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| 1 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 2 | Integrated Chinese-western therapy versus western therapy alone on survival rate in patients with non-small-cell lung cancer at middlelate stage显示文摘OBJECTIVE: To compare the effects of integrated Chinese-Western therapy versus Western therapy alone on the survival rate of patients with non-small-cell lung cancer (NSCLC) at middle-late stage and to evaluate prognostic factors. METHODS: We selected 98 inpatients with middle-late stage NSCLC diagnosed from March 2009 to March 2011 and randomly divided them into two groups, with 49 cases in each group, and the clinical data were analyzed retrospectively.The control group was treated by the combined methods of Western Medicine, including chemotherapy, supportive treatment and symptomatic treatment. The observation group was treated by injection and prescriptions of Chinese medicine based on Traditional Chinese Medicine syndrome differentiation and by the same combined methods of western treatment used in the control group. After treatment, the survival rates of the patients were compared by the stage of cancer and evaluation of 24 prognostic factors analyzed by a Cox regressionmodel, and the clinical data were statistically analyzed. RESULTS: The survival rates of all patients were over 90.0% at 1 and 3 months after treatment with no significant differences between the two groups (P>0.05); In the observation group the survival rates at 6 months and 1 year were 93.4% and 42.8%, respectively, being superior to 85.6% and 18.3% in the control group (P<0.05). The median survival time in the observation group was superior to the control group (P<0.05); The effects of 24 prognostic factors were significantly better in the observation group than in the control group (P<0.05). CONCLUSION: Integrated Chinese-western therapy can significantly improve the survival rate in patients with middle-late stage NSCLC and improve prognostic factors compared with western therapy alone. | Guoqiang Lin Yingqiu Li Shengxi Chen Haihe Jiang | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 7 |
| 3 | ESTIMATION METHOD ON THE BATTERY STATE OF CHARGE FOR HYBRID ELECTRIC VEHICLE显示文摘A combined algorithm for battery state of charge(SOC)estimation is proposed to solve the critical issue of hybrid electric vehicle(HEV).To obtain a more accurate SOC,both coulomb-accumulation and battery resistance-capacitor(RC)model are weighted combined to compensate the deficiencies of individual methods.In order to solve the key issue of coulomb-accumulation,the battery thermal model is used.Based on the principle of energy conservation,the heat generated from battery charge and discharge process is converted into the equivalent electricity to calculate charge and discharge efficiency under variable current.The extended Kalman filter(EKF)as a closed loop algorithm is applied to estimate the parameters of resistance-capacitor model.The input variables do not increase much computing difficulty.The proposed combined algorithm is implemented by adjusting the weighting factor of coulomb- accumulation and resistance-capacitor model In the end,four different methods including Ah-efficiency,Ah-Equip,RC-SOC and Combined-SOC are compared in federal testing procedure (FTP)drive cycle.The experiment results show that the proposed method has good robustness and high accuracy which is suitable for HEV application. | QIANG Jiaxi AO Guoqiang YANG Lin | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 7 |
| 4 | Identification of hydrodynamic coefficients from experiment of vortex-induced vibration of slender riser model显示文摘One of the challenges in predicting the dynamic response of deepwater risers under vortex-induced vibration (VIV) is that it runs short of believable fluid loading model. Moreover, the hydrodynamic loading is also difficult to be measured directly in the VIV experiments without disturbing the fluid field. In the present work, by means of a finite element analysis method based on the experimental data of the response displacements, the total instantaneous distributions of hydrodynamic forces together with the hydrodynamic coefficients on the riser model with large aspect ratio (length/diameter) of 1750 are achieved. The steady current speeds considered in the experiments of this work are ranging from 0.15 m/s to 0.60 m/s, giving the Reynolds Number between 2400 and 9600. The hydrodynamic coefficients are evaluated at the fundamental frequency and in the higher order frequency components for both in-line and cross-flow directions. It is found that the Root-Mean Squared hydrodynamic forces of the higher order response frequency are larger than those of the fundamental response frequency. Negative lift or drag coefficients are found in the numerical results which is equivalent to the effect of fluid damping. | TANG GuoQiang LU Lin TENG Bin PARK HanI1 SONG JiNing ZHANG JianQiao | 2011 | Science China(Technological Sciences)2011，54，7： | 5 |
| 5 | Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation显示文摘许多干细胞人口被他们的本地微型环境(壁龛) 紧调整,它包括 stromal 房间的不同类型。然而,很少对壁龛亚群并列地由决定干细胞命运的机制被知道。这里,我们识别那 Yki,关键河马小径部件,为护卫房间(EC ) 是必要的在在果蝇卵巢支持 germline 区别的功能。我们发现那个刺猬(Hh ) 发信号首先从帽子房间发出,支持 EC 的功能肘脉 interruptus (Ci ) ,表明受动器的 Hh,禁止河马 kinase 的行为串联活动。机械学地,我们发现 Ci 竞争地与 Hpo 交往并且损害表明复杂形成的 Hpo-Wts,从而支持的 Yki 原子本地化。Ci 的行动保证发信号在 EC 反对 Sd/Tgi/Vg-mediated 缺省压抑的有效 Yki。这研究揭开解释壁龛房间的亚群怎么协调经由表明串音的 Hh 河马决定干细胞命运的机制,并且提高我们发信号的 oncogenic Yki/YAP 的机械学的规定的理解。 | Chaoyi Li Lijuan Kan Yan Chen Xiudeng Zheng Weini Li Wenxin Zhang Lei Cao Xiaohui Lin Shanming Ji Shoujun Huang Guoqiang Zhang Xiaohui Liu Yi Tao Shian Wu Dahua Chen | 2015 | Cell Research2015，25，10： | 5 |
| 6 | Diffusion mechanism simulation of cloud manufacturing complex network based on cooperative game theory显示文摘Cloud manufacturing is a specific implementation form of the 'Internet + manufacturing' strategy. Why and how to develop cloud manufacturing platform(CMP), however, remains the key concern of both platform operators and users. A microscopic model is proposed to investigate advantages and diffusion forces of CMP through exploration of its diffusion process and mechanism. Specifically, a three-stage basic evolution process of CMP is innovatively proposed. Then, based on this basic process, a more complex CMP evolution model has been established in virtue of complex network theory, with five diffusion forces identified. Thereafter, simulations on CMP diffusion have been conducted. The results indicate that, CMP possesses better resource utilization,user satisfaction, and enterprise utility. Results of simulation on impacts of different diffusion forces show that both the time required for CMP to reach an equilibrium state and the final network size are affected simultaneously by the five diffusion forces. All these analyses indicate that CMP could create an open online cooperation environment and turns out to be an effective implementation of the 'Internet + manufacturing' strategy. | GENG Chao QU Shiyou XIAO Yingying WANG Mei SHI Guoqiang LIN Tingyu XUE Junjie JIA Zhengxuan | 2018 | Journal of Systems Engineering and Electronics2018，29，2： | 4 |
| 7 | Approximate Design of Alloy Composition of Cathode Target显示文摘为在用合金目标的阴极的弧离子 plating 的作文 demixing 分析的车验式基于平均控告的状态和相对 demixing 参数的概念被建立。作文 demixing 效果的水平被一个元素的 demixingdegree 介绍。为二进制成分合金目标,在涂层的作文变化趋势被讨论,为每个元素的 demixing 度的限制是坚定的。有更高平均的控告的状态的一个元素的内容比在合金目标在涂层变得更大,在同时,有更低的平均控告的状态的一个元素的内容得到更少。为二成分中的每一个,越不在合金目标的原子百分比,越 larger 它在涂层和目标之间的内容的差别。为三倍的成分合金目标,有中等一般水准的一个元素的内容变化控告了状态详细被讨论。它在涂层变得更大或更少的内容被另外的二个元素的内容的联合结果在合金目标决定。为有在三倍的合金目标的中等平均控告的状态的元素的一个给定的内容,到合金目标的从涂层的那个元素的内容偏差水平不比包含仅仅那个元素的那个使用的二元合金目标大并且二其它之一。根据想要的涂层作文,合金目标的作文设计容易从公式被推出。 | Jun ZHANG Yu ZHANG Li LI Guoqiang LIN Chuang DONG | 2006 | Journal of Materials Science & Technology2006，22，5： | 4 |
| 8 | HIGH VOLTAGE SAFETY MANAGEMENT SYSTEM OF ELECTRIC VEHICLE显示文摘In order to improve the drivability and energy efficiency of electric vehicle (EV),more and more batteries are connected in series with high voltage which makes it necessary to monitor the electric parameters of high voltage system (HVS) to ensure the high voltage safety.A high voltage safety management system is developed to solve this critical issue.Several key electric parameters including pre-charge,contact resistance,insulation resistance and remaining capacity are monitored and analyzed based on the presented equivalent models.An electronic unit called high voltage safety controller is developed.By the help of hardware-in-loop system,the equivalent models integrated in the high voltage safety controller are validated and the on-line electric parameters monitor strategy is discussed.The real vehicle experiment results indicate that the high voltage safety management system designed is suitable for EV application. | QIANG Jiaxi AO Guoqiang YANG Lin | 2008 | Chinese Journal of Mechanical Engineering2008，21，6： | 3 |
| 9 | High-risk phenotypes of genetic disease in a Neonatal Intensive Care Unit population显示文摘To the Editor: Genetic diseases contribute to 35% of deaths during the first year of life and are a significant cause of intensive care.[1] A previous study based on the China Neonatal Genomes Project investigated the genetic causes of early infant deaths and found that >25% of deceased neonates with genetic diagnoses can be cured if diagnosed in time.[2] Therefore, it is crucial to target and diagnose neonates with genetic diseases as early as possible. According to our experience, the typical phenotypes, such as special facial features or multiple congenital anomalies (MCAs), indicate a high risk of genetic disease and lead physicians to perform genetic testing in neonates as early as possible. However, in practice, infants without typical phenotypes typically undergo a long and costly diagnostic process before genetic diagnoses are confirmed. Moreover, a recent survey by the American College of Medical Genetics and Genomics (ACMG) and other national professional organizations indicated that there are insufficient numbers of qualified geneticists to fulfil genetic service needs.[3] The ACMG published the general clinical features for genetic testing indications. For example, patients with phenotypes or family history data that strongly implicate a genetic cause may undergo genetic testing.[1] However, the study indicated that many genetic conditions arise de novo or are inherited with no family history.[1] A previous study attempted to apply the non-phenotype-driven panel approach in neonates admitted to the neonate intensive care unit (NICU).[4] However, at present, the diagnostic yield is only 3.45% (1/29).[4] In addition, the economic and ethical issues associated with genomic screening remain challenging. Therefore, the available indications for genetic testing may improve the management of genetic diseases. | Tiantian Xiao Qi Ni Huiyao Chen Huijun Wang Lin Yang Bingbing Wu Yun Cao Guoqiang Cheng Laishuan Wang Liyuan Hu Hongfang Mei Yulan Lu Mengchun Gong Xinran Dong Wenhao Zhou | 2022 | Chinese Medical Journal2022，，5： | 2 |
| 10 | A new approach to the bicyclo[3.3.1]nonane framework of huperzine A-like molecules via palladium-catalyzed intramolecular γ-arylation显示文摘In our synthetic studies toward huperzine A, a diastereoselective α′-alkylation of the α-amido-γ-methyl hexenone 4 was realized through a dianion intermediate which significantly enhanced the reactivity. Under the attempted Heck reaction conditions, an unexpected and unprecedented palladium-catalyzed intramolecular γ-arylation of 3 was observed, which generated 18 with bicyclo[3.3.1]nonane framework in satisfactory yield. | DING Rui LU YunYu YAO HeQuan SUN BingFeng LIN GuoQiang | 2012 | Science China Chemistry2012，55，6： | 2 |
| 11 | Design study for the cascaded HGHG experiment based on the SDUV-FEL显示文摘Cascading stages of high-gain harmonic generation(HGHG) free electron laser(FEL) is a promising way to produce fully coherent X-ray radiation.As a test facility for modern FEL R&D,the Shanghai deep ultraviolet FEL(SDUV-FEL) is now under upgrading for the cascading two stages of HGHG experiment.Since the energy of the electron beam is as low as about 185 MeV after upgrade,the total harmonic number of this two stages HGHG is only 2×2,and the wavelength of the final radiation is 196.5 nm which is the 4th harmonic of the 786 nm seed laser.With help of three-dimensional simulation codes,design studies on the FEL physics for the cascaded HGHG experiment are present based on the parameters of the upgraded SDUV-FEL facility.It is found from the simulation results that the part of the electron beam which has been used in the first stage can still generate powerful radiation in the radiator of the second stage,and this radiation will be difficult to be separated from the radiation generated by the fresh part of the electron beam.To overcome this problem,a novel method based on the energy spectrum of the electron beam is proposed in this paper to demonstrate the 'fresh bunch' technique. | FENG Chao ZHANG Meng LIN GuoQiang GU Qiang DENG HaiXiao CHEN JianHui WANG Dong ZHAO ZhenTang | 2012 | Chinese Science Bulletin2012，57，26： | 2 |
| 12 | Influence of Nitrogen Flow Rate on the Microstructure and Properties of N and Me (Me=Cr,Zr) Co-doped Diamond-like Carbon Films显示文摘In this paper,Me (Me=Cr,Zr) and N co-doped diamond like carbon (DLC-MeN) composite films were prepared on cemented carbide substrates by pulsed bias arc ion plating.The effect of nitrogen flow rates on the microstructure and properties of the films were investigated by X-ray photoelectron spectroscopy (XPS),Raman spectra,grazing incident X-ray diffraction (GIXRD),high resolution transmission electron microscopy (HRTEM) and nano-indentation.Raman,GIXRD and HRTEM results show that the deposited films are nanocomposite films with MeN nanocrystalline phase embedded within DLC amorphous matrix,which are vital for the mechanical properties of the films.The nitrogen flow rate has significant effect on the compositions and structures and hence on the hardness and elastic modulus of the films,and increasing nitrogen flow rate decreases drastically the hardness and elastic modulus of the films. | Zhiyun Han,Hongkai Li,Guoqiang Lin and Chuang Dong Key Laboratory for Material Modification by Laser,Ion and Electron Beams,Dalian University of Technology,Dalian 116085,China | 2010 | Journal of Materials Science & Technology2010，26，11： | 2 |
| 13 | Field study on occupants’ thermal comfort and residential thermal environment in a hot-humid climate of China显示文摘 | Jie Han Guoqiang Zhang Quan Zhang Jinwen Zhang Jianlong Liu Liwei Tian Cong Zheng Junhong Hao Jianping Lin Yanhui Liu Demetrios. J. Moschandreas | 2006 | Building and Environment2006，，12： | 1 |
| 14 | Experimental control of banana scab disease using different fungicides显示文摘 | Zeng ZhongQiang Liu GuoQiang Lin ZhiQing | 2003 | China Fruits2003，1，： | 1 |
| 15 | Synthesis of (R)-cyanohydrins by crude (R)-oxynitrilasecatalyzed reactions in microaqueous medium 显示文摘 | Han Shiqing Lin Guoqiang Li Zuyi | 1998 | Tetrahedron: Asymmetry1998，9，11： | 1 |
| 16 | Experimental investigation on heat transfer of a specific fuel (RP-3) flows through downward tubes at supercritical pressure显示文摘 | Chunben Zhang Guoqiang Xu Lin Gao Zhi Tao Hongwu Deng Kun Zhu | 2012 | The Journal of Supercritical Fluids2012，，： | 1 |
| 17 | Velocity bunching for the linac of Shanghai Deep UV FEL facility显示文摘High brightness electron beam is one of the main goals of the research and development effort in RF photo-injectors.Compared with the normally used magnetic chicane,an alternative scheme,commonly known as 'velocity bunching',has been proposed as a tool to compress electron beam pulses in modern high brightness photo-injector sources.This paper presents numerical optimization systematically and the first attempt to demonstrate the velocity bunching scheme on SDUV-FEL linac experimentally.The relationship between the degree of bunching and the off-crest phase of the accelerating structure is explored experimentally.Velocity bunching operating mode illustrates flexible performances with an intrinsic machine jitter,which agrees well with the theoretical prediction. | ZHANG Meng GU Duan GU Qiang LIN Guoqiang LAN Taihe WANG Xingtao DENG Haixiao | 2012 | Nuclear Science and Techniques2012，23，3： | 1 |
| 18 | Synthesis of (R)- cyanohydrins by crude (R)-oxynitrilasecatalyzed reactions in micro-aqueous medium显示文摘 | Shiqing Han Guoqiang Lin Zuyi Li | 1998 | Tetrahedron: Asymmetry1998，9，11： | 1 |
| 19 | Ti/TiN multilayer thin films deposited by pulse biased arc ion plating显示文摘 | Yanhui Zhao Guoqiang Lin Jinquan Xiao Hao Du Chuang Dong Lijun Gao | 2010 | Applied Surface Science2010，，7： | 1 |
| 20 | Integrating local and partial network view for routing on scale-free networks显示文摘Traditional routing schemes,such as OSPF,optimize data plane routing efciency by maintaining full view of the network at the control plane.However,maintaining full network view and handling frequent routing information updates are costly in large-scale complex networks,which are considered to be the root causes for the routing scalability issue.Recently,it is suggested that routing on local or partial information is plausible if slight performance degradation is acceptable.This paper proposes a routing scheme,operating on an integrated network view at each node that consists of its local neighborhood and a globally unique skeleton tree.This scheme signifcantly reduces storage,communication and processing costs.On scale-free networks,this beneft only comes at the cost of marginal performance degradation,which implies that it is not worthwhile to do shortest path routing based on full view of the network on scale-free networks.In contrast,the routing efciency is severely aggravated on purely random networks,indicating the inappropriateness of this scheme and the rationality of maintaining full network view on random networks. | TANG MingDong ZHANG GuoQiang SUN Yi LIU JianXun YANG Jing LIN Tao | 2013 | Science China(Information Sciences)2013，56，10： | 1 |
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