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| 1 | Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo显示文摘Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer. | Guangyao Lv Dengjun Sun Jingwen Zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 6 |
| 2 | Escin:inhibting inflammation,promoting gastoin-testisal transit attenuate the postoperative adhesions显示文摘 | Fenghua FU | 2007 | World JSurgery2007，21，12： | 1 |
| 3 | Interleukin 6 protects H<sub>2</sub>O<sub>2</sub>‐induced cardiomyocytes injury through upregulation of prohibitin via STAT3 phosphorylation显示文摘 | Yuhua Jia Fenghua Zhou Peng Deng Qin Fan Chunhua Li Yawei Liu Xiuqiong Fu Yingchun Zhou Xin Xu Xuegang Sun | 2012 | Cell Biochem Funct2012，，5： | 1 |
| 4 | Cardioprotective Effects of Salvianolic Acid A on Myocardial Ischemia-Reperfusion Injury In Vivo and In Vitro显示文摘 | Huaying Fan Liu Ying Fenghua Fu | 2012 | Evidence-Based Complementary and Alternative Medicine2012，25，6： | 1 |
| 5 | Potent anti-inflammatory agent escin does not affect the healing oftibia fracture and abdominal wound in an animal model显示文摘 | Leiming Zhang Hongsheng Wang Tian Wang Na Jiang Pengfei Yu Feiyan Liu Yating Chong Fenghua Fu | 2012 | Experimental and Therapeutic Medicine2012，，4： | 1 |
| 6 | Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial显示文摘Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was conducted.Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied.The R-FPD regimen consisted of rituximab(375 mg/m2 i.v.on D0),fotemustine(100 mg/m2 i.v.on D1),pemetrexed(600 mg/m2 i.v.on D1),and dexamethasone(40 mg i.v.on D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of age.Results:A total of 30 patients were included.After 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL. | Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 7 | Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action显示文摘 | Xinbing Wei Huiqing Liu Xia Sun Fenghua Fu Xiumei Zhang Jin Wang Jie An Hua Ding | 2005 | Neuroscience Letters2005，，1： | 1 |
| 8 | Neuroprotective Effects of Hydroxysafflor Yellow A: In Vivo and in Vitro Studies显示文摘 | Haibo Zhu Zhenhua Wang Chengjun Ma Jingwei Tian Fenghua Fu Changling Li Dean Guo E. Roeder Ke Liu | 2003 | Planta Med2003，，05： | 1 |
| 9 | Ameliorative Effect of Ginsenoside RT-5 on CDDP-Induced Nephrotoxicity显示文摘The aim of this study is to explore whether RT-5, one novel active ginsenosides from Ginseng, has protective effects against cisplatin(CDDP)-induced nephrotoxicity in vivo. One model of acute renal failure induced by CDDP in rats and one model of xenograft tumors of human cervical cancer in nude mice are established. Four groups are assigned: control, CDDP, RT-5, CDDP plus RT-5, in which the RT-5 is administered via oral gavage 24 h before CDDP intraperitoneal injection. The significant increase in blood urea nitrogen and creatinine are induced by CDDP treatment at 6 mg/kg, which are attenuated by pre-treated with RT-5 at 10 mg/kg. RT-5 could ameliorate CDDP-induced morphological damages in kidney by PAS staining, and reduce tubular apoptosis evaluated by TUNEL staining. Pretreatment with RT-5 notably inhibits CDDP-induced oxidative stress in kidney tissues. Interestingly, RT-5 does not interfere with the in vivo anti-cancer effects of CDDP against the growth of xenograft tumors in nude mice. These data suggest that co-treatment RT-5 with CDDP might attenuate the following nephrotoxicity without inhibiting its anti-tumor efficiency, which could provide one novel strategy for cancer treatment in clinics. | JIANG Yongtao QIU Xiaolei MA Jinbo Lü Guangyao WANG Zongliang ZHANG Jingwen FU Fenghua WANG Hongbo | 2015 | Wuhan University Journal of Natural Sciences2015，20，4： | 1 |
| 10 | Escin: inhibiting inflammation, promoting gastrointestinal transit to attenuate the postoperative adhesions 显示文摘 | Fenghua FU | 2005 | World J Surgery2005，12，29： | 1 |
| 11 | Ocotillol Enhanced the Antitumor Activity of Doxorubicin via p53-Dependent Apoptosis显示文摘 | Hongbo Wang Pengfei Yu Jing Bai Jianqiao Zhang Liang Kong Fangxi Zhang Guangying Du Shiqian Pei Lixia Zhang Yongtao Jiang Jingwei Tian Fenghua Fu Gautam Sethi | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 12 | Escin attenuates acute lung injury induced by endotoxin in mice显示文摘 | Wenyu Xin Leiming Zhang Huaying Fan Na Jiang Tian Wang Fenghua Fu | 2010 | European Journal of Pharmaceutical Sciences2010，，1： | 1 |
| 13 | Protec- tions of SMND-309, a novel derivate of salvianolic acid B, on brain mitochondria contribute to injury ameliora- tion in cerebral ischemia rats显示文摘 | Tian Jingwei Fu Fenghua Li Guisheng | 2009 | Journal Phytomedi- cine2009，16，： | 1 |
| 14 | Escin: Inhibiting Inflammation and Promoting Gastrointestinal Transit to Attenuate Formation of Postoperative Adhesions显示文摘 | Fenghua Fu Yuezhi Hou Wanglin Jiang Ronghua Wang Ke Liu | 2005 | World Journal of Surgery2005，，： | 1 |
| 15 | Escin attenuates cognitive deficits and hippocampal injury after transient global cerebral ischemia in mice via regulating certain inflammatory genes显示文摘 | Leiming Zhang Fenghua Fu | 2010 | Neurochemistry International2010，57，2： | 1 |
| 16 | 中国地区NCEP再分析资料与台站观测的地表温度差异及其影响显示文摘作为时间序列非线性的一个重要指标,从NCEP再分析得到日气温异常的时间不可逆性(TI)与观测站的相比几乎一致地被高估了.因为非线性与可预报性/极端事件之间有着密切的关系,除了高估的TI外,这些大气测度也可能被高估.本文结果表明:NCEP再分析的日最低和最高气温异常序列的内在可预报性,预报技巧和极端事件发生次数也几乎一致被高估.而且,这些高估的测度与高估的TI只存在微弱的相关性,这表明利用NCEP再分析研究可预测性和极端事件时,需要仔细考虑其质量对结论的可能影响. | Ruichen Li Yu Huang Fenghua Xie Zuntao Fu | 2021 | Atmospheric and Oceanic Science Letters2021，14，1： | 0 |
| 17 | Individual variation in buffalo somatic cell cloning efficiency is related to glycolytic metabolism显示文摘Mammalian individuals differ in their somatic cell cloning efficiency,but the mechanisms leading to this variation is poorly understood.Here we found that high cloning efficiency buffalo fetal fibroblasts(BFFs)displayed robust energy metabolism,looser chromatin structure,high H3 K9 acetylation and low heterochromatin protein 1α(HP1α)expression.High cloning efficiency BFFs had more H3 K9 ac regions near to the upstream of glycolysis genes by Ch IP-seq,and involved more openness loci related to glycolysis genes through ATAC-seq.The expression of these glycolysis genes was also found to be higher in high cloning efficiency BFFs by q RT-PCR.Two key enzymes of glycolysis,PDKs and LDH,were confirmed to be associated with histone acetylation and chromatin openness of BFFs.Treatment of low cloning efficiency BFFs with PS48(activator of PDK1)resulted in an increase in the intracellular lactate production and H3 K9 acetylation,decrease in histone deacetylase activity and HP1αexpression,less condensed chromatin structure and more cloning embryos developing to blastocysts.These results indicate that the cloning efficiency of buffalo somatic cells is associated with their glycolytic metabolism and chromatin structure,and can be improved by increasing glycolytic metabolism. | Chan Luo Zhiqiang Wang Jinling Wang Feng Yun Fenghua Lu Jiayuan Fu Qingyou Liu Deshun Shi | 2022 | Science China(Life Sciences)2022，65，10： | 0 |
| 18 | Design,Synthesis and Biological Activities of Quinazoline Containing Sorafenib Analogs as Antitumor Agents显示文摘A series of novel sorafenib derivatives containing quinazoline moiety were designed and synthesized. Their anti-proliferative activities against HCT116 and HCT115 cell lines were evaluated using MTT assay. Most of the synthesized compounds showed significant cytotoxicity against the selected cell lines. These cytotoxicities were consistent with their inhibitory activity against the phosphorylation of c-Raf, MEK1/2 and ERK1/2. Compound GD-09 also showed much stronger anti-tumor activity than that of sorafenib in vivo by B16 melanoma xenograft model test. | ZHANG Jingwen WANG Ningning XIE Xiaoxia YAN Chunhong FU Fenghua YAO Jianwen WANG Hongbo | 2017 | Wuhan University Journal of Natural Sciences2017，22，3： | 0 |
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