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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | Overexpression of IbPAL1 promotes chlorogenic acid biosynthesis in sweetpotato显示文摘Sweetpotato[Ipomoea batatas(L.)Lam.],a food crop with both nutritional and medicinal uses,plays essential roles in food security and health-promoting.Chlorogenic acid(CGA),a polyphenol displaying several bioactivities,is distributed in all edible parts of sweetpotato.However,little is known about the specific metabolism of CGA in sweetpotato.In this study,IbPAL1,which encodes an endoplasmic reticulum-localized phenylalanine ammonia lyase(PAL),was isolated and characterized in sweetpotato.CGA accumulation was positively associated with the expression pattern of IbPAL1 in a tissue-specific manner,as further demonstrated by overexpression of IbPAL1.Overexpression of IbPAL1 promoted CGA accumulation and biosynthetic pathway genes expression in leaves,stimulated secondary xylem cell expansion in stems,and inhibited storage root formation.Our results support a potential role for IbPAL1 in sweetpotato CGA biosynthesis and establish a theoretical foundation for detailed mechanism research and nutrient improvement in sweetpotato breeding programs. | Yang Yu Yingjie Wang Yue Yu Peiyong Ma Zhaodong Jia Xiaoding Guo Yizhi Xie Xiaofeng Bian | 2021 | The Crop Journal2021，9，1： | 5 |
| 3 | Simulation of the Ising model, memory for Bell states and generation of four-atom entangled states in cavity QED显示文摘A scheme is proposed to simulate the Ising model and preserve the maximum entangled states (Bell states) in cavity quantum electrodynamics (QED) driven by a classical field with large detuning. In the strong driving and large-detuning regime, the effective Hamiltonian of the system is the same as the standard Ising model, and the scheme can also make the initial four Bell states of two atoms at the maximum entanglement all the time. So it is a simple memory for the maximal entangled states. The system is insensitive to the cavity decay and the thermal field and more immune to decoherence. These advantages can warrant the experimental feasibility of the current scheme. Furthermore, the genuine four-atom entanglement may be acquired via two Bell states through one-step implementation on four two-level atoms in the strong-driven model, and when two Greenberger-Horne-Zeilinger (GHZ) states are prepared in our scheme, the entangled cluster state may be acquired easily. The success probability for the scheme is 1. | ZHANG YingJie XIA YunJie MAN ZhongXiao GUO GuangCan | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，5： | 4 |
| 4 | Rh-doped PdAg nanoparticles as efficient methanol tolerance electrocatalytic materials for oxygen reduction显示文摘Direct methanol fuel cells(DMFCs)have received extensive attention on their high efficiency,high reliability,and no carbon emission.Unfortunately,the poor methanol tolerance and sluggish oxygen reduction reaction(ORR)at cathode have seriously hindered their further development.Herein we report the synthesis of a new class of Rh-doped PdAg alloy nanoparticles(NPs)for boosting ORR activity with high methanol tolerance capacity concurrently.The ORR mass activity of typical Rh_4Pd_(40)Ag_(56)NPs is 4.2 times higher than that of commercial Pt catalyst.Moreover,it shows a great methanol tolerance capability by maintaining 92.4%in ORR mass activity in alkaline solution with 0.1 mol L^(à1)methanol,against a big decrease of almost 100%for commercial Pt.Even after 30,000 potential cycles with 1.0 mol L^(à1)methanol,Rh_4Pd_(40)Ag_(56)NPs still retain ORR mass activity of up to 68.3%.DFT calculations reveal that excellent ORR performance with excellent methanol tolerance originates the active d-band-pinning engineering for an efficient site-independent electron-transfer.A generalized d-band mediated fine electron-transfer tuning path has blueprinted for effectively minimizing intrinsic ORR barriers with high current density.The present work highlights the key role of Rh doping in enhancing the ORR activity and methanol tolerance ability of PdAg NPs for future high-performance DMFCs. | Yingjun Sun Bolong Huang Nuoyan Xu Yingjie Li Mingchuan Luo Chunji Li Yingnan Qin Lei Wang Shaojun Guo | 2019 | Science Bulletin2019，64，1： | 4 |
| 5 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 6 | Compaction Performance of Biomimetic Press Roller to Soil显示文摘 | Jin Tong Qingzhu Zhang Li Guo Yuan Chang Yingjie Guo Fengwu Zhu Donghui Chen Xin Liu | 2015 | Journal of Bionic Engineering2015，12，1： | 3 |
| 7 | Comparative Assessment of Tundra Vegetation Changes Between North and Southwest Slopes of Changbai Mountains, China, in Response to Global Warming显示文摘Vegetation in high altitude areas normally exhibits the strongest response to global warming. We investigated the tundra vegetation on the Changbai Mountains and revealed the similarities and differences between the north and the southwest slopes of the Changbai Mountains in response to global warming. Our results were as follows: 1) The average temperatures in the growing season have increased from 1981 to 2015, the climate tendency rate was 0.38℃/10 yr, and there was no obvious change in precipitation observed. 2) The tundra vegetation of the Changbai Mountains has changed significantly over the last 30 years. Specifically, herbaceous plants have invaded into the tundra zone, and the proportion of herbaceous plants was larger than that of shrubs. Shrub tundra was transforming into shrub-grass tundra. 3) The tundra vegetation in the north and southwest slopes of the Changbai Mountains responded differently to global warming. The southwest slope showed a significantly higher degree of invasion from herbaceous plants and exhibited greater vegetation change than the north slope. 4) The species diversity of plant communities on the tundra zone of the north slope changed unimodally with altitude, while that on the tundra zone of the southwest slope decreased monotonously with altitude. Differences in the degree of invasion from herbaceous plants resulted in differences in species diversity patterns between the north and southwest slopes. Differences in local microclimate, plant community successional stage and soil fertility resulted in differential responses of tundra vegetation to global warming. | JIN Yinghua ZHANG Yingjie XU Jiawei TAO Yan HE Hongshi GUO Meng WANG Ailin LIU Yuxia NIU Liping | 2018 | Chinese Geographical Science2018，28，4： | 3 |
| 8 | Phospholipid Transfer Protein Deficiency Decreases the Content of S1P in HDL via the Loss of its Transfer Capability显示文摘 | Yang Yu Shoudong Guo Yumei Feng Lei Feng Yingjie Cui Guohua Song Tian Luo Ke Zhang Yiwei Wang Xian-Cheng Jiang Shucun Qin | 2014 | Lipids2014，，2： | 2 |
| 9 | An empirical model of the global distribution of plasmaspheric hiss based on Van Allen Probes EMFISIS measurements显示文摘Using wave measurements from the EMFISIS instrument onboard Van Allen Probes,we investigate statistically the spatial distributions of the intensity of plasmaspheric hiss waves.To reproduce these empirical results,we establish a fitting model that is a thirdorder polynomial function of L-shell,magnetic local time(MLT),magnetic latitude(MLAT),and AE*.Quantitative comparisons indicate that the model’s fitting functions can reflect favorably the major empirical features of the global distribution of hiss wave intensity,including substorm dependence and the MLT asymmetry.Our results therefore provide a useful analytic model that can be readily employed in future simulations of global radiation belt electron dynamics under the impact of plasmaspheric hiss waves in geospace. | JingZhi Wang Qi Zhu XuDong Gu Song Fu JianGuang Guo XiaoXin Zhang Juan Yi YingJie Guo BinBin Ni Zheng Xiang | 2020 | Earth and Planetary Physics2020，4，3： | 2 |
| 10 | On the loss mechanisms of radiation belt electron dropouts during the 12 September 2014 geomagnetic storm显示文摘Radiation belt electron dropouts indicate electron flux decay to the background level during geomagnetic storms,which is commonly attributed to the effects of wave-induced pitch angle scattering and magnetopause shadowing.To investigate the loss mechanisms of radiation belt electron dropouts triggered by a solar wind dynamic pressure pulse event on 12 September 2014,we comprehensively analyzed the particle and wave measurements from Van Allen Probes.The dropout event was divided into three periods:before the storm,the initial phase of the storm,and the main phase of the storm.The electron pitch angle distributions(PADs)and electron flux dropouts during the initial and main phases of this storm were investigated,and the evolution of the radial profile of electron phase space density(PSD)and the(μ,K)dependence of electron PSD dropouts(whereμ,K,and L^*are the three adiabatic invariants)were analyzed.The energy-independent decay of electrons at L>4.5 was accompanied by butterfly PADs,suggesting that the magnetopause shadowing process may be the major loss mechanism during the initial phase of the storm at L>4.5.The features of electron dropouts and 90°-peaked PADs were observed only for>1 MeV electrons at L<4,indicating that the wave-induced scattering effect may dominate the electron loss processes at the lower L-shell during the main phase of the storm.Evaluations of the(μ,K)dependence of electron PSD drops and calculations of the minimum electron resonant energies of H+-band electromagnetic ion cyclotron(EMIC)waves support the scenario that the observed PSD drop peaks around L^*=3.9 may be caused mainly by the scattering of EMIC waves,whereas the drop peaks around L^*=4.6 may result from a combination of EMIC wave scattering and outward radial diffusion. | Xin Ma Zheng Xiang BinBin Ni Song Fu Xing Cao Man Hua DeYu Guo YingJie Guo XuDong Gu ZeYuan Liu Qi Zhu | 2020 | Earth and Planetary Physics2020，4，6： | 2 |
| 11 | Electrical conductivities of two granite samples in southern Tibet and their geophysical implications显示文摘There are clear differences in the electrical conductivities of the crustal granites of the Qinghai-Tibet Plateau.Because these granites are among the major rock types on the Qinghai-Tibet Plateau, it is very important to detect the electrical conductivity of granites under high temperatures and pressures to study the electrical conductivity structure of this area. Using impedance spectroscopy at a frequency range of 10.1–106 Hz, the electrical conductivity of the muscovite-granite collected from Yadong was investigated at a confining pressure of 1.0 GPa and temperatures ranging from 577 to 996 K, while the electrical conductivity of the biotite-granite collected from Lhasa was investigated at a pressure of 1.0 GPa and temperatures ranging from587 to 1382 K. The calculated activation enthalpies of the Yadong muscovite-granite sample is 0.92 eV in the low-temperature range(577–919 K) and 2.16 eV in the high-temperature range(919–996 K). The activation enthalpies of the Lhasa biotite-granite sample is 0.48 eV in the low-temperature range(587–990 K) and 2.06 eV in the high-temperature range(990–1382 K). The change in the activation enthalpies of the granites at different temperature ranges may be associated with the dehydration of the two samples. The electrical conductivities of the granite samples obtained in the laboratory using impedance spectroscopy correspond well with field observations conducted near the sampling points, both in terms of the actual conductivity values and the observed variations between the low-temperature and high-temperature regimes. This correlation of laboratory and field conductivities indicates that the conductivities of the crustal rocks in the two regions closely correspond to granite conductivities.We calculated the electrical conductivities of muscovite-granite and biotite-granite samples using the effective medium and HS boundary models. When applied to the crustal rocks of southern Tibet, the results of the geophysical conductivity profiles lie within the range of laboratory data. Thus, the electrical characteristics of the crustal rocks underlying the southern Qinghai-Tibet Plateau can largely be attributed to granites, with the large changes to high conductivities at increasing depths resulting from the dehydration of crustal rocks with granitic compositions. | GUO YingXing WANG DuoJun ZHOU YongSheng LIU ZaiYang YU YingJie LI DanYang ZHANG DongNing ZHU AiYu | 2017 | Science China Earth Sciences2017，60，8： | 2 |
| 12 | Effects of typhoon Roke and Haitang on phytoplankton community structure in northeastern South China sea显示文摘The influence of typhoon and Kuroshio intrusion process on the natural phytoplankton assemblages in the northeastern South China Sea(neSCS)was examined during a cruise in summer 2017.One hundred ninety-six seawater samples were collected and analyzed in the neSCS.In total,299 species were identified belonging to 82 genera,mostly dominated by Bacillariophyta(159),followed by Dinophyta(132),Cyanophyta(4)and Chrysophyta(4).Among all,Thalassionema nitzschioides,Thalassionema frauenfeldii,Thalassiosira minima,in Bacillariophyta,Prorocentrum lenticulatum,Prorocentrum compressum in Dinophyta,and Trichodesmium thiebautii,in the Cyanophyta were the most dominated species,respectively.Correlation analysis shows compared with other groups Bacillariophyta was mostly influenced by silicate,whereas,Dinophyta and Cyanophyta showed significant correlation with temperature,salinity,phosphate,and nitrate.After the typhoon,the higher abundance of Dinophyta was observed,whereas it was lower in case of Bacillariophyta and Cyanophyta,shows typhoon“Roke“and”Haitang”had a significant influence on the phytoplankton assemblages,which could be manifested by the variations of total phytoplankton abundance in the surface water of neSCS.Overall,our present study provides the latest in-depth information about how the environmental factors influencing the phytoplankton density and diversity in the neSCS during summer. | Yingjie Mao Jun Sun Congcong Guo Yuqiu Wei Xingzhou Wang Shuang Yang Chao Wu | 2019 | Ecosystem Health and Sustainability2019，5，1： | 2 |
| 13 | Computational fluid dynamics simulation of aerosol transport and deposition显示文摘In this article computational fluid dynamics(CFD)simulation of aerosol transport and deposition,i.e.the transport and deposition of particles in an aerosol,is reviewed.The review gives a brief account of the basics of aerosol mechanics,followed by a description of the general CFD approach for flow field simulation,turbulence modeling,wall treatments and simulation of particle motion and deposition.Then examples from the literature are presented,including CFD simulation of particle deposition in human respiratory tract and particle deposition in aerosol devices.CFD simulation of particle transport and deposition may provide information that is difficult to obtain through physical experiments,and it may help reduce the number of experiments needed for device design.Due to the difficulty of describing turbulent flow and particle-eddy interaction,turbulent dispersion of particles remains one of the greatest challenges for CFD simulation.However,it is possible to take a balanced approach toward quantitative description of aerosol dispersion using CFD simulation in conjunction with empirical relations. | Yingjie TANG Bing GUO | 2011 | Frontiers of Environmental Science & Engineering2011，5，3： | 2 |
| 14 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 15 | Improved field emission properties of MgO nanoparticle doped car- bon nanotube films and their application in miniature vac- uum gauges 显示文摘 | Su Juan Guo Dengzhu Xin Yingjie | 2013 | Physica Status Solidi (a)2013，210，2： | 1 |
| 16 | Role of Adamantane Amide Based on L-Proline Double-H Potential Organocatalyst in Aidol Reaction with Product Separated via Host-guest Interaction显示文摘 | WANG Rui WEI Zhonglin GUO Jing FENG Yusha XU Enjie DUAN Haifeng LIN Yingjie YANG Qingbiao DU Jianshi LI Yaoxian | 2018 | Chemical Research in Chinese Universities2018，34，2： | 1 |
| 17 | Toward High Capacity and Stable SnO_(2)Hollow Nanosphere Electrode Materials:A Case Study of Ni-substituted Modification显示文摘To develop the urgent requirement for high-rate electrodes in next-generation lithium-ion batteries,SnO_(2)-based negative materials have been spotlighted as potential alternatives.However,the intrinsic problems,such as conspicuous volume variation and unremarkable conductivity,make the rate capability behave badly at a high-current density.Here,to solve these issues,this work demonstrate a new and facile strategy for synergistically enhancing their cyclic stability by combining the advantages of Ni doping and the fabrication of hollow nanosphere.Specifically,the incorporation of Ni^(2+)ions into the tetragonal rutile-type SnO_(2)shellsimproves the charge transfer kinetics effectively,leading to an excellent cycling stability.In addition,the growth of surface grains on the hollow nanospheres are restrained after Ni doping,which also reduces theunexpected polarization of negative electrodes.As a result,the as-prepared Ni doped electrode delivers a remarkable reversible capacity of 712 mAh g^(-1)at 0.1 A g^(-1)and exhibits outstanding capacity of 340 mAh g^(-1)at 1.6 A g^(-1),about 2.58 times higher than that of the pure SnO_(2)hollow sample. | Yannan ZHANG Peng DONG Yingjie ZHANG Hong GUO | 2021 | Research and Application of Materials Science2021，3，2： | 1 |
| 18 | Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy:Dynamic analysis on cytotoxic effects of LW-218显示文摘The integrity of lysosomes is of vital importance to survival of tumor cells.We demonstrated that LW-218,a synthetic flavonoid,induced rapid lysosomal enlargement accompanied with lysosomal membrane permeabilization in hematological malignancy.LW-218-induced lysosomal damage and lysosome-dependent cell death were mediated by cathepsin D,as the lysosomal damage and cell apoptosis could be suppressed by depletion of cathepsin D or lysosome alkalization agents,which can alter the activity of cathepsins.Lysophagy,was initiated for cell self-rescue after LW-218 treatment and correlated with calcium release and nuclei translocation of transcription factor EB.LW-218 treatment enhanced the expression of autophagy-related genes which could be inhibited by intracellular calcium chelator.Sustained exposure to LW-218 exhausted the lysosomal capacity so as to repress the normal autophagy.LW-218-induced enlargement and damage of lysosomes were triggered by abnormal cholesterol deposition on lysosome membrane which caused by interaction between LW-218 and NPC intracellular cholesterol transporter 1.Moreover,LW-218 inhibited the leukemia cell growth in vivo.Thus,the necessary impact of integral lysosomal function in cell rescue and death were illustrated. | Po Hu Hui Li Wenzhuo Sun Hongzheng Wang Xiaoxuan Yu Yingjie Qing Zhanyu Wang Mengyuan Zhu Jingyan Xu Qinglong Guo Hui Hui | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
| 19 | Statistical NLOS Identification Based on AOA,TOA and Signal Strength显示文摘 | Yu Kegen Guo Yingjie | 2009 | IEEE Transactions on Vehicular Technology2009，58，1： | 1 |
| 20 | Liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of cefoperazone and sulbactam in plasma and its application to a pharmacokinetic study显示文摘 | ZHOU YINGJIE ZHANG JING GUO BEINING | 2010 | Journal of Chromatography B2010，878，30： | 1 |
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