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| 1 | Suppressed expression of miR-378 targeting gzmb in N cells is required to control dengue virus infection显示文摘 | Shuyan Liu Lingming Chen Ying Zeng Lulu Si Xiaolan Guo Junmei Zhou Danyun Fang Gucheng Zeng Lifang Jiang | 2016 | Cellular & Molecular Immunology2016，13，5： | 7 |
| 2 | Thinking on the informatization development of China’s healthcare system in the post-COVID-19 era显示文摘With the application of Internet of Things,big data,cloud computing,artificial intelligence,and other cuttingedge technologies,China’s medical informatization is developing rapidly.In this paper,we summaried the role of information technology in healthcare sector’s battle against the coronavirus disease 2019(COVID-19)from the perspectives of early warning and monitoring,screening and diagnosis,medical treatment and scientific research,analyzes the bottlenecks of the development of information technology in the post-COVID-19 era,and puts forward feasible suggestions for further promoting the construction of medical informatization from the perspectives of sharing,convenience,and safety. | Ming Zhang Danyun Dai Siliang Hou Wei Liu Feng Gao Dong Xu Yu Hu | 2021 | Intelligent Medicine2021，1，1： | 4 |
| 3 | Aldehyde dehydrogenase ALDH3F1 involvement in flowering time regulation through histone acetylation modulation on FLOWERING LOCUS C显示文摘Flowering time regulation is one of the most important processes in the whole life of flowering plants and FLOWERING LOCUS C(FLC)is a central repressor of flowering time.However,whether metabolic acetate level affects flowering time is unknown.Here we report that ALDEHYDE DEHYDROGENASE ALDH3F1 plays essential roles in floral transition via FLC-dependent pathway.In the aldh3f1-1 mutant,the flowering time was significant earlier than Col-0 and the FLC expression level was reduced.ALDH3F1 had aldehyde dehydrogenase activity to affect the acetate level in plants,and the amino acids of E214 and C252 are essential for its catalytic activity.Moreover,aldh3f1 mutation reduced acetate level and the total acetylation on histone H3.The H3K9Ac level on FLC locus was decreased in aldh3f1-1,which reduced FLC expression.Expression of ALDH3F1 could rescue the decreased H3K9Ac level on FLC,FLC expression and also the early-flowering phenotype of aldh3f1-1,however ALDH3F1E214A or ALDH3F1C252A could not.Our findings demonstrate that ALDH3F1 participates in flowering time regulation through modulating the supply of acetate for acetyl-CoA,which functions as histone acetylation donor to modulate H3K9Ac on FLC locus. | Danyun Xu Qing Liu Gang Chen Zhiqiang Yan Honghong Hu | 2020 | Journal of Integrative Plant Biology2020，62，8： | 2 |
| 4 | Assessment and comparison of recombinant proteins from different sources for the detection of SARS-CoV-2 infection by using protein microarray显示文摘COVID-19 (the COVID-19 is a type of disease and resulted from being infected by virus SARS-CoV-2) pandemic is threatening tens of millions of lives around the world [1]. To date, specific drugs or vaccines are still not available for fighting the SARS-CoV-2. Diagnosis and quarantine are still the effective strategies for preventing the virus from spreading. Up to now, various detection methods for SARS-CoV-2 have been developed [2], which play critical roles in controlling the pandemics. According to the targets to be detected, these methods can be divided into three classes: methods for the nucleic acid [3], antigens [4], and antibodies elicited by the virus in the host [5]. Among these methods, the ones for antigens and antibodies could produce results in 10–15 min [6], which are suitable for point-of-care diagnosis, especially the ones for antibodies [7]. Meanwhile, the asymptomatic cases [8] and the false-negative results of nucleic acid testing [9] make the detection methods based on antibodies the best alternatives. The proteins, used in methods for detection of antibodies elicited by SARS-CoV-2 in the host, are critical agents, which could affect the diagnosis results. Given the strong immunogenicity of the nucleocapsid (N protein), spike protein (S protein), and related domains [10] and the potential diagnosis values, we collected 9 S1 proteins, 3 N proteins, 5 S2-related proteins, and receptor-binding domains (RBDs) from ACROBiosystems (Beijing, China), ABclonal (Wuhan, China), Novoprotein (Shanghai, China), Sino Biological (Beijing, China), and KactusBiosystems (Shanghai, China) and fabricated a protein microarray (Fig. 1A) to assess their diagnosis performance. In addition, other proteins such as the angiotensin converting enzyme 2 (ACE2), envelop protein (E), 3C-like protease, and papain-like protease were also included (Fig. 1B). | Huan Qi Mingliang Ma Danyun Lai Yang Li Fucheng Zhang Sheng-ce Tao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，2： | 2 |
| 5 | Synthesis,Crystal Structure and Biological Activity of a Nickel(Ⅱ) Complex of 2-acetylpyridine N( 4 )-methylthiosemicarbazone 显示文摘 | CHEN Danyun CHEN Chunling LI Mingxue | 2013 | J Coord Chem2013，63，9： | 1 |
| 6 | CdSe quantum dots as luminescent probes for spironolactone determination显示文摘 | LIANG Jiangong HUANG Shan ZENG Danyun | 2006 | Talanta2006，69，： | 1 |
| 7 | Ecosystem carbon stock of a tropical mangrove forest in North Sulawesi, Indonesia显示文摘Recent studies have highlighted the valuable role played by mangrove forests in carbon sequestration and storage.Although Indonesia accounts for a large proportion of global mangrove area, knowledge on the carbon stock and sources in the Indonesian mangrove is still limited. In this study, we quantified the ecosystem organic carbon(OC) stock and its spatial variation at an oceanic mangrove in Wori, North Sulawesi, Indonesia. The sources of soil OC were also investigated. The results showed that the mangrove soil had a substantial OC stock containing15.4 kg/m^2(calculated by carbon) in the top 50 cm soil, and represented the majority of the ecosystem OC stock at the Wori mangrove. The mangrove biomass and ecosystem OC stock were 8.3 kg/m^2 and 23.7 kg/m^2, respectively.There was no significantly difference in the soil OC stock among the stations with difference distances offshore,while the highest mangrove biomass OC stock was found at the seaward station. Isotope mixing calculations showed that the rich OC in mangrove soils was attributed to the accumulated autochthonous mangrove source while the suspended organic matter in tidal water and the mangrove-adjacent seagrass contributed less than 20%to the soil OC. The results further demonstrated the importances of the oceanic mangrove in carbon storage and the mangrove plants in contributing OC to their soils. | CHEN Shunyang CHEN Bin SASTROSUWONDO Pramudji DHARMAWAN I Wayan Eka OU Danyun YIN Xijie YU Weiwei CHEN Guangcheng | 2018 | Acta Oceanologica Sinica2018，37，12： | 1 |
| 8 | NbSe2 nanosheet supported PbBiO2Br as a high performance photocatalyst for the visible light-driven asymmetric alkylation of aldehyde显示文摘 | LI Xiaojie WANG Jun XU Danyun | 2015 | Sustainable Chem Eng2015，3，5： | 1 |
| 9 | Preferences in Wikipedia abstracts: Empirical findings and implications for automatic entity summarization显示文摘 | Xu Danyun Cheng Gong Qu Yunzhong | 2014 | Information Processing & Management2014，50，2： | 1 |
| 10 | A New Scalability of Hybrid Fuzzy C - Means Algorithm显示文摘 | Wang Hao Li Danyun Chu Yayun | 2010 | Artificial Intelligence and Compu- tational Intelligence (AICI)2010，，3： | 1 |
| 11 | CdSe quantum dots as luminescent probes for spironolactone determination显示文摘 | Jiangong Liang Shan Huang Danyun Zeng Zhike He Xinghu Ji Xinping Ai Hanxi Yang | 2005 | Talanta2005，，1： | 1 |
| 12 | The binding epitope of sintilimab on PD-1 revealed by AbMap显示文摘PD-1 plays an important role as an immune checkpoint.Sintilimab is a newly approved PD-1 antibody for cancer immunotherapy with an unknown binding epitope on PD-1.In this study,to elucidate the molecular mechanism by which sintilimab blocks PD-1 activation,we applied Antibody binding epitope Mapping(AbMap)to identify the binding epitope of sintilimab.An epitope was successfully identified,i.e.SLAPKA,aa 127-132.By constructing a series of point mutations,the dominant residues S127,L128,A129,P130,and A132 of PD-1 were further validated by western blot analysis,biolayer interferometry,and flow cytometry.Structural analysis showed that the epitope is partially within the binding interface of PD-1 and PD-L1,and this epitope also partially overlaps with that of nivolumab and pembrolizumab.These results demonstrate that sintilimab can attenuate PD-1 activation by directly competing with the interaction between PD-1 and PD-L1 through binding with the key residues of the FG loop on PD-1.This study also demonstrates the high efficiency and accuracy of AbMap for determining the binding epitope of therapeutic antibodies. | Mingliang Ma Huan Qi Chuansheng Hu Zhaowei Xu Fanlin Wu Nan Wang Danyun Lai Yang Li Hainan Zhang Hewei Jiang Qingfeng Meng Shujuan Guo Yani Kang Xiaodong Zhao Hua Li Sheng-ce Tao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 1 |
| 13 | Preparation of alumina-pillared montmorillonites with high thermal stability,regular microporosity and Lewis/Bronsted acidity显示文摘 | Ge Zhonghua Li Danyun Pinnavaia Thomas J | 1994 | Microporous Materials1994，，3： | 1 |
| 14 | CdSe quantum dots as luminescent probes for spironolactone determination 显示文摘 | Jiangong Liang Shan Huang Danyun Zeng Zhike He Xinghu Ji Xinping Ai Hanxi Yang | 2006 | Talanta2006，69，： | 1 |
| 15 | CdSc Quantum Dots as Lumincsccnt Probes for Spironolactone Determination 显示文摘 | LIANG Jiangong HUANG Shan ZENG Danyun ct al | 2006 | Talanta2006，69，1： | 1 |
| 16 | Regulation of FLC nuclear import by coordinated action of the NUP62-subcomplex and importinβSAD2显示文摘Flowering locus C(FLC)is a central transcriptional repressor that controls flowering time.However,how FLC is imported into the nucleus is unknown.Here,we report that Arabidopsis nucleoporins 62(NUP62),NUP58,and NUP54 composed NUP62-subcomplex modulates FLC nuclear import during floral transition in an importinα-independent manner,via direct interaction.NUP62 recruits FLC to the cytoplasmic filaments and imports it into the nucleus through the NUP62-subcomplex composed central channel.Importinβsupersensitive to ABA and drought 2(SAD2),a carrier protein,is critical for FLC nuclear import and flower transition,which facilitates FLC import into the nucleus mainly through the NUP62-subcomplex.Proteomics,RNAseq,and cell biological analyses indicate that the NUP62-subcomplex mainly mediates the nuclear import of cargos with unconventional nuclear localization sequences(NLSs),such as FLC.Our findings illustrate the mechanisms of the NUP62-subcomplex and SAD2 on FLC nuclear import process and floral transition,and provide insights into the role of NUP62-subcomplex and SAD2 in protein nucleocytoplasmic transport in plants. | Gang Chen Danyun Xu Qing Liu Zhichuang Yue Biao Dai Shujuan Pan Yongqiang Chen Xinhua Feng Honghong Hu | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
| 17 | Global Land Surface Climate Analysis Based on the Calculation of a Modified Bowen Ratio显示文摘A modified Bowen ratio(BRm),the sign of which is determined by the direction of the surface sensible heat flux,was used to represent the major divisions in climate across the globe,and the usefulness of this approach was evaluated. Five reanalysis datasets and the results of an offline land surface model were investigated. We divided the global continents into five major BRm zones using the climatological means of the sensible and latent heat fluxes during the period 1980–2010:extremely cold,extremely wet,semi-wet,semi-arid and extremely arid. These zones had BRm ranges of(-∞,0),(0,0.5),(0.5,2),(2,10) and(10,+∞),respectively. The climatological mean distribution of the Bowen ratio zones corresponded well with the K ¨oppen-like climate classification,and it reflected well the seasonal variation for each subdivision of climate classification. The features of climate change over the mean climatological BRm zones were also investigated. In addition to giving a map-like classification of climate,the BRm also reflects temporal variations in different climatic zones based on land surface processes. An investigation of the coverage of the BRm zones showed that the extremely wet and extremely arid regions expanded,whereas a reduction in area was seen for the semi-wet and semi-arid regions in boreal spring during the period 1980–2010. This indicates that the arid regions may have become drier and the wet regions wetter over this period of time. | Bo HAN Shihua Lü Ruiqing LI Xin WANG Lin ZHAO Cailing ZHAO Danyun WANG Xianhong MENG | 2017 | Advances in Atmospheric Sciences2017，34，5： | 0 |
| 18 | Phage display:an ideal platform for coupling protein to nucleic acid显示文摘Display technology,especially phage display technology,has been widely applied in many fields.The theoretical core of display technology is the physical linkage between the protein/peptide on the surface of a phage and the coding DNA sequence inside the same phage.Starting from phage-displayed peptide/protein/antibody libraries and taking advantage of the ever-growing power of next-generation sequencing(NGS)for DNA sequencing/decoding,rich protein-related information can easily be obtained in a high-throughput way.Based on this information,many scientific and clinical questions can be readily addressed.In the past few years,aided by the development of NGS,droplet technology,and massive oligonucleotide synthesis,we have witnessed and continue to witness large advances of phage display technology,in both technology development and application.The aim of this review is to summarize and discuss these recent advances. | Huan Qi Mingliang Ma Danyun Lai Sheng-ce Tao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 0 |
| 19 | De novo transcriptome assembly and metabolomic analysis of three tissue types in Cinnamomum cassia显示文摘Objective:The barks,leaves,and branches of Cinnamomum cassia have been historically used as a traditional Chinese medicine,spice,and food preservative,in which phenylpropanoids are responsible compounds.However phenylpropanoid biosynthesis pathways are not clear in C.cassia.We elucidated the pathways by descriptive analyses of differentially expressed genes related to phenylpropanoid biosynthesis as well as to identify various phenylpropanoid metabolites.Methods:Chemical analysis,metabolome sequencing,and transcriptome sequencing were performed to investigate the molecular mechanisms underlying the difference of active components content in the barks,branches and leaves of C.cassia.Results:Metabolomic analysis revealed that small amounts of flavonoids,coumarine,and cinnamaldehyde accumulated in both leaves and branches.Transcriptome analysis showed that genes associated with phenylpropanoid and flavonoid biosynthesis were downregulated in the leaves and branches relative to the barks.The observed differences in essential oil content among the three tissues may be attributable to the differential expression of genes involved in the phenylpropanoid and flavonoid metabolic pathways.Conclusion:This study identified the key genes in the phenylpropanoid pathway controling the flavonoid,coumarine,and cinnamaldehyde contents in the barks,branches and leaves by comparing the transcriptome and metabolome.These findings may be valuable in assessing phenylpropanoid and flavonoid metabolites and identifying specific candidate genes that are related to the synthesis of phenylpropanoids and flavonoids in C.cassia. | Hongyang Gao Huiju Zhang Yuqing Hu Danyun Xu Sikai Zheng Shuting Su Quan Yang | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
| 20 | Design and Hardware-in-the-loop Validation:A Fractional Full Feed-forward Method for Grid Voltage in LCL Grid-connected Inverter Systems显示文摘The harmonic disturbance in the background grid is a problem that must be considered in the design of a gridconnected inverter.However,the full feed-forward method cannot completely suppress the harmonic disturbance in theory and is sensitive to noise.To tackle these problems,a fractional full feed-forward method of grid voltage is proposed in this paper.First,the mathematical model of the full feed-forward method is deduced,and the differences with the theoretical solution,which can suppress all harmonics,are analyzed.Then,the parameter equation,the harmonic suppression performance,stability analysis and the implementation process of this method are given.Compared with the full feed-forward method,the proposed method not only further improves the harmonic suppression performance,but also reduces the order of the mathematical model of the differential term in the feed-forward loop.In addition,the proposed method can be used to flexibly design feed-forward coefficients by selecting the order of suppressed harmonics.Finally,the proposed method is validated by a hardware-in-the-loop experiment on a MT real-time control platform NI PXIE-1071. | Qingyi Wang Binlei Ju Yudi Lei Dan Zhou Shuai Yin Danyun Li | 2023 | CSEE Journal of Power and Energy Systems2023，9，5： | 0 |
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