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| 1 | Mantle upwelling beneath the South China Sea and links to surrounding subduction systems显示文摘The evolution of the South China Sea(SCS)is directly linked to the complex subduction systems of the surrounding Pacific,Philippine Sea and Indo-Australian Plates(Fig.1a).Major advances in the last several years are providing new insights into the SCSmantle dynamics,through regional seismic imaging of the upper mantle[1,2],unprecedented IODP drilling expeditions(349/367/368/368X)[3-5]that obtained the oceanic basement basalt samples for the first time,geochemical analyses of the SCS-mantle source compositions[6-8]and geodynamic modeling[9,10]. | Jian Lin Yigang Xu Zhen Sun Zhiyuan Zhou | 2019 | National Science Review2019，6，5： | 13 |
| 2 | Clinical characteristics and changes in living quality of patients with radiation encephalopathy induced by radiation therapy for treating nasopharyngeal carcinoma显示文摘BACKGROUND: Radiation encephalopathy (RE) caused by radiation therapy of nasopharyngeal carcinoma severely influences patients' quality of life (QOL). The factors, which influence such patients' QOL, have not been confirmed. OBJECTIVE: To observe the clinical and imageological characteristics of patients with radiation therapy of nasopharyngeal carcinoma-induced RE and the changes in QOL, and analyze QOL influencing factors. DESIGN: Retrospective case analysis. SETTING: Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University. PARTICIPANTS: Eighty-nine inpatients or outpatients with RE induced by radiation therapy of nasopharyngeal carcinoma admitted to Sun Yat-sen University Cancer Center and Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University from March 1994 to August 2004 were involved in this experiment. They all met the diagnosis criteria of RE from MERRITT'S neurology (10th edition). Thirty-three involved patients were randomly chosen as RE group. Another 34 concurrent inpatients or outpatients with nasopharyngeal carcinoma who received radiation therapy but without RE were chosen as control group. Informed consents of detected items were obtained from all the involved subjects. METHODS: ① Patients were evaluated when they were followed up. The World Health Organization Quality of Life Questionnaire abbreviated version (WHOQOL-BREF) was used for on-the-spot evaluation. High points of WHOQOL-BREF indicated better QOL. The Late Effects on Normal Tissues - Subjective, Objective, Management and Analytic (LENT-SOMA) scale for evaluating radiation injury was used to evaluate headache and neurologic disorder of patients with RE induced by radiation therapy of nasopharyngeal carcinoma. The evaluation was graded into 5 degrees. High degrees indicted severer clinical symptoms. ② Disease latency (i.e. time interval from symptoms and body signs appearing or radiation therapy ending to onset), initial symptoms, common symptoms, imageological characteristics, QOL and other related factors of patients were recorded. ③ Statistical management was carried out with SPSS 10.0 software. MAIN OUTCOME MEASURES: QOL and clinical characteristics of patients with RE induced by radiation therapy of nasopharyngeal carcinoma as well as QOL influencing factors. RESULTS: All the involved subjects participated in the final analysis. ① Disease latency of patients with RE ranged from 0 to 24 years, and 95% confidence interval was 0 to 15 years. There were significant differences in amount of invaded cases between 6 months after one radiation therapy and 6 months after two or more radiation therapies (χ2=36.76,P < 0.01). ② The common initial symptom of patients with RE was glossopharyngeal paralysis (33 cases, 37%). ③ The first 3 common symptoms of patients with RE were glossopharyngeal paralysis (52 cases, 58%), limb inertia and sensory disorder (25 cases, 28%) and headache (25 cases, 28%).④Imageology of patients with RE was characterized by long T1 and T2 signal shadow on magnetic resonance. ⑤Total scores of health, of daily life and of social relationship, measured with WHOQOL-BREF, of patients in RE group were significantly lower than those in the control group, respectively [(2.06±0.86)points vs. (2.59±0.66)points; (2.45±0.75)points vs. (2.91±0.75)points; (51.67±15.24) points vs. (59.22±13.03)points, P < 0.05]. Patients undergoing two or more radiation therapies were inferior to those undergoing one radiation therapy in total scores of health, and of daily life, scores of physiology, and of psychology (P < 0.05). ⑥Glossopharyngeal paralysis was negatively correlated with scores of psychology, total scores of daily life and of health in WHOQOL-BREF (P < 0.05); Head was negatively correlated with scores of psychology in WHOQOL-BREF (P < 0.05); Neurologic deficit wasnegatively correlated with scores of psychology, and total scores of health in WHOQOL-BREF (P < 0.05). CONCLUSION: ①The latency of RE of patients undergoing two or more radiation therapies is remarkably shortened, and QOL is decreased, but there is no difference in QOL between two genders. ② Brain edema is common in imageology of RE after radiation therapy. The first 3 ones of initial symptoms and common symptoms both are glossopharyngeal paralysis, neurologic deficit and headache, which greatly negatively influence QOL of patients. | Yamei Tang Yi Li Fusheng Zhang Yunlin Liu Haihong Zhou Jianhong Ye Yigang Xing | 2007 | Neural Regeneration Research2007，2，2： | 5 |
| 3 | Neuroprotective effects of vagus nerve stimulation on traumatic brain injury显示文摘Previous studies have shown that vagus nerve stimulation can improve the prognosis of traumatic brain injury. The aim of this study was to elucidate the mechanism of the neuroprotective effects of vagus nerve stimulation in rabbits with brain explosive injury. Rabbits with brain explosive injury received continuous stimulation(10 V, 5 Hz, 5 ms, 20 minutes) of the right cervical vagus nerve. Tumor necrosis factor-α, interleukin-1β and interleukin-10 concentrations were detected in serum and brain tissues, and water content in brain tissues was measured. Results showed that vagus nerve stimulation could reduce the degree of brain edema, decrease tumor necrosis factor-α and interleukin-1β concentrations, and increase interleukin-10 concentration after brain explosive injury in rabbits. These data suggest that vagus nerve stimulation may exert neuroprotective effects against explosive injury via regulating the expression of tumor necrosis factor-α, interleukin-1β and interleukin-10 in the serum and brain tissue. | Long Zhou Jinhuang Lin Junming Lin Guoju Kui Jianhua Zhang Yigang Yu | 2014 | Neural Regeneration Research2014，9，17： | 4 |
| 4 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 5 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 6 | Artificial neural network approach to predict the flow stress in the isothermal compression of as-cast TC21 titanium alloy显示文摘 | Yanchun Zhu Weidong Zeng Yu Sun Fei Feng Yigang Zhou | 2011 | Computational Materials Science2011，，5： | 2 |
| 7 | High-temperature deformation behavior of Ti60 titanium alloy显示文摘 | Weiju Jia Weidong Zeng Yigang Zhou Jianrong Liu Qingjiang Wang | 2011 | Materials Science & Engineering A2011，，12： | 2 |
| 8 | Isolation and rapid genetic characterization of a novel T4-like bacteriophage显示文摘无所不在在地球上,抗菌素是在每个生态系统,而是他们的人的知识的最丰富的实体仍然关于有机体的另外的形式与那相比被限制。充实人的知识并且支持抗菌素的利用,孤立并且描绘尽可能许多不同抗菌素是必要的。这里,我们为它的基因描述描述象 T4 一样抗菌素 IME08 和一个快速的方法的隔离。与这个方法,我们容易克隆抗菌素染色体的一些随机的碎片。这些随机的克隆的顺序分析证明抗菌素 IME08 与象 T4 一样 Enterobacteria 分享了最高的顺序类似噬菌体 T4 (94% 身份) , JS98 (95% 身份) , JS10 (95% 身份) 和 RB14 (94% 身份) 分别地,它建议 IME08 属于象 T4 一样抗菌素类。 | Wang Sheng Jiang Huanhuan Chen Jiankui Liu Dabin Li Cun Pan Bo An Xiaoping Zhang Xin Zhou Yusen Tong Yigang | 2010 | Journal of Medical Colleges of PLA(China)2010，25，6： | 2 |
| 9 | Dynamic globularization kinetics during hot working of Ti-17 alloy with initial lamellar microstructure显示文摘 | Kaixuan Wang Weidong Zeng Yongqing Zhao Yunjin Lai Yigang Zhou | 2010 | Materials Science & Engineering A2010，，10： | 1 |
| 10 | Responses of the functional structure of soil microbial community to livestock grazing in the T ibetan alpine grassland显示文摘 | Yunfeng Yang Linwei Wu Qiaoyan Lin Mengting Yuan Depeng Xu Hao Yu Yigang Hu Jichuang Duan Xiangzhen Li Zhili He Kai Xue Joy van Nostrand Shiping Wang Jizhong Zhou | 2012 | Glob Change Biol2012，，2： | 1 |
| 11 | Rela- tionship among forging technology, structure and properties of TC21 alloy bars显示文摘 | Qu Henglei Zhou Yigang Zhou Lian | 2005 | Trans Nonferrous Met Soc China2005，15，5： | 1 |
| 12 | Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium显示文摘 | Dongsheng Zhang Guo-Chang Fan Xiaoyang Zhou Tiemin Zhao Zeeshan Pasha Meifeng Xu Yi Zhu Muhammad Ashraf Yigang Wang | 2007 | Journal of Molecular and Cellular Cardiology2007，，2： | 1 |
| 13 | Design of a high temperature superconducting generator for wind power applications 显示文摘 | Li Xiaohang Zhou Yigang Hart Lei | 2011 | IEEE Transactions on Applied Super- conductivity2011，21，3： | 1 |
| 14 | The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro显示文摘Dear Editor,Since severe acute respiratory syndrome coronavirus 2(SARSCoV-2)RNA has been detected in human breastmilk,infants’safety with breastmilk feeding is of great concern for women with coronavirus disease 2019(COVID-19).1 It is known that milk has antiviral properties.2 However,little is known about the antiviral property of human breastmilk to SARS-CoV-2 and its related pangolin coronavirus(GX_P2V).Here we present for the first time that whey protein from human breastmilk effectively inhibited both SARS-CoV-2 and GX_P2V by blocking viral attachment and viral replication at entry and even post entry.Moreover,human whey protein inhibited infectious virus production,as proved by the plaque assay.We found that whey protein from different species,such as cow and goat,also showed anti-coronavirus properties.Commercial bovine formula milk also showed similar anti-SARS-CoV-2 activity. | Huahao Fan Bixia Hong Yuqian Luo Qi Peng Liqin Wang Xiangshu Jin Yangzhen Chen Yunjia Hu Yi Shi Tong Li Hui Zhuang Yi-Hua Zhou Yigang Tong Kuanhui Xiang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 15 | Changes of Aroma Components in 'Keitt' Mango during the Postharvest Period显示文摘[Objective]This study aimed to investigate the changes of aroma components in mango fruit at different post-harvest stages.[Method]The aroma components in‘Keitt'mango fruit at 3,6,9 and 13 d postharvest were extracted using head-space solid phase microextraction( HS-SPME) and analyzed by gas chromatograph-mass spectrophotometer( GC-MS).[Result]The results showed that a total of 42 aroma compounds were identified from the mango samples at four stages. To be specific,monoterpene and sesquiterpene were the major components; at 3,6,9 and 13 d postharvest,the relative contents of terpene were 94. 24%,98. 91%,55. 32% and 95. 97%,respectively.[Conclusion]1S-( +)-3-carene is the characteristic aroma component in ripe fruit of‘Keitt'mango. The aroma of mango fruit is also affected by ester,alcohol and aldehyde compounds. | Yigang ZHOU Hongxia WU Quansheng YAO Songbiao WANG Changbin WEI Xiaowei MA | 2014 | Agricultural Biotechnology2014，3，2： | 1 |
| 16 | Influence of thermal exposure on the tensile properties and microstructures of Ti60 titanium alloy显示文摘 | Weiju Jia Weidong Zeng Jianrong Liu Yigang Zhou Qingjiang Wang | 2011 | Materials Science & Engineering A2011，，： | 1 |
| 17 | Meta‐analysis of prospective studies on the effects of nut consumption on hypertension and type 2 diabetes mellitus 对食用坚果对高血压和2型糖尿病的影响的前瞻性研究进行的meta分析显示文摘 | Kai Guo Zhiwen Zhou Yibo Jiang Wei Li Yigang Li | 2015 | Journal of Diabetes2015，，： | 1 |
| 18 | Functional polymorphisms in NFκB1 / IκBα predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese显示文摘 | Dongsheng Huang Lei Yang Yehua Liu Yumin Zhou Yuan Guo Mingan Pan Yunnan Wang Yigang Tan Haibo Zhong Min Hu Wenju Lu Weidong Ji Jian Wang Pixin Ran Nanshan Zhong Yifeng Zhou Jiachun Lu | 2013 | Human Genetics2013，，4： | 1 |
| 19 | On the influence of processing parameters on microstructural evolution of a near alpha titanium alloy显示文摘 | Weiju Jia Weidong Zeng Jianrong Liu Yigang Zhou Qingjiang Wang | 2011 | Materials Science & Engineering A2011，，： | 1 |
| 20 | Design of a high temperature superconducting generator for wind power applications显示文摘 | Li Xiaohang Zhou Yigang Han Lei | 2011 | IEEE Transactions on Applied Superconductivity2011，21，3： | 1 |
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