocene eolian sediments is similar with the Quaternary loess,and thus further confirms the previous conclusions that the distribution of Asian arid lands and the pattern of atmospheric circulation during the Miocene are broadly similar with the Quaternary.(2)The detrital-zircon age spectrum of the fluvial deposits(with age about 11.5 Ma)from Tianshui region is different from the eroded materials of West Qinling Mountains,but similar with that of the Liupan Mountains to the east,which may suggest that the Liupan Mountains have already been exhumed by11.5 Ma. | LIANG MeiYan WANG ZhiXiang ZHOU Sen ZONG KeQing HU ZhaoChu | 2014 | Science China Earth Sciences2014，57，6： | 4 |
| 6 | CXCR4 nuclear localization follows binding of its ligand SDF-1 and occursin metastatic but not primary renal cell carcinoma显示文摘 | Linhui Wang Zhixiang Wang Bo Yang Qing Yang Liang Wang Yinghao Sun | 2009 | Oncology Reports2009，，6： | 1 |
| 7 | Tribological and electrochemical behavior of thick Cr-C alloy coatings electrodeposited in trivalent chromium bath as an alternative to conventional Cr coatings 显示文摘 | Zeng Zhixiang Wang Liping Liang Aimin | 2006 | Electrochimica Acta2006，52，： | 1 |
| 8 | Fabrication of a nanocrystalline Cr-C layer with excellent antiwear performance 显示文摘 | Zeng Zhixiang Wang Liping Liang Aimin | 2007 | Materials Letters2007，，1920： | 1 |
| 9 | Driver Deadtime Control and Its Impact on System Stability of Synchronous Buck Voltage Regulator显示文摘 | Qiu Weihong Mercer S Liang Zhixiang | | 0，，01： | 1 |
| 10 | An adaptivedetecting method for harmonic and reactive currents 显示文摘 | LUO Shiguo HOU Zhengcheng LIANG Zhixiang | 1995 | IEEETransactions on Industry Electronics1995，42，1： | 1 |
| 11 | Measuring the Performance of Nations at Beijing Summer Olympics Using Integer-Valued DEA Model显示文摘 | Wu Jie Zhou Zhixiang Liang Liang | 2010 | Journal of Sports Economics2010，11，5： | 1 |
| 12 | Performance Evaluation of an Anomaly-Detection Algorithm for Keystroke-Typing Based Insider Detection显示文摘Keystroke dynamics is the process to identify or authenticate individuals based on their typing rhythm behaviors. Several classifications have been proposed to verify a user's legitimacy, and the performances of these classifications should be confirmed to identify the most promising research direction. However, classification research contains several experiments with different conditions such as datasets and methodologies. This study aims to benchmark the algorithms to the same dataset and features to equally measure all performances. Using a dataset that contains the typing rhythm of 51 subjects, we implement and evaluate 15 classifiers measured by F1-measure, which is the harmonic mean of a false-negative identification rate and false-positive identification rate.We also develop a methodology to process the typing data. By considering a case in which the model will reject the outsider, we tested the algorithms on an open set. Additionally, we tested different parameters in random forest and k nearest neighbors classifications to achieve better results and explore the cause of their high performance. We also tested the dataset on one-class classification and explained the results of the experiment. The top-performing classifier achieves an F1-measure rate of 92% while using the normalized typing data of 50 subjects to train and the remaining data to test. The results, along with the normalization methodology, constitute a benchmark for comparing the classifiers and measuring the performance of keystroke dynamics for insider detection. | Liang He Zhixiang Li Chao Shen | 2018 | Tsinghua Science and Technology2018，23，5： | 1 |
| 13 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 14 | Measuring the performance of Chinese regional innovation systems with two-stage DEA-based model显示文摘 | Jie Wu Zhou Zhixiang Liang Liang | 2010 | International Journal of Sustainable Society2010，2，1： | 1 |
| 15 | Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study显示文摘Sorafenib therapy improves overall survival(OS)in patients with FLT3 internal tandem duplication(ITD)acute myeloid leukemia(AML)undergoing allogeneic hematopoietic stem cell transplantation.We explored the efficacy of sorafenib therapy in this population with different concomitant genetic patterns.In this multi-center,cohort study,we enrolled patients with FLT3-ITD AML undergoing allogenic hematopoietic cell transplantation.Patients with sorafenib maintenance post-transplantation for at least four weeks were allocated to the sorafenib group,and otherwise to the control group. | Ruoyang Shao Yu Zhang Jinping He Fen Huang Zhiping Fan Kaibo Yang Yajing Xu Na Xu Yi Luo Lan Deng Xi Zhang Jia Chen Mingzhe Han Xudong Li Sijian Yu Hui Liu Xinquan Liang Xiaodan Luo Pengcheng Shi Zhixiang Wang Ling Jiang Xuan Zhou Ren Lin Yan Chen Sanfang Tu Jing Sun Yu Wang Qifa Liu Li Xuan | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 16 | Expert consensus on organizing the multidisciplinary team(MDT) diagnosis and treatment of hepato-pancreato-biliary diseases in China显示文摘Multidisciplinary team(MDT) discussion has been well established in some European countries and widely carried out in various clinical professional fields(Festen et al.,2021;Fleissig et al.,2006).Many studies have reported the benefits of MDT,including improving survival and quality of cancer care(Munro et al.,2015;Nixon et al.,2021;Tsai et al.,2020). | Binhao Zhang Jian Zhou Weifen Xie Kaishan Tao Shichun Lu Xianglin Yuan Lianxin Liu Weilin Wang Yilei Mao Ping Bie Jingfeng Liu Xinyu Bi Zhiwei Zhang Changhong Liang Jianqiang Cai Zhixiang Jian Yi Lv Peng Zhu Wei Zhang Hongqiang Yang Weiping Zhou Bixiang Zhang Xiaoping Chen | 2022 | Science China(Life Sciences)2022，65，5： | 0 |
| 17 | VSOLassoBag:a variable-selection oriented LASSO bagging algorithm for biomarker discovery in omic-based translational research显示文摘Screening biomolecular markers from high-dimensional biological data is one of the long-standing tasks for biomedical translational research.With its advantages in both feature shrinkage and biological interpretability,Least Absolute Shrinkage and Selection Operator(LASSO)algorithm is one of the most popular methods for the scenarios of clinical biomarker development.However,in practice,applying LASSO on omics-based data with high dimensions and low-sample size may usually result in an excess number of predictive variables,leading to the overfitting of the model.Here,we present VSOLassoBag,a wrapped LASSO approach by integrating an ensemble learning strategy to help select efficient and stable variables with high confidence from omics-based data.Using a bagging strategy in combination with a parametric method or inflection point search method,VSOLassoBag can integrate and vote variables generated from multiple LASSO models to determine the optimal candidates.The application of VSOLassoBag on both simulation datasets and real-world datasets shows that the algorithm can effectively identify markers for either case-control binary classification or prognosis prediction.In addition,by comparing with multiple existing algorithms,VSOLassoBag shows a comparable performance under different scenarios while resulting in fewer features than others.In summary,VSOLassoBag,which is available at http://gffzza891166c5c83403bsw6pup6wnf9cc6cv6.ffgz.tsg.suse.edu.cn/VSOLassoBag/under the GPL v3 license,provides an alternative strategy for selecting reliable biomarkers from high-dimensional omics data.For user’s convenience,we implement VSOLassoBag as an R package that provides multithreading computing configurations. | Jiaqi Liang Chaoye Wang Di Zhang Yubin Xie Yanru Zeng Tianqin Li Zhixiang Zuo Jian Ren Qi Zhao | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 18 | Detecting fake reviewers in heterogeneous networks of buyers and sellers:a collaborative training-based spammer group algorithm显示文摘It is not uncommon for malicious sellers to collude with fake reviewers(also called spammers)to write fake reviews for multiple products to either demote competitors or promote their products'reputations,forming a gray industry chain.To detect spammer groups in a heterogeneous network with rich semantic information from both buyers and sellers,researchers have conducted extensive research using Frequent Item Mining-based and graph-based meth-ods.However,these methods cannot detect spammer groups with cross-product attacks and do not jointly consider structural and attribute features,and structure-attribute correlation,resulting in poorer detection performance.There-fore,we propose a collaborative training-based spammer group detection algorithm by constructing a heterogene-ous induced sub-network based on the target product set to detect cross-product attack spammer groups.To jointly consider all available features,we use the collaborative training method to learn the feature representations of nodes.In addition,we use the DBSCAN clustering method to generate candidate groups,exclude innocent ones,and rank them to obtain spammer groups.The experimental results on real-world datasets indicate that the overall detection performance of the proposed method is better than that of the baseline methods. | Qi Zhang Zhixiang Liang Shujuan Ji Benyong Xing Dickson K.W.Chiu | 2024 | Cybersecurity2024，7，2： | 0 |
| 19 | Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm显示文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects. | Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan Changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 20 | Immune checkpoint inhibitors-associated cardiotoxicity in immunotherapy trials on gastrointestinal cancer patients显示文摘To the editor:Gastrointestinal(GI)cancer is the most common malignancy in China.[1]For many decades,the treatment options for GI cancers have been limited to surgery,radiotherapy,and chemotherapy.Over recent years,immune checkpoint inhibitors(ICIs)that target programmed cell death 1(PD-1),or its programmed death-ligand 1(PD-L1),have demonstrated promising efficacies and changed the treatment landscape in GI cancer.[2]However,immune-related adverse events(irAEs)can occur during ICI treatment.Furthermore,ICI-associared cardiotoxicity is a rare but potentially fatal toxic effect. | Li Yiqun Wang Yanfeng Li Ning Liang Xinjun Zhang Shu Fan Qingxia Yin Xianli Zhuang Zhixiang Liu Yunpeng Zhang Jingdong Kou Xiaoge Zhong Haijun Xu Binghe Huang Jing | 2022 | Chinese Medical Journal2022，，8： | 0 |
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