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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Diversity characterization and association analysis of agronomic traits in a Chinese peanut (Arachis hypogaea L.) mini-core collection显示文摘Association mapping is a powerful approach for exploring the molecular basis of phenotypic variations in plants.A peanut(Arachis hypogaea L.)mini-core collection in China comprising 298 accessions was genotyped using 109 simple sequence repeat(SSR)markers,which identified 554 SSR alleles and phenotyped for 15 agronomic traits in three different environments,exhibiting abundant genetic and phenotypic diversity within the panel.A model-based structure analysis assigned all accessions to three groups.Most of the accessions had the relative kinship of less than 0.05,indicating that there were no or weak relationships between accessions of the mini-core collection.For 15 agronomic traits in the peanut panel,generally the Q t K model exhibited the best performance to eliminate the false associated positives compared to the Q model and the general linear model-simple model.In total,89SSR alleles were identified to be associated with 15 agronomic traits of three environments by the Q t K model-based association analysis.Of these,eight alleles were repeatedly detected in two or three environments,and 15 alleles were commonly detected to be associated with multiple agronomic traits.Simple sequence repeat allelic effects confirmed significant differences between different genotypes of these repeatedly detected markers.Our results demonstrate the great potential of integrating the association analysis and marker-assisted breeding by utilizing the peanut mini-core collection. | Huifang Jiang Li Huang Xiaoping Ren Yuning Chen Xiaojing Zhou Youlin Xia Jiaquan Huang Yong Lei Liying Yan Liyun Wan Boshou Liao | 2014 | Journal of Integrative Plant Biology2014，56，2： | 14 |
| 3 | Solid rocket motor propellant grain burnback simulation based on fast minimum distance function calculation and improved marching tetrahedron method显示文摘To efficiently compute arbitrary propellant grain evolution of the burning surface with uniform and non-uniform burning rate for solid rocket motor,a unified framework of burning surface regression simulation has been developed based on minimum distance function.In order to speed up the computation of the mini-mum distance between grid nodes of grain and the triangular mesh of burning surface,a fast distance querying method based on the equal size cube voxel structure was employed.An improved marching tetrahedron method based on piecewise linear approximation was carried out on second-order tetrahedral elements,achieved high-efficiency and adequate accuracy of burning surface extraction simultaneously.The cases of star grain,finocyl grain,and non-uniform tube grain were studied to verify the proposed method.The observed result indicates that the grain burnback computation method could realize the accurate simulation on unstructured tetrahedral mesh with a desirable performance on computational time. | Pengfei REN Hongbo WANG Guofeng ZHOU Jiani LI Qiang CAI Jiaquan YU Ya YUAN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 2 |
| 4 | Immunosup-pressive pregnane glycosides from Periploca sepium and Periploca forrestii 显示文摘 | Jiaquan Feng Rujun Zhang Yu Zhou | 2008 | Phytochemistry2008，8，： | 1 |
| 5 | Prediction of multicomponent adsorption equilibrium of gas mixtures including supercritical components显示文摘 | Li Zhou Jiaquan Wu Ming Li Qin Wu Yaping Zhou | 2005 | Chemical Engineering Science2005，，11： | 1 |
| 6 | Structural landscape investigations on bendable plastic crystals of isonicotinamide polymorphs显示文摘Three polymorphs(forms I,II and V)of isonicotinamide(INA)were mechanically flexible and exhibited one-dimensional(1 D)plasticity.Anisotropic intermolecular interactions contribute to the plasticity of single crystals:weak dispersive interactions between slip planes such as 1 D columns in forms I and II or 2 D layers in form V were stabilized by strong hydrogen bonds,allowing the layer or column's surface to glide smoothly without hindrance.The disparity of intermolecular interactions on plastic properties of INA polymorphic crystals was confirmed by energy framework analysis,nanoindentation tests and micro-Raman spectroscopy.The crystal which exhibits plastic property provides a promising application in pharmaceuticals and material sciences. | Jianting Li Jiaquan Li Hongji Liu Li Zhang Yang Lu Zhengzheng Zhou | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 7 | Research on Precipitation Prediction Model Based on Extreme Learning Machine Ensemble显示文摘Precipitation is a significant index to measure the degree of drought and flood in a region,which directly reflects the local natural changes and ecological environment.It is very important to grasp the change characteristics and law of precipitation accurately for effectively reducing disaster loss and maintaining the stable development of a social economy.In order to accurately predict precipitation,a new precipitation prediction model based on extreme learning machine ensemble(ELME)is proposed.The integrated model is based on the extreme learning machine(ELM)with different kernel functions and supporting parameters,and the submodel with the minimum root mean square error(RMSE)is found to fit the test data.Due to the complex mechanism and factors affecting precipitation change,the data have strong uncertainty and significant nonlinear variation characteristics.The mean generating function(MGF)is used to generate the continuation factor matrix,and the principal component analysis technique is employed to reduce the dimension of the continuation matrix,and the effective data features are extracted.Finally,the ELME prediction model is established by using the precipitation data of Liuzhou city from 1951 to 2021 in June,July and August,and a comparative experiment is carried out by using ELM,long-term and short-term memory neural network(LSTM)and back propagation neural network based on genetic algorithm(GA-BP).The experimental results show that the prediction accuracy of the proposed method is significantly higher than that of other models,and it has high stability and reliability,which provides a reliable method for precipitation prediction. | Xing Zhang Jiaquan Zhou Jiansheng Wu Lingmei Wu Liqiang Zhang | 2023 | Journal of Computer Science Research2023，5，1： | 0 |
| 8 | Molecular characterization of a peanut variety and its derivatives based on SSR and COP analysis显示文摘 | Xiaoping REN Huifang JIANG Zhongyuan YUAN Yuning CHEN Xiaojing ZHOU Li HUANG Jiaquan HUANG Yong LEI Liying YAN Boshou LIAO | 2016 | Oil Crop Science2016，1，2： | 0 |
| 9 | Gomparative analysis of DGAT3(diacylglycerol acyltraiisferase 3) gene from different peanut (Arachis hypogaea L.) varieties显示文摘 | Xiaoping Ren Yanli Zheng Xiaojing Zhou Yuning Chen Li Huang Xiangguo Jiang Guobin Xiao Yong Lei Liying Yan Jiaquan Huang Huifang Jiang Boshou Liao | 2016 | Oil Crop Science2016，1，4： | 0 |
| 10 | The molecular mechanisms of plasticity in crystal forms of theophylline显示文摘Plastic and elastic behaviors of organic crystals have profound influence on the processability of pharmaceutical substances.Analogous to metals,the identifications of molecular slip planes in organic crystals are regarded as a strategy for harnessing plasticity.In this work,we experimentally characterized the form II anhydrous theophylline(THPa)and its monohydrate(THPm)for their distinct plastic and elastic behaviors.Extensive DFT calculations were performed to model the effects of increasing lattice strains on molecular packing.We discovered that the energy barrier associated with the strain-induced molecular rearrangement would link to the plasticity of THPa,and possibly other simple aromatic compounds.Meanwhile,water molecules in THPm disrupt the stacking architecture from THPm and effectively undermine the general mechanism for plasticity.Hydrate formation would therefore be an alternative strategy to engineer the mechanical property of organic crystalline materials. | Hongji Liu H.C.Stephen Chan Li Zhang Yang Lu Jiaquan Li Jianting Li Liang Li Zhengzheng Zhou | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
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