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| 1 | Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12显示文摘Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis(OA).However,how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains unclear.Here,we show that the mechanistic target of rapamycin complex 1(mTORC1)pathway is activated in subchondral bone preosteoblasts(Osterix+)from OA patients and mice.Constitutive activation of mTORC1 in preosteoblasts by deletion of the mTORC1 upstream inhibitor,tuberous sclerosis 1,induced aberrant subchondral bone formation,and sclerosis with little-to-no effects on articular cartilage integrity,but accelerated posttraumatic OA development in mice.In contrast,inhibition of mTORC1 in preosteoblasts by disruption of Raptor(mTORC1-specific component)reduced subchondral bone formation and cartilage degeneration,and attenuated post-traumatic OA in mice.Mechanistically,mTORC1 activation promoted preosteoblast expansion and Cxcl12 secretion,which induced subchondral bone remodeling and cartilage degeneration during OA.A Cxcl12-neutralizing antibody reduced cartilage degeneration and alleviated OA in mice.Altogether,these findings demonstrate that mTORC1 activation in subchondral preosteoblasts is not sufficient to induce OA,but can induce aberrant subchondral bone formation and secrete of Cxcl12 to accelerate disease progression following surgical destabilization of the joint.Pharmaceutical inhibition of the pathway presents a promising therapeutic approach for OA treatment. | Chuangxin Lin Liangliang Liu Chun Zeng Zhong-Kai Cui Yuhui Chen Pinling Lai Hong Wang Yan Shao Haiyan Zhang Rongkai Zhang Chang Zhao Hang Fang Daozhang Cai Xiaochun Bai | 2019 | Bone Research2019，7，1： | 12 |
| 2 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 3 | The geomechanics of Shenhua carbon dioxide capture and storage(CCS) demonstration project in Ordos Basin,China显示文摘Carbon dioxide(CO_2) capture and storage(CCS) is considered widely as one of promising options for CO_2emissions reduction,especially for those countries with coal-dominant energy mix like China.Injecting and storing a huge volume of CO_2 in deep formations are likely to cause a series of geomechanical issues,including ground surface uplift,damage of caprock integrity,and fault reactivation.The Shenhua CCS demonstration project in Ordos Basin,China,is the first and the largest full-chain saline aquifer storage project of CO_2 in Asia.The injection started in 2010 and ended in 2015.during which totally 0.3 million tonnes(Mt) CO_2 was injected.The project is unique in which CO_2 was injected into 18 sandstone formations simultaneously and the overlying coal seams will be mined after the injection stopped in 2015.Hence,intense geomechanical studies and monitoring works have been conducted in recent years,including possible damage resulting from the temperature difference between injected CO_2 and formations,injection induced stress and deformation change,potential failure mode and safety factor,interaction between coal mining and CO_2 geological storage,determination of injection pressure limit,and surface monitoring by the interferometric synthetic aperture radar(InSAR) technology.In this paper,we first described the background and its geological conditions of the Shenhua CCS demonstration project.Then,we gave an introduction to the coupled thermo-hydro-mechano-chemical(THMC) processes in CO_2 geological storage,and mapped the key geomechanical issues into the THMC processes accordingly.Next,we proposed a generalized geomechanical research flowchart for CO_2 geological storage projects.After that,we addressed and discussed some typical geomechanical issues,including design of injection pressure limit.CO_2 injection induced near-field damage,and interaction between CO_2geological storage and coal mining,in the Shenhua CCS demonstration project.Finally,we concluded some insights to this CCS project. | Xiaochun Li Qi Li Bing Bai Ning Wei Wei Yuan | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，6： | 8 |
| 4 | Generation and selection of immunized Fab phage display library against human B cell lymphoma显示文摘与 B 房间淋巴瘤在病人的管理把单音的同种细胞的抗体用作指向的治疗的赞同为这组病人导致了新治疗选择。由传统的 hybridoma 技术的单音的同种细胞的抗体的生产是昂贵的,并且结果鼠科的抗体经常有触发人的反老鼠抗体(HAMA ) 反应的劣势。因此,噬菌体产生的重组体 Fab 抗体显示技术能是在管理 B 房间淋巴瘤的一种合适的选择。在这研究,我们从与人的 B 淋巴瘤房间使免疫的 BALB/c 老鼠的怒气房间提取了全部的 RNA,并且使用了 RT-PCR 为 kappa 光链和重链的 Fd 碎片放大 cDNAscoding。在适当限制文摘以后,这些 cDNA 碎片连续地被插入到噬菌体构造一个使免疫的 Fab 噬菌体显示图书馆的中间的向量 pComb3H-SS。构造图书馆的差异是近似 1.94x10 (7 ) 。跟随五轮简历 panning,可溶的 Fab 抗体从 ELISA 识别的积极克隆被生产。从八积极克隆, FabC06, FabC21, FabC43 andFabC59 为顺序分析被选择。在氨基酸顺序的水平,可变的重域(V (H)) 和可变的轻域(V (L)) 被发现分享 88-92% 和 89-94% 相同,序列分别地由相应鼠科的细菌行基因编码了。而且,有 B 房间淋巴瘤的膜蛋白质的反应被 immunohistochemistryand 表明西方的弄污。这些使免疫的 Fab 抗体可以为 B 房间淋巴瘤的进一步的学习提供一个珍贵工具并且能也贡献疾病治疗的改进。 | Yongmei Shen Xiaochun Yang Ningzheng Dong Xiaofang Xie Xia Bai Yizhen Shi | 2007 | Cell Research2007，17，7： | 7 |
| 5 | Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc显示文摘Intervertebral disc(IVD) degeneration(IVDD) is the main cause of low back pain with major social and economic burdens;however, its underlying molecular mechanisms remain poorly defined. Here we show that the focal adhesion protein Kindlin-2 is highly expressed in the nucleus pulposus(NP), but not in the anulus fibrosus and the cartilaginous endplates, in the IVD tissues. Expression of Kindlin-2 is drastically decreased in NP cells in aged mice and severe IVDD patients. Inducible deletion of Kindlin-2 in NP cells in adult mice causes spontaneous and striking IVDD-like phenotypes in lumbar IVDs and largely accelerates progression of coccygeal IVDD in the presence of abnormal mechanical stress. Kindlin-2 loss activates Nlrp3 inflammasome and stimulates expression of IL-1β in NP cells, which in turn downregulates Kindlin-2. This vicious cycle promotes extracellular matrix(ECM) catabolism and NP cell apoptosis. Furthermore, abnormal mechanical stress reduces expression of Kindlin-2, which exacerbates Nlrp3 inflammasome activation, cell apoptosis, and ECM catabolism in NP cells caused by Kindlin-2 deficiency. In vivo blocking Nlrp3 inflammasome activation prevents IVDD progression induced by Kindlin-2 loss and abnormal mechanical stress. Of translational significance, adeno-associated virus-mediated overexpression of Kindlin-2 inhibits ECM catabolism and cell apoptosis in primary human NP cells in vitro and alleviates coccygeal IVDD progression caused by mechanical stress in rat. Collectively, we establish critical roles of Kindlin-2 in inhibiting Nlrp3 inflammasome activation and maintaining integrity of the IVD homeostasis and define a novel target for the prevention and treatment of IVDD. | Sheng Chen Xiaohao Wu Yumei Lai Di Chen Xiaochun Bai Sheng Liu Yongchao Wu Mingjue Chen Yuxiao Lai Huiling Cao Zengwu Shao Guozhi Xiao | 2022 | Bone Research2022，10，1： | 6 |
| 6 | FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis显示文摘Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and diseases.However,the effect of FABP4 on RA remains unclear.Here,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in RA.The increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA progression.Further studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in mice.In contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in mice.Our findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in RA.BMS309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA development.Hence,FABP4 may represent a potential target for RA therapy. | Dong Guo Chuangxin Lin Yuheng Lu Hong Guan Weizhong Qi Hongbo Zhang Yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai | 2022 | Bone Research2022，10，4： | 5 |
| 7 | LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice显示文摘The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and adhesion.Here,we report that deleting Pinch1 in limb mesenchymal stem cells(MSCs)and Pinch2 globally(double knockout;dKO)in mice causes severe chondrodysplasia,while single mutant mice do not display marked defects.Pinch deletion decreases chondrocyte proliferation,accelerates cell differentiation and disrupts column formation.Pinch loss drastically reduces Smad2/3 protein expression in proliferative zone(PZ)chondrocytes and increases Runx2 and Col10a1 expression in both PZ and hypertrophic zone(HZ)chondrocytes.Pinch loss increases sclerostin and Rankl expression in HZ chondrocytes,reduces bone formation,and increases bone resorption,leading to low bone mass.In vitro studies revealed that Pinch1 and Smad2/3 colocalize in the nuclei of chondrocytes.Through its C-terminal region,Pinch1 interacts with Smad2/3 proteins.Pinch loss increases Smad2/3 ubiquitination and degradation in primary bone marrow stromal cells(BMSCs).Pinch loss reduces TGF-β-induced Smad2/3 phosphorylation and nuclear localization in primary BMSCs.Interestingly,compared to those from single mutant mice,BMSCs from dKO mice express dramatically lower protein levels ofβ-catenin and Yap1/Taz and display reduced osteogenic but increased adipogenic differentiation capacity.Finally,ablating Pinch1 in chondrocytes and Pinch2 globally causes severe osteopenia with subtle limb shortening.Collectively,our findings demonstrate critical roles for Pinch1/2 and a functional redundancy of both factors in the control of chondrogenesis and bone mass through distinct mechanisms. | Yiming Lei Xuekun Fu Pengyu Li Sixiong Lin Qinnan Yan Yumei Lai Xin Liu Yishu Wang Xiaochun Bai Chuanju Liu Di Chen Xuenong Zou Xu Cao Huiling Cao Guozhi Xiao | 2020 | Bone Research2020，8，4： | 2 |
| 8 | A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex显示文摘Tuberous sclerosis complex(TSC)is a dominant genetic neurocutaneous syndrome characterized by multiple organ hamartomas.Although rodent models bearing a germline mutation in either TSC1 or TSC2 gene have been generated,they do not develop pathogenic lesions matching those seen in patients with TSC because of the significant differences between mice and humans,highlighting the need for an improved large animal model of TSC.Here,we successfully generate monoallelic TSC1-modified Bama miniature pigs using the CRISPR/Cas9 system along with somatic cell nuclear transfer(SCNT)technology.The expression of phosphorylated target ribosomal protein S6 is significantly enhanced in the piglets,indicating that disruption of a TSC1 allele activate the mechanistic target of rapamycin(mTOR)signaling pathway.Notably,differing from the mouse TSC models reported previously,the TSC1^(+/−)Bama miniature pig developed cardiac rhabdomyoma and subependymal nodules,resembling the major clinical features that occur in patients with TSC.These TSC1^(+/−)Bama miniature pigs could serve as valuable large animal models for further elucidation of the pathogenesis of TSC and the development of therapeutic strategies for TSC disease. | Xiaoxue Li Tingdong Hu Jiying Liu Bin Fang Xue Geng Qiang Xiong Lining Zhang Yong Jin Xiaorui Liu Lin Li Ying Wang Rongfeng Li Xiaochun Bai Haiyuan Yang Yifan Dai | 2020 | Journal of Genetics and Genomics2020，47，12： | 2 |
| 9 | Selective separation of biobutanol from acetone–butanol–ethanol fermentation broth by means of sorption methodology based on a novel macroporous resin显示文摘 | Xiaoqing Lin Jinglan Wu Xiaohong Jin Jiansheng Fan Renjie Li Qingshi Wen Wenbin Qian Dong Liu Xiaochun Chen Yong Chen Jingjing Xie Jianxin Bai Hanjie Ying | 2012 | Biotechnol Progress2012，，4： | 1 |
| 10 | Characterization of Water Constituents Spectra Absorption in Chagan Lake of Jilin Province, Northeast China显示文摘Research on the optical characteristics of water color constituents in Chagan Lake of Jilin Province,Northeast China was carried out in order to investigate the variability of the spectra absorption parameters as inputs to bio-optical models and remote sensing algorithms for converting observed spectral signals into water quality information.Samples of total particulates,non-algal particles and colored dissolved organic matter (CDOM) were first prepared by quantitative filter technique (QFT) and then absorption coefficients of these color producing agents were determined by spectrophotometry.Spectral characteristics of absorption coefficients by total particulate matter,spectral specific absorption dependency on chlorophyll concentration (Chl-a) of phytoplankton,spectral absorption slopes variation for CDOM and non-algal particles and their corresponding reasons were examined and clarified over five months of 2009 and 2010 in this study.Results suggest that total particulate spectral absorption in Chagan Lake is mainly dominated by non-algal particles in most cases,but phytoplankton could be the dominant contributor when chlorophyll concentration is high (up to 84.48 mg/m3 in autumn 2010).The specific absorption coefficients of phytoplankton particulate (a*ph(λ)) dependency on Chl-a is significantly variable due to relative contributions of package effect and accessory pigments,and the parameters of power function are clearly biased on a long time span.The sources of variability in spectral absorption slopes of CDOM and non-algal particles are mainly attributed to the changing proportions of high molecular weight humic acids and mineral suspended sediments in waters,respectively. | WANG Yuandong LIU Dianwei SONG Kaishan DU Jia WANG Zongming ZHANG Bai TANG Xuguang LEI Xiaochun WU Yanqing | 2011 | Chinese Geographical Science2011，21，3： | 1 |
| 11 | Molecular mapping of wheat leaf rust resistance gene Lr42 显示文摘 | Xiaochun Sun Guihua Bai Brett F | 2010 | Crop Science2010，50，： | 1 |
| 12 | Mapping quantitative trait loci for quality factors in an inter-class cross of US and Chinese wheat显示文摘 | Xiaochun Sun Felix Marza Hongxiang Ma Brett F. Carver Guihua Bai | 2010 | Theoretical and Applied Genetics2010，，5： | 1 |
| 13 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 14 | Inverse analysis of thermal conductivities in transient non-homogeneous and non-linear heat conductions using BEM based on complex variable differentiation method显示文摘This paper presents a new inverse analysis approach to sensitivity analysis and material property identification in transient non-homogeneous and non-linear heat conduction Boundary Element Method (BEM) analysis based on Complex Variable Differentiation Method (CVDM). In this approach, the material properties are taken as the optimization variables, and the sensitivity coefficients are computed by CVDM. The advantages of using CVDM are that the computation of partial derivatives of an implicit function is reduced to function calculation in a complex domain, and the parameter sensitivity coefficients can be determined in a more accurate way than the traditional Finite Difference Method (FDM). Based on BEM and CVDM in evaluation of the sensitivity matrix of heat flux, the parameter such as thermal conductivity can be accurately identified. Six numerical examples are given to demonstrate the potential of the proposed approach. The results indicate that the presented method is efficient for identifying the thermal conductivity with single or multiple parameters. | YU XiaoChun BAI YuGuang CUI Miao GAO XiaoWei | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，5： | 1 |
| 15 | Carbon geological utilization and storage in China: current status and perspectives显示文摘 | Heping Xie Xiaochun Li Zhiming Fang Yufei Wang Qi Li Lu Shi Bing Bai Ning Wei Zhengmeng Hou | 2014 | Acta Geotechnica2014，，1： | 1 |
| 16 | Critical importance of current collector property to the performance of flexible electrochemical power sources显示文摘Flexible electrochemical power sources are attracting increasing attentions for their unique advantages like flexibility, shape diversity, light weight and excellent mechanical properties. In this research, we discover that the current collector can dramatically affect the performance of flexible electrochemical power sources with large size. For flexible air-breathing proton exchange membrane fuel cell (PEMFC), the performance could have more than 8 times increase by only adjusting the directions of current collectors. The different performances of different current collection types are mainly attributed to the diverse lengths of the electron transfer pathways. In addition, the conductivity of current collector can dramatically affect the capability of flexible PEMFCs with large-size. The flexible PEMFCs with thicker carbon nanotube membrane as current collector (low electric resistance) show higher ability. A mathematic model is successfully built in this work to further understand the performance. Moreover, the model and simulation are also applicable to other flexible power sources, such as flexible Li-ion battery and supercapacitor. | Fandi Ning Yangbin Shen Chuang Bai Jun Wei Guanbin Lu Yi Cui Xiaochun Zhou | 2019 | Chinese Chemical Letters2019，30，6： | 1 |
| 17 | Erratum to“A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex”[Journal of Genetics and Genomics(2020)47,735–742]显示文摘This erratum clarifies information in the article“A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex”by Li et al.(2020).In the“Acknowledgment”section,the statement that“This work was supported by grants from the National Natural Science Foundation of China(31701283,81970164)”should say“This work was supported by grants from the National Natural Science Foundation of China(81874144,81970164)”. | Xiaoxue Li Tingdong Hu Jiying Liu Bin Fang Xue Geng Qiang Xiong Lining Zhang Yong Jin Xiaorui Liu Lin Li Ying Wang Rongfeng Li Xiaochun Bai Haiyuan Yang Yifan Dai | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 18 | Development of environment-insensitive and highly emissive BODIPYs via installation of N,N'-dialkylsubstituted amide at meso position显示文摘Fluorescent dyes play a crucial role in fluorescence imaging and sensing technology.However,there is a dilemma that they are usually intrinsically hydrophobic which lacks of emission in water and modification with ionic groups to access water solubility may result in poor membrane permeability.Fluorescent dyes with strong fluorescence emission in both nonpolar and polar solvents are highly desirable.In this manuscript,we reported a strategy to develop fluorescent BODIPY dyes via installation of amide moiety at meso position of 1,3,5,7-tetramethyl-BODIPY and discovered that N,N'-dialkylsubstituted BODIPY amides possessed highly fluorescent emission with favorable environment-insensitive properties. | Junping Bai Junliang Zhou Xin Ji Nannan Wang Xiaochun Dong Wei Wu Weili Zhao | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 19 | Preparation and Performance of Corona-proof Conductive Composite Coatings显示文摘Because of its merits,acrylic resin was chosen to improve the mechanical,conductive and hydrophobic properties.Carbon fiber powders (CF),carbon nanotubes (MWCNT),and nano-TiO_(2) were incorporated into the acrylic resin to prepare the corona-proof conductive composite coatings.The incorporation of CF and MWCNT may improve the conductivity and mechanical strength of the coatings.However,the addition of nano-TiO_(2) may increase the hydrophobicity of the coatings.Thus,the effects of different additives on the mechanical properties,conductivity,hydrophobicity and heat resistance of the conductive film were studied.The experimental results show that the incorporation of carbon fiber powders and multi walled carbon nanotubes can significantly improve both the conductivity and mechanical properties of the conductive coatings,and the addition of nano titanium dioxide can improve the hydrophobicity of the conductive film. | 吴健 韩文 ZHAO Yalin YANG Bin JING Yan GENG Mingxin BAI Xiaochun TAN Haiying GE Qizhong LENG Pei 孙九霄 | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，4： | 0 |
| 20 | Advances in Nanomaterial-microbe Coupling System for Removal of Emerging Contaminants显示文摘Emerging contaminants are characterized by toxicity,environmental durability,and bioaccumulation.How to effectively remove them has attracted tremendous attention in the field of environmental science and engineering.Nanomaterial-microbe coupling systems driven by photo-electrochemistry have high degradation efficiency and low cost by combining the advantages of nanomaterials and microorganisms in pollutant treatment.This review summarizes the recent development of the nanomaterial-microbe system for the removal of emerging contaminants,which is divided into exogenous nanomaterial-microbe and endogenous nanomaterial-microbe.The interaction mechanism of materials and microorganisms is addressed from the particular perspective of extracellular electron transfer and redox reactions,and the advantages and challenges of the pollutants treatment are analyzed.Furthermore,future applications in the degradation of emerging contaminants in environmental fields have been prospected. | REN Chongyuan BAI Rui CHEN Wei LI Junpeng ZHOU Xudong TIAN Xiaochun ZHAO Feng | 2023 | Chemical Research in Chinese Universities2023，39，3： | 0 |
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