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| 1 | Protective effects of effective ingredients of Danshen (Radix Salviae Miltiorrhizae)and Honghua (Flos Carthami)compatibility after rat hippocampal neurons induced by hypoxia injury显示文摘OBJECTIVE: To investigate the effective ingredients of Danshen(Radix Salviae Miltiorrhizae) and Honghua(Flos Carthami)(Danhong) on protective properties towards neonatal rat hippocampal neurons under hypoxia condition.METHODS: Primary culture of neonatal rat hippocampal neurons was used to model hypoxia damage on the hippocampus. Methyl thiazolyl tetrazolium(MTT) assay and preliminary experiments were conducted to identify the four effective ingredients of Danhong, along with the injection of positive drug onto hippocampal neurons at a non-toxic dosage level. The cultured cells were randomly divided into 12 groups: the normal group, model group,positive drug control group and nine compatibility groups of the four effective ingredients. Different test methods were applied to determine lactate dehydrogenasein(LDH), total superoxide dismutase(T-SOD), malondialdehyde(MDA), 6-keto prostaglandin F_(la)(6-keto-PGF_(1 a)), thromboxane B_2(TXB_2),mitochondrial membrane potential(MMP), free calcium ions concentration([Ca^(2 +)]i) and early onsetcell apoptosis.RESULTS: Different compatibility groups could inhibit the content of LDH and intracellular calcium overload, increase activity in T-SOD, decrease level of MDA and TXB2, improve level of 6-keto-PGF1 aand MMP, and prevent the early onset cell apoptosis.CONCLUSION: The compatibility of four effective ingredients of Danhong had protective effect toward hippocampi hypoxia. The mechanism might be related to inhibit oxidative stress damage and cell apoptosis, resist thrombosis, and reduce the intracellular calcium ion of overload. | Yu Li Wan Haofang Jin Weifeng Yang Jiehong Li Chang Dai Liuling Ge Lijun Zhou Huifen Wan Haitong He Yu | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 4 |
| 2 | A Reemergent Case of COVID-19—Harbin City,Heilongjiang Province,China,April 9,2020显示文摘As of February 22,a total of 198 confirmed COVID-19 cases were reported in Harbin,Heilongjiang Province,and no new local cases were reported in Harbin over the next 54 days(1).However,on April 9,a newly confirmed COVID-19 case was reported with an unknown source of infection(2).The patient,a 54-year-old male,developed a fever on March 28 with the highest recorded temperature at 37.5℃.On April 7,the symptoms worsened and included dyspnea,cough,sputum,chest pain,and other symptoms,though he did not experience chest distress,heart palpitations,nausea and vomiting,abdominal pain or diarrhea.He went to the fever clinic of the Harbin Second Hospital and was admitted to the isolation ward with a temperature of 37.2°C.The patient also had a history of diabetes. | Jun Xu Yong Zhang Xiang Zhao Dayan Wang Weiping Dai Guangyu Jiao Shiwen Wang Jun Liu Weifeng Shi Cao Chen Shuhong Chen Shichun Yan Hua Hua George FGao Wenbo Xu Guizhen Wu | 2020 | China CDC weekly2020，2，25： | 2 |
| 3 | Equilibrium of liquid-liquid extraction of 2-phenylbutyric acid enantiomers: Experiment and model显示文摘The utilization of liquid–liquid extraction for the separation of 2-phenylbutyric acid(2-PBA) enantiomers was proposed. Factors affecting the extract process were investigated, including organic solvents, β-cyclodextrin derivatives, cyclodextrin concentration, p H and temperature. A model was proposed to describe the separation process based on the homogeneous phase reaction mechanism. Important parameters of this model were determined experimentally. The physical distribution coefficients for molecular and ionic 2-PBA were0.129 and 7.455, respectively. The equilibrium constants of the complexation reactions were 89.36 and36.78 L·mol^(-1) for(+)-and(-)-2-PBA, respectively. The model was verified by experiments and proved to be an excellent means to optimize the separation system. Through modeling prediction and experiment, the best conditions(e.g., pH value of 3.00, extractant concentration of 0.1 mol·L^(-1), temperature of 5.0 °C) were acquired. Under this condition, the maximum enantioselectivity(2.096) was obtained. | Weifeng Xu Guilin Dai Kewen Tang Panliang Zhang Biquan Xiong Yu Liu | 2018 | Chinese Journal of Chemical Engineering2018，26，4： | 2 |
| 4 | Polycyclic aromatic hydrocarbons in the surface sediments from Yellow River, China显示文摘 | Jian Xu Yong Yu Ping Wang Weifeng Guo Shugui Dai Hongwen Sun | 2006 | Chemosphere2006，，7： | 2 |
| 5 | Antioxidant synergism of greentea polyphenols withα-tocopherol and L-ascorbic acid in SDS micelles显示文摘 | DAI Fang CHEN Weifeng ZHOU Bo | 2008 | Biochimie2008，90，10： | 1 |
| 6 | A 3D Ba-MOF for selective adsorption of CO_(2)/CH_(4)and CO_(2)/N_(2)显示文摘An unexpected in-situ hydrolysis reaction occurred during the solvothermal reaction of N,N’-bis(4-carboxy-2-methylphenyl)pyromellitic di-imide)and Ba(NO3)2,and a novel porous Ba-MOF,[H_(2)N(CH_(3))_(2)]_(0.5)[Ba_(1.5)(L)(DMA)]·1.5 DMA·1.5 H_(2)O(UPC-70,H_(3)L=2-(4-ca rboxy-2-methylphenyl)-1,3-dioxoisoindoline-5,6-dicarboxylic acid,DMA=N,N-dimethylacetamide),was obtained on the basis of the partial hydrolysate.The as-synthesized 3 D network with 1 D open channels of different sizes(24 A and 10 A)contains abundant open metal sites after removal of solvents,which is conducive to the preferential adsorption of CO_(2).The subsequent gas sorption measurement reveals the high separation selectivity of UPC-70 for CO_(2)/CH_(4)(15)and CO_(2)/N_(2)(32)at ambient conditions,and GCMC theoretical simulation provides good verification of the experimental results,indicating that UPC-70 is a potential candidate for CO_(2)capture from flue gas and natural gas. | Xiaokang Wang Yutong Wang Kebin Lu Weifeng Jiang Fangna Dai | 2021 | Chinese Chemical Letters2021，32，3： | 1 |
| 7 | Petrology, mineralogy, and geochemistry of the Ge-rich coal from the Wulantuga Ge ore deposit, Inner Mongolia, China: New data and genetic implications显示文摘 | Shifeng Dai Xibo Wang Vladimir V. Seredin James C. Hower Colin R. Ward Jennifer M.K. O’Keefe Wenhui Huang Tian Li Xiao Li Huidong Liu Weifeng Xue Lixin Zhao | 2011 | International Journal of Coal Geology2011，，： | 1 |
| 8 | Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism显示文摘Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers. | Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi Weichang Chen Ye Tian Xiangdong Liu Xiong Ma Zhongsheng Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 1 |
| 9 | 3D numerical study of particle flow behavior in the impinging zone of an Opposed Multi-Burner gasifier显示文摘 | Chao Li Zhenghua Dai Weifeng Li Jianliang Xu Fuchen Wang | 2012 | Powder Technology2012，，： | 1 |
| 10 | Using vacuum pyrolysis and mechanical processing for recycling waste printed circuit boards显示文摘 | Long Laishou Sun Shuiyu Zhong Sheng Dai Wencan Liu Jingyong Song Weifeng | 2010 | Journal of Hazardous Materials2010，177，123： | 1 |
| 11 | A Review of Skin Banking Guidelines and Standards Worldwide:Towards the Harmonization of Guidelines for Skin Banking in Therapeutic Applications for the Regions under the Asia Pacific Burn Association(APBA)显示文摘Currently,there are no harmonized guidelines which govern skin banking in the Asia Pacific region.Therefore,skin banks are either unregulated or rely on their nation’s legislation or international accreditation to uphold their quality standards.A new set of skin banking guidelines was devel-oped through a comprehensive review and collation of best international practices for the Asia Pacific Burn Association(APBA)members,from donor screening and testing,to skin recovery,processing,storage and distribution,and quality assurance.National regulatory requirements reviewed include the European directives,Australia’s Therapeutic Goods Administration and Sin-gapore’s tissue banking standards.Further technical and quality management recommendations are referenced from the American Association of Tissue Banks(AATB),the United States Food and Drug Administration standards and guidance documents,various relevant European guides,Japanese Society of Tissue Transplantation guidelines and the Asia Pacific Association of Surgical Tissue Banking.Adapted mainly from the AATB standards,the new Asia Pacific Burn Association Guidelines for Skin Banking in Therapeutic Applications offer a comprehensive manual,address-ing:governance and contracts;staff responsibilities;quality management;facilities,equipment and supplies management;donor consent and testing;and recommendations of good practices pertaining to skin recovery,processing,storage and distribution.Besides complementing current generic regulations,they provide technical specifications of major aspects unaddressed in most legislations.This inaugural set of new regional skin banking guidelines would be a start for regional members of the APBA to adopt,and will hopefully culminate in a set of standards so that,in the long run,skin allografts from this region can be of similar quality,which can simplify import process and facilitate the exchange of allografts between members. | Wee Ling Heng Qi Wei Wang Renuka Sornarajah Jacynthe Tremblay Nandita Melati Putri Suzina Sheikh Ab Hamid Pornthep Pungrasmi Hsian-Jenn Wang Dong Chul Kim Daizo Saito Nhu Lam Nguyen Wan Azman Wan Sulaiman Aditya Wardhana Vinita Puri Hajime Matsumura Niann-Tzyy Dai Rajeev BAhuja Gaoxing Luo Weifeng He Si Jack Chong Alvin Wen Choong Chua | 2020 | Burns & Trauma2020，8，1： | 0 |
| 12 | Risk factors for incomplete polyp resection during colonoscopy显示文摘Colonoscopic polypectomy is extremely effective in protecting against colorectal cancers,and recognition of adenomas by colonoscopy is of paramount importance in preventing colorectal cancer(CRC)and CRC-associated mortality.Incomplete polyp resection(IPR)occurs routinely in medical practice following polypectomy.We conducted a comprehensive literature search to identify studies that reported on the potential risk factors for IPR using MEDLINE,EMBASE,and PubMed.Publication time was limited between January 2004 and July 2021.Our search revealed assessments of the position,morphology,and histologic variation of the polypsdas well as the relevant skills that may interfere with IPR.The included studies showed that colonic polyps with a diameter>20 mm and proximal in location should be dealt with cautiously.For smaller polyps,cold-snare polypectomy appeared to be the most effective method used to accomplish comprehensive polyp removal.In addition,endoscopist experience in narrow-band imaging in polyp detection were also associated with IPR.Therefore,polypectomy should be performed cautiously if the polyp growth is expected to be cancerous and situated in the proximal portion of the colon or rectum,and modalities should be standardized so as to lower the potential risk for IPR. | Weifeng Lao Pankaj Prasoon Gaoyang Cao Lian Tat Tan Sheng Dai Giridhar Hanumappa Devadasar Xuefeng Huang | 2021 | Laparoscopic, Endoscopic and Robotic Surgery2021，4，4： | 0 |
| 13 | Crosslinked solubilizer enables nitrate-enriched carbonate polymer electrolytes for stable,high-voltage lithium metal batteries显示文摘High-voltage lithium metal batteries(LMBs)have been considered promising next-generation highenergy-density batteries.However,commercial carbonate electrolytes can scarcely be employed in LMBs owing to their poor compatibility with metallic lithium.N,N-dimethylacrylamide(DMAA)-a crosslinkable solubilizer with a high Gutmann donor number-is employed to facilitate the dissolution of insoluble lithium nitrate(LiNO3)in carbonate-based electrolytes and to form gel polymer electrolytes(GPEs)through in situ polymerization.The Lit solvation structure of the GPEs is regulated using LiNO3 and DMAA,which suppresses the decomposition of LiPFe and facilitates the formation of an inorganic-rich solid electrolyte interface.Consequently,the Coulombic efficiency(CE)of the LillCu cell assembled with a GPE increases to 98.5%at room temperature,and the high-voltage LillNCM622 cell achieves a capacity retention of 80.1%with a high CE of 99.5%after 400 cycles.The bifunctional polymer electrolytes are anticipated to pave the way for next-generation high-voltage LMBs. | Chuyang Jing Kuan Dai Dong Liu Wenran Wang Libao Chen Chunxiao Zhang Weifeng Wei | 2024 | Science Bulletin2024，69，2： | 0 |
| 14 | Synthesis of graphene quantum dots for their supramolecular polymorphic architectures显示文摘How to regulate the supramolecular structures in the assembly of graphene quantum dots(GQDs)is still a great challenge to be overcome.Herein,the GQDs of 1-3 layers with high quality are synthesized from the new precursor m-trihydroxybenzene in a green method.More importantly,a strategy for designing the supramolecular structures of GQDs is demonstrated,and the novel supramolecular morphologies of GQDs have been constructed for the first time.Moreover,the supramolecular morphologies of GQDs can be well controlled by regulating the preparation conditions,and the formation mechanism of the branch-like supramolecular structure has been explained by the the diffusion-limited aggregation(DLA)model.This work not only develops a new precoursor to synthesize GQDs,but also opens up an effective route toform the polymorphic supermolecules,thus greatly facilitating their potential applications. | Weifeng Chen Guo Lv Qiyun Zhou Jialu Shen Jie Cao Xiang Liu Zhongxu Dai | 2021 | Nano Research2021，14，4： | 0 |
| 15 | Michael addition reactions of cyclanones with acrylamides:Producing 2-carbamoylethyl derivatives or ene-lactams显示文摘The electron-withdrawing groups (EWGs) in the electrophilic alkenes employed in the Michael addition reaction are almost only CO2R, CN, COR, NO2, and SO2Ph. Although amides (CONR1R2) are also typical electron-withdrawing groups and are of great importance in organic synthesis, they are scarcely em-ployed as the EWGs of the electrophilic alkenes in the Michael addition reaction. In this work, the Mi-chael reactions of acrylamide and its derivatives with cyclanones were successfully carried out in the presence of enough radical inhibitors. The amide groups play a key role in producing the preferred products. The N-substituted acrylamides, including N-monosubstituted and N,N-disubstituted acryla-mides could react with cyclohexanone (CHn) to give the expected 2-carbamoylethyl derivatives; how-ever, acrylamide reacting with cyclohexanone only produced ene-lactam. Cyclanones also have effects on the products, while the ring size of cyclanones influences the reaction yield and the α-substituent decides the ratio of resulting isomeric ene-lactams. | DAI WeiFeng WANG ChaoHua ZHANG Xi ZHANG JinMing LANG MeiDong | 2008 | Science China Chemistry2008，51，11： | 0 |
| 16 | Few-Atom Copper Catalyst for the Electrochemical Reduction of CO to Acetate:Synergetic Catalysis between Neighboring Cu Atoms显示文摘Single-atom catalysts(SACs)are gaining increasing recognition because of their superior catalytic properties for various reactions.However,the performance of SACs is often limited by the lack of neighboring metal centers to cooperate in catalysis.Herein,a synergetic interaction between neighboring Cu atoms of a few-atom catalyst(FAC)on graphdiyne(GDY)is found to greatly enhance the production of acetate in the CO electroreduction reaction relative to Cu SACs.In a 1.0 M KOH electrolyte,this Cu FAC exhibits an acetate Faradaic efficiency of 53.8±1.5%,an ultrahigh relative purity of up to 97 wt%for liquid products,and excellent stability over 23 h continuous electrolysis at–0.8 V versus reversible hydrogen electrode.Theoretical studies suggest that the intersite catalytic communication between two neighboring metal atoms confined in each pore of GDY facilitates the formation of acetic acid through either stepwise hydrogenation of CH_(2)CO^(*)or the direct reaction of H_(2)Owith CH_(2)CO^(*).Our study demonstrates the unprecedented synergetic catalysis of Cu FAC in promoting the selective CO electroreduction toward acetate production. | Weifeng Rong Haiyuan Zou Sha Tan Enyuan Hu Fan Li Chao Tang Hao Dai Shuting Wei Yongfei Ji Lele Duan | 2023 | CCS Chemistry2023，5，5： | 0 |
| 17 | Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome显示文摘Liver ischemia/reperfusion injury(IRI),a serious inflammatory response driven by innate immunity,occurs in liver surgeries such as liver resection and liver transplantation,leading to liver dysfunction,liver failure,and even rejection after transplantation.Liver kinase B1(LKB1)plays a pivotal anti-inflammatory role in IRI.One of the most important factors involved in liver IRI is the aberrant activation of the nucleotide binding oligomerization domain like receptor(NLR)family,pyrin domain-containing 3(NLRP3)inflammasome in Kupffer cells.However,the mechanisms underlying the effect of LKB1 on the NLRP3 inflammasome in liver IRI remain elusive.In this study,we found that the expression of LKB1 was decreased in liver IRI,while the NLRP3 inflammasome level was increased as shown,as revealed by RT-qPCR and western blot analysis.Furthermore,upregulation of LKB1 abrogated the expression of the NLRP3 inflammasome,which improved liver function and liver pathology in the liver IRI model in vivo.In vitro,overexpression of LKB1 inhibited the activation of NLRP3 inflammasome and nuclear factor-κB,while the inhibitory effect was reversed by silencing the expression of the forkhead box protein O1 in the RAW264.7 macrophage hypoxia/reoxygenation model.In conclusion,our results suggest that LKB1 exerts a protective effect against liver IRI by downregulating the NLRP3 inflammasome. | Jiangwen Dai Qingsong Chen Weifeng Huang Kun Shi Yuke Zhang Tingting Li Tong Mou Zuotian Huang Zhongjun Wu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 0 |
| 18 | First Total Synthesis of (±)-Latifolin and Its Antioxidant Mechanism显示文摘 | Yihua Dai Qiaoling Liu Zhifang Li Weifeng Chen Zhongli Liu | 2015 | Chinese Journal of Chemistry2015，33，11： | 0 |
| 19 | CASCIRE surveillance network and work on avian influenza viruses显示文摘Studies on influenza virus by Chinese Academy of Sciences(CAS)could be traced back as early as 2005 by the CAS Key Laboratory of Pathogenic Microbiology and Immunology(CASPMI),who discovered that Qinghai-like Clade 2.2H5N1 subtype highly pathogenic avian influenza virus(HPAIV)first caused severe outbreak in wild birds in Qinghai Lake(Liu et al.,2005). | Yuhai Bi Weifeng Shi Jianjun Chen Quanjiao Chen Zhenghai Ma Gary Wong Wenxia Tian Renfu Yin Guanghua Fu Yongchun Yang William J.Liu Chuansong Quan Qianli Wang Shenghu He Xiangdong Li Qianfeng Xia Lixin Wang Zhaohui Pan Laixing Li Hong Li Wen Xu Ying Luo Hui Zeng Lianpan Dai Haixia Xiao Kirill Sharshov Alexander Shestopalov Yi Shi Jinghua Yan Xuebing Li Yingxia Liu Fumin Lei Wenjun Liu George F.Gao | 2017 | Science China(Life Sciences)2017，60，12： | 0 |
| 20 | Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure without appropriate treatment(Terziroli Beretta-Piccoli et al.,2019). | Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu | 2023 | Journal of Genetics and Genomics2023，50，10： | 0 |
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