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| 1 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 20 |
| 2 | 成人缺血性卒中早期处理指南显示文摘本指南旨在对成年急性缺血性卒中患者评价和治疗各要素的现有证据做一回顾。目标读者是那些为发病后48h内的卒中患者提供治疗的内科医生和其他急诊医疗保健人员。另外,也包括向医疗保健政策制定者提供的信息。方法:专家小组成员由美国心脏协会(AHA)卒中委员会科学声明监督委员会任命,他们代表了来自不同领域的专家。专家小组以2003年后发表的报道为重点,对相关文献进行回顾,采用AHA卒中委员会的证据水平分级标准对证据进行分级并做出推荐。本声明经专家小组认可后,再由AHA科学顾问和协调委员会进行同行评议和正式批准。本指南打算在3年内做全面更新。结果:对急性缺血性卒中患者的处理仍然是多方面的,包括尚未在临床试验中进行过验证的一些医疗诊治方面。本声明包括从急诊医疗服务人员开始接触患者到入院初期处理的推荐意见。静脉重组组织型纤溶酶原激活剂仍然是已得到证实的最有效的卒中急诊治疗干预方法。包括动脉应用溶栓药和机械介入在内的一些方法显示出希望。因为许多推荐是在有限的证据基础上做出的,因此需要对急性缺血性卒中的治疗进行更多的研究。 | Harold P. Adams Gregory del Zoppo Mark J. Alberts Deepak L. Bhatt Lawrence Brass Anthony Furlan Robert L. Grubb Randall T. Higashida Edward C. Jauch Chelsea Kidwell Patrick D. Lyden Lewis B. Morgenstern Adnan I. Qureshi Robert H. Rosenwasser Phillip A. Scott Eelco F.M. Wijdicks 李焰生(译) 熊昕丽(译) 林岩(译) 沈沸(译) 俞羚(译) 邹静(译) 张静芳(译) 孙亚蒙(译) 周洁茹(译) 蒋仙国(译) 陈莺(译) | 2007 | 国际脑血管病杂志2007，15，6： | 18 |
| 3 | 普拉格雷临床价值分析显示文摘·对于非常可能实施PCI的急性冠脉综合征患者,普拉格雷治疗的效果较好,比如ST段抬高的心肌梗死患者,或者冠脉造影显示无ST段抬高的心肌梗死患者。·老年患者应避免使用,除非有高危因素。·低体重患者可选择低维持剂量,但还需要进一步证实。·无ST段抬高的心肌梗死患者急诊常规选择普拉格雷还为时尚早。·急性冠脉综合征患者初始治疗选择普拉格雷的疗效还不明确,但已在研究之中。·复杂选择性PCI之后常规使用普拉格雷是有临床需求的,但在有进一步的证据之前还不宜使用。 | Deepak L. Bhatt 海燕 | 2009 | 中国处方药2009，8，9： | 6 |
| 4 | 世界各地动脉粥样硬化血栓形成门诊患者心血管危险因素的流行及诊治情况显示文摘背景:动脉粥样硬化血栓形成是导致心血管疾病和死亡的主要原因。至今,尚无国际数据库阐述动脉粥样硬化血栓形成患者动脉硬化危险因素的特征和治疗强度。
目的:确定动脉粥样硬化危险因素的发生及治疗在世界许多国家是否具有可比性。设计、地点及参试者:“降低动脉粥样硬化血栓形成保持健康研究”(Reduction of Atherothrombosis for Continued Health,REACH)搜集了动脉粥样硬化危险因素及治疗情况的数据。从2003年到2004年,44个国家、5473位内科从业医师总共发现67888例年龄≥45岁的动脉病患者(冠心病[coronaryartery disease,CAD],n=40258;脑血管病,n=18843;周围动脉病,n=8273)或≥3个动脉粥样硬化血栓形成危险因素(n=12389)。主要观测指标:动脉粥样硬化危险因素的基线发生率、药物应用情况及危险因素控制程度。结果:全世界动脉粥样硬化血栓形成患者具有相似的危险因素,即高血压(81.8%)、高胆固醇血症(72.4%)以及糖尿病(44.3%)的比例高。超重(39.8%)、肥胖(26.6%)以及病态肥胖(3.6%)的发生率在大部分地区相似,但是以北美最高(超重:37.1%,肥胖:36.5%,病态肥胖:5.8%;与其他地区比较P〈0.001)。患者采用他汀(总共69.4%;范围:从脑血管病的56.4%到CAD的76.2%)、抗血小板治疗(总共78.6%;范围:从≥3个危险因素的53.9%到CAD的85.6%)及其他循证(降低危险)普遍不足。确诊有血管病的患者在吸烟者为数可观(14.4%)。高血压病治疗不足(基线50.0%血压升高)、高血糖诊断不足(4.9%)以及空腹血糖受损(其中36.5%不知已有糖尿病)均很常见。在有症状的动脉粥样硬化血栓形成患者中,15.9%是有症状的多血管疾病患者。
结论:这项当代大型国际数据库研究显示,在世界许多地区典型心血管危险因素的发生是一致且常见的,但是大多治疗不足、控制不得力。 | Deepak L. Bhatt, MD P. Gabriel Steg, MD E. Magnus Ohman, MD Alan T. Hirsch, MD Yasuo Ikeda, MD Jean-Louis Mas, MD Shinya Goto, MD Chlau-Suong Liau, MD, PhD Alain J. Richard, MD, PhD Joachim Roether, MD Peter W. F. Wilson, MD 徐成斌(译) | 2007 | 美国医学会杂志(中文版)2007，26，1： | 5 |
| 5 | Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD^(2) score显示文摘Background Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack(TIA)and role of ABCD^(2) score in identifying high-risk individuals are not studied.Methods We identified 40825 Medicare beneficiaries hospitalised from 2011 to 2014 for a TIA to a Get With The Guidelines(GWTG)-Stroke hospital and classified them using ABCD^(2)s of mortality and rehospitalisation(all-cause,ischaemic stroke,haemorrhagic stroke,myocardial infarction,and gastrointestinal and intracranial haemorrhage)for high-risk versus low-risk groups adjusted for patient and hospital characteristics.Results Of the 40825 patients,35118(86%)were high risk(ABCD^(2)≥4)and 5707(14%)were low risk(ABCD^(2)=0-3).Overall rate of mortality during 1-year follow-up after hospital discharge for the index TIA was 11.7%,44.3% were rehospitalised for any reason and 3.6%were readmitted due to stroke.Patients with ABCD^(2) score≥4 had higher mortality at 1 year than not(adjusted HR 1.18,95%CI 1.07 to 1.30).Adjusted risks for ischaemic stroke,all-cause readmission and mortality/all-cause readmission at 1 year were also significantly higher for patients with ABCD^(2) score≥4 vs 0-3.In contrast,haemorrhagic stroke,myocardial infarction,gastrointestinal bleeding and intracranial haemorrhage risk were not significantly different by ABCD^(2) score.Conclusions This study validates the use of ABCD^(2) score for long-term risk assessment after TIA in patients aged 65 years and older.Attentive efforts for community-based follow-up care after TIA are needed for ongoing prevention in Medicare beneficiaries who were hospitalised for TIA. | Shreyansh Shah Li Liang Durgesh Bhandary Saga Johansson Eric E Smith Deepak L Bhatt Gregg C Fonarow Naeem D Khan Eric Peterson Janet Prvu Bettger | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 6 | ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents显示文摘 | Deepak L. Bhatt James Scheiman Neena S. Abraham Elliott M. Antman Francis K.L. Chan Curt D. Furberg David A. Johnson Kenneth W. Mahaffey Eamonn M. Quigley Robert A. Harrington Eric R. Bates Charles R. Bridges Mark J. Eisenberg Victor A. Ferrari Mark A. Hl | 2008 | Circulation2008，，18： | 3 |
| 7 | Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate显示文摘 | Laurent Bonello Udaya S. Tantry Rossella Marcucci Ruediger Blindt Dominick J. Angiolillo Richard Becker Deepak L. Bhatt Marco Cattaneo Jean Philippe Collet Thomas Cuisset Christian Gachet Gilles Montalescot Lisa K. Jennings Dean Kereiakes Dirk Sibbing Die | 2010 | Journal of the American College of Cardiology2010，，12： | 3 |
| 8 | Role of aspiration and mechanical thrombectomy in patients with acute myocardial infarction undergoing primary angioplasty: An updated meta-analysis of randomized trials显示文摘 | Dharam J. Kumbhani Anthony A. Bavry Milind Y. Desai Sripal Bangalore Deepak L. Bhatt | 2013 | Journal of the American College of Cardiology2013，，： | 2 |
| 9 | ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use显示文摘 | Deepak L. Bhatt James Scheiman Neena S. Abraham Elliott M. Antman Francis K.L. Chan Curt D. Furberg David A. Johnson Kenneth W. Mahaffey Eamonn M. Quigley Robert A. Harrington Eric R. Bates Charles R. Bridges Mark J. Eisenberg Victor A. Ferrari Mark A. Hl | 2008 | Journal of the American College of Cardiology2008，，18： | 2 |
| 10 | Detection, evaluation, and treatment of severe and resistant hypertension显示文摘 | William B. White J. Rick Turner Domenic A. Sica John D. Bisognano David A. Calhoun Raymond R. Townsend Herbert D. Aronow Deepak L. Bhatt George L. Bakris | 2014 | Journal of the American Society of Hypertension2014，，10： | 1 |
| 11 | Incomplete Inhibition of Thromboxane Biosynthesis by Acetylsalicylic Acid: Determinants and Effect on Cardiovascular Risk显示文摘 | John W. Eikelboom Graeme J. Hankey Jim Thom Deepak L. Bhatt P Gabriel Steg Gilles Montalescot S Claiborne Johnston Steven R. Steinhubl Koon-Hou Mak J Donald Easton Christian Hamm Tingfei Hu Keith A.A. Fox Eric J. Topol | 2008 | Circulation2008，，17： | 1 |
| 12 | Adherence to Secondary Prevention Medications and Four-year Outcomes in Outpatients with Atherosclerosis显示文摘 | Dharam J. Kumbhani Ph. Gabriel Steg Christopher P. Cannon Kim A. Eagle Sidney C. Smith Elaine Hoffman Shinya Goto E. Magnus Ohman Deepak L. Bhatt | 2013 | The American Journal of Medicine2013，，： | 1 |
| 13 | Carotid Atherosclerosis and Risk of Subsequent Coronary Event in Outpatients With Atherothrombosis显示文摘 | Gaia Sirimarco Pierre Amarenco Julien Labreuche Pierre-Jean Touboul Mark Alberts Shinya Goto Joachim Rother Jean-Louis Mas Deepak L. Bhatt Philippe Gabriel Steg | 2013 | Stroke2013，，2： | 1 |
| 14 | Analysis of Risk of Bleeding Complications After Different Doses of Aspirin in 192,036 Patients Enrolled in 31 Randomized Controlled Trials显示文摘 | Victor L. Serebruany Steven R. Steinhubl Peter B. Berger Alex I. Malinin Jeffrey S. Baggish Deepak L. Bhatt Eric J. Topol | 2005 | The American Journal of Cardiology2005，，10： | 1 |
| 15 | Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers显示文摘 | Kathleen Maksimowicz-McKinnon Deepak L. Bhatt Leonard H. Calabrese | 2004 | Current Opinion in Rheumatology2004，，1： | 1 |
| 16 | Dempster shafer neural network algorithm for land vehicle navigation application显示文摘 | Priyanka Aggarwal Deepak Bhatt Vijay Devabhaktuni | 2013 | Information Sciences2013，253，： | 1 |
| 17 | Aspirin dose and six-month outcome after an acute coronary syndrome显示文摘 | Martin J Quinn Herbert D Aronow Robert M Califf Deepak L Bhatt Shelly Sapp Neal S Kleiman Robert A Harrington David F Kong David E Kandzari Eric J Topol | 2004 | Journal of the American College of Cardiology2004，，6： | 1 |
| 18 | Statins and Intracerebral Hemorrhage: Collaborative Systematic Review and Meta-Analysis显示文摘 | Daniel G. Hackam Mark Woodward L. Kristin Newby Deepak L. Bhatt Mingyuan Shao Eric E. Smith Allan Donner Muhammad Mamdani James D. Douketis Hisatomi Arima John Chalmers Stephen MacMahon David L. Tirschwell Bruce M. Psaty Cheryl D. Bushnell Maria I. Aguila | 2011 | Circulation2011，，20： | 1 |
| 19 | Leukocyte Count Predicts Microembolic Doppler Signals During Carotid Stenting: A Link Between Inflammation and Embolization显示文摘 | Herbert D. Aronow Mehdi Shishehbor DonaLee A. Davis Irene L. Katzan Deepak L. Bhatt Christopher T. Bajzer Alex Abou-Chebl Krieger W. Derk Patrick L. Whitlow Jay S. Yadav | 2005 | Stroke2005，，9： | 1 |
| 20 | Impact of Drug-Eluting Versus Bare-Metal Stents on Mortality in Patients With Anemia显示文摘 | Mehdi H. Shishehbor Steven J. Filby Adnan K. Chhatriwalla Ryan D. Christofferson Anil Jain Samir R. Kapadia A. Michael Lincoff Deepak L. Bhatt Stephen G. Ellis | 2009 | JACC: Cardiovascular Interventions2009，，： | 1 |
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