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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Petrogenesis of Kejie Granite in the Northern Changning-Menglian Zone, Western Yunnan: Constraints from Zircon U-Pb Geochronology, Geochemistry and Hf Isotope显示文摘The Kejie pluton is located in the north of the Changning-Menglian suture zone. The rock types are mainly biotite-granite. Zircon LA-ICP-MS U-Pb dating indicates that the Kejie pluton emplaced at about 80–77 Ma, Late Cretaceous. The Kejie pluton samples are characterized by high SiO2(71.68%–72.47%), K2O(4.73%–5.54%), total alkali(K2O + Na2O = 8.21%–8.53%), K2O/Na2O ratios(1.36–1.94) and low P2O5(0.13%–0.17%), with A/CNK of 1.025–1.055; enriched in U, Th, and K, depleted in Ba, Nb, Sr, Ti, P and Eu. They are highly fractionated, slightly peraluminous I-type granite. The two samples of the Kejie pluton give a large variation of εHf(t) values(-5.04 to 1.96) and Hf isotope crustal model ages of 1.16–1.5 Ga. Zircon Hf isotopes and zircon saturation temperatures of whole-rock(801°C–823°C) show that the mantle-derived materials maybe have played a vital role in the generation of the Kejie pluton. The Kejie pluton was most likely generated in a setting associated with the eastward subduction of the neo-Tethys ocean, where intrusion of mantle wedge basaltic magmas in the crust caused the anatexis of the latter, forming hybrid melts, which subsequently experienced high-degree fractional crystallization. | NIE Fei DONG Guochen MO Xuanxue WANG Xia FAN Wenyu DONG Meiling ZHU Huaping | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 3 |
| 3 | Bulk growth and separation of single-walled carbon nanotubes from rhenium catalyst显示文摘Bulk synthesis of single-walled carbon nanotubes(SWNTs)using solid catalyst has been challenging,despite of recent breakthrough in the chirality-specific growth on the flat substrate surface.In this work,we propose a porous magnesia support rhenium catalyst for bulk synthesis of SWNTs.It is found that the well-dispersed catalyst with a high melting point and the optimal chemical vapor deposition reaction conditions account for the growth of SWNTs.Detailed characterizations reveal the produced SWNTs are dominant in(n,n−1)and(n,n−2)species.Furthermore,by using a multicolumn chromatography post-growth separation method,SWNTs with three defined diameter ranges were obtained.This work guides the design of porous oxide supported catalyst for bulk synthesis and diameter-dependent sorting of SWNTs,which will ultimately help harness the extraordinary properties of SWNTs. | Chen Ma Yumin Liu Lili Zhang Liu Qian Yiming Zhao Ying Tian Qianru Wu Dong Li Nan Zhao Xueting Zhang Liantao Xin Huaping Liu Pengxiang Hou Chang Liu Maoshuai He Jin Zhang | 2022 | Nano Research2022，15，7： | 2 |
| 4 | Characterization of diatomite and its application for the retention of radiocobalt: role of environmental parameters显示文摘 | Guodong Sheng Huaping Dong Yimin Li | 2012 | Journal of Environmental Radioactivity2012，，： | 1 |
| 5 | An optical liquid level sensor based on polarization-maintaining fiber modal interferometer显示文摘 | Gong Huaping Song Haifeng Dong Xinyong | 2014 | Sensors and Actuators A:Physical2014，205，1： | 1 |
| 6 | Controlled Release of Herbicide Acetochlor from Clay/Carboxylmethylcellulose Gel Formulations 显示文摘 | Li Jianfa Li Yimin Dong Huaping | 2008 | J Agr Food Chem2008，56，： | 1 |
| 7 | Adaptive synchronization of weighted complex dynamical networks with coupling time-varying delays显示文摘 | WANG Lei DAI Huaping DONG Hui | 2008 | Physics Letters A2008，，： | 1 |
| 8 | The Risk Factors and Environm ental Risk Prediction during the Production of Yellow Phosphorus显示文摘Phosphorus is an important chemical raw material of economy. There are several risk factors in the entire production process of yellow phosphorus. The health of the production staff was greatly endangered by the toxic and harmful substances. The generation of risk factors was analyzed during the yellow phosphorus production and its harm was discussed,and several toxic and harmful substances were tested for a number of phosphorus manufacturing enterprises. The environmental risks of P2O5 in phosphorus pollution sources were scientifically predicted on the first time. | Gao Ye Dong Guoli Zhang Jie Gao Huaping Hu Xuewei Shi Jianwu | 2014 | Meteorological and Environmental Research2014，5，10： | 1 |
| 9 | Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes显示文摘 | Huaping Shi Lei Chen Huilan Wang Shoukang Zhu Chunming Dong Keith A. Webster Jianqin Wei | 2012 | Biochemical and Biophysical Research Communications2012，，： | 1 |
| 10 | En- antioselective hydrolysis of diethyl 3- hydroxyglutarate to ethyl (s)-3-hydroxyglutarate by immobilized candida ant- arctica lipase b显示文摘 | DONG HUAPING WANG YAJUN ZHENG YUGUO | 2010 | Journal of Molecular Catalysis B: En- zymatic2010，66，12： | 1 |
| 11 | 定位于内质网膜的转录因子MYRF经剪切后入核以调控秀丽线虫神经元突触发育重塑显示文摘文章简介本研究以遗传筛选的方式鉴别到突变体具有突触重塑障碍,并鉴别出该突变是个单点突变,发生在MYRF-1上。进一步的研究发现,MYRF-1蛋白全长定位在内质网上,并能发生剪切,之后释放出蛋白的氮端,氮端具有结合DNA的功能域,它进入细胞核并参与转录调控。 | Jun Meng Xiaoxia Ma Huaping Tao Xia Jin Daniel Witvliet James Mitchell Ming Zhu Meng-Qiu Dong Mei Zhen Yishi Jin 齐瀛川 | 2018 | 科学新闻2018，0，4： | 0 |
| 12 | Accurate modulation of photoprinting under stiffness imaging feedback for engineering ECMs with high-fidelity mechanical properties显示文摘Engineered extracellular matrices(ECMs)that replicate complex in-vivo features have shown great potential in tissue engineering.Biocompatible hydrogel microstructures have been widely used to replace these native ECMs for physiologically relevant research.However,accurate reproduction of the 3D hierarchical and nonuniform mechanical stffness inside one integrated microstructure to mimic the complex mechanical properties of native ECMs presents a major challenge.Here,by using digital holographic microscopy(DHM)-based stffness imaging feedback,we propose a novel closed-loop control algorithm to achieve high-accuracy control of mechanical properties for hydrogel microstructures that recapitulate the physiological properties of native ECMs with high fidelity.During photoprinting,the photocuring area of the hydrogel is divided into microscale grid areas to locally control the photocuring process.With the assistance of a motorized microfluidic channel,the curing thickness is controlled with layer-by-layer stacking.The DHM-based stiffness imaging feedback allows accurate adjustment of the photocuring degree in every grid area to change the crosslinking network density of the hydrogel,thus enabling large-span and high-resolution modulation of mechanical properties.Finally,the gelatin methacrylate was used as a typical biomaterial to construct the highfidelity biomimetic ECMs.The Young's modulus could be flexibly modulated in the 10 kPa to 50 kPa range.Additionally,the modulus gradient was accurately controlled to within 2.9 kPa.By engineering ECM with locally different mechanical properties,cell spreading along the stff areas was observed successfully.We believe that this method can regenerate complex biomimetic ECMs that closely recapitulate in-vivo mechanical properties for further applications in tissue engineering and biomedical research. | Xin Li Huaping Wang Xinyi Dong Qing Shi Tao Sun Shingo Shimoda Qiang Huang Toshio Fukuda | 2022 | Microsystems & Nanoengineering2022，8，3： | 0 |
| 13 | Highly selective growth of(6,5)single-walled carbon nanotubes from sigma phase alloy catalyst显示文摘The chirality structure of a single-walled carbon nanotube(SWNT)strongly depends on the composition of catalyst used in the chemical vapor deposition process.In this study,we develop a porous magnesia supported manganese-rhenium(MnRe/MgO)catalyst for chirality-selective synthesis of SWNTs.Detailed characterizations reveal that(6,5)tubes with a selectivity higher than 70%are grown from the Re-rich MnRe/MgO catalyst.By comparing the SWNT growth results with those of monometallic Mn or Re,the formation of sigma phase,an intermetallic compound occurring in transition-metal alloy systems,is revealed to be crucial for the dominant synthesis of(6,5)SWNTs.This work not only extends the application of sigma phase alloy for catalytic synthesis of SWNTs,but also sheds lights on the growth of SWNTs with a high chirality selectivity. | Liantao Xin Chen Ma Qianru Wu Shaokang Liu Linhai Li Xiuyun Zhang Liu Qian Maoshuai He Dong Li Fangqian Han Shulan Hao Lihu Feng Yahan Li Huaping Liu Lili Zhang Chang Liu Jin Zhang | 2024 | Nano Research2024，17，3： | 0 |
| 14 | Recent Progress of Fiber Loop Mirror-Based Sensors in China Jiliang University显示文摘作者概述纤维环镜子的最近的进步在中国 Jiliang 基于传感器大学。与各种各样的插入的纤维做的纤维循环镜子的唯一的特征,纤维循环镜子基于传感器有潜力在许多宽应用程序被利用。 | Chunliu ZHAO Yongxing JIN Juan KANG Huaping GONG, Xinyong DONG | 2012 | Photonic Sensors2012，2，1： | 0 |
| 15 | Prevalence and Types of Comorbidities in Pneumoconiosis—China,2018–2021显示文摘Summary What is already known about this topic?Pneumoconiosis,recognized as one of the most detrimental occupational diseases in China,exhibits a multimorbidity profile due to a plethora of comorbidities and complications.These factors significantly influence the treatment outcomes,progression,prognosis,and overall quality of life of the afflicted patients. | Huanqiang Wang Xiangpei Lyu Dong Luo Huaping Dai | 2023 | China CDC weekly2023，5，38： | 0 |
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