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| 1 | Expenditure of hospital care on cancer in China, from 2011 to 2015显示文摘Objective: A solid understanding of levels and trends of spending on cancer is important to evaluate whether our healthcare resources were wisely spent and to prioritize future resources for cancer treatment and prevention.However, studies on economic burden of cancers in China are scant and the results are inconsistent.Methods: The Chinese hospital information database and nearly 350 million inpatient medical record data were used. As the ratios of cancer inpatient payments to total inpatient payments were mainly influenced by the grades and sites of hospitals, the estimates of payments of cancer inpatients in this study were stratified by hospital grades and provinces. Only the payments of cancer inpatients happened in grade 2, grade 3 and specialized cancer hospitals were included in the analyses. The total medical payments of cancers in China were estimated based on the ratios of outpatient payments to inpatient payments in specialized cancer hospitals.Results: From 2011 to 2015, the payments of cancer inpatients in China have increased by 84.1% and the total inpatient payments reached 177.1 billion RMB in 2015, accounting for 4.3% of the total health expenditure in China. Based on the ratio of outpatient payments to inpatient payments, the total payments on cancer treatments in China were estimated to be 221.4 billion RMB in 2015. Among different cancer types, the highest payments were the treatment of trachea, bronchus and lung cancer. The major cancer inpatient payments(67.1% in 2015) spent in grade 3 general hospitals and this ratio increased continually from 2011 to 2015. The expenditure of cancer treatments also varies by region with the major expenditure in the eastern region of China.Conclusions: This study estimated the total payments of cancer treatments in China and analyzed how the money was spent on cancer treatments in the recent 5 years, which would provide information for decision makings on the allocation of resources to service provisioning, prevention strategies, research funding, and assessing whether the economic burden of cancer is affordable to the governments. | Yue Cai Ming Xue Wanqing Chen Maogui Hu Zhiwen Miao Lan Lan Rongshou Zheng Qun Meng | 2017 | Chinese Journal of Cancer Research2017，29，3： | 81 |
| 2 | OsWRKY03, a rice transcriptional activator that functions in defense signaling pathway upstream of OsNPR1显示文摘WRKY family proteins are a class of plant specific transcription factors that involve in many stress response pathways. It has been shown that one Arabidopsis WRKY protein, AtWRKY29/22, is activated by MAP kinase signaling cascade and confers resistance to both bacterial and fungal pathogens. However, little is known about the biological roles of WRKY proteins in rice. In this study, we investigated the expression patterns of rice AtWRKY29/22 homolog, OsWRKY03, under different conditions, and also its possible role involved in plant defense. Our results showed that OsWRKY03 was up-regulated by several defense signaling molecules or different treatments. Further analysis revealed that the expres- sion of OsWRKY03 was light dependent. Transcriptional activation activity of OsWRKY03 was also demonstrated by yeast functional assay. Transient expression of OsWRKY03-GFP fusion protein in onion epidermis cells showed that OsWRKY03 was a nuclear localized protein. OsNPR1 as well as several other pathogenesis-related genes, such as OsPR1b, phenylalanine ammonia-lyase (ZB8) and peroxidase (POX22.3), were induced in OsWRKY03-overexpressing transgenic plants. These results indicated that OsWRKY03 is located upstream of OsNPR1 as a transcriptional activator in salicylic acid (SA)-dependent or jasmonic acid (JA)-dependent defense signaling cascades. | Xiao Qiang LIU Xian Quan BAI Qian QIAN Xiu Jie WANG Ming Sheng CHEN Cheng Cai CHU | 2005 | Cell Research2005，15，8： | 55 |
| 3 | Safety threshold of high-speed railway pier settlement based on train-track-bridge dynamic interaction显示文摘This paper presents a method to determine the safety threshold of bridge pier settlement in high-speed railways.An analytical expression of the mapping relationship between the pier settlement and the rail deformation is derived theoretically for the double block ballastless track-bridge system.By adopting the superposition of the track random irregularity and the rail deformation caused by the pier settlement as the excitation inputs,the variations of vehicle dynamics indices with pier settlement are comparatively analyzed.Then,the safety threshold of the bridge pier settlement is obtained according to the limit of vehicle running safety and ride comfort indices of the high-speed trains.Results show that the dynamics indices of different trains have different sensitivities to the pier settlement,and the train CRH2C is the most sensitive one among all the types of Chinese high-speed trains.When passing through the bridges in common span with pier settlement at the speed of 250–350 km/h,the trains suffer the low-frequency excitations,and the vertical acceleration of car body is most sensitive to the pier settlement of all the dynamics indices.When the car body vertical acceleration just exceeds the allowable limit,the critical settlement value is 23.4 mm,which is much bigger than the pier differential settlement limit in the current code for Chinese high-speed railways. | CHEN Zhao Wei ZHAI Wan Ming CAI Cheng Biao SUN Yu | 2015 | Science China(Technological Sciences)2015，58，2： | 26 |
| 4 | Comparison of Talaromyces marneffei Infection in Human Immunodeficiency Virus-positive and Human Immunodeficiency Virus-negative Patients from Fujian, China显示文摘 | Hong-Ru Li Shao-Xi Cai Yu-Sheng Chen Mei-E Yu Neng-Luan Xu Bao-Song Xie Ming Lin Xin-Lan Hu | 2016 | Chinese Medical Journal2016，，9： | 23 |
| 5 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 6 | Endoscopic Surgery versus External Ventricular Drainage Surgery for Severe Intraventricular Hemorrhage显示文摘The efficacy and applied value of endoscopic hematoma evacuation vs. external ventricular drainage (EVD) in the treatment of severe ventficular hemorrhage (IVH) were explored and compared.From Jan.2015 to Dec.2016,the clinical data of 42 cases of IVH were retrospectively analyzed,including 18 patients undergoing endoscopic hematoma evacuation (group A),and 24patients receiving EVD (group B).The hematoma clearance rate was calculated by 3D Slicer software,and complications and outcomes were compared between the two groups.There were no significant differences in age,sex and Graeb score between groups A and B (P>0.05).The hematoma clearance rate was 70.81%±27.64% in group A and 48.72%±36.58% in group B with a statistically significant difference (P<0.05).The operative time in groups A and B was 72.45±25.26 min and 28.54±15.27min,respectively (P<0.05).The Glasgow Coma Scale (GCS) score increased from 9.28±2.72 at baseline to 11.83±2.91 at 1 week postoperatively in group A,and from 8.25±2.62 at baseline to 10.79±4.12 at 1 week postoperatively in group B (P<0.05).The length of hospital stay was 12.67±5.97 days in group A and 17.33±8.91 days in group B with a statistically significant difference (P<0.05).The GOS scores at 6 months after surgery were 3.83±1.12 in group A,and 2.75±1.23 in group B (P<0.05). These results suggested that endoscopic hematoma evacuation has an advantage of a higher hematoma clearance rate,fewer complications and better outcomes in the treatment of severe IVH,indicating it is a safe,effective and promising approach for severe IVH. | Ping SONG Fa-liang DUAN Qiang CAI Jing-lei WU Xiao-bin CHEN Yuan WANG Cong-gang HUANG Ji-qiang LI Zhu-qiang HE Qiao-chun HUANG Mei LIU Yan-gao ZHANG Ming LUO | 2018 | Current Medical Science2018，38，5： | 21 |
| 7 | Intraoperative endoscopic sphincterotomy for common bile duct stones during laparoscopic cholecystectomy显示文摘INTRODUCTION The advent of laparoscopic cholecystectomy(LC)inthe late 1980s gained widespread acceptance withina short period of time and has become the preferredtreatment for symptomatic gallstones,but themanagement of coexisting gallbladder and commonbile duct(CBD)stones has remained controversialbecause the various strategies proposed have theirlimitations.In fact,choledocholithiasis | De Fei Hong Ming Gao Urs Bryner Xiu Jun Cai Yi Ping Mou | 2000 | World Journal of Gastroenterology2000，6，3： | 19 |
| 8 | Soil erosion along a long slope in the gentle hilly areas of black soil region in Northeast China显示文摘沿着在在在东北中国的黑土壤区域的轻轻的多山的区域的一个长斜坡的土壤侵蚀变化的特征被讨论。一个简化斜坡模型基于片断被用来分析在 Heshan 农场与不同斜坡长度在 10 个地阴谋上在 2003 和 2004 之间观察的流量数据和土壤侵蚀数据, Heilongjiang 省。我们发现土壤侵蚀在沿着斜坡或者改变的黑土壤区域在长斜坡上评价并且创造集中的侵蚀和星期侵蚀的其他的地区。每个地区的准确地方为不同降雨条件是不同的。在有更少和温和降水的一年里,小河不能发生在顶以内 50 m 在有大、集中的降水的一年里,小河能被形成从斜坡的顶甚至在 15 m 开始。 | CUI Ming CAI Qiangguo ZHU Axing FAN Haoming | 2007 | Journal of Geographical Sciences2007，17，3： | 18 |
| 9 | Depositional architecture and developing settings of large-scale incised valley and sub-marine gravity flow systems in the Yinggehai and Qiong-dongnan basins,South China Sea显示文摘In the Ying-Qiong basins in the South China Sea developed a set of giant inner shelf slope and submarine gravity flow deposits in the Ying-Huang formations since the Late Miocene. These deposits can be classified into 9 sequences in which slope slump-debris flow, slope fan and particularly, the large-scale axial basin-floor incised valley fills have been recognized. They were distributed in a distinctive pattern attributed to tectonic control. The development ofshelf slopes and abyssal plains in the basins was related to the last episode of rapid subsidence and a large amount of sediment inputs. Large-scale basin-floor incised valleys, formed during the late Miocene and Pliocene, indicate several major sea level falls that occurred in the South China Sea. | LIN Changsong LIU Jingyan CAI Shixiang ZHANG Yanmei LU Ming LI Jie | 2001 | Chinese Science Bulletin2001，46，8： | 18 |
| 10 | The Prevalence of Nonalcoholic Fatty Liver Disease and its Association with Lifestyle/dietary Habits among University Faculty and Staff in Chengdu显示文摘Objective To investigate the prevalence of nonalcoholic fatty liver disease(NAFLD) in different university categories and its association with lifestyle/dietary habits.Methods A cross-sectional study was carried out on 9 378 faculty members and staff who participated in an annual health checkup at three universities selected by random cluster sampling.Demographic,anthropometric,biochemical indices and abdominal ultrasound measurements were collected.A nested case-control study was conducted with 200 NAFLD cases and 200 controls matched by gender,age(±3 years),and university.Results The overall prevalence of NAFLD was 10.3%(13.7% in males and 6.8% in females).The prevalence was significantly higher in the science and engineering university(22.1%) than in the comprehensive universities with(6.4%) and without(10.9%) medical colleges.Obesity/overweight,hyperlipidemia,diabetes mellitus,and family history of NAFLD were independently associated with higher risk of NAFLD,as were frequent consumption of desserts and salty/spicy foods.Using nutritional supplements was a protective factor against NAFLD.Intake of coarse cereals,potatoes,vegetables,fruits,and milk was significantly lower,and intake of red meat,viscera,candies and pastries,cooking oil,and total energy was significantly higher in participants with NAFLD than in controls.Conclusion Science and engineering university faculty and staff are key targets for NAFLD prevention.NAFLD is closely associated with age,gender,university type,metabolic diseases,and lifestyle/dietary habits. | SHI Lei LIU Zhong Wu LI Yun GONG Cai ZHANG Huan SONG Li Juan HUANG Cheng Yu LI Ming | 2012 | Biomedical and Environmental Sciences2012，25，4： | 16 |
| 11 | Poultry Manure Compost Alleviates the Phytotoxicity of Soil Cadmium: Influence on Growth of Pakchoi (Brassica chinensis L.)显示文摘The growth performance of pakchoi (Brassica chinensis L.) in relation to soil cadmium (Cd) fractionations was investigated to evaluate the remediating effect of poultry manure compost on Cd-contaminated soil. A yellow-brown soil (Alfisol) treated with various levels of Cd (0–50 mg Cd kg-1 soil) was amended with increasing amounts of compost from 0 to 120 g kg-1 . Compost application transformed 47.8%–69.8% of soluble/exchangeable Cd to the organic-bound fraction, and consequently decreased Cd uptake of pakchoi by 56.2%–62.5% as compared with unamended soil. Alleviation of Cd bioavailability by compost was attributed primarily to the increase of soil pH and complexation of Cd by organic matter including dissolved organic matter. In general, the improvement of pakchoi performance was more pronounced in higher Cd-contaminated soil. Addition of large amount of compost also favored the anti-oxidative capability of pakchoi against Cd toxicity. This low cost remediation method seems to be very effective in the restoration of Cd-contaminated soils. | CHEN Han-Song HUANG Qiao-Yun LIU Li-Na CAI Peng LIANG Wei LI Ming | 2010 | Pedosphere2010，20，1： | 14 |
| 12 | Colorectal cancer incidence and mortality:the current status,temporal trends and their attributable risk factors in 60 countries in 2000–2019显示文摘Background:Globally,colorectal cancer(CRC)imposes a substantial burden on healthcare systems and confers considerable medical expenditures.We aimed to evaluate the global and regional burden in epidemiological trends and factors associated with the incidence and mortality of CRC.Methods:We used data from the GLOBOCAN database to estimate CRC incidence and mortality worldwide in 2020 and their association with the human development index(HDI).Trends of age-standardized rates of incidence and mortality in 60 countries(2000–2019)were evaluated by Joinpoint regression analysis using data of Global Burden of Disease 2019.The association between exposure to country-level lifestyle,metabolic and socioeconomic factors obtained from the World Health Organization Global Health Observatory and World Bank DataBank data and CRC incidence and mortality was determined by multivariable linear regression.Results:CRC incidence and mortality varied greatly in the 60 selected countries,and much higher incidence and mortality were observed in countries with higher HDIs,and vice versa.From 2000 to 2019,significant increases of incidence and mortality were observed for 33 countries(average annual percent changes[AAPCs],0.24–3.82)and 18 countries(AAPCs,0.41–2.22),respectively.A stronger increase in incidence was observed among males(AAPCs,0.36–4.54)and individuals<50 years(AAPCs,0.56–3.86).Notably,15 countries showed significant decreases in both incidence(AAPCs,0.24 to2.19)and mortality(AAPCs,0.84 to2.74).A significant increase of incidence among individuals<50 years was observed in 30 countries(AAPCs,0.28–3.62).Countries with higher incidence were more likely to have a higher prevalence of alcohol drinking,higher level of cholesterol level,higher level of unemployment,and a poorer healthcare system.Conclusions:Some high-HDI countries showed decreasing trends in CRC incidence and mortality,whereas developing countries that previously had low disease burden showed significantly increased incidence and mortality trends,especially in males and populations≥50 years,which require targeted preventive health programs. | Bin Lu Na Li Chen-Yu Luo Jie Cai Ming Lu Yu-Han Zhang Hong-Da Chen Min Dai | 2021 | Chinese Medical Journal2021，，16： | 13 |
| 13 | Methane and Nitrous Oxide Emissions from Rice-Duck and Rice-Fish Complex Ecosystems and the Evaluation of Their Economic Significance显示文摘Rice-duck (RD) and rice-fish (RF) ecological systems are major complex planting and breeding models of rice paddy fields in southern China. Studying the methane (CH4) and nitrous oxide (N2O) emissions and their economic value from these two ecosystems can provide theoretical and practical basis for further development and utilization of these classical agricultural techniques. CH4 and N2O emissions from RD and RF ecological systems were measured in situ by using static chambers technique. Using global warming potentials (GWPs), we assessed the greenhouse effect of CH4 and N2O and their economic value. Results showed that the peaks of CH4 emission fluxes from RD and RF appeared at full tillering stage and at heading stage, and the average emission fluxes were significantly (P < 0.05) lower than that from CK. N2O fluxes remained low when the field is flooded and high after draining the water. Compared with CK, the total amount of N2O emissions was significantly (P < 0.05) higher and slightly lower than those from RD and RF, respectively. In 2006 and 2007, the total greenhouse effect of CH4 and N2O from RD and RF were 4 728.3 and 4 611 kg CO2 ha-1, 4 545 and 4 754.3 kg CO2 ha-1, respectively. The costs of greenhouse effect were 970.89 and 946.81 RMB yuan ha-1, and 933.25 and 976.23 RMB yuan ha-1, respectively, which were significant lower than those from CK (5 997.6 and 5 391.5 RMB yuan ha-1). Except for the environment cost of CH4 and N2O, the economic benefits from RD and RF were 2 210.64 and 4 881.92 RMB yuan ha-1; 3 798.37 and 5 310.64 RMB yuan ha-1, respectively, higher than those from CK. Therefore, RD and RF complex ecological planting and breeding models can effectively decrease and control CH4 and N2O emissions, and they are two of the effective strategies to reduce greenhouse gases from rice paddy fields and contribute in alleviating global warming. Thus, their adoption is important to the environment together with their economy benefits. | YUAN Wei-ling CAO Cou-gui LI Cheng-fang ZHAN Ming CAI Ming-li WANG Jin-ping | 2009 | Agricultural Sciences in China2009，8，10： | 13 |
| 14 | Molecular Typing of Leptospira interrogans Strains Isolated from Rattus tanezumi in Guizhou Province,Southwest of China显示文摘Objective To identify and type three leptospires isolated from Rattus tanezumi in Guizhou Province by using three molecular techniques (PFGE, MLVA, and MLST), reveal the molecular characteristic of causative agents of local leptospirosis and evaluate these three molecular methods based on their detection resolution and efficiency. Methods Three Leptospira strains were isolated from the kidney of Rattus tanezumi and cultured with EMJH medium. PFGE, MLVA, and MLST assays were applied to type the three strains isolated from Rattus tanezumi in Guizhou Province. Results PFGE, MLVA, and MLST typing showed that the three leptospiral isolates matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai. The findings of the genotyping methods were consistent. MLVA and MLST defined genotypes, whereas PFGE allowed the recognition of additional subgroups within the genotypes, and the findings of molecular typing were also consistent with those of traditional techniques. Conclusion Three leptospiral isolates from Guizhou Province matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai, and PFGE, MLVA, and MLST, as reliable molecular techniques for identifying and typing of Leptospira interrogans, would contribute to the active surveillance, outbreak investigation and source tracking for leptospirosis in Guizhou Province. | LI Shi Jun ZHANG Cui Cai LI Xiu Wen TIAN Ke Cheng TANG Guang Peng WANG Ding Ming LIU Ying NIE Yi Xin JIANG Xiu Gao | 2012 | Biomedical and Environmental Sciences2012，25，5： | 12 |
| 15 | 平流层-对流层相互作用研究进展:等熵位涡理论的应用及青藏高原影响显示文摘系统介绍了近年来应用等熵位涡理论研究平流层-对流层动力相互作用所发现的一些新的事实和机理,包括平流层冬季极涡振荡过程中平流层、对流层环流异常的时空传播特征,以及等熵质量理论框架下的平流层-对流层动力耦合机理,还介绍了影响平流层环流年际尺度异常的因子及影响过程。回顾了夏季青藏高原的热力作用所激发的负位涡强迫源对东亚及全球大气环流的影响。并基于对夏季高原周边等熵位涡经向输送垂直分布的诊断进一步说明,夏季青藏高原的存在使高原东缘及东亚地区成为平流层和对流层物质交换的独特区域,探讨了夏季青藏高原影响平流层-对流层动力耦合的一种重要途径及其影响全球气候的重要意义。 | 任荣彩 吴国雄 CAI Ming 孙舒悦 刘新 李伟平 | 2014 | 气象学报2014，72，5： | 12 |
| 16 | Biocatalytic synthesis of (R)-(-)-mandelic acid from racemic mandelonitrile by a newly isolated nitrilase-producer Alcaligenes sp. ECU0401显示文摘By using acetonitrile as the sole nitrogen source, a microbial strain with high nitrilase activity, named as Alcaligenes sp. ECU0401, was newly isolated from soil, which could enantioselectively transform racemic mandelonitrile into (R)-(-)-mandelic acid, with an enantiomeric excess of >99.9%. | Yu Cai He Jian He Xu Yi Xu Li Ming Ouyang Jiang Pan | 2007 | Chinese Chemical Letters2007，18，6： | 12 |
| 17 | Neuroprotective effects of Ginkgo biloba extract and GinkgoUde B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model显示文摘 | Xiaohan Yang Tiezheng Zheng Hao Hong Nan Cai Xiaofeng Zhou Changkai Sun Liying Wu Shuhong Liu Yongqi Zhao Lingling Zhu Ming Fan Xuezhong Zhou Fengxie Jin | 2018 | Frontiers of Medicine2018，12，3： | 12 |
| 18 | Polar Vortex Oscillation Viewed in an Isentropic Potential Vorticity Coordinate显示文摘在北半球的同温层的极的旋涡摆动(PVO ) 在使用地图从从 1979 ~ 2003 盖住时期的 NCEP/NCAR 分析 II 数据集导出的每日的 isentropic 潜力涡度构造的一个 semi-Lagrangian θ-PVLAT 坐标被检验。在 semi-Lagrangian θ-PVLAT 坐标,因为在它的地点和形状的变化将由 isentropic 表面上的后面的潜在的涡度轮廓自然地是不在的,极的旋涡的可变性完全被归因于它的紧张变化。文件结束和回归分析显示 PVO 能被一双杆病房和向下宣传的模式描述。这二个模式一起在全部北半球上说明每天潜在的涡度异例的大约 82% 变化。力量光谱分析在这二个模式的时间系列揭示大约 107 天的主导的时间规模,代表一个完全的 PVO 周期与杆病房宣传伴随了从赤道加热积极、否定的符号的异例到杆。强壮的极的旋涡在极的圆上并且反过来也如此对应于冷异例的到达。与杆病房繁殖伴随了一同时向下繁殖。向下繁殖时间规模是在高、低的纬度并且大约的大约 20 天 30 天在中间纬度。带的风异例落后杆病房和反面的向下宣传的温度异例在低、高的纬度并且到 20 天到 10 天签到中间纬度。主导的时间 8.7, 16.9,和 33.8 个月放大的模式也展出的领先的文件结束的时间系列。他们近似跟随一个双频率序列并且对应于 3 山峰热带以外的伪二年的摆动(QBO ) 信号。 | 任荣彩 Ming CAI | 2006 | Advances in Atmospheric Sciences2006，23，6： | 12 |
| 19 | The therapeutic effects of recombinant adenovirus RA538 on human gastric carcinoma cells in vitro and in vivo显示文摘AIM To evaluate the potential of RA-538 genetherapy for gastric carcinoma.METHODS Human gastric carcinoma cell lineSGC7901 treated with Ad-RA538 or Ad-LacZ wereanalysed by X-gal stain,MTT,DNA ladder,Tunel,flow cytometric analysis,PCR,andWestern Blot in vitro.The tumorigenicity andexperimental therapy in nude mice model wereassessed in vivo.RESULTS Ad-LacZ could efficiently transferthe LacZ gene into SGC7901 cells.X-gal-positivecells at MOI 25,50,100,and 200 were 90%,100%,100%,and 100% respectively.Ad-RA538could strongly inhibit cell growth and inducedapoptosis in SGC7901 cells.The proliferation ofthe Ad-RA538-infected SGC7901 cells wasreduced by 76.3%.The mechanism of killing ofgastric carcinoma cells by Ad-RA538 was foundto be apoptosis by DNA ladder,Tunel and flowcytometric analysis.The tumorigenicity in nudemice using Ad-RA538 showed that all three micefailed to form tumor from 7 to 30 days comparedwith Ad-LacZ and parent SGC7901 cells.Experimental therapy on the nude mice modelbearing subcutaneous tumor of SGC790| cells showed that intratumor instillation of Ad-RA538inhibited the growth of the tumors.Ad-RA538-treated tumors were inhibited by 60.66 %,compared with that of the tumor injected withAd-LacZ and mock.CONCLUSION The expression of Ad-RA538 can inhibit growth and induce apoptosis of gastric cancer cell in vitro and in vivo. Ad-RA538 can be used potentially in gene therapy for gastric carcinoma. | Jie Ping Chen Chen Lin Cai Pu Xu Xue Yan Zhang Ming Wu | 2000 | World Journal of Gastroenterology2000，6，6： | 12 |
| 20 | Analysis of rockburst in tunnels subjected to static and dynamic loads显示文摘The presence of geological structures such as faults, joints, and dykes has been observed near excavation boundaries in many rockburst case histories. In this paper, the role of discontinuities around tunnels in rockburst occurrence was studied. For this purpose, the Abaqus explicit code was used to simulate dynamic rock failure in deep tunnels. Material heterogeneity was considered using Python scripting in Abaqus. Rockbursts near fault regions in deep tunnels under static and dynamic loads were studied.Several tunnel models with and without faults were built and static and dynamic loads were used to simulate rock failure. The velocity and the released kinetic energy of failed rocks, the failure zone around the tunnel, and the deformed mesh were studied to identify stable and unstable rock failures. Compared with models without discontinuities, the results showed that the velocity and the released kinetic energy of failed rocks were higher, the failure zone around the tunnel was larger, and the mesh was more deformed in the models with discontinuities, indicating that rock failure in the models with discontinuities was more violent. The modeling results confirm that the presence of geological structures in the vicinity of deep excavations could be one of the major influence factors for the occurrence of rockburst. It can explain localized rockburst occurrence in civil tunnels and mining drifts. The presented methodology in this paper for rockburst analysis can be useful for rockburst anticipation and control during mining and tunneling in highly stressed ground. | Amin Manouchehrian Ming Cai | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，6： | 12 |
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