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| 1 | Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells显示文摘人的 pluripotent 干细胞代表功能的胰腺的内分泌的系房间的潜在地无限的来源。这里,我们报导一条高度有效的途径导致人的胚胎的茎(ES ) 细胞和导致的 pluripotent 茎(iPS ) 在一个定义化学药品的文化系统区分进成熟生产胰岛素的细胞的细胞。这条途径获得的区分的人的 ES 房间由流动 cytometry 分析作为 assayed 包括了将近 25% 胰岛素积极的房间,它以比得上成年人的小岛的一种方式响应葡萄糖刺激释放了 insulin/C-peptide。大多数这些生产胰岛素的房间共同表示成熟尾房间特定的标记象 NKX6-1 和 PDX1 那样,在 vivo 显示一个类似的基因表示模式到成年小岛尾房间。在这研究,我们也证明 EGF 便于 PDX1 积极的胰腺的祖先的扩大。而且,我们的协议也成功了高效地导致人的 iPS 房间区分进生产胰岛素的房间。因此,这个工作不仅提供一个新模型在 vitro 学习人的胰腺的专门化和成熟的机制,而且提高为糖尿病的处理利用病人特定的 iPS 房间的可能性。 | Donghui Zhang Wei Jiang Meng Liu Xin Sui Xiaolei Yin Song Chen Yan Shi Hongkui Deng | 2009 | Cell Research2009，19，4： | 90 |
| 2 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 3 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 4 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 5 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 6 | Latest research advances on magnesium and magnesium alloys worldwide显示文摘In the past two years,significant progresses have been achieved in high-performance cast and wrought magnesium and magnesium alloys,magnesium-based composites,advanced cast technologies,advanced processing technologies,and functional magnesium materials,such as Mg ion batteries,hydrogen storage Mg materials,bio-magnesium alloys,etc.Great contributions to the development of new magnesium alloys and their processing technologies have been made by Chongqing University,Shanghai Jiaotong University,Chinese Academy of Sciences,Helmholtz Zentrum Geesthacht,Queensland University,Brunel University,etc.This review paper is aimed to summarize the latest important advances in cast magnesium alloys,wrought magnesium alloys and functional magnesium materials worldwide in 2018–2019,including both the development of new materials and the innovation of their processing technologies.Based on the issues and challenges identified here,some future research directions are suggested,including further development of high-performance magnesium alloys having high strength and superior plasticity together with high corrosion resistance and low cost,and fundamental research on the phase diagram,diffusion,precipitation,etc.,as well as the development of advanced welding and joining technology. | Jiangfeng Song Jia She Daolun Chen Fusheng Pan | 2020 | Journal of Magnesium and Alloys2020，8，1： | 132 |
| 7 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 8 | Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death显示文摘混合的系 kinase 像域的蛋白质(MLKL ) 被识别受体交往下游地工作蛋白质 3 (RIP3 ) 在肿瘤坏死 factor-α(TNF ) 导致了坏死(也叫的 necroptosis ) 。然而, MLKL 怎么工作调停 necroptosis 是未知的。由在 MLKL 大美人房间的 MLKL 功能的宪法,我们证明 MLKL 的 N 终点在 necroptosis 为它的功能被要求。在对待 TNF 的房间的 MLKL 的 oligomerization 为 necroptosis 是必要的,当人工地由使用荷尔蒙绑定领域一起强迫 MLKL (HBD*) 扳机 necroptosis。尤其是,一起强迫 N 终端领域(ND ) 然而并非 MLKL 的 C 终端 kinase 领域引起 necroptosis。进一步的删除分析证明 four-α MLKL (1-130 氨基酸) 的螺旋捆是足够的触发 necroptosis。两 HBD*调停并且 MLKL (ND ) 或 MLKL 的导致 TNF 的建筑群是到血浆膜的类脂化合物椽子的这些建筑群的 tetramers,和 translocation 先于房间死亡。homo-oligomerization 为 MLKL translocation 被要求,为血浆膜地点的信号顺序位于第一和第二 α 的连接; MLKL 的 -helices。MLKL 或 MLKL (ND ) 的血浆膜 translocation 导致钠流入,并且从房间文化媒介的钠的弄空禁止 necroptosis。上述所有现象没在 apoptosis 被看见。因此, MLKL oligomerization 导致 MLKL 的 translocation 到血浆膜,和血浆膜的类脂化合物椽子由自己或经由到增加的另外的蛋白质的 MLKL 复杂行为任何一个钠流入,增加渗透的压力,最后导致膜破裂。 | Xin Chen Wenjuan Li Junming Ren Deli Huang Wan-ting He Yunlong Song Chao Yang Wanyun Li Xinru Zheng PengdaChen Jiahuai Han | 2014 | Cell Research2014，24，1： | 67 |
| 9 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 10 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 11 | Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China显示文摘Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged. | Zhiliang Hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin Hu Yongxiang Yi Hongbing Shen | 2020 | Science China(Life Sciences)2020，63，5： | 77 |
| 12 | Synthesis and paste properties of octenyl succinic anhydride modified early Indica rice starch显示文摘Octenyl succinic anhydride (OSA) modified early Indica rice starch was prepared in aqueous slurry systems using response surface methodology. The paste properties of the OSA starch were also investigated. Results indicated that the suitable parameters for the preparation of OSA starch from early Indica rice starch were as follows: reaction period 4 h, reaction tem- perature 33.4 °C, pH of reaction system 8.4, concentration of starch slurry 36.8% (in proportion to water, w/w), amount of OSA 3% (in proportion to starch, w/w). The degree of substitution was 0.0188 and the reaction efficiency was 81.0%. The results of paste properties showed that with increased OSA modification, the starch derivatives had higher paste clarity, decreased retro- gradation and better freeze-thaw stability. | SONG Xiao-yan CHEN Qi-he RUAN Hui HE Guo-qing XU Qiong | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，10： | 51 |
| 13 | Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro显示文摘Bckground 干细胞,有能力区分进生产胰岛素的房间(欧洲电脑生产厂商) ,将为移植提供小岛房间的潜在地无限的来源并且减轻可获得性和 allogeneic 拒绝的主要限制。因此,干细胞的利用为糖尿病 mellitus (DM ) 正在成为最有希望的治疗。这里,我们学习了糖尿病的病人的骨头的区别能力导出髓的间充质的干细胞( MSC )并且测试了使用 MSC 的可行性因为房间 replacement.Methods 骨头导出髓的 MSC 从 10 个 DM 病人被获得( 5 打 1 DM , 5 打 2 DM )并且在一个三阶段的协议下面导致了到欧洲电脑生产厂商。MSC 的代表性的房间表面抗原表示侧面被流动 cytometric 分析分析。反向的抄写聚合酶链反应(RT-PCR ) 被执行检测与胰腺的房间开发和功能有关的多重基因。欧洲电脑生产厂商的身份被形态学, ditizone 染色和 immunocytochemistry 的分析说明。由这些房间的胰岛素的版本被 MSC 的 immunoradioassay.Results 流动 cytometric 分析在 3 显示出的经过证实这些房间表示了 CD29 (98.28%) 的高水平, CD44 (99.56%) 和 CD106 (98.34%) 。典型像小岛的房间簇在协议(18 天) 的结束被观察。染色的 Ditizone 和为胰岛素的 immunohistochemistry 两个都是积极的。在舞台 2 点的这些区分的房间(10 天) 表示了 nestin,胰腺的十二指肠的 homeobox-1 (PDX-1 ) , Neurogenin3, Pax4,胰岛素, glucagon,但是(18 天) 在舞台 3 点,我们观察了 PDX-1 的高表示,胰岛素, glucagon。胰岛素被这些房间以从 DM 病人的 .Conclusions 骨头导出髓的 MSC 能在 vitro 在某些条件下面区分进功能的欧洲电脑生产厂商的一种调整方式(P0.05 ) 响应葡萄糖刺激的不同集中分泌。用糖尿病的病人的自己的骨头,导出髓的 MSC 将作为为房间代替的自体同源的欧洲电脑生产厂商的来源是可行的。 | SUN Yu CHEN Li HOU Xin-guo HOU Wei-kai DONG Jian-jun SUN Lei TANG Kuan-xiao WANG Bin SONG Jun LI Hui WANG Ke-xin | 2007 | Chinese Medical Journal2007，，9： | 57 |
| 14 | Heavy metal pollution of soils and vegetables in the midstream and downstream of the Xiangjiang River, Hunan Province显示文摘219 农业土壤和 48 件蔬菜样品的一个总数在湖南省 Xiangjiang 河(Hengyang 长沙节) 从中流并且下游地被收集。累积特征。 | WANG Lixia GUO Zhaohui XIAO Xiyuan CHEN Tongbin LIAO Xiaoyong SONG Jie WU Bin | 2008 | Journal of Geographical Sciences2008，18，3： | 56 |
| 15 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 16 | Oral microbiomes: more and more importance in oral cavity and whole body显示文摘微生物在人的生活的每个角落出现,并且微生物影响人的生活的每个方面。人的口头的洞包含很多个不同产地。可变口头的微生物的协同作用和相互作用在外面对不受欢迎的刺激的侵略帮助人的身体。然而,微生物引起的植物群的不平衡贡献口头的疾病和全身的疾病。口头的 microbiomes 玩在人的微生物引起的社区和人的健康的一个重要角色。最近的使用开发了分子的方法极大地处于健康和疾病扩展了我们作文的知识和口头的 microbiome 的功能。在有在可变身体地点和可变健康状况的 microbiomes 的口头的 microbiomes 和他们的相互作用的研究在我们我们的身体的认知是批评的并且怎么在人的健康上做效果改进。 | Lu Gao Tiansong Xu Gang Huang Song Jiang Yan Gu Feng Chen | 2018 | Protein & Cell2018，9，5： | 55 |
| 17 | Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients显示文摘Background:A patient’s infectivity is determined by the presence of the virus in different body fluids,secretions,and excreta.The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease(COVID-19)remain unclear.This study analyzed the clearance time and factors influencing 2019 novel coronavirus(2019-nCoV)RNA in different samples from patients with COVID-19,providing further evidence to improve the management of patients during convalescence.Methods:The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20,2020 to February 10,2020 were collected retrospectively.The reverse transcription polymerase chain reaction(RT-PCR)results for patients’oropharyngeal swab,stool,urine,and serum samples were collected and analyzed.Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive(minimum 24 h sampling interval)negative RT-PCR results for viral RNA from oropharyngeal swabs.The effects of cluster of differentiation 4(CD4)+T lymphocytes,inflammatory indicators,and glucocorticoid treatment on viral nucleic acid clearance were analyzed.Results:In the 292 confirmed cases,66 patients recovered after treatment and were included in our study.In total,28(42.4%)women and 38 men(57.6%)with a median age of 44.0(34.0-62.0)years were analyzed.After in-hospital treatment,patients’inflammatory indicators decreased with improved clinical condition.The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5(6.0-11.0)days.By February 10,2020,11 convalescent patients(16.7%)still tested positive for viral RNA from stool specimens and the other 55 patients’stool specimens were negative for 2019-nCoV following a median duration of 11.0(9.0-16.0)days after symptom onset.Among these 55 patients,43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs,with a median delay of 2.0(1.0-4.0)days.Results for only four(6.9%)urine samples were positive for viral nucleic acid out of 58 cases;viral RNA was still present in three patients’urine specimens after throat swabs were negative.Using a multiple linear regression model(F=2.669,P=0.044,and adjusted R2=0.122),the analysis showed that the CD4+T lymphocyte count may help predict the duration of viral RNA detection in patients’stools(t=-2.699,P=0.010).The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(15 days vs.8.0 days,respectively;t=2.550,P=0.013)and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(20 days vs.11 days,respectively;t=4.631,P<0.001).There was no statistically significant difference in inflammatory indicators between patients with positive fecal viral RNA test results and those with negative results(P>0.05).Conclusions:In brief,as the clearance of viral RNA in patients’stools was delayed compared to that in oropharyngeal swabs,it is important to identify viral RNA in feces during convalescence.Because of the delayed clearance of viral RNA in the glucocorticoid treatment group,glucocorticoids are not recommended in the treatment of COVID-19,especially for mild disease.The duration of RNA detection may relate to host cell immunity. | Yun Ling Shui-Bao Xu Yi-Xiao Lin Di Tian Zhao-Qin Zhu Fa-Hui Dai Fan Wu Zhi-Gang Song Wei Huang Jun Chen Bi-Jie Hu Sheng Wang En-Qiang Mao Lei Zhu Wen-Hong Zhang Hong-Zhou Lu | 2020 | Chinese Medical Journal2020，，9： | 58 |
| 18 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 19 | Paleogene-Neogene stratigraphic realm and sedimentary sequence of the Qinghai-Tibet Plateau and their response to uplift of the plateau显示文摘Based on the data of 1:250000 geological mapping completed by CGS and the previous literature of the Cenozoic strata, 98 remnant basins and 5 stratigraphic realms with 13 stratigraphic subrealms have been recognized on the Qinghai-Tibet Plateau and its adjacent area. Through the research of the types of remnant basins, tectonic setting, stratigraphic sequence and sedimentary characteristics, contact relationship between the strata, the formation time and evolution history of sediments, we divided the uplift process and sedimentary response of the Qinghai-Tibet Plateau into 3 stages and 8 sub-stages, namely, subduction-collision uplift stage (65-34 Ma) with three sub-stages, intercontinental convergence and compressive uplift stage (34-13 Ma) with three sub-stages, and intercontinental isostatic adjustment uplift stage (since 13 Ma) with two sub-stages. | ZHANG KeXin WANG GuoCan JI JunLiang LUO ManSheng KOU XiaoHu WANG YueMing XU YaDong CHEN FenNing CHEN RuiMing SONG BoWen ZHANG JianYu LIANG YinPing | 2010 | Science China Earth Sciences2010，53，9： | 49 |
| 20 | Review:Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier显示文摘Acute pancreatitis (AP) is a common acute abdomen in clinic with a rapid onset and dangerous pathogenetic condition. AP can cause an injury of intestinal mucosa barrier, leading to translocation of bacteria or endotoxin through multiple routes, bacterial translocation (BT), gutorigin endotoxaemia, and secondary infection of pancreatic tissue, and then cause systemic in- flammatory response syndrome (SIRS) or multiple organ dysfunction syndrome (MODS), which are important factors influencing AP’s severity and mortality. Meanwhile, the injury of intestinal mucosa barrier plays a key role in AP’s process. Therefore, it is clinically important to study the relationship between the injury of intestinal mucosa barrier and AP. In addition, many factors such as microcirculation disturbance, ischemical reperfusion injury, excessive release of inflammatory mediators and apoptosis may also play important roles in the damage of intestinal mucosa barrier. In this review, we summarize studies on mechanisms of AP. | ZHANG Xi-ping ZHANG Jie SONG Qiao-ling CHEN Han-qin | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，12： | 44 |
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