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| 1 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 2 | Biosensor-based assay of exosome biomarker for early diagnosis of cancer显示文摘Cancer imposes a severe threat to people’s health and lives,thus pressing a huge medical and economic burden on individuals and communities.Therefore,early diagnosis of cancer is indispensable in the timely prevention and effective treatment for patients.Exosome has recently become an attractive cancer biomarker in noninvasive early diagnosis because of the unique physiology and pathology functions,which reflects remarkable information regarding the cancer microenvironment,and plays an important role in the occurrence and evolution of cancer.Meanwhile,biosensors have gained great attention for the detection of exosomes due to their superior properties,such as convenient operation,real-time readout,high sensitivity,and remarkable specificity,suggesting promising biomedical applications in the early diagnosis of cancer.In this review,the latest advances of biosensors regarding the assay of exosomes were summarized,and the superiorities of exosomes as markers for the early diagnosis of cancer were evaluated.Moreover,the recent challenges and further opportunities of developing effective biosensors for the early diagnosis of cancer were discussed. | Ying Deng Zhaowei Sun Lei Wang Minghui Wang Jie Yang Genxi Li | 2022 | Frontiers of Medicine2022，16，2： | 3 |
| 3 | Numerical Simulation of Dam-Break Flooding of Cascade Reservoirs显示文摘Previous studies at home and abroad have mainly focused on single dam-break, and little attention has been paid so far to the dam-break of cascade reservoirs.Multi-source flooding, which can lead to three-dimensional turbulent phenomena and superposition effects, is the main difference between the dam-break of cascade and single reservoirs. Detailed descriptions of the coupled numerical simulation of multi-source flooding have little been reported, and the initial wet riverbed is rarely considered in current models. Therefore, in this paper, a method based on the three-dimensional k-ε turbulence model coupled with the volume-of-fluid method is proposed to simulate the dam-break flooding of cascade reservoirs. The upstream river, reservoir, and downstream river are connected by the internal boundary method, and the initial conditions,including river flow and reservoir water, are determined according to the results of the numerical simulation. Coupled numerical simulation of different dam-break flooding is then achieved. The present work solves the challenges presented by the enhancement and superposition of natural river flow, upstream flooding, and downstream flooding.This paper provides a theoretical basis for future studies on the dam-break flood routing of cascade reservoirs. | Zhengyin Zhou Xiaoling Wang Wenlong Chen Shaohui Deng Minghui Liu | 2017 | Transactions of Tianjin University2017，23，6： | 3 |
| 4 | Identification of Molecular Subtypes of Gastric Cancer with Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil显示文摘 | Zhengdeng Lei Iain Beehuat Tan Kakoli Das Niantao Deng Hermioni Zouridis Sharon Pattison Clarinda Chua Zhu Feng Yeoh Khay Guan Chia Huey Ooi Tatiana Ivanova Shenli Zhang Minghui Lee Jeanie Wu Anna Ngo Sravanthy Manesh Elisabeth Tan Bin Tean Teh Jimmy Bok | 2013 | Gastroenterology2013，，： | 2 |
| 5 | Reduced graphene oxide aerogel decorated with Mo_(2)C nanoparticles toward multifunctional properties of hydrophobicity,thermal insulation and microwave absorption显示文摘Reduced graphene oxide(rGO)aerogels are emerging as very attractive scaffolds for high-performance electromagnetic wave absorption materials(EWAMs)due to their intrinsic conductive networks and intricate interior microstructure,as well as good compatibility with other electromagnetic(EM)components.Herein,we realized the decoration of rGO aerogel with Mo_(2)C nanoparticles by sequential hydrothermal assembly,freeze-drying,and high-temperature pyrolysis.Results show that Mo_(2)C nanoparticle loading can be easily controlled by the ammonium molybdate to glucose molar ratio.The hydrophobicity and thermal insulation of the rGO aerogel are effectively improved upon the introduction of Mo_(2)C nanoparticles,and more importantly,these nanoparticles regulate the EM properties of the rGO aerogel to a large extent.Although more Mo_(2)C nanoparticles may decrease the overall attenuation ability of the rGO aerogel,they bring much better impedance matching.At a molar ratio of 1:1,a desirable balance between attenuation ability and impedance matching is observed.In this context,the Mo_(2)C/r GO aerogel displays strong reflection loss and broad response bandwidth,even with a small applied thickness(1.7 mm)and low filler loading(9.0wt%).The positive effects of Mo_(2)C nanoparticles on multifunctional properties may render Mo_(2)C/r GO aerogels promising candidates for high-performance EWAMs under harsh conditions. | Yahui Wang Minghui Zhang Xuesong Deng Zhigang Li Zongsheng Chen Jiaming Shi Xijiang Han Yunchen Du | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，3： | 2 |
| 6 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 7 | Research and Simulation on Application of the Mobile IP Network显示文摘 | Deng Yibing Hu Wei Li Minghui | 2012 | Physics Procedia2012，33，： | 1 |
| 8 | A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens显示文摘Currently,the cancer immunotherapy has made great progress while antitumor vaccine attracts substantial attention.Still,the selection of adjuvants as well as antigens are always the most crucial issues for better vaccination.In this study,we proposed a biomimetic antitumor nanovaccine based on biocompatible nanocarriers and tumor cell membrane antigens.Briefly,endogenous calcium pyrophosphate nanogranules with possible immune potentiating effect are designed and engineered,both as delivery vehicles and adjuvants.Then,these nanocarriers are coated with lipids and B16-OVA tumor cell membranes,so the biomembrane proteins can serve as tumor-specific antigens.It was found that calcium pyrophosphate nanogranules themselves were compatible and possessed adjuvant effect,while membrane proteins including tumor associated antigen were transferred onto the nanocarriers.It was demonstrated that such a biomimetic nanovaccine could be well endocytosed by dendritic cells,promote their maturation and antigen-presentation,facilitate lymph retention,and trigger obvious immune response.It was confirmed that the biomimetic vaccine could induce strong T-cell response,exhibit excellent tumor therapy and prophylactic effects,and simultaneously possess nice biocompatibility.In general,the present investigation might provide insights for the further design and application of antitumor vaccines. | Minghui Li Mengmeng Qin Ge Song Hailiang Deng Dakuan Wang Xueqing Wang Wenbing Dai Bing He Hua Zhang Qiang Zhang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，1： | 1 |
| 9 | Electrochemical determination of dop- amine in the presence of ascorbic acid based on the gold nanorods/ carbon nanotubes composite film 显示文摘 | Chunyan Deng Jinzhuo Chena Minghui Yang | 2011 | Electrochimica Acta2011，56，24： | 1 |
| 10 | Distributed Data Mining Based on Grid Services Pool显示文摘 | DENG Song WANG Ruchuan YANG Minghui | 2009 | Chinese Journal of Electronics2009，18，2： | 0 |
| 11 | A review of structural modification and biological activities of oleanolic acid显示文摘Oleanolic acid(OA),a pentacyclic triterpenoid,exhibits a broad spectrum of biological activities,including antitumor,antiviral,antibacterial,anti-inflammatory,hepatoprotective,hypoglycemic,and hypolipidemic effects.Since its initial isolation and identification,numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives.Despite this,there has been a dearth of comprehensive reviews in the past two decades,leading to challenges in subsequent research on OA.Based on the main biological activities of OA,this paper comprehensively summarized the modification strategies and structureactivity relationships(SARs)of OA and its derivatives to provide valuable reference for future investigations into OA. | YANG Huali DENG Minghui JIA Hongwei ZHANG Kaicheng LIU Yang CHENG Maosheng XIAO Wei | 2024 | Chinese Journal of Natural Medicines2024，22，1： | 0 |
| 12 | Perioperative risk factors for delayed gastric emptying after pancreaticoduodenectomy:a meta-analysis of the complications显示文摘Objective:To evaluate the correlation between the incidence of delayed gastric emptying(DGE)in pancreaticoduodenectomy(PD)and the perioperative possible risk factors.Methods:We searched PubMed,Embase,Cochrane Library,and Medline for studies describing complications related to PD from 2018 to 2022.Statistical analysis was performed using Stata/SE16.0 software.Results:In 6 retrospective studies,1 systematic review,and 1 randomized controlled trial(RCT)experiment,12,419 patients(2174 and 10,245 patients,respectively,in DGE and no delayed gastric emptying[NDGE]groups).The preoperative American Society of Anesthesiologists(ASA)score between DGE and NDGE groups(log odds ratio[OR]=0.23,95%credible interval[CI]:0.11-0.35,P<.01),operation time(mean diff.=21.87,95%CI:15.96-27.78,P<.01),estimated intraoperative blood loss(EIBL;mean diff.=70.67,95%CI:17.75-123.58,P<.05),postoperative pancreatic fistula(POPF)(log OR=0.85,95%CI:0.24-1.46,P<.05)were statistically significant.No significant differences in preoperative body mass index(BMI),preoperative biliary drain-age,and pancreatic texture were observed(P>.05).Conclusion:The incidence of DGE is significantly correlated with the operation time,preoperative ASA score,POPF,and EIBL,which suggests that the surgeon should thoroughly evaluate the patient through adequate preoperative examination before the operation.Finally,standardized practice and perfect technology are undoubtedly necessary to reduce complications. | Xiaowei Deng Ting Niu Zhaolong Han Xing Liang Zhiping Fu Liang Tang Guang Yang Judong Li An’an Liu Junfeng Peng Minghui Zheng Chenghao Shao | 2023 | Journal of Pancreatology2023，6，2： | 0 |
| 13 | Self-assembled interlayer aiming at the stability of NiOx based perovskite solar cells显示文摘Inorganic NiO_(x) based inverted structure perovskite solar cells (PSCs) is reported to be more stable than that with the organic hole transport materials.In this work,NiO_(x)/MAPbI_(3) interface chemical reaction induced instability of perovskite is unveiled:Ni^(3+) and I^(-) exhibit redox reactions and deprotonation of MA^(+) happens,which result in interface defects and perovskite lattice deformation.Thus the defective interface accelerates the degradation of perovskite by defect pathways from the bottom interface to the perovskite surface contacting H_(2)O/O_(2).Self-assembled interlayer of NH_(2)^(-)end silane on NiO_(x)separates the reactive NiO_(x)and MAPbI_(3),tunes the interface energy states by–NH_(2) end group.As a result,the PSC based on the silane treated NiO_(x)achieves enhanced PCE of 20.1%with decent stability under environmental and extreme conditions (high temperature,high humidity,light infiltration).Our work highlights the interface chemical problem induced PSC instability and a simple interface modification to achieve the stable PSCs. | Tonghui Guo Zhi Fang Zequn Zhang Zhiqiang Deng Rui Zhao Jing Zhang Minghui Shang Xiaohui Liu Ziyang Hu Yuejin Zhu Liyuan Han | 2022 | Journal of Energy Chemistry2022，31，6： | 0 |
| 14 | 11S蛋白酶体PSME3通过正反馈调节NF-κB信号通路调节机体抗菌反应与宿主防御显示文摘巨噬细胞在宿主防御以及机体内环境稳定的维持中发挥着至关重要的作用。当机体受到外来病原微生物入侵时,巨噬细胞能够通过分泌促炎因子和杀伤物质,杀死入侵的病原菌。然而,关于巨噬细胞在宿主防御过程中是如何被严格调控的,至今仍不是很清楚。 | Jinxia Sun Yi Luan Dong Xiang Xiao Tan Hui Chen Qi Deng Jiaojiao Zhang Minghui Chen Hongjun Huang Weichao Wang Tingting Niu Wenjie Li Hu Peng Shuangxi Li Lei Li Wenwen Tang 李晓涛 Dianqing Wu 王平 | 2017 | 科学新闻2017，19，4： | 0 |
| 15 | The Influential Factors of Semi-Flexible Pavement Cracking Performance显示文摘The cracking performance of semi-flexible pavement(SFP) was investigated by using the semi-circular bending(SCB) test in this paper. Thirteen grouting slurries were prepared. The compressive strength of these materials ranges from 3 to 100 MPa. The relationship between the compressive strength of the grouting slurry and the cracking property of SFP was obtained at different loading rates and different temperatures. The peak load, fracture energy(E), flexible index(FI), and cracking resistance index(CRI) were calculated to determine the material performance. The results show that the compressive strength of the grout influences the cracking behavior. With a higher comprehensive strength grouting slurry, the FI value of SFP decreased initially and then increased slightly at 25 ℃ in 50 mm/min. The CRI value decreased at the same time. E values changed just according to the test temperature and loading rate. The damage paths of SFP are different. The damage path of the SFP sample appears as diffuse damage at 1 mm/min at 60 ℃ or clean damage at 50 mm/min at 25 ℃. These findings indicate that there is a correlation between the compressive strength of grouting slurry and SFP cracking behavior. The cracking form is influenced by loading rate and temperature. | 熊子佳 GONG Minghui 洪锦祥 DENG Cheng | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，5： | 0 |
| 16 | Using Augmented Reality Techniques to Simulate Training and Assistance in Electric Power显示文摘In combination with the augmented reality (AR) technology and Hololens device, an electric power work assist system is developed to provide a more realistic and convenient training experience for electric power training. The training effect was improved, and help guidance information was provided in the actual operation of electric power work. Experimental results show that difficulty of electric power work is reduced and the efficiency of actual work is improved. | Zifeng Tang Jiyao Deng Hao Gao Jiageng Song Qinlun Li Peixin Zhang Minghui Sun | 2019 | 国际计算机前沿大会会议论文集2019，，2： | 0 |
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