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| 1 | Synthesis, characterization and size control of zerovalent iron nanoparticles anchored on montmorillonite显示文摘Zerovalent iron nanoparticles have been successfully synthesized using sodium borohydride solution reduction of ferric trichloride hexahydrate in the presence of montmorillonite as an effective protective reagent and support as well. A combination of characterizations reveals that with high monodispersity these obtained iron nanoparticles are well dispersed on clay surface, virginal from boron related impurity, and oxidation resistant well with iron core-iron oxide shell structure. The shell thickness of 3 nm remains almost invariable under ambient conditions. The size control of these iron nanoparticles has been achieved by tailoring the amount of the ferric iron, which mainly depends on the protective action of montmorillonite. | FAN MingDe YUAN Peng CHEN TianHu HE HongPing YUAN AiHua CHEN KangMin ZHU JianXi LIU Dong | 2010 | Chinese Science Bulletin2010，55，11： | 15 |
| 2 | Overcoming HBV immune tolerance to eliminate HBsAg-positive hepatocytes via pre-administration of GM-CSF as a novel adjuvant for a hepatitis B vaccine in HBV transgenic mice显示文摘尽管有矛盾的结果, Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 从动物和人的研究被知道是一个潜在的疫苗的助手。差异可能由于被使用的 GM-CSF 的不同剂量和政体,给那成熟或不成熟的树枝状的房间(DC ) 能在不同条件下面被导致。为了测试假设,那 GM-CSF 能为一个肝炎 B 病毒(HBV ) 被用作一个新奇助手治疗学的疫苗,我们与 recombinant HBV 疫苗(rHBVvac ) 在种痘以前每天管理了 GM-CSF 一次三天在老鼠。我们在作为与白天 1 每日的 GM-CSF 管理或白天 2 相比的白天 3 点在这些预先对待的动物观察了更大的 DC 成熟。这策略进一步为它打破在肝炎 B 表面建立的有免疫力的忍耐的能力被调查抗原转基因(HBsAg-Tg ) 动物。我们发现导致的 anti-HBsAg 抗体的层次在在第三免疫以后在 rHBV 种痘前跟随三天 GM-CSF 预告的处理的动物是显著地更高的。除了 anti-HBsAg 抗体层次的增加,调停房间的 anti-HBsAg 回答包括延期类型超敏性, T 房间增长, interferon-γ生产,和细胞毒素的 T 淋巴细胞,戏剧性地在三天的 GM-CSF 被提高预先对待的组。在从使免疫的动物的 CD8 + T 房间的采纳转移以后,抗原特定的 CD8 + T 房间在接受者 HBsAg-Tg 动物的肝被观察。而且,有在 rHBVvac 种痘以前的 GM-CSF 的三天的预告的处理能显著地消除 HBsAg 积极的 hepatocytes,建议有益的治疗学的效果。因此,与 rHBVvac 疫苗在联合作为一个助手利用 GM-CSF 的这个协议有潜力为长期的肝炎 B 病人成为新奇免疫疗法。 | Xianzheng Wang Aihua Dong Jingjing Xiao Xingjun Zhou Haili Mi Hanqian Xu Jiming Zhang Bin Wang | 2016 | Cellular & Molecular Immunology2016，13，6： | 11 |
| 3 | Land use change characteristics affected by water saving practices in Manas River Basin,China using Landsat satellite images显示文摘The characteristics and influencing factors of land use change under arid conditions were studied in the Manas River Basin in Xinjiang Region,Northwest China.Landsat satellite images acquired in 1976,1990,2000,2010 and 2015 over the study area were used as basic data.Land use change,the rate of change of land use,land use transfer and other aspects revealed the characteristics of land use change and related factors as influenced by water conditions in the basin.The results showed that:(1)Over nearly 50 years,land reclamation in the Manas River Basin resulted in the rapid expansion of an artificial oasis area,and promoted the process of‘oasis urbanization’,and accelerated the development of the river basin economy.(2)In 2000,the popularization of drip irrigation under mulch technology led to the rapid growth of cultivated land and development land in the watershed.Meanwhile,the water table declined in the desert area of the lower reaches of the river basin,and the area occupied by sparse shrub forest and grassland decreased.(3)Before popularization of water-saving technology,woodland,grassland and development land transformed to cultivated land in the amounts of 93.46 km^(2),2542.93 km^(2) and 137.53 km^(2),respectively,and woodland transformed in the amount of 189.64 km^(2).After water-saving technology was popularized,woodland,grassland and development land were transformed into cultivated land in the amounts of 567.41 km^(2),1756.2 km^(2) and 37.36 km^(2),respectively.(4)The popularization of water-saving technology made the dynamic degree of cultivated land and development land more active,and further increased landscape fragmentation and landscape heterogeneity.The level of urbanization development,the level of economic development and the dry humidity of the basin became the main factors affecting the change of land use in the basin. | Yang Guang Chen Dong He Xinlin Long Aihua Yang Mingjie Li Xiaolong | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 5 |
| 4 | Security Risk Assessment of Cyber Physical Power System Based on Rough Set and Gene Expression Programming显示文摘Risk assessment is essential for the safe and reliable operation of cyber physical power system. Traditional security risk assessment methods do not take integration of cyber system and physical system of power grid into account. In order to solve this problem, security risk assessment algorithm of cyber physical power system based on rough set and gene expression programming is proposed. Firstly, fast attribution reduction based on binary search algorithm is presented. Secondly, security risk assessment function for cyber physical power system is mined based on gene expression programming. Lastly, security risk levels of cyber physical power system are predicted and analyzed by the above function model. Experimental results show that security risk assessment function model based on the proposed algorithm has high efficiency of function mining, accuracy of security risk level prediction and strong practicality. | Song Deng Dong Yue Xiong Fu Aihua Zhou | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，4： | 3 |
| 5 | Ultrastructural changes of rat cortical neurons following ligustrazine intervention for cerebral ischemia/reperfusion injury显示文摘BACKGROUND: Ligustrazine can reduce the production of free radicals and the content of malonaldehyde, and improve the enzymatic activity of adenosine-triphosphate in cerebral anoxia. It also can increase the expression of heat shock protein-70 and Bcl-2, thus alleviating brain tissue injury caused by cerebral ischemia/reperfusion. This study aimed to address the question of whether ligustrazine can protect the membrane structure of neurons. OBJECTIVE: To establish rat models of cerebral ischemia/reperfusion, observe the membrane structure and main organelles of neurons with electron microscope after ligustrazine intervention, and to analyze the dose-dependent effects of ligustrazine on neuronal changes. DESIGN: A randomized controlled study. SETTING: Department of Anatomy Research and Electron Microscopy, Hebei North University. MATERIALS: Forty Wistar rats of SPS grade, weighing 180-250 g and equal proportion of female and male, were provided by Hebei Medical University Animal Center (No. 060126). The ligustrazine injection (40 g/L, No. 05012) was produced by Beijing Yongkang Yaoye. LKB4 Ultramicrotome was purchased from LKB Company in Sweden. JEM100CXII electron microscope was purchased from JEOL in Japan. METHODS: The experiment was performed in the Laboratory of the Department of Anatomy and Electron Microscopy, Hebei North University from June to August 2006. ① Wistar rats were allowed to adapt for 3 days, and were then randomly divided into four groups, according to the numeration table method: normal group, model group, low-dose ligustrazine group, and high-dose ligustrazine group. There were 10 rats in each group. ②Rats in the model group, low-dose ligustrazine group, and high-dose ligustrazine group un- derwent cerebral ischemia/reperfusion model, according to Bannister's method. The carotid artery was opened for reperfusion after 90 minutes of cerebral ischemia. Samples were collected from the cerebral cor- tex after 24 hours. Animals from the ligustrazine low-dose group and ligustrazine high-dose group received ligustrazine injections, 50 mg/kg and 100 mg/kg, respectively. Samples were collected at the same time as the model group. MAIN OUTCOME MEASURES: Alterations of the neuronal ultrastructure and main organelles were ob- served by electron microscopy. RESULTS: Forty Wistar rats were included in the final analysis. Plentiful ribosome and rough endoplasmic reticulum existed in the cytoplasm of cortical neurons in the normal group. Edema existed in the nucleus and cytoplasm of neurons in the model group. The cell membrane was damaged, resulting in the external eruption of certain cellular organelles. In the low-dose ligustrazine group, neuronal swelling was decreased in the cy- toplasm, whereas cellular organelles were relatively increased. However, the mitochondria remained swollen. The double layer structure disappeared in parts of the mitochondrial membrane. The caryotheca was still broken, and neuronal damage was significantly decreased in the high-dose ligustrazine group. In addition, cytoplasmic swelling was reduced andmost part of caryotheca was complete. Fragmentation of the cellular membrane was not detected. Mitochondrial cristae and the lysosome could also be detected. The number of rough endoplasmic reticulum and free ribosomes was increased, and the structure of great part of caryotheca was clear. In addition, the number of nuclear pore was increased. However, the nuclear hetero- chromatin was relatively reduced. CONCLUSION: In the rat, the protective effects of ligustrazine were significant on neuronal membrane structures and main organelles after cerebral ischemia/reperfusion. There was a dose-dependent effect be- tween neuronal changes and Ligustrazine. | Hui Zhang Jianfeng Dong Qiuzhen Zhao Wen Song Aihua Bo | 2008 | Neural Regeneration Research2008，3，1： | 2 |
| 6 | Determination of molecular weight of hyaluronic acid by near-infrared spectroscopy显示文摘 | DONG Qing ZANG Hengchang LIU Aihua | 2010 | Journal of Pharmaceutical and Biomedical Analysis2010，53，3： | 1 |
| 7 | Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein显示文摘SARS-CoV-2 and SARS-CoV are genetically related coronavirus and share the same cellular receptor ACE2.By replacing the VSV glycoprotein with the spikes(S)of SARS-CoV-2 and SARS-CoV,we generated two replication-competent recombinant viruses,rVSVSARS-CoV-2 and rVSV-SARS-CoV.Using wild-type and human ACE2(hACE2)knock-in mouse models,we found a single dose of rVSV-SARS-CoV could elicit strong humoral immune response via both intranasal(i.n.)and intramuscular(i.m.)routes.Despite the high genetic similarity between SARS-CoV-2 and SARS-CoV,no obvious cross-neutralizing activity was observed in the immunized mice sera.In macaques,neutralizing antibody(NAb)titers induced by one i.n.dose of rVSV-SARS-CoV-2 were eight-fold higher than those by a single i.m.dose.Thus,our data indicates that rVSV-SARS-CoV-2 might be suitable for i.n.administration instead of the traditional i.m.immunization in human.Because rVSV-SARS-CoV elicited significantly stronger NAb responses than rVSV-SARS-CoV2 in a route-independent manner,we generated a chimeric antigen by replacing the receptor binding domain(RBD)of SARS-CoV S with that from the SARS-CoV-2.rVSV expressing the chimera(rVSV-SARS-CoV/2-RBD)induced significantly increased NAbs against SARS-CoV-2 in mice and macaques than rVSV-SARS-CoV-2,with a safe Th1-biased response.Serum immunized with rVSV-SARS-CoV/2-RBD showed no cross-reactivity with SARS-CoV.hACE2 mice receiving a single i.m.dose of either rVSV-SARS-CoV-2 or rVSV-SARSCoV/2-RBD were fully protected against SARS-CoV-2 challenge without obvious lesions in the lungs.Our results suggest that transplantation of SARS-CoV-2 RBD into the S protein of SARS-CoV might be a promising antigen design for COVID-19 vaccines. | Hongyue Li Yuhang Zhang Dong Li Yong-Qiang Deng Hongde Xu Chaoyue Zhao Jiandong Liu Dan Wen Jianguo Zhao Yongchun Li Yong Wu Shujun Liu Jiankai Liu Junfeng Hao Fei Yuan Shuguang Duo Cheng-Feng Qin Aihua Zheng | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 8 | Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes显示文摘 | Qinyuan Xu Li Huang Juan Liu Liang Ma Tao Chen Jinying Chen Fei Peng Dong Cao Zhuang Yang Neng Qiu Jingxiang Qiu Guangcheng Wang Xiaolin Liang Aihua Peng Mingli Xiang Yuquan Wei Lijuan Chen | 2012 | European Journal of Medicinal Chemistry2012，，： | 1 |
| 9 | Superb VOCs capture engineering carbon adsorbent derived from shaddock peel owning uncompromising thermal-stability and adsorption property显示文摘High applied thermal-stability and superior structural property for activated carbon adsorbent are extremely promising,which also is the determining short slab in volatile organic compounds(VOCs)adsorption applications.Herein,we develop the outstanding engineering carbon adsorbents from waste shaddock peel which affords greatly-enhanced thermal-stability and super structural property(S_(Lang)=4962.6 m2·g^(-1),Vmicro=1.67 cm^(3)·g^(-1)).Such character endows the obtained adsorbent with ultrahigh adsorption capture performance of VOCs specific to benzene(16.58 mmol·g^(-1))and toluene(15.50 mmol·g^(-1),far beyond traditional zeolite and activated carbon even MOFs materials.The structural expression characters were accurately correlated with excellent adsorption efficiency of VOCs by studying synthetic factor-controlling comparative samples.Ulteriorly,adsorption selectivity prediction at different relative humidity was demonstrated through DIH(difference of the isosteric heats),exceedingly highlighting great superiority(nearly sixfold)in selective adsorption of toluene compared to volatile benzene.Our findings provide the possibility for practical industrial application and fabrication of waste biomass-derived outstanding biochar adsorbent in the environmental treatment of threatening VOCs pollutants. | Fu Yang Wenhao Li Rui Ou Yutong Lu Xuexue Dong Wenlong Tu Wenjian Zhu Xuyu Wang Lulu Li Aihua Yuan Jianming Pan | 2022 | Chinese Journal of Chemical Engineering2022，35，7： | 1 |
| 10 | Enabling tandem oxidation of benzene to benzenediol over integrated neighboring V-Cu oxides in mesoporous silica显示文摘The direct tandem oxidation synthesis of benzenediol from benzene could simplify or even avoid the separation and purification of reaction intermediates, which is promising but challenged because of the further required immediate consecutive activation of intermediate phenol. In this work, a synergistic benzene tandem-oxidation catalyst that V-Cu bimetallic oxides modified nanoporous silica(VCu-NS)was constructed via a facile assembly strategy which involves addictive negative anion citric acid mediating the intercalation of metal-citric acid chelate in mesopore of silica and subsequent thermal calcination inducing dual-metal active site formation. Such a tactic could make amorphous VOxspecies well covered on the surface of mesopore, and ultrafine copper oxide particles surrounded and neighbored by highly dispersed VOxwith strong interplay in mesopore, which was comprehensively confirmed by various characterizations. Benefiting from the unique V-Cu neighboring effect, the desorption of formed phenol over the catalytic site might be restricted therefore easily further activated by the formed reactive oxidative species, 3VCu-NS shows synergetic tandem-oxidation catalytic activities for benzene towards benzenediol with a selectivity of 57%. The result allows optimal 3VCu-NS to be a promising catalyst for benzenediol synthesis from benzene. | Mengting Liu Xuexue Dong Zengjing Guo Aihua Yuan Shuying Gao Fu Yang | 2023 | Chinese Journal of Chemical Engineering2023，55，3： | 0 |
| 11 | Rotation Effect on Flow and Heat Transfer for High-Temperature Rotor Blade in a Heavy Gas Turbine显示文摘In this paper,the composite inner cooling structures of the rotating blade in the first stage heavy gas turbine were modeled and simulated by coupling heat transfer (CHT).The flow characteristics and heat transfer performances were comparatively analyzed under two operations of the stationary and the rotational states.The results show that the turbulence intensity,the flow resistance and the heat transfer level of the rotating coolant are significantly increased compared with the stationary state,which is considered to be obtained by the combined effects of the Coriolis force,the centrifugal force and their derived buoyancy forces.It is pointed out that the rotation leads to the non-uniform flow of film holes at the leading edge of the pressure surface along blade height.In addition,it increases the slope of the limiting streamline,which has a decisive influence on the heat transfer of both the pressure and suction surfaces.The paper provides guidance for the design of a rotating composite cooling structure based on the relations between the stationary and rotational conditions. | DONG Aihua YAN Peigang QIAN Xiaoru HAN Wanjin WANG Qingchao | 2021 | Journal of Thermal Science2021，30，2： | 0 |
| 12 | Implantation Energy Selection in Molecular-Beam Epitaxy GaAs Films on Si Substrates显示文摘GaAs films made by molecular beam epitaxy with thicknesses ranging from 0.9 to 1.25μm on Si have been implanted with Si ions at 1.2MeV to dose of 1×10^(15)/cm^(2).A rapid infrared thermal annealing and white light annealing were then used for recrystallization.Crystalline quality was analysed by using backscattering channeling technique with Li ion beam of 4.2MeV.The experimental result show that energy selection is important for obtaining better and uniform recrystallized GaAs epilayers. | XIAO Guangming YIN Shiduan ZHANG Jingping DING Aiju DONG Aihua ZHU Peiran ZHOU Junming LIU Jiarui | 1991 | Chinese Physics Letters1991，8，3： | 0 |
| 13 | Characteristics of Soil Respiration of Terraces and Slope Farmland in Loess Hilly and Gully Regions显示文摘Soil CO_2 emissions of terraces and slope farmland in loess hilly and gully regions were measured by using Infra Red Gas Analysis(IRGA),and the diurnal variation characteristics of soil respiration rate in different slope positions of terraces and slope farmland were analyzed.The results show that the diurnal variation curves of soil respiration rate of terraces and slope farmland in loess hilly and gully regions had a single peak.The soil respiration rate of terraces reached the peak during 13:00-15:00,while the soil respiration rate of slope farmland reached the peak from 11:00 to13:00,and it was the lowest at next 07:00.The daily average of soil respiration rate in slope farmland was 0.86μmol/(m^2·s),accounting for 93.48% of that of terraces.The daily average of soil respiration rate in different slope positions of terraces and slope farmland is shown as follows:the bottom of the slope>the middle of the slope>the top of the slope.At the top of the slope,the daily averages of soil respiration rate in terraces and slope farmland were the same;at the middle and bottom of the slope,the daily average of soil respiration rate in terraces was larger than that of slope farmland. | Ma Tao Zhou Bo Chen Aihua Zhang Feng Dong Yanli | 2017 | Meteorological and Environmental Research2017，8，1： | 0 |
| 14 | Research Progress of Tung Oil/UV Photocomposite Curing Material显示文摘Tung oil(TO)/ultraviolet(UV)photo-composite curing material possesses the characteristics of low curing temperature,low material shrinkage and low environmental pollution.Accordingly,this material must be developed and utilized with the conjugated double bonds contained in the long chain of the main structure(α-tung acid)molecules in the refined TO.The aforementioned material can be chemically modified using a variety of chemical methods to develop a new TO-based UV photocurable material due to its unique chemical properties.This work reviews the research progress of TO/UV photo-composite curing materials in recent years.Firstly,the chemical structure and application of TO and UV Photocatalysis Technology were briefly introduced.Secondly,the research status of novel TO/UV photo-composite curing materials developed by the Diels-Alder reaction was discussed.The method and curing effect of the UVcuring system constructed by other chemically modified TO were also discussed.Thereafter,the application of TO in industrial production is introduced from four directions:the application of TO in biodiesel,the application in synthetic resin,the application in self-healing coating and microcapsules and other applications.Finally,the research and application prospects of TO/UV photo-composite curing materials were presented. | Zicheng Zhao Zhihong Xiao Xudong Liu Desheng Kang Wenzheng Dong Qiquan Lin Aihua Zhang | 2023 | Journal of Renewable Materials2023，11，4： | 0 |
| 15 | Mesoporous magnetic nanoparticles conjugated aptamers for exosomes capture and detection of Alzheimer’s disease显示文摘Exosomes are nanoscale membrane-enclosed extracellular vesicles secreted by various cells,which have enormous potential as disease biomarkers for clinical application.However,the isolation and detection of exosomes remain enormous challenges,which limits their further application.Herein,inspired by immunomagnetic beads,a magnetic nanoparticle conjugated aptamer was repurposed for the effective capture and detection of exosomes.The magnetic nanoparticles,composed of Fe 3 O 4 synthesized by the hydrothermal method as the core and coupled with gold nanoparticles(Fe 3 O 4@Au),provide a large specific surface area,making the resulting composite material an effective platform for exosome capture.Furthermore,the elution of captured exosomes with 1.0 M NaCl made downstream analysis of exosomes possible.The preliminary clinical application value of the composite in exosome analyses of serum from healthy individuals and patients with Alzheimer’s disease(AD)has also been verified,which could provide a promising platform for biomedical and clinical diagnosis. | Guidan Wang Zhenshan Pan Xiaorui Zhu Ruyue Yang Rong Yang Tingting Yang Dong Hu Aihua Jing Gaofeng Liang | 2023 | Engineered Regeneration2023，4，4： | 0 |
| 16 | A flexible and high temperature tolerant strain sensor of La0.7Sr0.3MnO3/Mica显示文摘Flexible sensors have been widely investigated due to their broad application prospects in various flexible electronics.However,most of the presently studied flexible sensors are only suitable for working at room temperature,and their applications at high or low temperatures are still a big challenge.In this work,we present a multimodal flexible sensor based on functional oxide La0.7Sr0.3MnO3(LSMO)thin film deposited on mica substrate.As a strain sensor,it shows excellent sensitivity to mechanical bending and high bending durability(up to 3600 cycles).Moreover,the LSMO/Mica sensor also shows a sensitive response to the magnetic field,implying its multimodal sensing ability.Most importantly,it can work in a wide temperature range from extreme low temperature down to 20K to high temperature up to 773 K.The flexible sensor based on the flexible LSMO/mica hetero-structure shows great potential applications for flexible electronics using at extreme temperature environment in the future. | Min Guo Cheng Yang Dong Gao Qiang Li Aihua Zhang Jiajun Feng Hui Yang Ruiqiang Tao Zhen Fan Min Zeng Guofu Zhou Xubing Lu J-MLiu | 2020 | Journal of Materials Science & Technology2020，44，9： | 0 |
| 17 | Rapid determination of hyaluronic acid concentration in fermentation broth with near-infrared spectroscopy显示文摘Hyaluronic acid(HA)concentration is an important parameter in fermentation process.Cur-rently,carbazole assay is widely used for HA content determination in routine analysis.However,this method is time-consuming,environment polluting and has the risk of microbial contarmi-nation,as well as the results lag behind fermentation process.This paper attempted the feasibility to predict the concentration of HA in fermentation broth by using near infrared(NIR)spec-troscopy in transmission mode.In this work,a total of 56 samples of fermentation broth from 7 batches were analyzed,which contained HA in the range of 2.35-9.69 g/L.Diferent data pre-processing methods were applied to construct calibration models.The final optimal model was obtained with first derivative using Savitzky-Golay smoothing(9 points window,second-order polynomial)and partial least squares(PLS)regression with leave-one-block out CrOsS validation.The correlation cofficient and Root Mean Square Error of prediction set is 0.98 and 0.43 g/L,respetively,which show the possibility of NIR as a rapid method for microanalysis and to be a promising tool for a rapid assay in HA fermentation. | Qin Dong Hengchang Zang Lixuan Zang Aihua Liu Yanli Shi Hui Zhang | 2014 | Journal of Innovative Optical Health Sciences2014，7，6： | 0 |
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