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| 1 | Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function显示文摘Geniposide 是从栀子 jasminoides 埃利斯的水果净化的 iridoid glycosides,它被知道有 antiinflammatory,抗氧化并且反肿瘤活动。现在的学习试图在试验性的老鼠大肠炎上调查 geniposide 的效果并且揭示相关机制。试验性的老鼠大肠炎被一个 TNBS 答案的直肠的管理导致。老鼠与 geniposide 被对待(25, 50 mg 挠湯楳敤慲汢? ?灰敲獳摥琠敨攠灸敲獳潩 ? 景 ? 虡 H?? 湡 ??? 琠畨 ? 敤牣慥楳杮琠敨渠浵敢 ? 景愠瑵灯慨潧潳敭 ?湩琠敨氠癩牥 | Bin XU Yan-li LI Ming XU Chang-chun YU Meng-qiao LIAN Ze-yao TANG Chuan-xun LI Yuan LIN | 2017 | Acta Pharmacologica Sinica2017，38，5： | 19 |
| 2 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 3 | Effect of Bacillus mucilaginosus on weathering of phosphorite and a preliminary analysis of bacterial proteins显示文摘The authors investigated the effect of Bacillus mucilaginosus on weathering of phosphorite. Analysis of different proteins was of significance in exploring the molecular biological mechanism in the bacterial weathering process. The concrete methods are described as follows: Mineral powder was put into liquid culture medium and B. mucilaginosus was incubated in the medium. The control (group) had no mineral powder in the medium. The treatments and controls were cultured simultaneously under the same condition. In a few days, the supernatant was filtrated, the main cations (Ca2+, Mg2+, Na+, Mn2+, Al3+, Fe3+, K+) were measured by ICP-OES, and the contents of water soluble phosphorus (Pws) and silicon (Siws) were determined by colorimetry. The residual solid was weighed on the filter paper, followed by digestion with concentrated HNO3. The concentrations of the main cations and Pws, Siws in the digest liquid were measured by using the method mentioned above. After the supernatant was centrifuged, the precipitation was used to analyze the protein differences between the treatment groups and the control groups by 2-dimentional gel electrophoresis (2-DE). The experimental results showed that apatite and quartz were partially weathered, but kaolinite was dissolved completely. The population of bacteria increased when mineral powder was added in the liquid medium. Software analysis and comparison of the 2-DE pictures of bacterial proteins revealed 1134 visible protein spots in the treatment group, and 729 visible protein spots in the control group. To compare the bacterial protein expression contents of the treatment group with those of the control group, there were 496 different protein spots, including 214 protein spots which indicated that the protein contents increased, 75 protein spots were indicative of a decrease, and 207 proteins were newly synthesized. It is proposed that the increased bacterial contents may be related to some protein expression and activation after the input of mineral powder. Newly synthesized proteins, the increase of expression contents and the reduction of proteins may be connected with bacterial metabolic regulations, cell activation and signal transmission. | CHEN Shu LIAN Bin LIU Congqiang | 2008 | Chinese Journal Of Geochemistry2008，27，2： | 14 |
| 4 | Effect of microbes on karstification in karst ecosystems显示文摘The role of microbes in the karstification process was determined based on the karst dynamics,CO2 capture,and carbonate deposition.A close relationship was found among microbial activity,karst dynamics and stability,and the carbon cycle in a karst ecosystem.More in-depth studies were needed to investigate the impact of microbes on karst dynamics within different eco-envi-ronments under natural conditions to determine the response of biological organisms to a changing environment,as well as the relationship between microbial organisms and the karstification process. | LIAN Bin YUAN DaoXian LIU ZaiHua | 2011 | Chinese Science Bulletin2011，56，35： | 14 |
| 5 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 6 | Zeolite and fungi’s flocculability of simulated wastewater containing heavy metal ions or phosphorus显示文摘This paper focuses on the flocculability of simulated wastewater containing heavy metal ions (Fe3+, Cd2+) or phosphorus by zeolite, microbial flocculants (MBF) produced by Aspergillus niger and the composite flocculant composed of zeolite and MBF. The main results are presented as follows: zeolite was a good flocculant when the contamination of the three simulated wastewaters was low, but the treated water is of turbidness and the particles in it are hard to precipitate. The MBF have a good flocculability toward Fe3+ wastewater, as well as particulate matter. Significant changes in flocculability occurred after adding the composite flocculant in different simulated wastewa-ters, the best or least effect respective for Fe3+ and Cd2+ wastewater. The research we have done shows that the method by which the composite flocculant is used to treat the wastewater containing heavy metal ions or phosphorus provides important reference value for practical application. | CAO Wenchuan HAO Jianchao LIAN Bin LIU Congqiang WU Fengchang | 2010 | Chinese Journal Of Geochemistry2010，29，2： | 10 |
| 7 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 8 | ANTI-HYPOXIA AND ANTI-OXIDATION EFFECTS OF AMINOPHYLLINE ON HUMAN WITH ACUTE HIGH-ALTITUDE EXPOSURE显示文摘Objective To investigate the anti-hypoxia and anti-oxidation effects of aminophylline on human with acute high- altitude exposure. Methods Totally 100 young male army members newly recruited from Sichuan province (400 meters above sea level) were enrolled. They were randomly divided into two groups: 50 in aminophylline group (A group) and 50 in control group (C group). A group and C group orally took aminophylline and placebo respectively for 10 days, 7 days before entering Lhasa (3 658 meters above sea level) by air and 3 days after it. Several parameters were measured at three time points: before drug taken, 7 days after drug taken, and 3 days after ascending high altitude. These parameters included serum levels of nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT), hydrogen dioxide (H2O2), lactic acid (LA), as well as arterial oxygen saturation (SO2), arterial oxygen partial pressure (PaO2), and arterial carbon dioxide partial pressure (PaCO2). Statistical analysis was conducted to compare the difference between two groups with Stata 7.0 software system. Results There were no statistical differences between groups in hypoxia and oxidation indicators before and after drug taken in plain area. Three days after ascending high altitude, the serum levels of SOD, CAT, H2O2, LA, PaCO2 increased in both groups, yet to a much larger degree in C group than A group (P<0.01); and NO, SO2, PaO2 decreased more markedly in C group (P<0.05 for NO, P<0.0001 for SO2 and PaO2). Conclusion Aminophylline has significant anti-hypoxia and anti-oxidation effects at high altitude. | Bo Yang Guang-yi Wang Bin Chen Rong-bin Qin Si Lang Zha Xi Lian Chen | 2007 | Chinese Medical Sciences Journal2007，22，1： | 8 |
| 9 | Biodegradation of 2-naphthol and its metabolites by coupling Aspergillus niger with Bacillus subtilis显示文摘To explore biodegradation of 2-naphthol and its metabolites accumulated in wastewater treatment,a series of bio-degradation experiments were conducted.Two main metabolites of 2-naphthol,1,2-naphthalene-diol and 1,2-naphthoquinone,were identified by high-performance liquid chromatography with standards.Combining fungus Aspergillus niger with bacterium Bacillus subtilis in the treatment enhanced 2-naphthol degradation efficiency,lowered the accumulation of the two toxic metabolites.There were two main phases during the degradation process by the kinetic analysis:2-naphthol was first partly degraded by the fungus,producing labile and easily accumulated metabolites,and then the metabolites were mainly degraded by the bacterium,attested by the degradation processes of 1,2-naphthalene-diol and 1,2-naphthoquinone as sole source of carbon and energy.Sodium succinate,as a co-metabolic substrate,was the most suitable compound for the continuous degradation.The optimum concentration of 2-naphthol was 50 mg/L.The overall 2-naphthol degradation rate was 92%,and the COD Cr removal rate was 80% on day 10.These results indicated that high degradation rate of 2-naphthol should not be considered as the sole desirable criterion for the bioremediation of 2-naphtholcontaminated soils/wastewater. | Shuyan Zang Bin Lian Juan Wang Yanjie Yang | 2010 | Journal of Environmental Sciences2010，22，5： | 8 |
| 10 | Interactions between Bacillus mucilaginosus and silicate minerals(weathered adamellite and feldspar):Weathering rate,products,and reaction mechanisms显示文摘Bacillus mucilaginosus is a common soil bacterium,and usually used as a model bacterium in studying microbe-mineral interactions.Several reaction mechanisms of B.mucilaginosus weathering silicate minerals were proposed.However,the molecule mechanisms and detailed processes were still unclear.In this paper,bacterium-mineral interactions were studied in terms of variations in pH value over the experimental period,variations in mineral composition,weathering rates of silicate minerals and volatile metabolites in the culture medium,etc.,to further explore the bacterium-mineral interaction mechanisms.The results showed that B.mucilaginosus could enhance silicate mineral weathering obviously.The weathering rates were quite different for various kinds of silicate minerals,and the weathering rate of weathered adamellite could reach 150 mg/m2/d.Although B.mucilaginosus produced little acidic substance,pH in the microenvironment of bacterium-mineral complex might be far lower than that of the circumjacent environment;a large amount of acetic acid was found in the metabolites,and was likely to play an important role as a ligand.These results appear to suggest that acidolysis and ligand degradation are the main mechanisms of B.mucilaginosus dissolving silicate minerals,the formation of bacterium-mineral complexes is the necessary condition for the bacteria weathering silicate minerals,and extracelluar polysaccharides played important roles in bacterium-mineral interaction processes by forming bacterium-mineral complexes and maintaining the spe-cial physicochemical properties of microenvironment. | Mo, Binbin Lian, Bin | 2011 | Chinese Journal Of Geochemistry2011，30，2： | 7 |
| 11 | Iron and lead ion adsorption by microbial flocculants in synthetic wastewater and their related carbonate formation显示文摘Although microbial treatments of heavy metal ions in wastewater have been studied, the removal of these metals through incorporation into carbonate minerals has rarely been reported. To investigate the removal of Fe3+and Pb2+, two representative metals in wastewater, through the precipitation of carbonate minerals by a microbial flocculant(MBF) produced by Bacillus mucilaginosus. MBF was added to synthetic wastewater containing diferent Fe3+and Pb2+concentrations, and the extent of flocculation was analyzed. CO2 was bubbled into the mixture of MBF and Fe3+/Pb2+to initiate the reaction. The solid substrates were analyzed via X-ray difraction, transmission electron microscopy and energy dispersive spectroscopy. The results showed that the removal efciency decreased and the MBF adsorption capacity for metals increased with increasing heavy metal concentration. In the system containing MBF, metals(Fe3+ and Pb2+), and CO2, the concentrated metals adsorbed onto the MBF combined with the dissolved CO2, resulting in oversaturation of metal carbonate minerals to form iron carbonate and lead carbonates. These results may be used in designing a method in which microbes can be utilized to combine CO2 with wastewater heavy metals to form carbonates, with the aim of mitigating environmental problems. | Minjie Yao Bin Lian Hailiang Dong Jianchao Hao Congqiang Liu | 2013 | Journal of Environmental Sciences2013，25，12： | 7 |
| 12 | Ectomycorrhizal Fungi in Jiangsu Province,China显示文摘A survey was conducted for about 3 years to study the abundance and diversity of ectomycorrhizal fungi (EMF) in Jiangsu Province, China. The identification of the fungal species was based on the microscopic and macroscopic characteristics of their fruiting bodies. About 126 species of EMF were found in Jiangsu Province. These fungi were largely categorized into three orders (of 121 species), four families (of 96 species), and six genera (of about 86 species). | LIAN Bin DONG Yuan-Rong HOU Wei-Guo TONG Li-Hua YUAN Sheng | 2007 | Pedosphere2007，17，1： | 7 |
| 13 | Preparation and Electrochemical Characters of Parathion Molecule Imprinted Polymeric Sensors显示文摘A sensitive, fast and low-cost molecular imprinted polymeric sensor for quantitative determination of parathion was prepared with chitosan(CS) as function matrix and parathion(PT) as template molecule via constant potential electrochemical deposition. Sensitive response was obtained with a detection limit of 1.0×10–7 mol/L and an excellent recognition for PT was achieved due to the good memory capacity of the sensor. The developed sensor exhibited good fabrication reproducibility and acceptable stability, which provided a new promising tool for pesticide analysis. | HUANG Yong-xing LIAN Hui-ting SUN Xiang-ying LIU Bin | 2011 | Chemical Research in Chinese Universities2011，27，1： | 6 |
| 14 | A Label-free Fluorescent Aptasensor for Turn-on Monitoring Ochratoxin A Based on AIE-active Probe and Graphene Oxide显示文摘 | MA Lian XU Bin LIU Leijing TIAN Wenjing | 2018 | Chemical Research in Chinese Universities2018，34，3： | 6 |
| 15 | Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53显示文摘Our preliminary study shows that cinnamaldehyde(CA)could protect against intestinal ischemia/reperfusion(I/R)injuries,in which p53 and NF-κB p65 play a synergistic role.In this study,we conducted in vivo and in vitro experiments to verify this proposal.SD rats were pretreated with CA(10 or 40 mg·kg−1·d−1,ig)for 3 days,then subjected to 1 h mesenteric ischemia followed by 2 h reperfusion.CA pretreatment dose-dependently ameliorated morphological damage and reduced inflammation evidenced by decreased TNF-α,IL-1β,and IL-6 levels and MPO activity in I/R-treated intestinal tissues.CA pretreatment also attenuated oxidative stress through restoring SOD,GSH,LDH,and MDA levels in I/R-treated intestinal tissues.Furthermore,CA pretreatment significantly reduced the expression of inflammation/apoptosis-related NF-κB p65,IKKβ,IK-α,and NF-κB p50,and downregulated apoptotic protein expression including p53,Bax,caspase-9 and caspase-3,and restoring Bcl-2,in I/R-treated intestinal tissues.We pretreated IEC-6 cells in vitro with CA for 24 h,followed by 4 h hypoxia and 3 h reoxygenation(H/R)incubation.Pretreatment with CA(3.125,6.25,and 12.5μmol·L−1)significantly reversed H/R-induced reduction of IEC-6 cell viability.CA pretreatment significantly suppressed oxidative stress,NF-κB activation and apoptosis in H/R-treated IEC-6 cells.Moreover,CA pretreatment significantly reversed mitochondrial dysfunction in H/R-treated IEC-6 cells.CA pretreatment inhibited the nuclear translocation of p53 and NF-κB p65 in H/R-treated IEC-6 cells.Double knockdown or overexpression of p53 and NF-κB p65 caused a synergistic reduction or elevation of p53 compared with knockdown or overexpression of p53 or NF-κB p65 alone.In H/R-treated IEC-6 cells with double knockdown or overexpression of NF-κB p65 and p53,CA pretreatment caused neither further decrease nor increase of NF-κB p65 or p53 expression,suggesting that CA-induced synergistic inhibition on both NF-κB and p53 played a key role in ameliorating intestinal I/R injuries.Finally,we used immunoprecipitation assay to demonstrate an interaction between p53 and NF-κB p65,showing the basis for CA-induced synergistic inhibition.Our results provide valuable information for further studies. | Marwan Almoiliqy Jin Wen Bin Xu Yu-chao Sun Meng-qiao Lian Yan-li Li Eskandar Qaed Mahmoud Al-Azab Da-peng Chen Abdullah Shopit Li Wang Peng-yuan Sun Yuan Lin | 2020 | Acta Pharmacologica Sinica2020，41，9： | 5 |
| 16 | Weathering of Carbonate Rocks by Biological Soil Crusts in Karst Areas显示文摘The weathering of carbonate rocks by biological soil crusts(BSC) in karst areas is very common. It is helpful to understand the weathering mechanisms and processes for avoiding karst rock-desertification. The weathering of carbonate rocks by BSC in karst areas, namely the expansion, contraction and curl resulting from environmental wetting-drying cycles, was investigated and analyzed in this paper. The bulk density, area and thickness of BSC were determined and the weathering amount of limestone and dolomite per unit area of BSC was calculated as 3 700 and 3 400 g·m-2; the amount of biomass on the surface of limestone and dolomite was calculated as 1 146 and 1 301 g·m-2, respectively. Such an increased weathering amount was not only the result of chemical and physical weathering of BSC on carbonate rocks, but also the attachment and cementation of BSC to clay particles, dust-fall, sand particles, solid particles brought by strong air currents, wind and other factors in the surrounding environment, which may also be related to the special environment and the special time period. Based on the results obtained, a weathering mode of BSC is studied, and the mechanisms of weathering by BSC are discussed. In conclusion, we suggest that the mechanical force exerted by the expansion and constriction of gelatinous and mucilaginous substances through wetting and drying of BSC play a significant role in the physical weathering process of the carbonate substrates. | Ye Chen Bin Lian Zuoying Yin Yuan Tang | 2014 | Journal of Earth Science2014，25，4： | 5 |
| 17 | Algorithms for k-fault tolerant power assignments in wireless sensor networks显示文摘This paper addresses fault-tolerant many-to-many routing power assignments in heterogeneous wire-less sensor networks.We introduce the k-fault tolerant power assignments problem with the objective of assigning each sensor node transmission power such that(1) any pairwise sensor node is k-vertex connected and(2) the to-tal power consumption is minimized.We propose three solutions for this problem:two centralized algorithms,a greedy algorithm and an O(√n/ε)-approximation algorithm,and an h-hop distributed and localized algorithm.Related theorems and proofs are presented to prove the correctness of our approaches.Furthermore,simulation and experiment results are presented to verify the efficiency of our approaches. | LIU Li 1,2,LI Lian 1,3 & HU Bin 1,4 1 School of Information Science and Engineering,Lanzhou University,Lanzhou 730000,China 2 LRI,Univ Paris-sud and CNRS,Orsay F-91405,France 3 School of Computer and Information,Hefei University of Technology,Hefei 230009,China 4 Department of Computing,Birmingham City University,Galton Building,Perry Barr,Birmingham B42 2SU,UK | 2010 | Science China(Information Sciences)2010，53，12： | 5 |
| 18 | A practical soil management to improve soil quality by applying mineral organic fertilizer显示文摘Heavy use of chemical fertilizer causes increasing soil and environmental crisis, and the use of organic fertilizer increases obvious in recent years. In this study,mineral organic fertilizer(MOF) and compound fertilizer(CF) were applied in amaranth culture to explore the effects of these two kinds of fertilizers on soil quality and the potential function for CO_2 fixation. Some soil parameters were tested, e.g. p H value, organic carbon content, microbial biomass, urease activity, and available potassium content. In addition, some parameters of soil infiltration water were also determined, such as p H and HCO_3^- concentration. Experimental results showed that MOF improved soil quality and amaranth biomass and increased possible soil carbon sink.On the contrary, the utilization of CF worsened soil quality and made the soil acidize. These results suggested that MOF can partially replace CF to improve plant growth, soil quality and possible CO_2 sink. | Leilei Xiao Qibiao Sun Huatao Yuan Bin Lian | 2017 | Acta Geochimica2017，36，2： | 5 |
| 19 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 20 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
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